CN1742082A - 原肝干细胞和近肝干细胞 - Google Patents

原肝干细胞和近肝干细胞 Download PDF

Info

Publication number
CN1742082A
CN1742082A CNA038099896A CN03809989A CN1742082A CN 1742082 A CN1742082 A CN 1742082A CN A038099896 A CNA038099896 A CN A038099896A CN 03809989 A CN03809989 A CN 03809989A CN 1742082 A CN1742082 A CN 1742082A
Authority
CN
China
Prior art keywords
stem cells
cells
cell
liver stem
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA038099896A
Other languages
English (en)
Chinese (zh)
Inventor
洛拉·里德
尼古拉斯·G·莫斯
马克·E·福斯
约翰·W·拉德洛
安德鲁·T·布鲁斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
Original Assignee
University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, Vesta Therapeutics Inc filed Critical University of North Carolina at Chapel Hill
Publication of CN1742082A publication Critical patent/CN1742082A/zh
Granted legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNA038099896A 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞 Granted CN1742082A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410815377.2A Division CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

Publications (1)

Publication Number Publication Date
CN1742082A true CN1742082A (zh) 2006-03-01

Family

ID=28042021

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA038099896A Granted CN1742082A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN201410815377.2A Pending CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN03809989.6A Expired - Fee Related CN1742082B (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201410815377.2A Pending CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN03809989.6A Expired - Fee Related CN1742082B (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

Country Status (18)

Country Link
US (4) US7413897B2 (cg-RX-API-DMAC10.html)
EP (2) EP3023491A1 (cg-RX-API-DMAC10.html)
JP (2) JP4723811B2 (cg-RX-API-DMAC10.html)
KR (1) KR101119878B1 (cg-RX-API-DMAC10.html)
CN (3) CN1742082A (cg-RX-API-DMAC10.html)
AU (2) AU2003233399B2 (cg-RX-API-DMAC10.html)
CA (1) CA2479510C (cg-RX-API-DMAC10.html)
CY (1) CY1118167T1 (cg-RX-API-DMAC10.html)
DK (1) DK1490480T3 (cg-RX-API-DMAC10.html)
ES (1) ES2569951T3 (cg-RX-API-DMAC10.html)
HK (1) HK1209783A1 (cg-RX-API-DMAC10.html)
HU (1) HUE032238T2 (cg-RX-API-DMAC10.html)
IL (1) IL164048A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA04009031A (cg-RX-API-DMAC10.html)
PL (1) PL372619A1 (cg-RX-API-DMAC10.html)
RU (1) RU2327479C2 (cg-RX-API-DMAC10.html)
SI (1) SI1490480T1 (cg-RX-API-DMAC10.html)
WO (1) WO2003078588A2 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105264065A (zh) * 2013-03-13 2016-01-20 北卡罗来纳大学教堂山分校 通过将干细胞移植到胆管壁来治疗胰腺和肝脏病症的方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
TWI641688B (zh) * 2009-10-30 2018-11-21 北卡羅來納大學教堂山 來自肝外樹狀膽管的多潛能幹細胞及其分離方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue)
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
RU2008124158A (ru) 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
AU2006331706A1 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
MY146352A (en) * 2006-04-25 2012-08-15 Univ Louisiana State Adipose derived adult stem cells in hepatic regeneration
PT2029725T (pt) * 2006-05-26 2018-04-12 Univ North Carolina Chapel Hill Precursores de células hepáticas estreladas e métodos para isolar as mesmas
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
US8877497B2 (en) * 2008-05-22 2014-11-04 Vesta Therapeutics Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
US9341550B2 (en) * 2010-11-19 2016-05-17 On-Chip Biotechnologies Co., Ltd. Method for detecting low concentrations of specific cell from high concentrations of cell populations, and method for collecting and analyzing detected cell
CN103842497A (zh) * 2011-05-27 2014-06-04 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
WO2013084190A1 (en) * 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
EP2864472A4 (en) * 2012-06-20 2015-12-30 Celula Inc MATERIALS AND METHOD FOR PROCESSING CELL POPULATIONS
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
SG10201914005TA (en) * 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
KR102338815B1 (ko) 2013-12-16 2021-12-13 프레제니우스 메디칼 케어 도이칠란드 게엠베하 췌장섬-유사 세포 구조물 및 이의 제조 방법
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
ES3063334T3 (en) 2015-06-18 2026-04-16 Yeda Res & Dev Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2019148143A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
CA2115140A1 (en) 1991-08-07 1993-02-18 Lola M. Reid Proliferation of hepatocyte precursors
CA2177043C (en) * 1993-11-19 2011-08-09 Lola C.M. Reid Hepatoblasts and method of isolating same
ZA951199B (en) * 1994-02-14 1996-08-14 Kirin Brewery Protein having tpo activity
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
HK1038881A1 (zh) * 1998-04-17 2002-04-04 利思进药品公司 通过共同给予前列腺素抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
PE20001250A1 (es) * 1998-11-16 2000-11-21 Detroit Diesel Corp Metodo y sistema para el control de material devuelto
JP2000287680A (ja) * 1999-04-09 2000-10-17 Sentan Kagaku Gijutsu Incubation Center:Kk 未成熟肝細胞を成熟肝細胞へ分化させる方法
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
EP1325111A1 (en) * 2000-10-03 2003-07-09 University of North Carolina Processes for clonal growth of hepatic progenitor cells
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ERIC R. LEMMER等: "Isolation from human fetal liver of cells co-expressing CD34 haematopoietic stem cell and CAM 5.2 pancytokeratin markers", 《JOURNAL OF HEPATOLOGY》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI641688B (zh) * 2009-10-30 2018-11-21 北卡羅來納大學教堂山 來自肝外樹狀膽管的多潛能幹細胞及其分離方法
CN105264065A (zh) * 2013-03-13 2016-01-20 北卡罗来纳大学教堂山分校 通过将干细胞移植到胆管壁来治疗胰腺和肝脏病症的方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
US11795436B2 (en) 2015-06-12 2023-10-24 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof

Also Published As

Publication number Publication date
US8691523B2 (en) 2014-04-08
CN1742082B (zh) 2015-01-21
EP1490480A4 (en) 2006-06-14
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
EP1490480B1 (en) 2016-02-03
WO2003078588A9 (en) 2003-12-11
RU2005125598A (ru) 2006-01-27
SI1490480T1 (sl) 2016-06-30
US20070099297A1 (en) 2007-05-03
JP2005520513A (ja) 2005-07-14
AU2008202656B2 (en) 2011-03-17
CN104630129A (zh) 2015-05-20
RU2327479C2 (ru) 2008-06-27
WO2003078588A3 (en) 2004-04-01
EP1490480A2 (en) 2004-12-29
DK1490480T3 (en) 2016-04-11
ES2569951T3 (es) 2016-05-13
US20140302601A1 (en) 2014-10-09
CA2479510A1 (en) 2003-09-25
MXPA04009031A (es) 2005-12-12
AU2008202656A8 (en) 2011-12-15
KR101119878B1 (ko) 2012-03-09
JP5463271B2 (ja) 2014-04-09
AU2008202656A1 (en) 2008-07-10
US20170096641A1 (en) 2017-04-06
AU2008202656B8 (en) 2011-12-15
KR20060010693A (ko) 2006-02-02
HUE032238T2 (en) 2017-09-28
WO2003078588A2 (en) 2003-09-25
US20040018621A1 (en) 2004-01-29
IL164048A0 (en) 2005-12-18
AU2003233399A1 (en) 2003-09-29
JP4723811B2 (ja) 2011-07-13
PL372619A1 (en) 2005-07-25
EP3023491A1 (en) 2016-05-25
US7413897B2 (en) 2008-08-19
AU2003233399B2 (en) 2008-03-20
CA2479510C (en) 2019-10-29
HK1209783A1 (en) 2016-04-08

Similar Documents

Publication Publication Date Title
CN1742082B (zh) 原肝干细胞和近肝干细胞
Nagai et al. Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cells
Brill et al. Hepatic progenitor populations in embryonic, neonatal, and adult liver
JP5254221B2 (ja) 肝星細胞前駆細胞及びその細胞を単離する方法
CN1461341A (zh) 肝祖先细胞克隆生长的方法
Tsuchiya et al. Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system
CN1258589C (zh) 分离双能肝祖细胞的方法
CN101037669A (zh) 一种从人胚胎干细胞诱导肝细胞的方法
HK1225070A (en) Primitive and proximal hepatic stem cells
HK1225070A1 (en) Primitive and proximal hepatic stem cells
WO2006128681A1 (en) Primitive endodermal stem cells, a process for preparing them and their use, in particular for obtaining primitive epithelial liver cells

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150121

Termination date: 20210314