AU2003233399B2 - Primitive and proximal hepatic stem cells - Google Patents

Primitive and proximal hepatic stem cells Download PDF

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Publication number
AU2003233399B2
AU2003233399B2 AU2003233399A AU2003233399A AU2003233399B2 AU 2003233399 B2 AU2003233399 B2 AU 2003233399B2 AU 2003233399 A AU2003233399 A AU 2003233399A AU 2003233399 A AU2003233399 A AU 2003233399A AU 2003233399 B2 AU2003233399 B2 AU 2003233399B2
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Australia
Prior art keywords
cells
cell
liver
hepatic
stem cells
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Ceased
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AU2003233399A
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AU2003233399A1 (en
Inventor
Andrew T. Bruce
Mark E. Furth
John W. Ludlow
Nicholas G. Moss
Lola Reid
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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Priority to AU2008202656A priority Critical patent/AU2008202656B8/en
Assigned to UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, VESTA THERAPEUTICS, INC. reassignment UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Request for Assignment Assignors: INCARA CELL TECHNOLOGIES, INC., UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2003233399A 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells Ceased AU2003233399B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008202656A AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15
PCT/US2003/007852 WO2003078588A2 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008202656A Division AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Publications (2)

Publication Number Publication Date
AU2003233399A1 AU2003233399A1 (en) 2003-09-29
AU2003233399B2 true AU2003233399B2 (en) 2008-03-20

Family

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Application Number Title Priority Date Filing Date
AU2003233399A Ceased AU2003233399B2 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells
AU2008202656A Ceased AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2008202656A Ceased AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Country Status (18)

Country Link
US (4) US7413897B2 (cg-RX-API-DMAC10.html)
EP (2) EP3023491A1 (cg-RX-API-DMAC10.html)
JP (2) JP4723811B2 (cg-RX-API-DMAC10.html)
KR (1) KR101119878B1 (cg-RX-API-DMAC10.html)
CN (3) CN1742082A (cg-RX-API-DMAC10.html)
AU (2) AU2003233399B2 (cg-RX-API-DMAC10.html)
CA (1) CA2479510C (cg-RX-API-DMAC10.html)
CY (1) CY1118167T1 (cg-RX-API-DMAC10.html)
DK (1) DK1490480T3 (cg-RX-API-DMAC10.html)
ES (1) ES2569951T3 (cg-RX-API-DMAC10.html)
HK (1) HK1209783A1 (cg-RX-API-DMAC10.html)
HU (1) HUE032238T2 (cg-RX-API-DMAC10.html)
IL (1) IL164048A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA04009031A (cg-RX-API-DMAC10.html)
PL (1) PL372619A1 (cg-RX-API-DMAC10.html)
RU (1) RU2327479C2 (cg-RX-API-DMAC10.html)
SI (1) SI1490480T1 (cg-RX-API-DMAC10.html)
WO (1) WO2003078588A2 (cg-RX-API-DMAC10.html)

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HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
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US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
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RU2008124158A (ru) 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
AU2006331706A1 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
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PT2029725T (pt) * 2006-05-26 2018-04-12 Univ North Carolina Chapel Hill Precursores de células hepáticas estreladas e métodos para isolar as mesmas
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CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
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ES2819028T3 (es) * 2009-10-30 2021-04-14 Univ North Carolina Chapel Hill Células madre multipotentes del árbol biliar extrahepático y métodos para su aislamiento
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CN103842497A (zh) * 2011-05-27 2014-06-04 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
WO2013084190A1 (en) * 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
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JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG10201914005TA (en) * 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
KR102338815B1 (ko) 2013-12-16 2021-12-13 프레제니우스 메디칼 케어 도이칠란드 게엠베하 췌장섬-유사 세포 구조물 및 이의 제조 방법
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
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US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
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US8691523B2 (en) 2014-04-08
CN1742082B (zh) 2015-01-21
EP1490480A4 (en) 2006-06-14
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
EP1490480B1 (en) 2016-02-03
WO2003078588A9 (en) 2003-12-11
RU2005125598A (ru) 2006-01-27
SI1490480T1 (sl) 2016-06-30
US20070099297A1 (en) 2007-05-03
JP2005520513A (ja) 2005-07-14
AU2008202656B2 (en) 2011-03-17
CN104630129A (zh) 2015-05-20
RU2327479C2 (ru) 2008-06-27
WO2003078588A3 (en) 2004-04-01
EP1490480A2 (en) 2004-12-29
DK1490480T3 (en) 2016-04-11
ES2569951T3 (es) 2016-05-13
US20140302601A1 (en) 2014-10-09
CA2479510A1 (en) 2003-09-25
MXPA04009031A (es) 2005-12-12
AU2008202656A8 (en) 2011-12-15
KR101119878B1 (ko) 2012-03-09
JP5463271B2 (ja) 2014-04-09
AU2008202656A1 (en) 2008-07-10
US20170096641A1 (en) 2017-04-06
AU2008202656B8 (en) 2011-12-15
KR20060010693A (ko) 2006-02-02
CN1742082A (zh) 2006-03-01
HUE032238T2 (en) 2017-09-28
WO2003078588A2 (en) 2003-09-25
US20040018621A1 (en) 2004-01-29
IL164048A0 (en) 2005-12-18
AU2003233399A1 (en) 2003-09-29
JP4723811B2 (ja) 2011-07-13
PL372619A1 (en) 2005-07-25
EP3023491A1 (en) 2016-05-25
US7413897B2 (en) 2008-08-19
CA2479510C (en) 2019-10-29
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