RU2327479C2 - Примитивные и проксимальные печеночные стволовые клетки - Google Patents

Примитивные и проксимальные печеночные стволовые клетки Download PDF

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RU2327479C2
RU2327479C2 RU2005125598/15A RU2005125598A RU2327479C2 RU 2327479 C2 RU2327479 C2 RU 2327479C2 RU 2005125598/15 A RU2005125598/15 A RU 2005125598/15A RU 2005125598 A RU2005125598 A RU 2005125598A RU 2327479 C2 RU2327479 C2 RU 2327479C2
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cells
stem cells
precursors
hepatic stem
primitive
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RU2005125598/15A
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RU2005125598A (ru
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Лола РЕЙД (US)
Лола РЕЙД
Николас Дж. МОСС (US)
Николас Дж. МОСС
Марк Э. ФЁРТ (US)
Марк Э. ФЁРТ
Джон В. ЛАДЛОУ (US)
Джон В. ЛАДЛОУ
Эндрю Т. БРЮС (US)
Эндрю Т. БРЮС
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Юниверсити Оф Норт Каролина Эт Чепел Хилл
Веста Терапьютикс, Инк.
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
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    • C12N2500/20—Transition metals
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    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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RU2005125598/15A 2002-03-15 2003-03-14 Примитивные и проксимальные печеночные стволовые клетки RU2327479C2 (ru)

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US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15

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RU2327479C2 true RU2327479C2 (ru) 2008-06-27

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US (4) US7413897B2 (cg-RX-API-DMAC10.html)
EP (2) EP3023491A1 (cg-RX-API-DMAC10.html)
JP (2) JP4723811B2 (cg-RX-API-DMAC10.html)
KR (1) KR101119878B1 (cg-RX-API-DMAC10.html)
CN (3) CN1742082A (cg-RX-API-DMAC10.html)
AU (2) AU2003233399B2 (cg-RX-API-DMAC10.html)
CA (1) CA2479510C (cg-RX-API-DMAC10.html)
CY (1) CY1118167T1 (cg-RX-API-DMAC10.html)
DK (1) DK1490480T3 (cg-RX-API-DMAC10.html)
ES (1) ES2569951T3 (cg-RX-API-DMAC10.html)
HK (1) HK1209783A1 (cg-RX-API-DMAC10.html)
HU (1) HUE032238T2 (cg-RX-API-DMAC10.html)
IL (1) IL164048A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA04009031A (cg-RX-API-DMAC10.html)
PL (1) PL372619A1 (cg-RX-API-DMAC10.html)
RU (1) RU2327479C2 (cg-RX-API-DMAC10.html)
SI (1) SI1490480T1 (cg-RX-API-DMAC10.html)
WO (1) WO2003078588A2 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013192342A1 (en) * 2012-06-20 2013-12-27 Celula, Inc. Materials and methods for processing cell populations
RU2580246C2 (ru) * 2009-10-30 2016-04-10 Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл Мультипотентные стволовые клетки внепеченочных желчных путей и способы их выделения
RU2620947C2 (ru) * 2011-05-27 2017-05-30 ДЕПУИ СИНТЕЗ ПРОДАКТС, ЭлЭлСи Биосинтетические системы проксимального канальца и способы использования

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue)
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
RU2008124158A (ru) 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
AU2006331706A1 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
MY146352A (en) * 2006-04-25 2012-08-15 Univ Louisiana State Adipose derived adult stem cells in hepatic regeneration
PT2029725T (pt) * 2006-05-26 2018-04-12 Univ North Carolina Chapel Hill Precursores de células hepáticas estreladas e métodos para isolar as mesmas
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
US8877497B2 (en) * 2008-05-22 2014-11-04 Vesta Therapeutics Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
US9341550B2 (en) * 2010-11-19 2016-05-17 On-Chip Biotechnologies Co., Ltd. Method for detecting low concentrations of specific cell from high concentrations of cell populations, and method for collecting and analyzing detected cell
WO2013084190A1 (en) * 2011-12-08 2013-06-13 Yeda Research And Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG10201914005TA (en) * 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
KR102338815B1 (ko) 2013-12-16 2021-12-13 프레제니우스 메디칼 케어 도이칠란드 게엠베하 췌장섬-유사 세포 구조물 및 이의 제조 방법
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
US10683484B2 (en) * 2015-06-12 2020-06-16 National University Of Singapore Derivation of hepatic stem cells and mature liver cell types and uses thereof
ES3063334T3 (en) 2015-06-18 2026-04-16 Yeda Res & Dev Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2019148143A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576207A (en) * 1991-08-07 1996-11-19 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of expanding hepatic precursor cells
RU2194074C2 (ru) * 1994-02-14 2002-12-10 Кирин Брюэри Компани, Лимитед Полипептид тромбопоэтин (тро), днк, кодирующая полипептид тро (варианты), способ получения полипептида (варианты), фармацевтическая композиция, способ лечения (варианты), антитело к полипептиду тро

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
CA2177043C (en) * 1993-11-19 2011-08-09 Lola C.M. Reid Hepatoblasts and method of isolating same
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
HK1038881A1 (zh) * 1998-04-17 2002-04-04 利思进药品公司 通过共同给予前列腺素抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
PE20001250A1 (es) * 1998-11-16 2000-11-21 Detroit Diesel Corp Metodo y sistema para el control de material devuelto
JP2000287680A (ja) * 1999-04-09 2000-10-17 Sentan Kagaku Gijutsu Incubation Center:Kk 未成熟肝細胞を成熟肝細胞へ分化させる方法
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
EP1325111A1 (en) * 2000-10-03 2003-07-09 University of North Carolina Processes for clonal growth of hepatic progenitor cells
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576207A (en) * 1991-08-07 1996-11-19 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of expanding hepatic precursor cells
US5789246A (en) * 1991-08-07 1998-08-04 Albert Einstein College Of Medicine Compositions comprising hepatocyte precursors
RU2194074C2 (ru) * 1994-02-14 2002-12-10 Кирин Брюэри Компани, Лимитед Полипептид тромбопоэтин (тро), днк, кодирующая полипептид тро (варианты), способ получения полипептида (варианты), фармацевтическая композиция, способ лечения (варианты), антитело к полипептиду тро

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE BOER et al. Expression of Ер-САМ in Normal, Regenerating, Metaplastic and Neoplstic Liver., Journal of Pathology, 1999, v.188, n 2, p.201-206. LEMMER et al., Isolation from Human Fetal of Cells Co-Expressing CD34. Hematopoetic Stem Cell and CAM 5.2 Pancytokeratin Markers, Journal of Hepatology, 1998, v.29, n 3, p.450-454. ROSKAMS et al., Hepatic OV-6 Expression in Human Liver. Disease and Rat Experiments, Journal of Hepatology, 1998, v.29, n 3, p.455-463. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2580246C2 (ru) * 2009-10-30 2016-04-10 Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл Мультипотентные стволовые клетки внепеченочных желчных путей и способы их выделения
RU2756584C2 (ru) * 2009-10-30 2021-10-01 Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл Мультипотентные стволовые клетки внепечёночных желчных путей и способы их выделения
RU2620947C2 (ru) * 2011-05-27 2017-05-30 ДЕПУИ СИНТЕЗ ПРОДАКТС, ЭлЭлСи Биосинтетические системы проксимального канальца и способы использования
WO2013192342A1 (en) * 2012-06-20 2013-12-27 Celula, Inc. Materials and methods for processing cell populations

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US8691523B2 (en) 2014-04-08
CN1742082B (zh) 2015-01-21
EP1490480A4 (en) 2006-06-14
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
EP1490480B1 (en) 2016-02-03
WO2003078588A9 (en) 2003-12-11
RU2005125598A (ru) 2006-01-27
SI1490480T1 (sl) 2016-06-30
US20070099297A1 (en) 2007-05-03
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