CN1731995A - 用于经皮给药d2促进素碱的器具 - Google Patents
用于经皮给药d2促进素碱的器具 Download PDFInfo
- Publication number
- CN1731995A CN1731995A CNA2003801080893A CN200380108089A CN1731995A CN 1731995 A CN1731995 A CN 1731995A CN A2003801080893 A CNA2003801080893 A CN A2003801080893A CN 200380108089 A CN200380108089 A CN 200380108089A CN 1731995 A CN1731995 A CN 1731995A
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- Prior art keywords
- augmentor
- substrate
- matrix polymer
- silicone
- mentioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
批料号 | 生产条件 | 活性成分浓度 | 基质重量(g/m2) | 透过人体皮肤的累计通量μg/cm2/72h | 透过小鼠皮肤的累计通量μg/cm2/72h |
20204071 | 经回火的95℃,75分钟 | 8.87重量% | 129 | 850 | 1030 |
20107012 | 溶剂法1 | 9重量% | 110 | n.b. | 1080 |
WE11682 | 溶剂法1 | 9重量% | 50 | 900 | n.b. |
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2002161696 DE10261696A1 (de) | 2002-12-30 | 2002-12-30 | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE10261696.5 | 2002-12-30 | ||
PCT/EP2003/014902 WO2004058247A1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1731995A true CN1731995A (zh) | 2006-02-08 |
CN1731995B CN1731995B (zh) | 2010-05-26 |
Family
ID=32519524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2003801080893A Expired - Fee Related CN1731995B (zh) | 2002-12-30 | 2003-12-24 | 用于经皮给药d2促进素碱的器具 |
Country Status (22)
Country | Link |
---|---|
US (2) | US20050175678A1 (zh) |
EP (1) | EP1490052B1 (zh) |
JP (1) | JP5134187B2 (zh) |
KR (1) | KR100875532B1 (zh) |
CN (1) | CN1731995B (zh) |
AT (1) | ATE363274T1 (zh) |
AU (1) | AU2003294007B2 (zh) |
BR (1) | BR0311637A (zh) |
CA (1) | CA2485656C (zh) |
CY (1) | CY1108084T1 (zh) |
DE (2) | DE10261696A1 (zh) |
DK (1) | DK1490052T3 (zh) |
ES (1) | ES2285234T3 (zh) |
HK (1) | HK1088227A1 (zh) |
IL (1) | IL165131A (zh) |
MX (1) | MXPA04012151A (zh) |
NO (1) | NO335200B1 (zh) |
PL (1) | PL215307B1 (zh) |
PT (1) | PT1490052E (zh) |
RU (1) | RU2340339C2 (zh) |
WO (1) | WO2004058247A1 (zh) |
ZA (1) | ZA200408523B (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009006787A1 (fr) * | 2007-07-06 | 2009-01-15 | Beijing Kangbeide Pharmaceutical Technology Development Co., Ltd. | Composition comprenant de la rotigotine, son utilisation et timbre transdermique comprenant la composition |
CN102770128A (zh) * | 2009-11-12 | 2012-11-07 | Lts勒曼治疗系统股份公司 | 防止药物在聚合物薄膜中结晶的方法 |
CN103027903A (zh) * | 2011-09-29 | 2013-04-10 | 日东电工株式会社 | 贴剂的制造方法 |
US8592477B2 (en) | 2007-11-28 | 2013-11-26 | Ucb Pharma Gmbh | Polymorphic form of rotigotine and process for production |
CN103919755A (zh) * | 2013-01-15 | 2014-07-16 | 江苏康倍得药业有限公司 | 妥洛特罗透皮贴剂及其制备方法 |
CN104138366A (zh) * | 2013-06-28 | 2014-11-12 | 久光制药株式会社 | 贴附剂的制造方法、贴附剂及包装体 |
CN104144683A (zh) * | 2011-12-30 | 2014-11-12 | 优时比制药有限公司 | 低自结晶倾向的透皮治疗系统 |
CN106074455A (zh) * | 2007-03-16 | 2016-11-09 | 迈兰技术公司 | 无定形药物透皮系统、制备方法和稳定化 |
TWI576245B (zh) * | 2010-09-06 | 2017-04-01 | 拜耳知識產權公司 | 具抑制結晶保護膜(離型襯墊)之經皮治療系統 |
CN106604748A (zh) * | 2014-05-21 | 2017-04-26 | Sk化学株式会社 | 具有改进的稳定性的含有罗替戈汀的经皮吸收制剂 |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
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DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
DK1426049T3 (da) * | 2002-12-02 | 2005-08-22 | Sanol Arznei Schwarz Gmbh | Iontophoretisk tilförsel af rotigotin til behandling af Parkinsons sygdom |
DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
EP1594483B1 (de) | 2003-02-21 | 2006-07-19 | Schering AG | Uv-stabiles transdermales pflaster |
DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
US8668925B2 (en) * | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
DE10359528A1 (de) | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
JP2008514376A (ja) * | 2004-09-29 | 2008-05-08 | シュウォーツ ファーマ インコーポレイテッド | パーキンソン病のための経皮治療システム |
US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
JP2007284370A (ja) * | 2006-04-14 | 2007-11-01 | Alcare Co Ltd | 体表面用貼付材 |
TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途 |
DE102006054732B4 (de) * | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
EP1987815A1 (en) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
KR20100022081A (ko) * | 2007-05-30 | 2010-02-26 | 케마지스 리미티드 | 결정성 로티고틴 염기 및 이의 제조 방법 |
US20090202647A1 (en) * | 2008-02-11 | 2009-08-13 | Mayur Devjibhai Khunt | Solid form of racemic rotigotine |
DE102008013123A1 (de) | 2008-03-07 | 2009-09-10 | GM Global Technology Operations, Inc., Detroit | Kopfstütze für einen Kraftfahrzeugsitz mit einem Kleiderbügel |
BRPI0913214B1 (pt) * | 2008-05-30 | 2022-05-17 | Mylan Laboratories Inc | Dispositivo de fornecimento de drogas transdérmico e método de fabricação do mesmo |
CA2739380C (en) * | 2008-10-06 | 2014-12-09 | Mylan Technologies, Inc. | Amorphous rotigotine transdermal system |
DE102008060203A1 (de) | 2008-12-07 | 2010-06-10 | Dietrich Wilhelm Schacht | Wirkstoffstabilisierende flächenförmige Vorrichtung |
EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
EP2490673A2 (en) | 2009-10-19 | 2012-08-29 | Actavis Group Ptc Ehf | Amorphous rotigotine co-precipitates |
SI2515887T1 (sl) | 2009-12-22 | 2018-10-30 | Ucb Biopharma Sprl | Polivinilpirolidon za stabilizacijo trdne disperzije nekristalinične oblike rotigotina |
JP5766475B2 (ja) | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
LT2613772T (lt) | 2010-09-06 | 2017-03-27 | Bayer Intellectual Property Gmbh | Mažos dozės transderminiai pleistrai, pasižymintys aktyviu vaisto atpalaidavimu |
EP2457565A1 (de) | 2010-11-29 | 2012-05-30 | Ratiopharm GmbH | Transdermales therapeutisches System enthaltend Rotigotin |
WO2012074988A1 (en) * | 2010-12-02 | 2012-06-07 | Ratiopharm Gmbh | Rotigotine ionic liquid |
WO2012165254A1 (ja) | 2011-05-31 | 2012-12-06 | 久光製薬株式会社 | ロピニロール含有貼付剤及びその包装体 |
WO2012165253A1 (ja) | 2011-05-31 | 2012-12-06 | 久光製薬株式会社 | ロピニロール含有貼付剤及びその包装体 |
WO2013075823A1 (en) * | 2011-11-22 | 2013-05-30 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermal therapeutic system comprising rotigotine and crystallization inhibitor |
DE102011119043A1 (de) | 2011-11-22 | 2013-05-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TDS) mit Rotigotin |
TW201431570A (zh) * | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
WO2014198422A1 (de) * | 2013-06-14 | 2014-12-18 | Tesa Labtec Gmbh | Transdermales therapiesystem (tts) mit rotigotin |
US20160199316A1 (en) * | 2013-06-14 | 2016-07-14 | Tesa Labtec Gmbh | Three-layer transdermal therapy system (tts) |
CA2916183C (en) | 2013-07-03 | 2022-03-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with electronic component |
CA2948220C (en) | 2014-05-20 | 2023-06-20 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system containing rotigotine |
CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
EP4238580A3 (en) | 2014-05-20 | 2023-10-25 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system including an interface mediator |
DE102018120506A1 (de) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Stabilisiertes transdermales Darreichungssystem |
KR102363218B1 (ko) | 2017-12-19 | 2022-02-14 | 히사미쓰 세이야꾸 가부시키가이샤 | 로티고틴 함유 첩부제 |
WO2019234662A1 (en) * | 2018-06-07 | 2019-12-12 | Nal Pharmaceutical Group Limited | Transdermal drug delivery system containing rotigotine |
KR20210104101A (ko) | 2019-02-15 | 2021-08-24 | 히사미쓰 세이야꾸 가부시키가이샤 | 로티고틴 안정화 방법 |
EP3854388B1 (de) | 2020-01-24 | 2023-10-04 | Luye Pharma Switzerland AG | Transdermales therapeutisches system mit dem wirkstoff rotigotin und mindestens einem nicht aminresistenten silikonkleber |
CN112076177B (zh) * | 2020-10-28 | 2021-08-31 | 江苏集萃新型药物制剂技术研究所有限公司 | 一种口腔粘膜给药系统 |
KR102363479B1 (ko) | 2021-03-12 | 2022-02-15 | 환인제약 주식회사 | 로티고틴 함유 경피 흡수 제제 |
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2002
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2003
- 2003-12-24 PL PL378243A patent/PL215307B1/pl unknown
- 2003-12-24 AT AT03789421T patent/ATE363274T1/de active
- 2003-12-24 DK DK03789421T patent/DK1490052T3/da active
- 2003-12-24 WO PCT/EP2003/014902 patent/WO2004058247A1/de active IP Right Grant
- 2003-12-24 AU AU2003294007A patent/AU2003294007B2/en not_active Ceased
- 2003-12-24 PT PT03789421T patent/PT1490052E/pt unknown
- 2003-12-24 EP EP03789421A patent/EP1490052B1/de not_active Expired - Lifetime
- 2003-12-24 US US10/517,157 patent/US20050175678A1/en not_active Abandoned
- 2003-12-24 CA CA002485656A patent/CA2485656C/en not_active Expired - Fee Related
- 2003-12-24 DE DE50307373T patent/DE50307373D1/de not_active Expired - Lifetime
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WO2009006787A1 (fr) * | 2007-07-06 | 2009-01-15 | Beijing Kangbeide Pharmaceutical Technology Development Co., Ltd. | Composition comprenant de la rotigotine, son utilisation et timbre transdermique comprenant la composition |
US9265752B2 (en) | 2007-07-06 | 2016-02-23 | Jiangsu Kangbeide Pharmaceuticals Co. Ltd. | Transdermal patch containing Rotigotine |
US8592477B2 (en) | 2007-11-28 | 2013-11-26 | Ucb Pharma Gmbh | Polymorphic form of rotigotine and process for production |
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CN103027903A (zh) * | 2011-09-29 | 2013-04-10 | 日东电工株式会社 | 贴剂的制造方法 |
CN104144683A (zh) * | 2011-12-30 | 2014-11-12 | 优时比制药有限公司 | 低自结晶倾向的透皮治疗系统 |
CN103919755A (zh) * | 2013-01-15 | 2014-07-16 | 江苏康倍得药业有限公司 | 妥洛特罗透皮贴剂及其制备方法 |
CN104138366A (zh) * | 2013-06-28 | 2014-11-12 | 久光制药株式会社 | 贴附剂的制造方法、贴附剂及包装体 |
CN106604748A (zh) * | 2014-05-21 | 2017-04-26 | Sk化学株式会社 | 具有改进的稳定性的含有罗替戈汀的经皮吸收制剂 |
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