CN1694868A - 用于调节IgE和抑制细胞增殖的苯基－吲哚化合物 - Google Patents

用于调节IgE和抑制细胞增殖的苯基－吲哚化合物 Download PDF

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Publication number
CN1694868A
CN1694868A CNA038250829A CN03825082A CN1694868A CN 1694868 A CN1694868 A CN 1694868A CN A038250829 A CNA038250829 A CN A038250829A CN 03825082 A CN03825082 A CN 03825082A CN 1694868 A CN1694868 A CN 1694868A
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China
Prior art keywords
substituted
group
alkyl
heteroaryl
general formula
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Pending
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CNA038250829A
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English (en)
Chinese (zh)
Inventor
伽各蒂施·C·索卡
贾拉尔·罗姆斯
马克·L·理查德斯
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Avanir Pharmaceuticals Inc
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Avanir Pharmaceuticals Inc
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Publication of CN1694868A publication Critical patent/CN1694868A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA038250829A 2002-09-12 2003-09-12 用于调节IgE和抑制细胞增殖的苯基－吲哚化合物 Pending CN1694868A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41077702P 2002-09-12 2002-09-12
US60/410,777 2002-09-12

Publications (1)

Publication Number Publication Date
CN1694868A true CN1694868A (zh) 2005-11-09

Family

ID=31994205

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038250829A Pending CN1694868A (zh) 2002-09-12 2003-09-12 用于调节IgE和抑制细胞增殖的苯基－吲哚化合物

Country Status (16)

Country Link
US (1) US7375118B2 (enExample)
EP (1) EP1537079A4 (enExample)
JP (1) JP2006512293A (enExample)
KR (1) KR20050051658A (enExample)
CN (1) CN1694868A (enExample)
AR (1) AR041251A1 (enExample)
AU (2) AU2003270426A1 (enExample)
BR (1) BR0314223A (enExample)
CA (1) CA2498493A1 (enExample)
MX (1) MXJL05000009A (enExample)
PE (1) PE20050035A1 (enExample)
PL (1) PL375812A1 (enExample)
RU (1) RU2005109912A (enExample)
TW (1) TW200407303A (enExample)
WO (2) WO2004024655A2 (enExample)
ZA (1) ZA200502739B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755461A (zh) * 2012-10-17 2015-07-01 霍夫曼-拉罗奇有限公司 作为trp通道拮抗剂的6-氨基吲哚衍生物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755461A (zh) * 2012-10-17 2015-07-01 霍夫曼-拉罗奇有限公司 作为trp通道拮抗剂的6-氨基吲哚衍生物

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AU2003277152A1 (en) 2004-04-30
CA2498493A1 (en) 2004-03-25
WO2004024655A2 (en) 2004-03-25
PE20050035A1 (es) 2005-01-24
JP2006512293A (ja) 2006-04-13
RU2005109912A (ru) 2006-04-27
EP1537079A4 (en) 2007-05-16
WO2004024896A2 (en) 2004-03-25
BR0314223A (pt) 2005-07-26
US7375118B2 (en) 2008-05-20
AR041251A1 (es) 2005-05-11
MXJL05000009A (es) 2005-06-07
PL375812A1 (en) 2005-12-12
KR20050051658A (ko) 2005-06-01
ZA200502739B (en) 2005-10-13
WO2004024896A3 (en) 2004-06-24
EP1537079A2 (en) 2005-06-08
TW200407303A (en) 2004-05-16
US20040180946A1 (en) 2004-09-16
AU2003270426A1 (en) 2004-04-30

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