AR041251A1 - Compuestos de fenilindol para modular la ige e inhibir la proliferacion celular - Google Patents

Compuestos de fenilindol para modular la ige e inhibir la proliferacion celular

Info

Publication number
AR041251A1
AR041251A1 ARP030103320A ARP030103320A AR041251A1 AR 041251 A1 AR041251 A1 AR 041251A1 AR P030103320 A ARP030103320 A AR P030103320A AR P030103320 A ARP030103320 A AR P030103320A AR 041251 A1 AR041251 A1 AR 041251A1
Authority
AR
Argentina
Prior art keywords
substituted
group
alkyl
heteroaryl
naphthyl
Prior art date
Application number
ARP030103320A
Other languages
English (en)
Inventor
Jagadish C Sircar
Jailall Rammauth
Mark Richards
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of AR041251A1 publication Critical patent/AR041251A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicación 1: Una composición farmacéutica para tratar o prevenir reacciones alérgicas asociadas con niveles elevados de IgE, inhibir la proliferación celular, y/o inhibir las citocinas o leucocitos en mamíferos incluyendo uno o más de loscompuestos de fórmula (1) a (8); donde R se selecciona del grupo formado por H, alquil C1-5, benzil, p-fluorobenzil y di-alquilamino alquil, donde el alquil C1-5 se selecciona del grupo que consiste en un alquil de cadena recta, ramificada ocíclico; donde R1 y R2 son independientemente seleccionados del grupo formado por H, alquil, alquil sustituido, cicloalquil C3-9, cicloalquil C3-9 sustituido, policíclico grupos alifáticos, fenil, fenil sustituido, naftil, naftil sustituido,heteroaril y heteroaril sustituido, donde el heteroaril y el heteroaril sustituido contienen de 1-3 heteroátomos, que se seleccionan independientemente del grupo de nitrógeno, oxígeno y azufre; donde el fenil sustituido, naftil sustituido yheteroaril sustituido contienen de 1-3 sustituidos, que se seleccionan del grupo formado por H, halógenos, polihalógenos, grupo alcoxil, alcoxil sustituido, alquil, alquil sustituido, dialquilaminoalquil, hidroxialquil, OH, OCH3, COOH, COOR', COR',CN, CF3, OCF3, NO2, NR'R', NHCOR' y CONR'R'; donde R' se selecciona del grupo formado por H, alquil, alquil sustituido, cicloalquil C3-9, cicloalquil C3-9 sustituido, alifáticos policíclicos, fenil, fenil sustituido, naftil, naftil sustituido,heteroaril y heteroaril sustituido, donde el heteroaril y el heteroaril sustituido contienen de 1-3 heteroátomos, que se seleccionan independientemente del grupo de nitrógeno, oxígeno y azufre; y donde R'' es un alquil C1-8, que se selecciona delgrupo que consiste en un alquil de cadena recta, ramificada o cíclica. Reivindicación 2: El compuesto de la reivindicación 1, donde el grupo alifático policíclico se selecciona del grupo que consiste en adamantil, bicicloheptil, canforil,biciclo[2,2,2]octanil y norbornil. Reivindicación 3: El compuesto de la reivindicación 1, donde el heteroaril y el heteroaril sustituido se seleccionan del grupo que consiste en piridinas, tiazol, isotiazol, oxazol, pirimidinas, pirazinas, furanos,tiofenos, isoxazol, pirroles, piridazinas, 1,2,3-triazinas, 1,2,4-triazinas, 1,3,5-triazinas, pirazoles, imidazoles, indoles, quinolinas, isoquinolinas, benzotiofinas, benzofuranos, paratiazinas, piranos, cromenes, pirrolidinas, pirazolidinas,imidazolidinas, morfolinas, tiomorfolinas, y los heterocíclicos correspondientes.
ARP030103320A 2002-09-12 2003-09-12 Compuestos de fenilindol para modular la ige e inhibir la proliferacion celular AR041251A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41077702P 2002-09-12 2002-09-12

Publications (1)

Publication Number Publication Date
AR041251A1 true AR041251A1 (es) 2005-05-11

Family

ID=31994205

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103320A AR041251A1 (es) 2002-09-12 2003-09-12 Compuestos de fenilindol para modular la ige e inhibir la proliferacion celular

Country Status (16)

Country Link
US (1) US7375118B2 (es)
EP (1) EP1537079A4 (es)
JP (1) JP2006512293A (es)
KR (1) KR20050051658A (es)
CN (1) CN1694868A (es)
AR (1) AR041251A1 (es)
AU (2) AU2003270426A1 (es)
BR (1) BR0314223A (es)
CA (1) CA2498493A1 (es)
MX (1) MXJL05000009A (es)
PE (1) PE20050035A1 (es)
PL (1) PL375812A1 (es)
RU (1) RU2005109912A (es)
TW (1) TW200407303A (es)
WO (2) WO2004024655A2 (es)
ZA (1) ZA200502739B (es)

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Publication number Publication date
AU2003270426A1 (en) 2004-04-30
ZA200502739B (en) 2005-10-13
WO2004024655A2 (en) 2004-03-25
WO2004024896A2 (en) 2004-03-25
CN1694868A (zh) 2005-11-09
PL375812A1 (en) 2005-12-12
MXJL05000009A (es) 2005-06-07
US20040180946A1 (en) 2004-09-16
CA2498493A1 (en) 2004-03-25
RU2005109912A (ru) 2006-04-27
JP2006512293A (ja) 2006-04-13
WO2004024896A3 (en) 2004-06-24
EP1537079A4 (en) 2007-05-16
AU2003277152A1 (en) 2004-04-30
TW200407303A (en) 2004-05-16
US7375118B2 (en) 2008-05-20
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PE20050035A1 (es) 2005-01-24
BR0314223A (pt) 2005-07-26

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