AR045886A1 - Derivados de imidazol para el tratamiento de trastornos alergicos e hiperproliferativos - Google Patents
Derivados de imidazol para el tratamiento de trastornos alergicos e hiperproliferativosInfo
- Publication number
- AR045886A1 AR045886A1 ARP040101207A ARP040101207A AR045886A1 AR 045886 A1 AR045886 A1 AR 045886A1 AR P040101207 A ARP040101207 A AR P040101207A AR P040101207 A ARP040101207 A AR P040101207A AR 045886 A1 AR045886 A1 AR 045886A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- group
- heterocycle
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Las realizaciones preferidas son pequenas moléculas inhibidoras de la respuesta de la IgE a alérgenos, que son útiles en el tratamiento de las alergias y/o el asma o cualquier enfermedad donde la IgE sea patogénica. Las realizaciones preferidas también se relacionan con moléculas de imidazol que son inhibidores de la proliferación celular y por lo tanto son útiles como agentes anticancerígeno. Las realizaciones preferidas además se relacionan con pequenas moléculas las cuales suprimen las citoquinas y los leucocitos. Reivindicación 1: Una composición farmacéutica para tratar o prevenir una reacción alérgica asociada con niveles incrementados de IgE o para inhibir la proliferación celular en un mamífero que comprende uno o más de cualquiera del resto de grupo de fórmulas (1), donde R se selecciona entre el grupo que consiste en H, alquilo C1-5, bencilo, p-fluorobencilo, y dialquilaminoalquilo, donde dicho alquilo C1-5 se selecciona entre el grupo que consiste en un alquilo de cadena lineal, ramificada o cíclica; donde R3, X y Y se seleccionan en forma independiente entre el grupo que consiste en H, halógeno, alcoxi, alcoxi, sustituido, alquilo, alquilo sustituido, dialquilaminoalquilo, hidroxialquilo, OH, OCH3, COOH, CN, CF3, OCF3, NO2, COOR'', CHO, y COR''; donde R1 y R2 se seleccionan en forma independiente entre el grupo que consiste en H, alquilo, alquilo sustituido, cicloalquilo C3-9, cicloalquilo C3-9 sustituido, grupos alifáticos policíclicos, fenilo, fenilo sustituido, naftilo, naftilo sustituido, heterociclo, y heterociclo sustituido, donde dicho heterociclo y dicho heterociclo sustituido contienen 1-3 heteroátomos, donde dicho heteroátomo se selecciona en forma independiente entre el grupo que consiste en nitrógeno, oxígeno y azufre; donde dichos sustituyentes se seleccionan entre el grupo que consisten en H, halógeno, alcoxi, alcoxi sustituido, alquilo, alquilo sustituido, dialquilaminoalquilo, hidroxialquilo, OH, OCH3, COOH, COOR', COR', CN, CF3, OCF3, NO2, NR'R', NHCOR' y CONR'R'; donde R' se selecciona entre el grupo que consiste en H, alquilo, alquilo sustituido, cicloalquilo C3-9, cicloalquilo C3-9 sustituido, grupos alifáticos policíclicos, fenilo, fenilo sustituido, naftilo, naftilo sustituido, heteroarilo, y heteroarilo sustituido, donde dicho heteroarilo y dicho heteroarilo sustituido contienen 1-3 heteroátomos, donde dicho heteroátomo se selecciona en forma independiente entre el grupo que consiste en nitrógeno, oxígeno y azufre; y donde R'' se selecciona entre el grupo que consiste en alquilo C1-9, donde dicho alquilo C1-9 se selecciona entre el grupo que consiste en alquilo de cadena lineal, alquilo ramificado, y alquilo cíclico. Reivindicación 2: El compuesto de la reivindicación 1, en el cual dicho grupo alifático policíclico se selecciona entre el grupo que consiste en adamantilo, bicicloheptilo, camforilo, biciclo[2,2,2]octanilo, y norbonilo. Reivindicación 3: El compuesto de la reivindicación 1, en el cual dicho heterociclo y dicho heterociclo sustituido se selecciona entre el grupo que consiste en piridinas, tiazoles, isotiazoles, oxazoles, pirimidinas, pirazinas, furanos, tiofenos, isoxazoles, pirroles, piridazinas, 1,2,3-triazinas, 1,2,4-triazinas, 1,3,5-triazinas, pirazoles, imidazoles, indoles, quinolinas, iso-quinolinas, benzotiofinas, benzofuranos, paratiazinas, piranos, cromenos, pirrolidinas, pirazolidinas, imidazolidinas, morfolinas, tiomorfolinos, y los heterociclos saturados correspondientes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46209003P | 2003-04-10 | 2003-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045886A1 true AR045886A1 (es) | 2005-11-16 |
Family
ID=33299906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101207A AR045886A1 (es) | 2003-04-10 | 2004-04-12 | Derivados de imidazol para el tratamiento de trastornos alergicos e hiperproliferativos |
Country Status (15)
Country | Link |
---|---|
US (1) | US20040229927A1 (es) |
EP (1) | EP1613310A1 (es) |
JP (1) | JP2006522820A (es) |
KR (1) | KR20050120711A (es) |
CN (1) | CN1826111A (es) |
AR (1) | AR045886A1 (es) |
AU (1) | AU2004229466A1 (es) |
BR (1) | BRPI0409097A (es) |
CA (1) | CA2521841A1 (es) |
MX (1) | MXJL05000041A (es) |
PL (1) | PL378919A1 (es) |
RU (1) | RU2005134670A (es) |
TW (1) | TW200503695A (es) |
WO (1) | WO2004091610A1 (es) |
ZA (1) | ZA200508108B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
ES2291455T3 (es) * | 2001-03-12 | 2008-03-01 | Avanir Pharmaceuticals | Compuestos de bencimidazol para modular ige e inhibir la proliferacion celular. |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
AU2004263190A1 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
CN101022728B (zh) * | 2004-03-25 | 2012-08-08 | 詹森药业有限公司 | 咪唑化合物 |
WO2007132307A1 (en) * | 2006-05-09 | 2007-11-22 | Pfizer Products Inc. | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
PE20080948A1 (es) | 2006-07-25 | 2008-09-10 | Irm Llc | Derivados de imidazol como moduladores de la senda de hedgehog |
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
ES2927660T3 (es) | 2008-06-16 | 2022-11-10 | Univ Tennessee Res Found | Compuestos para el tratamiento del cáncer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
RU2506260C2 (ru) * | 2008-06-25 | 2014-02-10 | Энвиво Фармасьютикалз, Инк. | 1,2-дизамещенные гетероциклические соединения |
KR20120130777A (ko) | 2010-03-01 | 2012-12-03 | 유니버시티 오브 테네시 리서치 파운데이션 | 암 치료용 화합물 |
TWI640507B (zh) | 2013-11-05 | 2018-11-11 | 拜耳作物科學股份有限公司 | 用於控制節肢動物的新穎化合物(三) |
EP3237413A4 (en) | 2014-12-23 | 2018-09-12 | FGH Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
CN109476635B (zh) | 2016-04-29 | 2021-07-13 | Fgh生物科技公司 | 用于治疗疾病的二取代吡唑类化合物 |
EP3510027B1 (en) | 2016-09-07 | 2022-11-02 | FGH BioTech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
WO2018140504A1 (en) * | 2017-01-24 | 2018-08-02 | Patel Manoj K | Compositions and methods for blocking sodium channels |
CN108191667B (zh) * | 2018-01-04 | 2021-03-26 | 利尔化学股份有限公司 | 2-硝基-4-三氟甲基苯甲酸甲酯的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206257A (en) * | 1987-03-05 | 1993-04-27 | May & Baker Limited | Pesticidal method using 2-phenylimidazole derivatives |
JP2630432B2 (ja) * | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
JPH01224759A (ja) * | 1988-03-03 | 1989-09-07 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
JPH01225949A (ja) * | 1988-03-04 | 1989-09-08 | Konica Corp | ハロゲン化銀写真感光材料 |
JPH01262546A (ja) * | 1988-04-13 | 1989-10-19 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
JPH0361946A (ja) * | 1989-07-29 | 1991-03-18 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
JPH03245140A (ja) * | 1990-02-23 | 1991-10-31 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
US5656762A (en) * | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
JPH09304897A (ja) * | 1996-05-10 | 1997-11-28 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
TW467902B (en) * | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
CA2232467A1 (en) * | 1997-03-20 | 1998-09-20 | Richard A. Glennon | Imidazoles with serotonin receptor binding activity |
GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
-
2004
- 2004-04-09 CN CNA2004800162918A patent/CN1826111A/zh active Pending
- 2004-04-09 JP JP2006509872A patent/JP2006522820A/ja active Pending
- 2004-04-09 WO PCT/US2004/011010 patent/WO2004091610A1/en active Application Filing
- 2004-04-09 RU RU2005134670/04A patent/RU2005134670A/ru not_active Application Discontinuation
- 2004-04-09 KR KR1020057019229A patent/KR20050120711A/ko not_active Application Discontinuation
- 2004-04-09 PL PL378919A patent/PL378919A1/pl not_active Application Discontinuation
- 2004-04-09 US US10/821,667 patent/US20040229927A1/en not_active Abandoned
- 2004-04-09 CA CA002521841A patent/CA2521841A1/en not_active Abandoned
- 2004-04-09 AU AU2004229466A patent/AU2004229466A1/en not_active Abandoned
- 2004-04-09 BR BRPI0409097-7A patent/BRPI0409097A/pt not_active IP Right Cessation
- 2004-04-09 MX MXJL05000041A patent/MXJL05000041A/es unknown
- 2004-04-09 EP EP04759360A patent/EP1613310A1/en not_active Withdrawn
- 2004-04-12 AR ARP040101207A patent/AR045886A1/es not_active Application Discontinuation
- 2004-04-12 TW TW093110069A patent/TW200503695A/zh unknown
-
2005
- 2005-10-07 ZA ZA200508108A patent/ZA200508108B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004229466A1 (en) | 2004-10-28 |
MXJL05000041A (es) | 2005-12-22 |
ZA200508108B (en) | 2007-03-28 |
TW200503695A (en) | 2005-02-01 |
JP2006522820A (ja) | 2006-10-05 |
RU2005134670A (ru) | 2006-06-10 |
BRPI0409097A (pt) | 2006-04-11 |
PL378919A1 (pl) | 2006-06-12 |
CA2521841A1 (en) | 2004-10-28 |
WO2004091610A1 (en) | 2004-10-28 |
CN1826111A (zh) | 2006-08-30 |
US20040229927A1 (en) | 2004-11-18 |
KR20050120711A (ko) | 2005-12-22 |
EP1613310A1 (en) | 2006-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |