JP2006512293A - ＩｇＥを調節し、細胞増殖を阻害するためのフェニル−インドール化合物 - Google Patents
ＩｇＥを調節し、細胞増殖を阻害するためのフェニル−インドール化合物 Download PDFInfo
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- JP2006512293A JP2006512293A JP2004536642A JP2004536642A JP2006512293A JP 2006512293 A JP2006512293 A JP 2006512293A JP 2004536642 A JP2004536642 A JP 2004536642A JP 2004536642 A JP2004536642 A JP 2004536642A JP 2006512293 A JP2006512293 A JP 2006512293A
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| DE60221804T2 (de) * | 2001-03-12 | 2008-05-15 | Avanir Pharmaceuticals, San Diego | Benzimidazolderivate zur ige-modulierung und zellproliferationshemmung |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| WO2004024655A2 (en) * | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| WO2005013950A2 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| JP2008506702A (ja) | 2004-07-14 | 2008-03-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するための方法 |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
| ITMI20061368A1 (it) * | 2006-07-14 | 2008-01-15 | Acraf | Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo |
| RU2015115677A (ru) * | 2012-10-17 | 2016-12-10 | Ф. Хоффманн-Ля Рош Аг | Производные 6-аминоиндола в качестве антагонистов канала с транзиторным рецепторным потенциалом (trp) |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| TW201835070A (zh) * | 2017-02-21 | 2018-10-01 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| PL3723790T3 (pl) * | 2017-12-12 | 2024-05-13 | Kamada Ltd | Sposoby indukowania tolerancji immunologicznej i redukcji odpowiedzi przeciwciała antylekowego |
| WO2020078454A1 (en) * | 2018-10-18 | 2020-04-23 | Sinomab Bioscience Limited | Method of modulating autoimmunity by disrupting cis‐ligand binding of siglec type antigens |
| CA3176436A1 (en) | 2020-05-08 | 2021-11-11 | Tahamtan Ahmadi | Bispecific antibodies against cd3 and cd20 |
| US20240034788A1 (en) * | 2020-08-20 | 2024-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Abscopal therapy for cancer |
| JP2023542289A (ja) | 2020-09-10 | 2023-10-06 | ジェンマブ エー／エス | 濾胞性リンパ腫を治療するための併用療法におけるｃｄ３及びｃｄ２０に対する二重特異性抗体 |
| CN116406293A (zh) | 2020-09-10 | 2023-07-07 | 健玛保 | 用于治疗滤泡性淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体 |
| JP2023541858A (ja) | 2020-09-10 | 2023-10-04 | ジェンマブ エー／エス | 慢性リンパ球性白血病を治療するためのｃｄ３及びｃｄ２０に対する二重特異性抗体 |
| US20240034812A1 (en) | 2020-09-10 | 2024-02-01 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| JP2023542291A (ja) | 2020-09-10 | 2023-10-06 | ジェンマブ エー／エス | びまん性大細胞型ｂ細胞リンパ腫を治療するための併用療法におけるｃｄ３及びｃｄ２０に対する二重特異性抗体 |
| TWI909603B (zh) * | 2023-08-09 | 2025-12-21 | 南韓商大熊製藥股份有限公司 | 用於預防或治療癌症或腫瘤之新穎化合物及包含該化合物的醫藥組成物 |
| US20250275978A1 (en) * | 2024-03-04 | 2025-09-04 | Cardiff Oncology, Inc. | Use of onvansertib as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer |
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| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) * | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| DE3680636D1 (de) | 1985-05-03 | 1991-09-05 | Foxboro Co | Regelung des trennungspunktes bei der destillation. |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
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-
2003
- 2003-09-09 WO PCT/US2003/028145 patent/WO2004024655A2/en not_active Ceased
- 2003-09-09 AU AU2003270426A patent/AU2003270426A1/en not_active Withdrawn
- 2003-09-10 TW TW092124977A patent/TW200407303A/zh unknown
- 2003-09-12 JP JP2004536642A patent/JP2006512293A/ja not_active Withdrawn
- 2003-09-12 RU RU2005109912/04A patent/RU2005109912A/ru not_active Application Discontinuation
- 2003-09-12 MX MXJL05000009A patent/MXJL05000009A/es not_active Application Discontinuation
- 2003-09-12 PE PE2003000932A patent/PE20050035A1/es not_active Application Discontinuation
- 2003-09-12 KR KR1020057004244A patent/KR20050051658A/ko not_active Withdrawn
- 2003-09-12 AR ARP030103320A patent/AR041251A1/es not_active Application Discontinuation
- 2003-09-12 BR BR0314223-0A patent/BR0314223A/pt not_active IP Right Cessation
- 2003-09-12 CN CNA038250829A patent/CN1694868A/zh active Pending
- 2003-09-12 CA CA002498493A patent/CA2498493A1/en not_active Abandoned
- 2003-09-12 EP EP03795717A patent/EP1537079A4/en not_active Withdrawn
- 2003-09-12 US US10/661,139 patent/US7375118B2/en not_active Expired - Fee Related
- 2003-09-12 PL PL03375812A patent/PL375812A1/xx not_active Application Discontinuation
- 2003-09-12 AU AU2003277152A patent/AU2003277152A1/en not_active Abandoned
- 2003-09-12 WO PCT/US2003/030959 patent/WO2004024896A2/en not_active Ceased
-
2005
- 2005-04-05 ZA ZA200502739A patent/ZA200502739B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL375812A1 (en) | 2005-12-12 |
| AR041251A1 (es) | 2005-05-11 |
| BR0314223A (pt) | 2005-07-26 |
| CN1694868A (zh) | 2005-11-09 |
| WO2004024655A2 (en) | 2004-03-25 |
| PE20050035A1 (es) | 2005-01-24 |
| RU2005109912A (ru) | 2006-04-27 |
| MXJL05000009A (es) | 2005-06-07 |
| TW200407303A (en) | 2004-05-16 |
| CA2498493A1 (en) | 2004-03-25 |
| ZA200502739B (en) | 2005-10-13 |
| EP1537079A2 (en) | 2005-06-08 |
| US20040180946A1 (en) | 2004-09-16 |
| EP1537079A4 (en) | 2007-05-16 |
| AU2003270426A1 (en) | 2004-04-30 |
| AU2003277152A1 (en) | 2004-04-30 |
| US7375118B2 (en) | 2008-05-20 |
| KR20050051658A (ko) | 2005-06-01 |
| WO2004024896A2 (en) | 2004-03-25 |
| WO2004024896A3 (en) | 2004-06-24 |
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