CN1680426B - 防止抗体变性的精制方法 - Google Patents

防止抗体变性的精制方法 Download PDF

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Publication number
CN1680426B
CN1680426B CN200510004669.9A CN200510004669A CN1680426B CN 1680426 B CN1680426 B CN 1680426B CN 200510004669 A CN200510004669 A CN 200510004669A CN 1680426 B CN1680426 B CN 1680426B
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China
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antibody
arginine
albumin
wash
acid
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Expired - Lifetime
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CN200510004669.9A
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English (en)
Chinese (zh)
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CN1680426A (zh
Inventor
弓冈良辅
江岛大辅
荒川力
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN200510004669.9A 2004-01-21 2005-01-21 防止抗体变性的精制方法 Expired - Lifetime CN1680426B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53750304P 2004-01-21 2004-01-21
US60/537503 2004-01-21
US63140704P 2004-11-30 2004-11-30
US60/631407 2004-11-30

Publications (2)

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CN1680426A CN1680426A (zh) 2005-10-12
CN1680426B true CN1680426B (zh) 2010-05-26

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CN200510004669.9A Expired - Lifetime CN1680426B (zh) 2004-01-21 2005-01-21 防止抗体变性的精制方法

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US (3) US8084032B2 (enExample)
EP (1) EP1568710B1 (enExample)
JP (1) JP4826995B2 (enExample)
CN (1) CN1680426B (enExample)
DE (1) DE602005018406D1 (enExample)

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EP2583973B1 (en) * 2010-06-21 2018-03-21 Kyowa Hakko Kirin Co., Ltd. Method for purifying protein using amino acid
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CN105273041A (zh) * 2014-07-08 2016-01-27 上海中信国健药业股份有限公司 一种蛋白质亲和层析洗脱方法
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EP3374371A4 (en) * 2015-11-09 2019-12-11 University of Notre Dame SMALL MOLECULE AFFINITY MEMBRANE PURIFICATION SYSTEMS AND USE THEREOF
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EP3455241B1 (en) 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Method of cleaning and/or sanitizing a separation matrix
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KR102759512B1 (ko) 2016-10-25 2025-02-03 리제너론 파아마슈티컬스, 인크. 크로마토그래피 데이터 분석을 위한 방법 및 시스템
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
JP6897761B2 (ja) * 2017-04-07 2021-07-07 コニカミノルタ株式会社 タンパク質修飾蛍光体集積粒子の精製物を製造する方法、蛍光染色液の製造方法、タンパク質修飾蛍光体集積粒子の精製物、蛍光染色液およびタンパク質修飾蛍光体集積粒子精製用フィルター
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JP7158015B2 (ja) * 2017-11-09 2022-10-21 国立研究開発法人産業技術総合研究所 ポリペプチドの凝集化抑制方法
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Also Published As

Publication number Publication date
US8084032B2 (en) 2011-12-27
EP1568710A2 (en) 2005-08-31
EP1568710B1 (en) 2009-12-23
DE602005018406D1 (de) 2010-02-04
CN1680426A (zh) 2005-10-12
US20050176109A1 (en) 2005-08-11
US8470328B2 (en) 2013-06-25
US20120264918A1 (en) 2012-10-18
US20120142901A1 (en) 2012-06-07
JP2005206602A (ja) 2005-08-04
EP1568710A3 (en) 2005-10-05
US8435527B2 (en) 2013-05-07
JP4826995B2 (ja) 2011-11-30

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Granted publication date: 20100526