CN1659143A - 具有hiv整合酶抑制活性的含氮杂芳基化合物 - Google Patents

具有hiv整合酶抑制活性的含氮杂芳基化合物 Download PDF

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CN1659143A
CN1659143A CN028089219A CN02808921A CN1659143A CN 1659143 A CN1659143 A CN 1659143A CN 028089219 A CN028089219 A CN 028089219A CN 02808921 A CN02808921 A CN 02808921A CN 1659143 A CN1659143 A CN 1659143A
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富士雅弘
三神山秀勋
村井均
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Shionogi and Co Ltd
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN028089219A 2001-03-01 2002-02-27 具有hiv整合酶抑制活性的含氮杂芳基化合物 Pending CN1659143A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001057037 2001-03-01
JP057037/2001 2001-03-01
JP243530/2001 2001-08-10
JP2001243530 2001-08-10
JP395022/2001 2001-12-26
JP2001395022 2001-12-26

Publications (1)

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CN1659143A true CN1659143A (zh) 2005-08-24

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CN028089219A Pending CN1659143A (zh) 2001-03-01 2002-02-27 具有hiv整合酶抑制活性的含氮杂芳基化合物

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US (2) US7148237B2 (https=)
EP (2) EP2033952B1 (https=)
JP (2) JP3616628B2 (https=)
KR (1) KR20030078958A (https=)
CN (1) CN1659143A (https=)
AT (1) ATE411292T1 (https=)
BR (1) BR0207809A (https=)
CA (1) CA2439666A1 (https=)
CZ (1) CZ20032332A3 (https=)
DE (1) DE60229364D1 (https=)
HU (1) HUP0400175A2 (https=)
IL (1) IL157638A0 (https=)
MX (1) MXPA03007765A (https=)
NO (1) NO20033848L (https=)
PL (1) PL365027A1 (https=)
WO (1) WO2002070486A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102770181A (zh) * 2009-12-23 2012-11-07 勒芬天主教大学 新型抗病毒化合物
CN103554019A (zh) * 2013-09-30 2014-02-05 浙江工业大学 一种甲溴羟喹的合成方法
CN104140402A (zh) * 2014-05-27 2014-11-12 天津市斯芬克司药物研发有限公司 一种苯并噻唑类化合物及其制备方法
CN104447547A (zh) * 2014-11-10 2015-03-25 苏州康润医药有限公司 4-氨基异喹啉-8-甲酸甲酯的合成方法
CN104447543A (zh) * 2014-11-10 2015-03-25 苏州康润医药有限公司 3-氨基-7,8-二氟喹啉及其中间体的合成方法
WO2025264844A1 (en) * 2024-06-20 2025-12-26 Lieber Institute, Inc. Heterocyclic gpr52 modulators and methods of use thereof

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NZ511255A (en) * 2001-04-20 2003-12-19 Deep Video Imaging Ltd Multi-focal plane display having an optical retarder and a diffuser interposed between its screens
BR0211750A (pt) 2001-08-10 2004-10-13 Shionogi & Co Agente antiviral
DE10145457A1 (de) * 2001-09-14 2003-04-03 Basf Ag Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen
NZ533057A (en) * 2001-10-26 2005-11-25 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase
EP1441734B1 (en) * 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
WO2003077857A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
EP1541558B1 (en) * 2002-08-13 2008-08-13 Shionogi & Co., Ltd. Heterocyclic compounds having hiv integrase inhibitory activity
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
EP2161258A3 (en) 2002-11-20 2010-04-07 Japan Tabacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
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