CN1649874A - 抗寄生虫药青蒿素衍生物(内过氧化物) - Google Patents

抗寄生虫药青蒿素衍生物(内过氧化物) Download PDF

Info

Publication number
CN1649874A
CN1649874A CNA038095998A CN03809599A CN1649874A CN 1649874 A CN1649874 A CN 1649874A CN A038095998 A CNA038095998 A CN A038095998A CN 03809599 A CN03809599 A CN 03809599A CN 1649874 A CN1649874 A CN 1649874A
Authority
CN
China
Prior art keywords
group
alkyl
hydrogen atom
atom
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038095998A
Other languages
English (en)
Chinese (zh)
Inventor
R·K·海恩斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Business Services GmbH
Original Assignee
Bayer Business Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Business Services GmbH filed Critical Bayer Business Services GmbH
Publication of CN1649874A publication Critical patent/CN1649874A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA038095998A 2002-03-08 2003-02-24 抗寄生虫药青蒿素衍生物(内过氧化物) Pending CN1649874A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02005233 2002-03-08
EP02005233.8 2002-03-08

Publications (1)

Publication Number Publication Date
CN1649874A true CN1649874A (zh) 2005-08-03

Family

ID=27798779

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038095998A Pending CN1649874A (zh) 2002-03-08 2003-02-24 抗寄生虫药青蒿素衍生物(内过氧化物)

Country Status (21)

Country Link
US (1) US20050119232A1 (enExample)
EP (1) EP1485389B1 (enExample)
JP (1) JP2005526073A (enExample)
KR (1) KR20040104493A (enExample)
CN (1) CN1649874A (enExample)
AR (1) AR038842A1 (enExample)
AT (1) ATE334987T1 (enExample)
AU (1) AU2003215584A1 (enExample)
BR (1) BR0308291A (enExample)
CA (1) CA2478600A1 (enExample)
DE (1) DE60307239D1 (enExample)
HR (1) HRP20040927A2 (enExample)
IL (1) IL163870A0 (enExample)
MX (1) MXPA04008638A (enExample)
NZ (1) NZ535084A (enExample)
PL (1) PL372341A1 (enExample)
RU (1) RU2004130284A (enExample)
TW (1) TW200400964A (enExample)
WO (1) WO2003076446A1 (enExample)
YU (1) YU79304A (enExample)
ZA (1) ZA200407102B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103183682A (zh) * 2011-12-31 2013-07-03 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
CN104379587A (zh) * 2012-04-18 2015-02-25 香港科技大学 用于治疗病毒感染的方法和组合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004027871B3 (de) * 2004-06-08 2006-03-16 Lanxess Deutschland Gmbh Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin
EP1714967A1 (en) * 2005-04-22 2006-10-25 Bayer HealthCare AG Antiparasitic artemisinin derivatives
NZ568049A (en) * 2005-10-20 2011-10-28 Epipharm Gmbh Treatment and prevention of benign pigmented moles (nevi) using artemisinine and the derivatives thereof
WO2008127381A2 (en) * 2006-10-20 2008-10-23 Johns Hopkins University Artemisinin derivatives
US20100286154A1 (en) * 2007-11-15 2010-11-11 Susanne Christine Wieland-Berghausen Antihelmintic paste
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
CN102010422B (zh) * 2010-11-23 2014-11-26 沈阳药科大学 含有胍基的青蒿素类衍生物及其应用
US8232417B1 (en) 2010-12-01 2012-07-31 Bioderm Research Artemisinin derivatives with natural amino acids, peptides, and amino sugars for skin imperfections and infection in mammals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713877A1 (en) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosu derivatives against aids
SK542001A3 (en) * 1998-07-14 2001-08-06 Bayer Ag Antiparasitic artemisinin derivatives (endoperoxides)
EP0974594A1 (en) * 1998-07-14 2000-01-26 The Hong Kong University of Science & Technology Artemisinin derivatives as anti-infective agent

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103183682A (zh) * 2011-12-31 2013-07-03 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
CN104379587A (zh) * 2012-04-18 2015-02-25 香港科技大学 用于治疗病毒感染的方法和组合物
US9616067B2 (en) 2012-04-18 2017-04-11 Hadasit Medical Research Services And Development Ltd. Methods and compositions for treating viral infections
US10111884B2 (en) 2012-04-18 2018-10-30 Hadasit Medical Research Services And Development Ltd. Methods and compositions for treating viral infections

Also Published As

Publication number Publication date
BR0308291A (pt) 2005-01-11
TW200400964A (en) 2004-01-16
IL163870A0 (en) 2005-12-18
CA2478600A1 (en) 2003-09-18
NZ535084A (en) 2006-05-26
AR038842A1 (es) 2005-01-26
DE60307239D1 (de) 2006-09-14
HRP20040927A2 (en) 2005-06-30
US20050119232A1 (en) 2005-06-02
ZA200407102B (en) 2005-09-06
YU79304A (sh) 2006-08-17
JP2005526073A (ja) 2005-09-02
KR20040104493A (ko) 2004-12-10
EP1485389A1 (en) 2004-12-15
PL372341A1 (en) 2005-07-11
EP1485389B1 (en) 2006-08-02
ATE334987T1 (de) 2006-08-15
WO2003076446A1 (en) 2003-09-18
WO2003076446A8 (en) 2004-10-07
AU2003215584A1 (en) 2003-09-22
MXPA04008638A (es) 2005-04-19
RU2004130284A (ru) 2005-05-10

Similar Documents

Publication Publication Date Title
CN1122035C (zh) 抗寄生虫青蒿素衍生物，制备方法及组合物和用途
EA019655B1 (ru) Конденсированные имидазолы и содержащие их композиции, предназначенные для лечения паразитарных заболеваний, таких как, например, малярия
CN1649874A (zh) 抗寄生虫药青蒿素衍生物(内过氧化物)
JP5148478B2 (ja) マラリア治療用のフェロキンとアーテミシニン誘導体との組合せ
HK1081183A (en) Antiparasitic artemisinin derivatives (endoperoxides)
EP0974594A1 (en) Artemisinin derivatives as anti-infective agent
WO2000004025A1 (en) Antiparasitic artemisinin derivatives (endoperoxides)
EP0974354A1 (en) Artemisinin derivatives
EP1714967A1 (en) Antiparasitic artemisinin derivatives
EP0974593A1 (en) Artemisinin derivatives as antiparasitic agents
MXPA01000396A (en) Antiparasitic artemisinin derivatives (endoperoxides)
HK1028234A (en) Artemisinin derivatives as antiparasitic agents
HK1028235A (en) Artemisinin derivatives as anti-infective agent

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1081183

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1081183

Country of ref document: HK