CN1649874A - 抗寄生虫药青蒿素衍生物(内过氧化物) - Google Patents

抗寄生虫药青蒿素衍生物(内过氧化物) Download PDF

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Publication number
CN1649874A
CN1649874A CNA038095998A CN03809599A CN1649874A CN 1649874 A CN1649874 A CN 1649874A CN A038095998 A CNA038095998 A CN A038095998A CN 03809599 A CN03809599 A CN 03809599A CN 1649874 A CN1649874 A CN 1649874A
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CN
China
Prior art keywords
group
alkyl
hydrogen atom
atom
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038095998A
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English (en)
Chinese (zh)
Inventor
R·K·海恩斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Business Services GmbH
Original Assignee
Bayer Business Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Business Services GmbH filed Critical Bayer Business Services GmbH
Publication of CN1649874A publication Critical patent/CN1649874A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA038095998A 2002-03-08 2003-02-24 抗寄生虫药青蒿素衍生物(内过氧化物) Pending CN1649874A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02005233.8 2002-03-08
EP02005233 2002-03-08

Publications (1)

Publication Number Publication Date
CN1649874A true CN1649874A (zh) 2005-08-03

Family

ID=27798779

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038095998A Pending CN1649874A (zh) 2002-03-08 2003-02-24 抗寄生虫药青蒿素衍生物(内过氧化物)

Country Status (21)

Country Link
US (1) US20050119232A1 (enExample)
EP (1) EP1485389B1 (enExample)
JP (1) JP2005526073A (enExample)
KR (1) KR20040104493A (enExample)
CN (1) CN1649874A (enExample)
AR (1) AR038842A1 (enExample)
AT (1) ATE334987T1 (enExample)
AU (1) AU2003215584A1 (enExample)
BR (1) BR0308291A (enExample)
CA (1) CA2478600A1 (enExample)
DE (1) DE60307239D1 (enExample)
HR (1) HRP20040927A2 (enExample)
IL (1) IL163870A0 (enExample)
MX (1) MXPA04008638A (enExample)
NZ (1) NZ535084A (enExample)
PL (1) PL372341A1 (enExample)
RU (1) RU2004130284A (enExample)
TW (1) TW200400964A (enExample)
WO (1) WO2003076446A1 (enExample)
YU (1) YU79304A (enExample)
ZA (1) ZA200407102B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103183682A (zh) * 2011-12-31 2013-07-03 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
CN104379587A (zh) * 2012-04-18 2015-02-25 香港科技大学 用于治疗病毒感染的方法和组合物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004027871B3 (de) * 2004-06-08 2006-03-16 Lanxess Deutschland Gmbh Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin
EP1714967A1 (en) * 2005-04-22 2006-10-25 Bayer HealthCare AG Antiparasitic artemisinin derivatives
AU2006303809B2 (en) * 2005-10-20 2012-11-15 Epipharm Ag Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof
WO2008127381A2 (en) * 2006-10-20 2008-10-23 Johns Hopkins University Artemisinin derivatives
CA2703008A1 (en) * 2007-11-15 2009-05-22 Novartis Ag Anthelmintic paste comprising praziquantel, a macrolide lactone, cyclodextrin and a thickener
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
CN102010422B (zh) * 2010-11-23 2014-11-26 沈阳药科大学 含有胍基的青蒿素类衍生物及其应用
US8232417B1 (en) 2010-12-01 2012-07-31 Bioderm Research Artemisinin derivatives with natural amino acids, peptides, and amino sugars for skin imperfections and infection in mammals
CN121311595A (zh) 2023-04-17 2026-01-09 阿斯克生物公司 转基因在灵长类动物中可调节的受控表达

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713877A1 (en) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosu derivatives against aids
EP0974594A1 (en) * 1998-07-14 2000-01-26 The Hong Kong University of Science & Technology Artemisinin derivatives as anti-infective agent
NZ509324A (en) * 1998-07-14 2003-07-25 Bayer Ag Antiparasitic artemisinin derivatives (endoperoxides)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103183682A (zh) * 2011-12-31 2013-07-03 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
CN104379587A (zh) * 2012-04-18 2015-02-25 香港科技大学 用于治疗病毒感染的方法和组合物
US9616067B2 (en) 2012-04-18 2017-04-11 Hadasit Medical Research Services And Development Ltd. Methods and compositions for treating viral infections
US10111884B2 (en) 2012-04-18 2018-10-30 Hadasit Medical Research Services And Development Ltd. Methods and compositions for treating viral infections

Also Published As

Publication number Publication date
TW200400964A (en) 2004-01-16
WO2003076446A1 (en) 2003-09-18
NZ535084A (en) 2006-05-26
JP2005526073A (ja) 2005-09-02
BR0308291A (pt) 2005-01-11
AU2003215584A1 (en) 2003-09-22
WO2003076446A8 (en) 2004-10-07
YU79304A (sh) 2006-08-17
ATE334987T1 (de) 2006-08-15
KR20040104493A (ko) 2004-12-10
PL372341A1 (en) 2005-07-11
IL163870A0 (en) 2005-12-18
CA2478600A1 (en) 2003-09-18
ZA200407102B (en) 2005-09-06
MXPA04008638A (es) 2005-04-19
HRP20040927A2 (en) 2005-06-30
DE60307239D1 (de) 2006-09-14
RU2004130284A (ru) 2005-05-10
EP1485389B1 (en) 2006-08-02
EP1485389A1 (en) 2004-12-15
AR038842A1 (es) 2005-01-26
US20050119232A1 (en) 2005-06-02

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