CN1592737A - 制造西司他汀的方法 - Google Patents

制造西司他汀的方法 Download PDF

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Publication number
CN1592737A
CN1592737A CNA028212843A CN02821284A CN1592737A CN 1592737 A CN1592737 A CN 1592737A CN A028212843 A CNA028212843 A CN A028212843A CN 02821284 A CN02821284 A CN 02821284A CN 1592737 A CN1592737 A CN 1592737A
Authority
CN
China
Prior art keywords
cilastatin
solution
pure
crude
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028212843A
Other languages
English (en)
Chinese (zh)
Inventor
Y·库马
O·D·塔亚吉
T·K·斯里瓦斯塔瓦
A·潘迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN1592737A publication Critical patent/CN1592737A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA028212843A 2001-08-24 2002-08-23 制造西司他汀的方法 Pending CN1592737A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN879/DEL/2001 2001-08-24
IN879DE2001 IN192179B (enExample) 2001-08-24 2001-08-24

Publications (1)

Publication Number Publication Date
CN1592737A true CN1592737A (zh) 2005-03-09

Family

ID=11097101

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028212843A Pending CN1592737A (zh) 2001-08-24 2002-08-23 制造西司他汀的方法

Country Status (15)

Country Link
US (1) US20050119346A1 (enExample)
EP (1) EP1423360B1 (enExample)
JP (1) JP2005525996A (enExample)
CN (1) CN1592737A (enExample)
AR (1) AR052751A1 (enExample)
AT (1) ATE360610T1 (enExample)
BR (1) BR0212390A (enExample)
CA (1) CA2458505A1 (enExample)
DE (1) DE60219800T2 (enExample)
ES (1) ES2282448T3 (enExample)
IN (1) IN192179B (enExample)
RU (1) RU2004108465A (enExample)
SI (1) SI1423360T1 (enExample)
WO (1) WO2003018544A1 (enExample)
ZA (1) ZA200402006B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138228A1 (en) * 2007-05-16 2008-11-20 Shenzhen Haibin Pharmaceutical Co., Ltd. A process for the preparation of cilastatin sodium
CN107522642A (zh) * 2017-08-14 2017-12-29 新乡海滨药业有限公司 一种西司他丁的精制方法
CN115260067A (zh) * 2022-08-26 2022-11-01 同舟纵横（厦门）流体技术有限公司 一种西司他丁母液纯化的方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638471B1 (ko) * 2004-08-25 2006-10-25 동국제약 주식회사 실라스타틴 나트륨염의 신규한 제조 방법
US8134026B2 (en) * 2005-11-09 2012-03-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of Cilastatin and sodium salt
KR100833202B1 (ko) * 2006-12-11 2008-05-28 (주)위즈켐 7-클로로-(2,2-디메틸시클로프로판카르복스아미도)-2-헵텐산 제조방법
KR100913694B1 (ko) * 2008-07-09 2009-08-24 (주)하이텍팜 신규한 결정형 실라스타틴 암모늄염 및 그 제조방법
CN101851186B (zh) * 2010-05-31 2012-11-14 浙江师范大学 西司他丁钠的合成方法
CN102675175B (zh) * 2011-03-08 2014-02-19 深圳市海滨制药有限公司 一种西司他丁的分离纯化方法
CN102702051B (zh) * 2011-03-26 2016-04-13 山东新时代药业有限公司 一种西司他丁钠的制备方法
CN102875433A (zh) * 2012-10-29 2013-01-16 江西金顿香料有限公司 一种西司他丁酸的制备方法
CA2937311A1 (en) * 2014-01-24 2015-07-30 Ea Pharma Co., Ltd. Megalin antagonist
CN104926701B (zh) * 2015-06-30 2017-05-03 西安蓝晓科技新材料股份有限公司 一种蛋氨酸纯化的工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138228A1 (en) * 2007-05-16 2008-11-20 Shenzhen Haibin Pharmaceutical Co., Ltd. A process for the preparation of cilastatin sodium
CN101307015B (zh) * 2007-05-16 2012-06-13 深圳市海滨制药有限公司 一种制备西司他丁钠的方法
CN107522642A (zh) * 2017-08-14 2017-12-29 新乡海滨药业有限公司 一种西司他丁的精制方法
CN115260067A (zh) * 2022-08-26 2022-11-01 同舟纵横（厦门）流体技术有限公司 一种西司他丁母液纯化的方法

Also Published As

Publication number Publication date
SI1423360T1 (sl) 2007-08-31
ES2282448T3 (es) 2007-10-16
BR0212390A (pt) 2004-07-27
IN192179B (enExample) 2004-03-06
AR052751A1 (es) 2007-04-04
US20050119346A1 (en) 2005-06-02
DE60219800D1 (de) 2007-06-06
JP2005525996A (ja) 2005-09-02
WO2003018544A1 (en) 2003-03-06
DE60219800T2 (de) 2008-01-17
ZA200402006B (en) 2004-09-15
CA2458505A1 (en) 2003-03-06
EP1423360B1 (en) 2007-04-25
EP1423360A1 (en) 2004-06-02
RU2004108465A (ru) 2005-09-20
ATE360610T1 (de) 2007-05-15

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