KR20040072397A - 탐술로신의 정제 방법 - Google Patents
탐술로신의 정제 방법 Download PDFInfo
- Publication number
- KR20040072397A KR20040072397A KR1020030008871A KR20030008871A KR20040072397A KR 20040072397 A KR20040072397 A KR 20040072397A KR 1020030008871 A KR1020030008871 A KR 1020030008871A KR 20030008871 A KR20030008871 A KR 20030008871A KR 20040072397 A KR20040072397 A KR 20040072397A
- Authority
- KR
- South Korea
- Prior art keywords
- tamsulosin
- acid
- formula
- hydrochloride
- carboxylate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (3)
- 유기 용매 하에서 하기 화학식 1의 탐술로신에 카르복시산을 가하여, 하기 화학식 3의 탐술로신 카르복시산염을 침전시키는 단계; 및상기 탐술로신 카르복시산염에 염산을 가하여 하기 화학식 4의 구조를 가지는 탐술로신 염산염을 제조하는 단계를 포함하여 구성되는 탐술로신 정제 방법.[화학식 1][화학식 3]상기 식에서, R은 알킬, 아릴, 알릴, 비닐 또는 벤질이다.[화학식 4]
- 제 1 항에 있어서, 상기 유기 용매로는 에틸아세테이트, 아세톤, 클로로포름, 이소프로판올, 메탄올 및 에탄올로 이루어진 군에서 선택된 어느 하나 이상의 용매를 사용함을 특징으로 하는 탐술로신 정제 방법.
- 제 1 항 또는 제 2 항에 있어서, 카르복시산으로는 만델산(mandelic acid), 살리실산(salicylic acid), 말레산(maleic acid), 말론산(malonic acid), 능금산(malic acid) 및 아니스산(anisic acid)으로 이루어진 그룹에서 선택된 어느 하나의 카르복시산을 사용함을 특징으로 하는 탐술로신 정제 방법.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2003-0008871A KR100503639B1 (ko) | 2003-02-12 | 2003-02-12 | 탐술로신의 정제 방법 |
ES04250684T ES2335496T3 (es) | 2003-02-12 | 2004-02-09 | Procedimiento de preparacion de cloridrato de tamsulosina. |
DE602004023777T DE602004023777D1 (de) | 2003-02-12 | 2004-02-09 | Verfahren zur Herstellung von Tamsulosin Hydrochlorid |
EP04250684A EP1449829B1 (en) | 2003-02-12 | 2004-02-09 | Process for preparing Tamsulosin hydrochloride |
IL160322A IL160322A (en) | 2003-02-12 | 2004-02-10 | Process of preparation of Thamesulosin Hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2003-0008871A KR100503639B1 (ko) | 2003-02-12 | 2003-02-12 | 탐술로신의 정제 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040072397A true KR20040072397A (ko) | 2004-08-18 |
KR100503639B1 KR100503639B1 (ko) | 2005-07-26 |
Family
ID=32733142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2003-0008871A KR100503639B1 (ko) | 2003-02-12 | 2003-02-12 | 탐술로신의 정제 방법 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1449829B1 (ko) |
KR (1) | KR100503639B1 (ko) |
DE (1) | DE602004023777D1 (ko) |
ES (1) | ES2335496T3 (ko) |
IL (1) | IL160322A (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4800213B2 (ja) * | 2004-07-07 | 2011-10-26 | 浜理薬品工業株式会社 | 光学活性フェニルプロピルアミン誘導体の製法 |
US20090137844A1 (en) * | 2005-06-15 | 2009-05-28 | Fermion Oy | Crystallization process |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56110665A (en) | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Sulfamoyl-substituted phenetylamine derivative and its preparation |
JPS62114952A (ja) | 1985-11-13 | 1987-05-26 | Yamanouchi Pharmaceut Co Ltd | 置換フエネチルアミン誘導体の製造法 |
KR100405090B1 (ko) | 2001-05-07 | 2003-11-12 | 보령제약 주식회사 | 펜에틸아민 유도체의 제조방법 |
-
2003
- 2003-02-12 KR KR10-2003-0008871A patent/KR100503639B1/ko active IP Right Grant
-
2004
- 2004-02-09 EP EP04250684A patent/EP1449829B1/en not_active Expired - Lifetime
- 2004-02-09 ES ES04250684T patent/ES2335496T3/es not_active Expired - Lifetime
- 2004-02-09 DE DE602004023777T patent/DE602004023777D1/de not_active Expired - Lifetime
- 2004-02-10 IL IL160322A patent/IL160322A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1449829B1 (en) | 2009-10-28 |
KR100503639B1 (ko) | 2005-07-26 |
DE602004023777D1 (de) | 2009-12-10 |
IL160322A0 (en) | 2004-07-25 |
IL160322A (en) | 2010-06-16 |
EP1449829A1 (en) | 2004-08-25 |
ES2335496T3 (es) | 2010-03-29 |
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