AR052751A1 - Proceso de preparacion de cilastatina - Google Patents

Proceso de preparacion de cilastatina

Info

Publication number
AR052751A1
AR052751A1 ARP020103200A ARP020103200A AR052751A1 AR 052751 A1 AR052751 A1 AR 052751A1 AR P020103200 A ARP020103200 A AR P020103200A AR P020103200 A ARP020103200 A AR P020103200A AR 052751 A1 AR052751 A1 AR 052751A1
Authority
AR
Argentina
Prior art keywords
cilastatin
imipenem
amino
prevent
solution
Prior art date
Application number
ARP020103200A
Other languages
English (en)
Inventor
Udaya P Kumar
Om Dutt Tyagi
Tushar Kumar Srivastava
Anand Pandley
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR052751A1 publication Critical patent/AR052751A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso efectivo e industrialmente ventajosa para la preparacion de cilastatina. La cilastalina posee la capacidad de prevenir la nefroxicidad asociada con el uso de antibioticos B-lactámicos como el imipenem y es un inhibidor renal de la dehidropeptidasa que se administra junto con la sal de sodio con imipenem con el objeto de prevenir su metabolismo renal. La combinacion Imipenem/cilastatina tiene aplicacion como agente antibacteriano potente de amplio espectro. El proceso para la purificacion de cilastatina, químicamente [R-[R*, S-(Z)]]-7-[(2-amino-2-carboxietil)tio]-2-[[2,2-dimetilciclopropil)carbonil]amino-2-ácidoheptenoico segun la formula (1) estructural, comprende poner la solucion de cilastatina cruda en contacto con una resina absorbente no ionica y recuperar la cilastatina pura de una solucion de la misma.
ARP020103200A 2001-08-24 2002-08-26 Proceso de preparacion de cilastatina AR052751A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN879DE2001 IN192179B (es) 2001-08-24 2001-08-24

Publications (1)

Publication Number Publication Date
AR052751A1 true AR052751A1 (es) 2007-04-04

Family

ID=11097101

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103200A AR052751A1 (es) 2001-08-24 2002-08-26 Proceso de preparacion de cilastatina

Country Status (15)

Country Link
US (1) US20050119346A1 (es)
EP (1) EP1423360B1 (es)
JP (1) JP2005525996A (es)
CN (1) CN1592737A (es)
AR (1) AR052751A1 (es)
AT (1) ATE360610T1 (es)
BR (1) BR0212390A (es)
CA (1) CA2458505A1 (es)
DE (1) DE60219800T2 (es)
ES (1) ES2282448T3 (es)
IN (1) IN192179B (es)
RU (1) RU2004108465A (es)
SI (1) SI1423360T1 (es)
WO (1) WO2003018544A1 (es)
ZA (1) ZA200402006B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638471B1 (ko) * 2004-08-25 2006-10-25 동국제약 주식회사 실라스타틴 나트륨염의 신규한 제조 방법
EP2402312B1 (en) 2005-11-09 2013-07-17 Orchid Chemicals&Pharmaceuticals Limited An improved process for the preparation of cilastatin acid
KR100833202B1 (ko) * 2006-12-11 2008-05-28 (주)위즈켐 7-클로로-(2,2-디메틸시클로프로판카르복스아미도)-2-헵텐산 제조방법
CN101307015B (zh) * 2007-05-16 2012-06-13 深圳市海滨制药有限公司 一种制备西司他丁钠的方法
KR100913694B1 (ko) * 2008-07-09 2009-08-24 (주)하이텍팜 신규한 결정형 실라스타틴 암모늄염 및 그 제조방법
CN101851186B (zh) * 2010-05-31 2012-11-14 浙江师范大学 西司他丁钠的合成方法
CN102675175B (zh) * 2011-03-08 2014-02-19 深圳市海滨制药有限公司 一种西司他丁的分离纯化方法
CN102702051B (zh) * 2011-03-26 2016-04-13 山东新时代药业有限公司 一种西司他丁钠的制备方法
CN102875433A (zh) * 2012-10-29 2013-01-16 江西金顿香料有限公司 一种西司他丁酸的制备方法
CA2937311A1 (en) 2014-01-24 2015-07-30 Ea Pharma Co., Ltd. Megalin antagonist
CN104926701B (zh) * 2015-06-30 2017-05-03 西安蓝晓科技新材料股份有限公司 一种蛋氨酸纯化的工艺
CN107522642A (zh) * 2017-08-14 2017-12-29 新乡海滨药业有限公司 一种西司他丁的精制方法
CN115260067A (zh) * 2022-08-26 2022-11-01 同舟纵横（厦门）流体技术有限公司 一种西司他丁母液纯化的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors

Also Published As

Publication number Publication date
ATE360610T1 (de) 2007-05-15
WO2003018544A1 (en) 2003-03-06
CA2458505A1 (en) 2003-03-06
SI1423360T1 (sl) 2007-08-31
EP1423360A1 (en) 2004-06-02
CN1592737A (zh) 2005-03-09
DE60219800D1 (de) 2007-06-06
EP1423360B1 (en) 2007-04-25
ZA200402006B (en) 2004-09-15
JP2005525996A (ja) 2005-09-02
IN192179B (es) 2004-03-06
DE60219800T2 (de) 2008-01-17
US20050119346A1 (en) 2005-06-02
BR0212390A (pt) 2004-07-27
ES2282448T3 (es) 2007-10-16
RU2004108465A (ru) 2005-09-20

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