CN1537019A - 醛固酮受体拮抗剂和HMG CoA还原酶抑制剂的药物组合 - Google Patents

醛固酮受体拮抗剂和HMG CoA还原酶抑制剂的药物组合 Download PDF

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Publication number
CN1537019A
CN1537019A CNA028145577A CN02814557A CN1537019A CN 1537019 A CN1537019 A CN 1537019A CN A028145577 A CNA028145577 A CN A028145577A CN 02814557 A CN02814557 A CN 02814557A CN 1537019 A CN1537019 A CN 1537019A
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CN
China
Prior art keywords
hmg
reductase inhibitor
receptor antagonist
aldosterone receptor
eplerenone
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Pending
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CNA028145577A
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English (en)
Chinese (zh)
Inventor
Bt
B·T·凯勒
E·G·麦克马洪
R·罗查
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Pharmacia LLC
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Pharmacia LLC
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Publication of CN1537019A publication Critical patent/CN1537019A/zh
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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CNA028145577A 2001-07-19 2002-07-18 醛固酮受体拮抗剂和HMG CoA还原酶抑制剂的药物组合 Pending CN1537019A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30633601P 2001-07-19 2001-07-19
US60/306,336 2001-07-19

Publications (1)

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CN1537019A true CN1537019A (zh) 2004-10-13

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US (2) US20030149010A1 (enExample)
EP (1) EP1406660B1 (enExample)
JP (1) JP2004537553A (enExample)
KR (1) KR20040023660A (enExample)
CN (1) CN1537019A (enExample)
AP (1) AP2004002951A0 (enExample)
AT (1) ATE363917T1 (enExample)
BR (1) BR0211274A (enExample)
CA (1) CA2452678A1 (enExample)
CO (1) CO5550464A2 (enExample)
DE (1) DE60220522T2 (enExample)
EA (1) EA200400029A1 (enExample)
EC (1) ECSP044950A (enExample)
ES (1) ES2286270T3 (enExample)
GE (1) GEP20063811B (enExample)
IL (1) IL159588A0 (enExample)
IS (1) IS7093A (enExample)
MA (1) MA27050A1 (enExample)
MX (1) MXPA04000586A (enExample)
NO (1) NO20040211L (enExample)
OA (1) OA12983A (enExample)
PL (1) PL367417A1 (enExample)
TN (1) TNSN04001A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106461636A (zh) * 2014-01-10 2017-02-22 重症监护诊断股份有限公司 用于测定心力衰竭风险的方法和系统

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
PT1773768T (pt) 2004-07-30 2018-11-30 Exelixis Inc Derivados de pirrol como agentes farmacêuticos
WO2007005941A2 (en) 2005-07-05 2007-01-11 President And Fellows Of Harvard College Liver targeted conjugates
CN1310941C (zh) * 2005-07-13 2007-04-18 南京大学 依普利酮的合成方法
BRPI0618379A2 (pt) * 2005-11-08 2011-08-30 Ranbaxy Lab Ltd processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
GB0600967D0 (en) * 2006-01-18 2006-03-01 Imp Innovations Ltd Methods
WO2007106862A2 (en) * 2006-03-14 2007-09-20 Kinemed, Inc. The use of statins to stimulate neurogenesis
EP2051696A2 (en) * 2006-08-18 2009-04-29 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
EP2367554A4 (en) * 2008-11-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid reflux inhibitor for the treatment of obesity and diabetes
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
MX337603B (es) * 2009-11-30 2016-03-10 Adare Pharmaceuticals Inc Composiciones y tabletas farmaceuticas con recubrimiento compresible y metodos de fabricacion.
EP4137137A1 (en) 2010-05-26 2023-02-22 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
RS53227B (sr) 2011-03-01 2014-08-29 Pharnext Terapija neuroloških poremećaja kombinacijom baklofena i akamprosata
DE102011015142A1 (de) * 2011-03-17 2012-09-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer
US9308190B2 (en) 2011-06-06 2016-04-12 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
EA038594B1 (ru) 2011-10-28 2021-09-21 Шайр Хьюман Дженетик Терапис, Инк. Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
KR20160002773A (ko) 2013-03-15 2016-01-08 루메나 파마수티컬즈, 인코포레이티드 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
EP4424363B1 (en) 2019-02-12 2026-04-29 Mirum Pharmaceuticals, Inc. Methods for increasing growth in pediatric subjects having cholestatic liver disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9609872A (pt) * 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
KR20010006443A (ko) * 1997-04-18 2001-01-26 쥐.디. 씨얼리 앤드 컴퍼니 심장혈관 질환 예방에의 시클로 옥시게나제-2 억제제 사용방법
GT199800126A (es) * 1997-08-29 2000-01-29 Terapia de combinacion.
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
UA74141C2 (uk) * 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
WO2000062775A1 (en) * 1999-04-19 2000-10-26 The Regents Of The University Of Michigan Compositions and methods for increasing the bioavailability of lactone ring containing drugs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106461636A (zh) * 2014-01-10 2017-02-22 重症监护诊断股份有限公司 用于测定心力衰竭风险的方法和系统
CN113744876A (zh) * 2014-01-10 2021-12-03 重症监护诊断股份有限公司 用于测定心力衰竭风险的方法和系统

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GEP20063811B (en) 2006-05-10
NO20040211L (no) 2004-03-16
CO5550464A2 (es) 2005-08-31
MA27050A1 (fr) 2004-12-20
EP1406660B1 (en) 2007-06-06
KR20040023660A (ko) 2004-03-18
IS7093A (is) 2003-12-23
US20030149010A1 (en) 2003-08-07
EA200400029A1 (ru) 2004-08-26
PL367417A1 (en) 2005-02-21
US20060003975A1 (en) 2006-01-05
ATE363917T1 (de) 2007-06-15
ECSP044950A (es) 2004-02-26
ZA200400288B (en) 2005-06-29
JP2004537553A (ja) 2004-12-16
DE60220522D1 (de) 2007-07-19
TNSN04001A1 (fr) 2006-06-01
BR0211274A (pt) 2004-08-03
UA76475C2 (en) 2006-08-15
AP2004002951A0 (en) 2004-03-31
IL159588A0 (en) 2004-06-01
DE60220522T2 (de) 2007-09-27
MXPA04000586A (es) 2004-04-20
EP1406660A1 (en) 2004-04-14
WO2003007993A1 (en) 2003-01-30
CA2452678A1 (en) 2003-01-30
OA12983A (en) 2006-10-13

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