CA2452678A1 - Combination of eplerenone and an hmg coa reductase inhibitor - Google Patents
Combination of eplerenone and an hmg coa reductase inhibitor Download PDFInfo
- Publication number
- CA2452678A1 CA2452678A1 CA002452678A CA2452678A CA2452678A1 CA 2452678 A1 CA2452678 A1 CA 2452678A1 CA 002452678 A CA002452678 A CA 002452678A CA 2452678 A CA2452678 A CA 2452678A CA 2452678 A1 CA2452678 A1 CA 2452678A1
- Authority
- CA
- Canada
- Prior art keywords
- hmg
- reductase inhibitor
- receptor antagonist
- aldosterone receptor
- eplerenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title description 37
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 30
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Addiction (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30633601P | 2001-07-19 | 2001-07-19 | |
| US60,306,336 | 2001-07-19 | ||
| PCT/US2002/022896 WO2003007993A1 (en) | 2001-07-19 | 2002-07-18 | Combination of an aldosterone receptor antagonist and an hmg coa reductase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2452678A1 true CA2452678A1 (en) | 2003-01-30 |
Family
ID=23184836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002452678A Abandoned CA2452678A1 (en) | 2001-07-19 | 2002-07-18 | Combination of eplerenone and an hmg coa reductase inhibitor |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20030149010A1 (enExample) |
| EP (1) | EP1406660B1 (enExample) |
| JP (1) | JP2004537553A (enExample) |
| KR (1) | KR20040023660A (enExample) |
| CN (1) | CN1537019A (enExample) |
| AP (1) | AP2004002951A0 (enExample) |
| AT (1) | ATE363917T1 (enExample) |
| BR (1) | BR0211274A (enExample) |
| CA (1) | CA2452678A1 (enExample) |
| CO (1) | CO5550464A2 (enExample) |
| DE (1) | DE60220522T2 (enExample) |
| EA (1) | EA200400029A1 (enExample) |
| EC (1) | ECSP044950A (enExample) |
| ES (1) | ES2286270T3 (enExample) |
| GE (1) | GEP20063811B (enExample) |
| IL (1) | IL159588A0 (enExample) |
| IS (1) | IS7093A (enExample) |
| MA (1) | MA27050A1 (enExample) |
| MX (1) | MXPA04000586A (enExample) |
| NO (1) | NO20040211L (enExample) |
| OA (1) | OA12983A (enExample) |
| PL (1) | PL367417A1 (enExample) |
| TN (1) | TNSN04001A1 (enExample) |
| UA (1) | UA76475C2 (enExample) |
| WO (1) | WO2003007993A1 (enExample) |
| ZA (1) | ZA200400288B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003901812A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphates of secondary alcohols |
| WO2006012642A2 (en) * | 2004-07-30 | 2006-02-02 | Exelixis, Inc. | Pyrrole derivatives as pharmaceutical agents |
| EP1948600B1 (en) * | 2005-07-05 | 2014-04-16 | The President & Fellows Of Harvard College | Liver targeted conjugates |
| CN1310941C (zh) * | 2005-07-13 | 2007-04-18 | 南京大学 | 依普利酮的合成方法 |
| JP2009514851A (ja) * | 2005-11-08 | 2009-04-09 | ランバクシー ラボラトリーズ リミテッド | （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法 |
| GB0600967D0 (en) * | 2006-01-18 | 2006-03-01 | Imp Innovations Ltd | Methods |
| WO2007106862A2 (en) * | 2006-03-14 | 2007-09-20 | Kinemed, Inc. | The use of statins to stimulate neurogenesis |
| WO2008021666A2 (en) * | 2006-08-18 | 2008-02-21 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
| FR2917975B1 (fr) * | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| CN102316872B (zh) | 2008-11-26 | 2016-12-21 | 萨蒂奥根制药公司 | 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| JP5854476B2 (ja) * | 2009-11-30 | 2016-02-09 | アデア ファーマスーティカルズ，インコーポレイテッド | 圧縮性コーティングで被覆された医薬組成物及び錠剤並びに製造方法 |
| EP3593802A3 (en) | 2010-05-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| ES2665569T3 (es) | 2011-03-01 | 2018-04-26 | Pharnext | Tratamiento de la isquemia cerebral |
| DE102011015142A1 (de) * | 2011-03-17 | 2012-09-20 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer |
| WO2012170417A2 (en) | 2011-06-06 | 2012-12-13 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
| WO2013063526A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| EA030839B1 (ru) | 2011-10-28 | 2018-10-31 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
| CN105228615A (zh) | 2013-03-15 | 2016-01-06 | 鲁美纳医药公司 | 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂 |
| JP2016514684A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤 |
| JP6655016B2 (ja) * | 2014-01-10 | 2020-02-26 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | 心不全のリスクを決定するための方法 |
| AU2020221834B2 (en) | 2019-02-12 | 2025-10-23 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69634054T2 (de) * | 1995-07-17 | 2005-12-08 | Warner-Lambert Co. | Kristalline (R-(R*, R*))-2-(4-Fluorophenyl)-β, δ-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-1H-Pyrrol-1-Heptancarbonsäure Hemi Calcium Salz (Atorvastatin) |
| NZ500141A (en) * | 1997-04-18 | 2002-05-31 | G | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| US6638937B2 (en) * | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| AU4348200A (en) * | 1999-04-19 | 2000-11-02 | Regents Of The University Of Michigan, The | Compositions and methods for increasing the bioavailability of lactone ring containing drugs |
-
2002
- 2002-07-18 UA UA2004010388A patent/UA76475C2/uk unknown
- 2002-07-18 ES ES02756521T patent/ES2286270T3/es not_active Expired - Lifetime
- 2002-07-18 EA EA200400029A patent/EA200400029A1/ru unknown
- 2002-07-18 OA OA1200400005A patent/OA12983A/en unknown
- 2002-07-18 CN CNA028145577A patent/CN1537019A/zh active Pending
- 2002-07-18 US US10/198,475 patent/US20030149010A1/en not_active Abandoned
- 2002-07-18 GE GE5410A patent/GEP20063811B/en unknown
- 2002-07-18 AT AT02756521T patent/ATE363917T1/de not_active IP Right Cessation
- 2002-07-18 WO PCT/US2002/022896 patent/WO2003007993A1/en not_active Ceased
- 2002-07-18 EP EP02756521A patent/EP1406660B1/en not_active Expired - Lifetime
- 2002-07-18 CA CA002452678A patent/CA2452678A1/en not_active Abandoned
- 2002-07-18 JP JP2003513598A patent/JP2004537553A/ja active Pending
- 2002-07-18 IL IL15958802A patent/IL159588A0/xx unknown
- 2002-07-18 PL PL02367417A patent/PL367417A1/xx not_active Application Discontinuation
- 2002-07-18 AP APAP/P/2004/002951A patent/AP2004002951A0/en unknown
- 2002-07-18 MX MXPA04000586A patent/MXPA04000586A/es active IP Right Grant
- 2002-07-18 DE DE60220522T patent/DE60220522T2/de not_active Expired - Fee Related
- 2002-07-18 KR KR10-2004-7000846A patent/KR20040023660A/ko not_active Ceased
- 2002-07-18 BR BR0211274-4A patent/BR0211274A/pt not_active IP Right Cessation
-
2003
- 2003-12-23 IS IS7093A patent/IS7093A/is unknown
-
2004
- 2004-01-06 TN TNP2004000001A patent/TNSN04001A1/fr unknown
- 2004-01-14 ZA ZA2004/00288A patent/ZA200400288B/en unknown
- 2004-01-15 MA MA27479A patent/MA27050A1/fr unknown
- 2004-01-16 NO NO20040211A patent/NO20040211L/no not_active Application Discontinuation
- 2004-01-19 CO CO04002848A patent/CO5550464A2/es not_active Application Discontinuation
- 2004-01-19 EC EC2004004950A patent/ECSP044950A/es unknown
-
2005
- 2005-08-18 US US11/206,499 patent/US20060003975A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE363917T1 (de) | 2007-06-15 |
| EP1406660B1 (en) | 2007-06-06 |
| IL159588A0 (en) | 2004-06-01 |
| WO2003007993A1 (en) | 2003-01-30 |
| JP2004537553A (ja) | 2004-12-16 |
| ECSP044950A (es) | 2004-02-26 |
| OA12983A (en) | 2006-10-13 |
| DE60220522D1 (de) | 2007-07-19 |
| DE60220522T2 (de) | 2007-09-27 |
| ZA200400288B (en) | 2005-06-29 |
| MA27050A1 (fr) | 2004-12-20 |
| UA76475C2 (en) | 2006-08-15 |
| NO20040211L (no) | 2004-03-16 |
| TNSN04001A1 (fr) | 2006-06-01 |
| US20060003975A1 (en) | 2006-01-05 |
| MXPA04000586A (es) | 2004-04-20 |
| KR20040023660A (ko) | 2004-03-18 |
| US20030149010A1 (en) | 2003-08-07 |
| CN1537019A (zh) | 2004-10-13 |
| EP1406660A1 (en) | 2004-04-14 |
| PL367417A1 (en) | 2005-02-21 |
| AP2004002951A0 (en) | 2004-03-31 |
| EA200400029A1 (ru) | 2004-08-26 |
| CO5550464A2 (es) | 2005-08-31 |
| BR0211274A (pt) | 2004-08-03 |
| GEP20063811B (en) | 2006-05-10 |
| IS7093A (is) | 2003-12-23 |
| ES2286270T3 (es) | 2007-12-01 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |