ATE363917T1 - Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer - Google Patents

Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer

Info

Publication number
ATE363917T1
ATE363917T1 AT02756521T AT02756521T ATE363917T1 AT E363917 T1 ATE363917 T1 AT E363917T1 AT 02756521 T AT02756521 T AT 02756521T AT 02756521 T AT02756521 T AT 02756521T AT E363917 T1 ATE363917 T1 AT E363917T1
Authority
AT
Austria
Prior art keywords
combination
receptor antagonist
coa reductase
reductase inhibitor
hmg coa
Prior art date
Application number
AT02756521T
Other languages
German (de)
English (en)
Inventor
Bradley Keller
Ellen Mcmahon
Ricardo Rocha
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE363917T1 publication Critical patent/ATE363917T1/de

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Pain & Pain Management (AREA)
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  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
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AT02756521T 2001-07-19 2002-07-18 Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer ATE363917T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30633601P 2001-07-19 2001-07-19

Publications (1)

Publication Number Publication Date
ATE363917T1 true ATE363917T1 (de) 2007-06-15

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AT02756521T ATE363917T1 (de) 2001-07-19 2002-07-18 Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer

Country Status (26)

Country Link
US (2) US20030149010A1 (enExample)
EP (1) EP1406660B1 (enExample)
JP (1) JP2004537553A (enExample)
KR (1) KR20040023660A (enExample)
CN (1) CN1537019A (enExample)
AP (1) AP2004002951A0 (enExample)
AT (1) ATE363917T1 (enExample)
BR (1) BR0211274A (enExample)
CA (1) CA2452678A1 (enExample)
CO (1) CO5550464A2 (enExample)
DE (1) DE60220522T2 (enExample)
EA (1) EA200400029A1 (enExample)
EC (1) ECSP044950A (enExample)
ES (1) ES2286270T3 (enExample)
GE (1) GEP20063811B (enExample)
IL (1) IL159588A0 (enExample)
IS (1) IS7093A (enExample)
MA (1) MA27050A1 (enExample)
MX (1) MXPA04000586A (enExample)
NO (1) NO20040211L (enExample)
OA (1) OA12983A (enExample)
PL (1) PL367417A1 (enExample)
TN (1) TNSN04001A1 (enExample)
UA (1) UA76475C2 (enExample)
WO (1) WO2003007993A1 (enExample)
ZA (1) ZA200400288B (enExample)

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CN1310941C (zh) * 2005-07-13 2007-04-18 南京大学 依普利酮的合成方法
JP2009514851A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
GB0600967D0 (en) * 2006-01-18 2006-03-01 Imp Innovations Ltd Methods
WO2007106862A2 (en) * 2006-03-14 2007-09-20 Kinemed, Inc. The use of statins to stimulate neurogenesis
WO2008021666A2 (en) * 2006-08-18 2008-02-21 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
CN102316872B (zh) 2008-11-26 2016-12-21 萨蒂奥根制药公司 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
JP5854476B2 (ja) * 2009-11-30 2016-02-09 アデア ファーマスーティカルズ，インコーポレイテッド 圧縮性コーティングで被覆された医薬組成物及び錠剤並びに製造方法
EP3593802A3 (en) 2010-05-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
ES2665569T3 (es) 2011-03-01 2018-04-26 Pharnext Tratamiento de la isquemia cerebral
DE102011015142A1 (de) * 2011-03-17 2012-09-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer
WO2012170417A2 (en) 2011-06-06 2012-12-13 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
WO2013063526A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
EA030839B1 (ru) 2011-10-28 2018-10-31 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
JP2016514684A (ja) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤
JP6655016B2 (ja) * 2014-01-10 2020-02-26 クリティカル ケア ダイアグノスティクス インコーポレイテッド 心不全のリスクを決定するための方法
AU2020221834B2 (en) 2019-02-12 2025-10-23 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency

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AU4348200A (en) * 1999-04-19 2000-11-02 Regents Of The University Of Michigan, The Compositions and methods for increasing the bioavailability of lactone ring containing drugs

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CA2452678A1 (en) 2003-01-30
EP1406660B1 (en) 2007-06-06
IL159588A0 (en) 2004-06-01
WO2003007993A1 (en) 2003-01-30
JP2004537553A (ja) 2004-12-16
ECSP044950A (es) 2004-02-26
OA12983A (en) 2006-10-13
DE60220522D1 (de) 2007-07-19
DE60220522T2 (de) 2007-09-27
ZA200400288B (en) 2005-06-29
MA27050A1 (fr) 2004-12-20
UA76475C2 (en) 2006-08-15
NO20040211L (no) 2004-03-16
TNSN04001A1 (fr) 2006-06-01
US20060003975A1 (en) 2006-01-05
MXPA04000586A (es) 2004-04-20
KR20040023660A (ko) 2004-03-18
US20030149010A1 (en) 2003-08-07
CN1537019A (zh) 2004-10-13
EP1406660A1 (en) 2004-04-14
PL367417A1 (en) 2005-02-21
AP2004002951A0 (en) 2004-03-31
EA200400029A1 (ru) 2004-08-26
CO5550464A2 (es) 2005-08-31
BR0211274A (pt) 2004-08-03
GEP20063811B (en) 2006-05-10
IS7093A (is) 2003-12-23
ES2286270T3 (es) 2007-12-01

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