ECSP044950A - COMBINACIÓN DE UN ANTAGONISTA DEL RECEPTOR DE ALDOSTERONA CON UN INHIBIDOR DE LA HMG CoA REDUCTASA - Google Patents
COMBINACIÓN DE UN ANTAGONISTA DEL RECEPTOR DE ALDOSTERONA CON UN INHIBIDOR DE LA HMG CoA REDUCTASAInfo
- Publication number
- ECSP044950A ECSP044950A EC2004004950A ECSP044950A ECSP044950A EC SP044950 A ECSP044950 A EC SP044950A EC 2004004950 A EC2004004950 A EC 2004004950A EC SP044950 A ECSP044950 A EC SP044950A EC SP044950 A ECSP044950 A EC SP044950A
- Authority
- EC
- Ecuador
- Prior art keywords
- disorders
- combination
- aldosterone
- hmg coa
- inhibitor
- Prior art date
Links
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 title 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 title 1
- 229960002478 aldosterone Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 9
- 208000035475 disorder Diseases 0.000 abstract 9
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 2
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 2
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 abstract 2
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 231100000255 pathogenic effect Toxicity 0.000 abstract 2
- 229940044551 receptor antagonist Drugs 0.000 abstract 2
- 239000002464 receptor antagonist Substances 0.000 abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000750 endocrine system Anatomy 0.000 abstract 1
- 229960001208 eplerenone Drugs 0.000 abstract 1
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical compound C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002395 mineralocorticoid Substances 0.000 abstract 1
- 210000002346 musculoskeletal system Anatomy 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
Abstract
La presente invención se refiere a procedimientos y/o profilaxis de uno o más efectos patogénicos en un sujeto que surgen a partir de o son exacerbados por actividad mineralocorticoide endógena, especialmente en presencia de dislipidemia o en un sujeto susceptible a o que padece dislipidemia. Particularmente, la invención se refiere al antagonista del receptor de aldosterona combinando con un inhibidor de la HMG CoA reductasa para uno o más efectos patogénicos seleccionados de, pero no limitados a, trastornos relacionados con el sistema cardiovascular, trastornos relacionados con la inflamación, trastornos relacionados con el sistema neurológico, trastornos relacionados con el sistema músculo-esquelético, trastornos relacionados con el metabolismo, trastornos relacionados con el sistema endocrino, trastornos relacionados con la dermatología y trastornos relacionados con el cáncer. Más particularmente, la invención se refiere a dichos trastornos con dicha terapia de combinación, en la que el antagonista del receptor de aldosterona es un compuesto epoxi-esteroídico, como por ejemplo eplerenona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30633601P | 2001-07-19 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP044950A true ECSP044950A (es) | 2004-02-26 |
Family
ID=23184836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004004950A ECSP044950A (es) | 2001-07-19 | 2004-01-19 | COMBINACIÓN DE UN ANTAGONISTA DEL RECEPTOR DE ALDOSTERONA CON UN INHIBIDOR DE LA HMG CoA REDUCTASA |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20030149010A1 (es) |
| EP (1) | EP1406660B1 (es) |
| JP (1) | JP2004537553A (es) |
| KR (1) | KR20040023660A (es) |
| CN (1) | CN1537019A (es) |
| AP (1) | AP2004002951A0 (es) |
| AT (1) | ATE363917T1 (es) |
| BR (1) | BR0211274A (es) |
| CA (1) | CA2452678A1 (es) |
| CO (1) | CO5550464A2 (es) |
| DE (1) | DE60220522T2 (es) |
| EA (1) | EA200400029A1 (es) |
| EC (1) | ECSP044950A (es) |
| ES (1) | ES2286270T3 (es) |
| GE (1) | GEP20063811B (es) |
| IL (1) | IL159588A0 (es) |
| IS (1) | IS7093A (es) |
| MA (1) | MA27050A1 (es) |
| MX (1) | MXPA04000586A (es) |
| NO (1) | NO20040211L (es) |
| OA (1) | OA12983A (es) |
| PL (1) | PL367417A1 (es) |
| TN (1) | TNSN04001A1 (es) |
| UA (1) | UA76475C2 (es) |
| WO (1) | WO2003007993A1 (es) |
| ZA (1) | ZA200400288B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003901812A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphates of secondary alcohols |
| SG155188A1 (en) * | 2004-07-30 | 2009-09-30 | Exelixis Inc | Pyrrole derivatives as pharmaceutical agents |
| US20090162316A1 (en) * | 2005-07-05 | 2009-06-25 | Harvard University | Liver targeted conjugates |
| CN1310941C (zh) * | 2005-07-13 | 2007-04-18 | 南京大学 | 依普利酮的合成方法 |
| CA2627599A1 (en) * | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
| GB0600967D0 (en) * | 2006-01-18 | 2006-03-01 | Imp Innovations Ltd | Methods |
| WO2007106862A2 (en) * | 2006-03-14 | 2007-09-20 | Kinemed, Inc. | The use of statins to stimulate neurogenesis |
| WO2008021666A2 (en) * | 2006-08-18 | 2008-02-21 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
| FR2917975B1 (fr) * | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| CA2744817C (en) * | 2008-11-26 | 2020-07-07 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| BR112012012999A2 (pt) * | 2009-11-30 | 2019-04-02 | Aptalis Pharmatech, Inc. | Composição farmacêutica, e composição de tablete de desintegração oral (odt) outablete de dispersão rápida (rdt) |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| TR201809351T4 (tr) | 2011-03-01 | 2018-07-23 | Pharnext | Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi. |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| DE102011015142A1 (de) * | 2011-03-17 | 2012-09-20 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer |
| US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
| CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| CN104023727B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| US20140275090A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| CN105228615A (zh) | 2013-03-15 | 2016-01-06 | 鲁美纳医药公司 | 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂 |
| CA2935958A1 (en) * | 2014-01-10 | 2015-07-16 | Critical Care Diagnostics, Inc. | Methods and systems for determining risk of heart failure |
| PL3923943T3 (pl) | 2019-02-12 | 2024-12-09 | Mirum Pharmaceuticals, Inc. | Zależna od genotypu i dawki odpowiedź na asbti u pacjentów z niedoborem pompy eksportu soli żółciowych |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100389518B1 (ko) * | 1995-07-17 | 2003-11-15 | 워너-램버트 캄파니 엘엘씨 | 결정질[r-(r*,r*)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1h-피롤-1-헵탄산헤미칼슘염(아토르바스타틴) |
| EA199900837A1 (ru) * | 1997-04-18 | 2000-10-30 | Дж.Д.Сирл Энд Ко. | Способ применения ингибиторов циклооксигеназы-2 для предупреждения сердечно-сосудистых расстройств |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| US6638937B2 (en) * | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| AU4348200A (en) * | 1999-04-19 | 2000-11-02 | Regents Of The University Of Michigan, The | Compositions and methods for increasing the bioavailability of lactone ring containing drugs |
-
2002
- 2002-07-18 UA UA2004010388A patent/UA76475C2/uk unknown
- 2002-07-18 US US10/198,475 patent/US20030149010A1/en not_active Abandoned
- 2002-07-18 GE GE5410A patent/GEP20063811B/en unknown
- 2002-07-18 BR BR0211274-4A patent/BR0211274A/pt not_active IP Right Cessation
- 2002-07-18 EA EA200400029A patent/EA200400029A1/ru unknown
- 2002-07-18 DE DE60220522T patent/DE60220522T2/de not_active Expired - Fee Related
- 2002-07-18 JP JP2003513598A patent/JP2004537553A/ja active Pending
- 2002-07-18 CN CNA028145577A patent/CN1537019A/zh active Pending
- 2002-07-18 PL PL02367417A patent/PL367417A1/xx not_active Application Discontinuation
- 2002-07-18 ES ES02756521T patent/ES2286270T3/es not_active Expired - Lifetime
- 2002-07-18 WO PCT/US2002/022896 patent/WO2003007993A1/en not_active Ceased
- 2002-07-18 OA OA1200400005A patent/OA12983A/en unknown
- 2002-07-18 AP APAP/P/2004/002951A patent/AP2004002951A0/en unknown
- 2002-07-18 IL IL15958802A patent/IL159588A0/xx unknown
- 2002-07-18 EP EP02756521A patent/EP1406660B1/en not_active Expired - Lifetime
- 2002-07-18 AT AT02756521T patent/ATE363917T1/de not_active IP Right Cessation
- 2002-07-18 CA CA002452678A patent/CA2452678A1/en not_active Abandoned
- 2002-07-18 MX MXPA04000586A patent/MXPA04000586A/es active IP Right Grant
- 2002-07-18 KR KR10-2004-7000846A patent/KR20040023660A/ko not_active Ceased
-
2003
- 2003-12-23 IS IS7093A patent/IS7093A/is unknown
-
2004
- 2004-01-06 TN TNP2004000001A patent/TNSN04001A1/fr unknown
- 2004-01-14 ZA ZA2004/00288A patent/ZA200400288B/en unknown
- 2004-01-15 MA MA27479A patent/MA27050A1/fr unknown
- 2004-01-16 NO NO20040211A patent/NO20040211L/no not_active Application Discontinuation
- 2004-01-19 CO CO04002848A patent/CO5550464A2/es not_active Application Discontinuation
- 2004-01-19 EC EC2004004950A patent/ECSP044950A/es unknown
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- 2005-08-18 US US11/206,499 patent/US20060003975A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030149010A1 (en) | 2003-08-07 |
| IS7093A (is) | 2003-12-23 |
| US20060003975A1 (en) | 2006-01-05 |
| DE60220522T2 (de) | 2007-09-27 |
| WO2003007993A1 (en) | 2003-01-30 |
| ZA200400288B (en) | 2005-06-29 |
| IL159588A0 (en) | 2004-06-01 |
| CO5550464A2 (es) | 2005-08-31 |
| DE60220522D1 (de) | 2007-07-19 |
| AP2004002951A0 (en) | 2004-03-31 |
| TNSN04001A1 (fr) | 2006-06-01 |
| CN1537019A (zh) | 2004-10-13 |
| JP2004537553A (ja) | 2004-12-16 |
| CA2452678A1 (en) | 2003-01-30 |
| EP1406660B1 (en) | 2007-06-06 |
| GEP20063811B (en) | 2006-05-10 |
| MA27050A1 (fr) | 2004-12-20 |
| EA200400029A1 (ru) | 2004-08-26 |
| OA12983A (en) | 2006-10-13 |
| PL367417A1 (en) | 2005-02-21 |
| MXPA04000586A (es) | 2004-04-20 |
| ES2286270T3 (es) | 2007-12-01 |
| KR20040023660A (ko) | 2004-03-18 |
| UA76475C2 (en) | 2006-08-15 |
| EP1406660A1 (en) | 2004-04-14 |
| NO20040211L (no) | 2004-03-16 |
| BR0211274A (pt) | 2004-08-03 |
| ATE363917T1 (de) | 2007-06-15 |
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