CN1469919A - 包含甘露聚糖酶和蛋白酶的洗涤剂组合物 - Google Patents

Info

Publication number

CN1469919A

CN1469919A CNA988100487A CN98810048A CN1469919A CN 1469919 A CN1469919 A CN 1469919A CN A988100487 A CNA988100487 A CN A988100487A CN 98810048 A CN98810048 A CN 98810048A CN 1469919 A CN1469919 A CN 1469919A

Authority

CN

China

Prior art keywords

enzyme

mannase

detergent composition

acid

alkyl

Prior art date

1997-08-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 title claims abstract description 251
• 108090000790 Enzymes Proteins 0.000 title claims abstract description 139
• 239000003599 detergent Substances 0.000 title claims abstract description 139
• 102000004190 Enzymes Human genes 0.000 title claims abstract description 138
• 108091005804 Peptidases Proteins 0.000 title claims description 50
• 102000035195 Peptidases Human genes 0.000 title claims description 50
• TWNIBLMWSKIRAT-RWOPYEJCSA-N (1r,2s,3s,4s,5r)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol Chemical compound O1[C@@]2([H])OC[C@]1([H])[C@@H](O)[C@H](O)[C@@H]2O TWNIBLMWSKIRAT-RWOPYEJCSA-N 0.000 title 1
• 235000019833 protease Nutrition 0.000 title 1
• 108010055059 beta-Mannosidase Proteins 0.000 claims description 104
• 102100032487 Beta-mannosidase Human genes 0.000 claims description 103
• 238000000034 method Methods 0.000 claims description 51
• 238000005406 washing Methods 0.000 claims description 46
• 239000013543 active substance Substances 0.000 claims description 28
• 239000011734 sodium Substances 0.000 claims description 27
• 230000003287 optical effect Effects 0.000 claims description 24
• 229910052708 sodium Inorganic materials 0.000 claims description 22
• HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 18
• 229910021536 Zeolite Inorganic materials 0.000 claims description 17
• 239000010457 zeolite Substances 0.000 claims description 17
• 241000282326 Felis catus Species 0.000 claims description 11
• 239000003945 anionic surfactant Substances 0.000 claims description 11
• 235000019832 sodium triphosphate Nutrition 0.000 claims description 9
• 239000004615 ingredient Substances 0.000 claims description 8
• 239000012141 concentrate Substances 0.000 claims description 7
• 101710194948 Protein phosphatase PhpP Proteins 0.000 claims description 6
• HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 claims description 6
• NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 5
• 239000004115 Sodium Silicate Substances 0.000 claims description 3
• 108090000787 Subtilisin Proteins 0.000 claims description 3
• 229910052911 sodium silicate Inorganic materials 0.000 claims description 3
• UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 3
• 108010022999 Serine Proteases Proteins 0.000 claims description 2
• 102000012479 Serine Proteases Human genes 0.000 claims description 2
• 239000004753 textile Substances 0.000 claims 1
• 238000004140 cleaning Methods 0.000 abstract description 23
• 230000000593 degrading effect Effects 0.000 abstract description 7
• 150000001720 carbohydrates Chemical class 0.000 abstract description 5
• 229940088598 enzyme Drugs 0.000 description 134
• -1 D-galactosyl side chain Chemical group 0.000 description 98
• 108090000765 processed proteins & peptides Proteins 0.000 description 78
• 102000004196 processed proteins & peptides Human genes 0.000 description 71
• 229920001184 polypeptide Polymers 0.000 description 70
• 108090000623 proteins and genes Proteins 0.000 description 58
• 210000004027 cell Anatomy 0.000 description 50
• 108020004414 DNA Proteins 0.000 description 48
• 102000004169 proteins and genes Human genes 0.000 description 43
• 125000000217 alkyl group Chemical group 0.000 description 41
• 230000001580 bacterial effect Effects 0.000 description 40
• 230000000694 effects Effects 0.000 description 40
• 241000193830 Bacillus <bacterium> Species 0.000 description 38
• 235000018102 proteins Nutrition 0.000 description 38
• 239000000463 material Substances 0.000 description 36
• 108010059892 Cellulase Proteins 0.000 description 33
• 239000002253 acid Substances 0.000 description 33
• 239000003795 chemical substances by application Substances 0.000 description 33
• 229940106157 cellulase Drugs 0.000 description 32
• 239000000126 substance Substances 0.000 description 32
• 239000013612 plasmid Substances 0.000 description 30
• 150000001875 compounds Chemical class 0.000 description 29
• 108090001060 Lipase Proteins 0.000 description 28
• 102000004882 Lipase Human genes 0.000 description 28
• 239000004367 Lipase Substances 0.000 description 28
• 108091028043 Nucleic acid sequence Proteins 0.000 description 28
• 235000019421 lipase Nutrition 0.000 description 28
• 239000000047 product Substances 0.000 description 28
• 150000003839 salts Chemical class 0.000 description 28
• 241000894006 Bacteria Species 0.000 description 27
• 229940024606 amino acid Drugs 0.000 description 27
• 235000001014 amino acid Nutrition 0.000 description 27
• 125000004432 carbon atom Chemical group C* 0.000 description 27
• 239000004744 fabric Substances 0.000 description 27
• 238000003752 polymerase chain reaction Methods 0.000 description 26
• 108091033319 polynucleotide Proteins 0.000 description 26
• 102000040430 polynucleotide Human genes 0.000 description 26
• 239000002157 polynucleotide Substances 0.000 description 26
• 150000001413 amino acids Chemical class 0.000 description 25
• 238000002360 preparation method Methods 0.000 description 25
• 239000004382 Amylase Substances 0.000 description 24
• 108010065511 Amylases Proteins 0.000 description 24
• 102000013142 Amylases Human genes 0.000 description 24
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
• 235000019418 amylase Nutrition 0.000 description 24
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 23
• 150000002500 ions Chemical class 0.000 description 23
• 239000007788 liquid Substances 0.000 description 23
• 229920000768 polyamine Polymers 0.000 description 23
• 239000000975 dye Substances 0.000 description 22
• 239000004094 surface-active agent Substances 0.000 description 22
• 239000000523 sample Substances 0.000 description 21
• 150000001412 amines Chemical class 0.000 description 20
• 239000007844 bleaching agent Substances 0.000 description 20
• 229910052757 nitrogen Inorganic materials 0.000 description 20
• 241001292348 Salipaludibacillus agaradhaerens Species 0.000 description 19
• BQODPTQLXVVEJG-UHFFFAOYSA-N [O].C=C Chemical compound [O].C=C BQODPTQLXVVEJG-UHFFFAOYSA-N 0.000 description 19
• 239000002585 base Substances 0.000 description 19
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
• 238000004061 bleaching Methods 0.000 description 18
• 239000011575 calcium Substances 0.000 description 18
• 229920002678 cellulose Polymers 0.000 description 17
• 239000001913 cellulose Substances 0.000 description 17
• 239000007859 condensation product Substances 0.000 description 17
• 235000019441 ethanol Nutrition 0.000 description 17
• 229920000642 polymer Polymers 0.000 description 17
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 16
• 125000003275 alpha amino acid group Chemical group 0.000 description 16
• 229910052791 calcium Inorganic materials 0.000 description 16
• 239000012634 fragment Substances 0.000 description 16
• 239000003352 sequestering agent Substances 0.000 description 16
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 15
• 150000001204 N-oxides Chemical class 0.000 description 15
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
• 229920001206 natural gum Polymers 0.000 description 15
• 229920005646 polycarboxylate Polymers 0.000 description 15
• 239000000344 soap Substances 0.000 description 15
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
• 239000000654 additive Substances 0.000 description 14
• 238000005516 engineering process Methods 0.000 description 14
• 244000005700 microbiome Species 0.000 description 14
• 239000002773 nucleotide Substances 0.000 description 14
• 125000003729 nucleotide group Chemical group 0.000 description 14
• 239000001301 oxygen Substances 0.000 description 14
• 229910052760 oxygen Inorganic materials 0.000 description 14
• 239000006228 supernatant Substances 0.000 description 14
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 13
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 13
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 13
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 12
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 12
• 239000003112 inhibitor Substances 0.000 description 12
• 238000000746 purification Methods 0.000 description 12
• 235000013599 spices Nutrition 0.000 description 12
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 11
• 241000196324 Embryophyta Species 0.000 description 11
• 108010076504 Protein Sorting Signals Proteins 0.000 description 11
• 230000000996 additive effect Effects 0.000 description 11
• 239000003513 alkali Substances 0.000 description 11
• 125000002768 hydroxyalkyl group Chemical group 0.000 description 11
• 239000000243 solution Substances 0.000 description 11
• 239000003760 tallow Substances 0.000 description 11
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
• 125000001931 aliphatic group Chemical group 0.000 description 10
• 125000000539 amino acid group Chemical group 0.000 description 10
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 10
• 229920001577 copolymer Polymers 0.000 description 10
• 230000029087 digestion Effects 0.000 description 10
• 239000006185 dispersion Substances 0.000 description 10
• 239000013604 expression vector Substances 0.000 description 10
• 235000013305 food Nutrition 0.000 description 10
• 230000004048 modification Effects 0.000 description 10
• 238000012986 modification Methods 0.000 description 10
• 230000003248 secreting effect Effects 0.000 description 10
• 150000003512 tertiary amines Chemical class 0.000 description 10
• 238000012546 transfer Methods 0.000 description 10
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 9
• 229940077388 benzenesulfonate Drugs 0.000 description 9
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 9
• 230000008859 change Effects 0.000 description 9
• 235000015165 citric acid Nutrition 0.000 description 9
• 238000013461 design Methods 0.000 description 9
• 150000002148 esters Chemical class 0.000 description 9
• 238000007046 ethoxylation reaction Methods 0.000 description 9
• 238000013467 fragmentation Methods 0.000 description 9
• 238000006062 fragmentation reaction Methods 0.000 description 9
• JPZROSNLRWHSQQ-UHFFFAOYSA-N furan-2,5-dione;prop-2-enoic acid Chemical compound OC(=O)C=C.O=C1OC(=O)C=C1 JPZROSNLRWHSQQ-UHFFFAOYSA-N 0.000 description 9
• 239000008103 glucose Substances 0.000 description 9
• 230000002209 hydrophobic effect Effects 0.000 description 9
• 238000004519 manufacturing process Methods 0.000 description 9
• 229920001282 polysaccharide Polymers 0.000 description 9
• 239000005017 polysaccharide Substances 0.000 description 9
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 9
• 241000894007 species Species 0.000 description 9
• 241000193744 Bacillus amyloliquefaciens Species 0.000 description 8
• 230000003321 amplification Effects 0.000 description 8
• 239000004567 concrete Substances 0.000 description 8
• WOZVHXUHUFLZGK-UHFFFAOYSA-N dimethyl terephthalate Chemical compound COC(=O)C1=CC=C(C(=O)OC)C=C1 WOZVHXUHUFLZGK-UHFFFAOYSA-N 0.000 description 8
• 238000004851 dishwashing Methods 0.000 description 8
• 235000010417 guar gum Nutrition 0.000 description 8
• 230000007062 hydrolysis Effects 0.000 description 8
• 238000006460 hydrolysis reaction Methods 0.000 description 8
• 230000000968 intestinal effect Effects 0.000 description 8
• 238000003199 nucleic acid amplification method Methods 0.000 description 8
• 239000002245 particle Substances 0.000 description 8
• 229920001296 polysiloxane Polymers 0.000 description 8
• 239000000758 substrate Substances 0.000 description 8
• 235000000346 sugar Nutrition 0.000 description 8
• 238000012360 testing method Methods 0.000 description 8
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 8
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 7
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
• 229920002907 Guar gum Polymers 0.000 description 7
• 229920002472 Starch Polymers 0.000 description 7
• BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 7
• 125000003342 alkenyl group Chemical group 0.000 description 7
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 7
• 239000000499 gel Substances 0.000 description 7
• 150000004676 glycans Chemical class 0.000 description 7
• 239000000665 guar gum Substances 0.000 description 7
• 125000000623 heterocyclic group Chemical group 0.000 description 7
• JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 7
• 239000002736 nonionic surfactant Substances 0.000 description 7
• 239000003921 oil Substances 0.000 description 7
• 235000019198 oils Nutrition 0.000 description 7
• 125000001453 quaternary ammonium group Chemical group 0.000 description 7
• 230000008521 reorganization Effects 0.000 description 7
• 238000000926 separation method Methods 0.000 description 7
• 239000000377 silicon dioxide Substances 0.000 description 7
• 238000005507 spraying Methods 0.000 description 7
• 239000008107 starch Substances 0.000 description 7
• 235000019698 starch Nutrition 0.000 description 7
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
• BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 6
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
• 244000063299 Bacillus subtilis Species 0.000 description 6
• 102000003992 Peroxidases Human genes 0.000 description 6
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
• 230000004913 activation Effects 0.000 description 6
• 239000012190 activator Substances 0.000 description 6
• 125000002723 alicyclic group Chemical group 0.000 description 6
• 238000004458 analytical method Methods 0.000 description 6
• 239000002518 antifoaming agent Substances 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• 229910052799 carbon Inorganic materials 0.000 description 6
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 6
• 238000009826 distribution Methods 0.000 description 6
• 238000011156 evaluation Methods 0.000 description 6
• 238000000855 fermentation Methods 0.000 description 6
• 230000004151 fermentation Effects 0.000 description 6
• 239000012530 fluid Substances 0.000 description 6
• 239000006260 foam Substances 0.000 description 6
• 229960002154 guar gum Drugs 0.000 description 6
• 238000009396 hybridization Methods 0.000 description 6
• 239000000416 hydrocolloid Substances 0.000 description 6
• 108010011519 keratan-sulfate endo-1,4-beta-galactosidase Proteins 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 229940072417 peroxidase Drugs 0.000 description 6
• 108040007629 peroxidase activity proteins Proteins 0.000 description 6
• 230000002186 photoactivation Effects 0.000 description 6
• IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 6
• 239000000843 powder Substances 0.000 description 6
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 6
• 238000006277 sulfonation reaction Methods 0.000 description 6
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 6
• LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 5
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 5
• 229920000936 Agarose Polymers 0.000 description 5
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 5
• 235000014469 Bacillus subtilis Nutrition 0.000 description 5
• 101100022267 Bacillus subtilis (strain 168) gmuG gene Proteins 0.000 description 5
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
• 101100159694 Escherichia coli (strain K12) ydhT gene Proteins 0.000 description 5
• 241000233866 Fungi Species 0.000 description 5
• 229920002324 Galactoglucomannan Polymers 0.000 description 5
• 229920002581 Glucomannan Polymers 0.000 description 5
• 102000004157 Hydrolases Human genes 0.000 description 5
• 108090000604 Hydrolases Proteins 0.000 description 5
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 5
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
• 239000004365 Protease Substances 0.000 description 5
• 229920002684 Sepharose Polymers 0.000 description 5
• 229920002125 Sokalan® Polymers 0.000 description 5
• IPZLLSGGQARVMU-UHFFFAOYSA-N [Na].[Na].C=1(C(=CC=CC1)S(=O)(=O)O)C=CC=1C(=CC=CC1)S(=O)(=O)O Chemical compound [Na].[Na].C=1(C(=CC=CC1)S(=O)(=O)O)C=CC=1C(=CC=CC1)S(=O)(=O)O IPZLLSGGQARVMU-UHFFFAOYSA-N 0.000 description 5
• 150000008052 alkyl sulfonates Chemical class 0.000 description 5
• WQZGKKKJIJFFOK-PQMKYFCFSA-N alpha-D-mannose Chemical group OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-PQMKYFCFSA-N 0.000 description 5
• 230000015572 biosynthetic process Effects 0.000 description 5
• 210000004899 c-terminal region Anatomy 0.000 description 5
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 5
• 239000003054 catalyst Substances 0.000 description 5
• 238000006243 chemical reaction Methods 0.000 description 5
• 230000000295 complement effect Effects 0.000 description 5
• 238000009833 condensation Methods 0.000 description 5
• 230000005494 condensation Effects 0.000 description 5
• 239000002537 cosmetic Substances 0.000 description 5
• 229920006037 cross link polymer Polymers 0.000 description 5
• 230000008034 disappearance Effects 0.000 description 5
• 238000006073 displacement reaction Methods 0.000 description 5
• 239000000284 extract Substances 0.000 description 5
• 229940046240 glucomannan Drugs 0.000 description 5
• 229910052739 hydrogen Inorganic materials 0.000 description 5
• 239000012535 impurity Substances 0.000 description 5
• FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 5
• 239000011572 manganese Substances 0.000 description 5
• 239000012528 membrane Substances 0.000 description 5
• 230000000813 microbial effect Effects 0.000 description 5
• 238000002156 mixing Methods 0.000 description 5
• WGYKZJWCGVVSQN-UHFFFAOYSA-N mono-n-propyl amine Natural products CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 5
• 230000000474 nursing effect Effects 0.000 description 5
• 238000007254 oxidation reaction Methods 0.000 description 5
• 229920000728 polyester Polymers 0.000 description 5
• 239000011591 potassium Substances 0.000 description 5
• 229910052700 potassium Inorganic materials 0.000 description 5
• 239000001294 propane Substances 0.000 description 5
• 230000002797 proteolythic effect Effects 0.000 description 5
• 229920006395 saturated elastomer Polymers 0.000 description 5
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 5
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 5
• 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 5
• VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 description 4
• OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 4
• HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 4
• RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 4
• IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 4
• AXAVXPMQTGXXJZ-UHFFFAOYSA-N 2-aminoacetic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol Chemical compound NCC(O)=O.OCC(N)(CO)CO AXAVXPMQTGXXJZ-UHFFFAOYSA-N 0.000 description 4
• MHKLKWCYGIBEQF-UHFFFAOYSA-N 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine Chemical compound C1COCCN1SC1=NC2=CC=CC=C2S1 MHKLKWCYGIBEQF-UHFFFAOYSA-N 0.000 description 4
• NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 4
• 241000193764 Brevibacillus brevis Species 0.000 description 4
• 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 description 4
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 4
• 239000004375 Dextrin Substances 0.000 description 4
• 229920001353 Dextrin Polymers 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 241001480714 Humicola insolens Species 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
• PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 4
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 4
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
• SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 108010056079 Subtilisins Proteins 0.000 description 4
• 102000005158 Subtilisins Human genes 0.000 description 4
• ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 4
• 150000007513 acids Chemical class 0.000 description 4
• 150000003973 alkyl amines Chemical class 0.000 description 4
• 125000000129 anionic group Chemical group 0.000 description 4
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 4
• 235000014633 carbohydrates Nutrition 0.000 description 4
• 230000003197 catalytic effect Effects 0.000 description 4
• 125000002091 cationic group Chemical group 0.000 description 4
• 239000000460 chlorine Substances 0.000 description 4
• 229910052801 chlorine Inorganic materials 0.000 description 4
• 238000013016 damping Methods 0.000 description 4
• 235000019425 dextrin Nutrition 0.000 description 4
• MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 4
• 238000001962 electrophoresis Methods 0.000 description 4
• 150000002191 fatty alcohols Chemical group 0.000 description 4
• 238000010353 genetic engineering Methods 0.000 description 4
• 125000003147 glycosyl group Chemical group 0.000 description 4
• 239000001963 growth medium Substances 0.000 description 4
• 108010002430 hemicellulase Proteins 0.000 description 4
• 229940059442 hemicellulase Drugs 0.000 description 4
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
• 229910052748 manganese Inorganic materials 0.000 description 4
• 229910052751 metal Inorganic materials 0.000 description 4
• 239000002184 metal Substances 0.000 description 4
• 229930182817 methionine Natural products 0.000 description 4
• 230000003647 oxidation Effects 0.000 description 4
• 239000002243 precursor Substances 0.000 description 4
• 229920005604 random copolymer Polymers 0.000 description 4
• 238000011084 recovery Methods 0.000 description 4
• 108091008146 restriction endonucleases Proteins 0.000 description 4
• MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 4
• 239000002689 soil Substances 0.000 description 4
• 229910052717 sulfur Inorganic materials 0.000 description 4
• 238000001890 transfection Methods 0.000 description 4
• REZQBEBOWJAQKS-UHFFFAOYSA-N triacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO REZQBEBOWJAQKS-UHFFFAOYSA-N 0.000 description 4
• 229920002554 vinyl polymer Polymers 0.000 description 4
• DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 3
• RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical class C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 3
• MPNXSZJPSVBLHP-UHFFFAOYSA-N 2-chloro-n-phenylpyridine-3-carboxamide Chemical compound ClC1=NC=CC=C1C(=O)NC1=CC=CC=C1 MPNXSZJPSVBLHP-UHFFFAOYSA-N 0.000 description 3
• YJHSJERLYWNLQL-UHFFFAOYSA-N 2-hydroxyethyl(dimethyl)azanium;chloride Chemical compound Cl.CN(C)CCO YJHSJERLYWNLQL-UHFFFAOYSA-N 0.000 description 3
• YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical class OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 description 3
• 108010013043 Acetylesterase Proteins 0.000 description 3
• 241000228215 Aspergillus aculeatus Species 0.000 description 3
• 241000193422 Bacillus lentus Species 0.000 description 3
• 241000194108 Bacillus licheniformis Species 0.000 description 3
• 101100055551 Bacillus licheniformis amyS gene Proteins 0.000 description 3
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
• 108020004705 Codon Proteins 0.000 description 3
• 244000303965 Cyamopsis psoralioides Species 0.000 description 3
• 238000001712 DNA sequencing Methods 0.000 description 3
• MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 description 3
• 241000588724 Escherichia coli Species 0.000 description 3
• 241000192125 Firmicutes Species 0.000 description 3
• 101001001462 Homo sapiens Importin subunit alpha-5 Proteins 0.000 description 3
• 102100035692 Importin subunit alpha-1 Human genes 0.000 description 3
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
• 101100216056 Lactobacillus amylovorus amyL gene Proteins 0.000 description 3
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 3
• 239000006142 Luria-Bertani Agar Substances 0.000 description 3
• 241001575980 Mendoza Species 0.000 description 3
• BCXBKOQDEOJNRH-UHFFFAOYSA-N NOP(O)=O Chemical class NOP(O)=O BCXBKOQDEOJNRH-UHFFFAOYSA-N 0.000 description 3
• 108091034117 Oligonucleotide Proteins 0.000 description 3
• 238000012408 PCR amplification Methods 0.000 description 3
• 229920002873 Polyethylenimine Polymers 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• 229910004298 SiO 2 Inorganic materials 0.000 description 3
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
• 241000223259 Trichoderma Species 0.000 description 3
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
• 125000004183 alkoxy alkyl group Chemical group 0.000 description 3
• 125000003368 amide group Chemical group 0.000 description 3
• 150000001408 amides Chemical class 0.000 description 3
• 235000019270 ammonium chloride Nutrition 0.000 description 3
• 230000003625 amylolytic effect Effects 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 125000003118 aryl group Chemical group 0.000 description 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
• 239000000872 buffer Substances 0.000 description 3
• 229960000846 camphor Drugs 0.000 description 3
• 230000010261 cell growth Effects 0.000 description 3
• 230000004087 circulation Effects 0.000 description 3
• 238000007334 copolymerization reaction Methods 0.000 description 3
• 235000014113 dietary fatty acids Nutrition 0.000 description 3
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 3
• 235000020776 essential amino acid Nutrition 0.000 description 3
• 235000019197 fats Nutrition 0.000 description 3
• 239000000194 fatty acid Substances 0.000 description 3
• 229930195729 fatty acid Natural products 0.000 description 3
• 150000004665 fatty acids Chemical class 0.000 description 3
• 239000000835 fiber Substances 0.000 description 3
• 238000011049 filling Methods 0.000 description 3
• 125000000524 functional group Chemical group 0.000 description 3
• 230000002538 fungal effect Effects 0.000 description 3
• 230000002068 genetic effect Effects 0.000 description 3
• 235000011187 glycerol Nutrition 0.000 description 3
• KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
• 230000013595 glycosylation Effects 0.000 description 3
• 238000006206 glycosylation reaction Methods 0.000 description 3
• 229910052736 halogen Inorganic materials 0.000 description 3
• 150000002367 halogens Chemical class 0.000 description 3
• 230000012447 hatching Effects 0.000 description 3
• 238000000760 immunoelectrophoresis Methods 0.000 description 3
• 230000008676 import Effects 0.000 description 3
• 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
• 125000005647 linker group Chemical group 0.000 description 3
• 150000002632 lipids Chemical class 0.000 description 3
• 230000002366 lipolytic effect Effects 0.000 description 3
• 229910052744 lithium Inorganic materials 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
• 239000003550 marker Substances 0.000 description 3
• 230000035800 maturation Effects 0.000 description 3
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 3
• 239000012764 mineral filler Substances 0.000 description 3
• 239000000178 monomer Substances 0.000 description 3
• 238000002703 mutagenesis Methods 0.000 description 3
• 231100000350 mutagenesis Toxicity 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• 125000006353 oxyethylene group Chemical group 0.000 description 3
• 229920000058 polyacrylate Polymers 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 229920000098 polyolefin Polymers 0.000 description 3
• 229940093916 potassium phosphate Drugs 0.000 description 3
• 229910000160 potassium phosphate Inorganic materials 0.000 description 3
• 235000011009 potassium phosphates Nutrition 0.000 description 3
• 150000003141 primary amines Chemical group 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 235000019260 propionic acid Nutrition 0.000 description 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
• 229960004063 propylene glycol Drugs 0.000 description 3
• 238000000197 pyrolysis Methods 0.000 description 3
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 3
• 239000002516 radical scavenger Substances 0.000 description 3
• 239000011347 resin Substances 0.000 description 3
• 229920005989 resin Polymers 0.000 description 3
• 150000003335 secondary amines Chemical class 0.000 description 3
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
• 159000000000 sodium salts Chemical class 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 239000000375 suspending agent Substances 0.000 description 3
• 108010075550 termamyl Proteins 0.000 description 3
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
• 230000014616 translation Effects 0.000 description 3
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 3
• 229910052725 zinc Inorganic materials 0.000 description 3
• 239000011701 zinc Substances 0.000 description 3
• YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 description 2
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
• TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical compound C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 description 2
• SDGKUVSVPIIUCF-UHFFFAOYSA-N 2,6-dimethylpiperidine Chemical compound CC1CCCC(C)N1 SDGKUVSVPIIUCF-UHFFFAOYSA-N 0.000 description 2
• FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 2
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
• XMVBHZBLHNOQON-UHFFFAOYSA-N 2-butyl-1-octanol Chemical compound CCCCCCC(CO)CCCC XMVBHZBLHNOQON-UHFFFAOYSA-N 0.000 description 2
• BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• 239000004475 Arginine Substances 0.000 description 2
• 241000193752 Bacillus circulans Species 0.000 description 2
• 241000193749 Bacillus coagulans Species 0.000 description 2
• 241000193388 Bacillus thuringiensis Species 0.000 description 2
• KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
• 108010084185 Cellulases Proteins 0.000 description 2
• 102000005575 Cellulases Human genes 0.000 description 2
• 241000905957 Channa melasoma Species 0.000 description 2
• 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
• 229920000742 Cotton Polymers 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 102000012410 DNA Ligases Human genes 0.000 description 2
• 108010061982 DNA Ligases Proteins 0.000 description 2
• 108010001682 Dextranase Proteins 0.000 description 2
• RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 2
• 108010083608 Durazym Proteins 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
• QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
• 244000182067 Fraxinus ornus Species 0.000 description 2
• 235000002917 Fraxinus ornus Nutrition 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• 108010029541 Laccase Proteins 0.000 description 2
• 102100025532 Male-enhanced antigen 1 Human genes 0.000 description 2
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
• XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 description 2
• 241001597008 Nomeidae Species 0.000 description 2
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 241000194109 Paenibacillus lautus Species 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
• 241000589614 Pseudomonas stutzeri Species 0.000 description 2
• 239000012722 SDS sample buffer Substances 0.000 description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
• 229920002323 Silicone foam Polymers 0.000 description 2
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical class [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 2
• 241001085826 Sporotrichum Species 0.000 description 2
• PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• 244000223014 Syzygium aromaticum Species 0.000 description 2
• 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
• KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
• 241001494489 Thielavia Species 0.000 description 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
• 239000004473 Threonine Substances 0.000 description 2
• 235000011941 Tilia x europaea Nutrition 0.000 description 2
• 239000007983 Tris buffer Substances 0.000 description 2
• UAOKXEHOENRFMP-ZJIFWQFVSA-N [(2r,3r,4s,5r)-2,3,4,5-tetraacetyloxy-6-oxohexyl] acetate Chemical compound CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C=O UAOKXEHOENRFMP-ZJIFWQFVSA-N 0.000 description 2
• 108010084631 acetolactate decarboxylase Proteins 0.000 description 2
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 150000001298 alcohols Chemical class 0.000 description 2
• 101150019439 aldB gene Proteins 0.000 description 2
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
• 150000004996 alkyl benzenes Chemical class 0.000 description 2
• 125000005037 alkyl phenyl group Chemical group 0.000 description 2
• 150000008051 alkyl sulfates Chemical class 0.000 description 2
• 125000005466 alkylenyl group Chemical group 0.000 description 2
• 239000004411 aluminium Substances 0.000 description 2
• 229910052782 aluminium Inorganic materials 0.000 description 2
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
• 150000003863 ammonium salts Chemical class 0.000 description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
• 239000012752 auxiliary agent Substances 0.000 description 2
• 229940054340 bacillus coagulans Drugs 0.000 description 2
• 229940097012 bacillus thuringiensis Drugs 0.000 description 2
• 229910052728 basic metal Inorganic materials 0.000 description 2
• 150000003818 basic metals Chemical class 0.000 description 2
• QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
• 239000004305 biphenyl Substances 0.000 description 2
• 235000010290 biphenyl Nutrition 0.000 description 2
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
• 239000004327 boric acid Substances 0.000 description 2
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
• 229940041514 candida albicans extract Drugs 0.000 description 2
• 150000007942 carboxylates Chemical class 0.000 description 2
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
• 230000015556 catabolic process Effects 0.000 description 2
• 238000006555 catalytic reaction Methods 0.000 description 2
• 150000001768 cations Chemical class 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
• 239000013611 chromosomal DNA Substances 0.000 description 2
• 150000001860 citric acid derivatives Chemical class 0.000 description 2
• 230000008878 coupling Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• 238000005859 coupling reaction Methods 0.000 description 2
• 238000005336 cracking Methods 0.000 description 2
• 230000009260 cross reactivity Effects 0.000 description 2
• RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 2
• 238000006731 degradation reaction Methods 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• GSPKZYJPUDYKPI-UHFFFAOYSA-N diethoxy sulfate Chemical compound CCOOS(=O)(=O)OOCC GSPKZYJPUDYKPI-UHFFFAOYSA-N 0.000 description 2
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 2
• 239000002270 dispersing agent Substances 0.000 description 2
• 125000005066 dodecenyl group Chemical group C(=CCCCCCCCCCC)* 0.000 description 2
• JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 description 2
• 229940009662 edetate Drugs 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 238000010828 elution Methods 0.000 description 2
• IFQUWYZCAGRUJN-UHFFFAOYSA-N ethylenediaminediacetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 description 2
• 239000002979 fabric softener Substances 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• 229930182830 galactose Natural products 0.000 description 2
• 238000001879 gelation Methods 0.000 description 2
• 238000002523 gelfiltration Methods 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• 229930182478 glucoside Natural products 0.000 description 2
• 150000008131 glucosides Chemical class 0.000 description 2
• 230000012010 growth Effects 0.000 description 2
• 150000002402 hexoses Chemical class 0.000 description 2
• 230000036571 hydration Effects 0.000 description 2
• 238000006703 hydration reaction Methods 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 description 2
• 150000002460 imidazoles Chemical class 0.000 description 2
• 230000028993 immune response Effects 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 238000007852 inverse PCR Methods 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• LFEUVBZXUFMACD-UHFFFAOYSA-H lead(2+);trioxido(oxo)-$l^{5}-arsane Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-][As]([O-])([O-])=O.[O-][As]([O-])([O-])=O LFEUVBZXUFMACD-UHFFFAOYSA-H 0.000 description 2
• 229920005610 lignin Polymers 0.000 description 2
• 239000004571 lime Substances 0.000 description 2
• 229910052749 magnesium Inorganic materials 0.000 description 2
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
• 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
• YDSWCNNOKPMOTP-UHFFFAOYSA-N mellitic acid Chemical compound OC(=O)C1=C(C(O)=O)C(C(O)=O)=C(C(O)=O)C(C(O)=O)=C1C(O)=O YDSWCNNOKPMOTP-UHFFFAOYSA-N 0.000 description 2
• 229920000609 methyl cellulose Polymers 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 239000001923 methylcellulose Substances 0.000 description 2
• 108010020132 microbial serine proteinases Proteins 0.000 description 2
• 231100000219 mutagenic Toxicity 0.000 description 2
• 230000003505 mutagenic effect Effects 0.000 description 2
• YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 description 2
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
• 239000002751 oligonucleotide probe Substances 0.000 description 2
• 229920001542 oligosaccharide Polymers 0.000 description 2
• 150000002482 oligosaccharides Chemical class 0.000 description 2
• 239000003605 opacifier Substances 0.000 description 2
• AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 description 2
• 229940049547 paraxin Drugs 0.000 description 2
• 239000013618 particulate matter Substances 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 150000004965 peroxy acids Chemical class 0.000 description 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 2
• 239000002953 phosphate buffered saline Substances 0.000 description 2
• XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 2
• UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
• 229920002401 polyacrylamide Polymers 0.000 description 2
• 239000004584 polyacrylic acid Substances 0.000 description 2
• 229920000573 polyethylene Polymers 0.000 description 2
• 238000006116 polymerization reaction Methods 0.000 description 2
• 239000001103 potassium chloride Substances 0.000 description 2
• 235000011164 potassium chloride Nutrition 0.000 description 2
• 235000019353 potassium silicate Nutrition 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 230000008569 process Effects 0.000 description 2
• BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical class CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
• 150000003233 pyrroles Chemical class 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 238000012216 screening Methods 0.000 description 2
• 230000028327 secretion Effects 0.000 description 2
• 239000013514 silicone foam Substances 0.000 description 2
• 238000002741 site-directed mutagenesis Methods 0.000 description 2
• 235000011091 sodium acetates Nutrition 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
• MSFGZHUJTJBYFA-UHFFFAOYSA-M sodium dichloroisocyanurate Chemical compound [Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O MSFGZHUJTJBYFA-UHFFFAOYSA-M 0.000 description 2
• FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
• 229910052938 sodium sulfate Inorganic materials 0.000 description 2
• 235000011152 sodium sulphate Nutrition 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 125000001424 substituent group Chemical group 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 229960005137 succinic acid Drugs 0.000 description 2
• 150000003462 sulfoxides Chemical class 0.000 description 2
• 239000012747 synergistic agent Substances 0.000 description 2
• 238000010998 test method Methods 0.000 description 2
• 229940095068 tetradecene Drugs 0.000 description 2
• QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 2
• 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
• QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
• XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
• 229960004418 trolamine Drugs 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 239000012138 yeast extract Substances 0.000 description 2
• 150000003751 zinc Chemical class 0.000 description 2
• MEIRRNXMZYDVDW-MQQKCMAXSA-N (2E,4E)-2,4-hexadien-1-ol Chemical compound C\C=C\C=C\CO MEIRRNXMZYDVDW-MQQKCMAXSA-N 0.000 description 1
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
• JQFLYFRHDIHZFZ-RXMQYKEDSA-N (2s)-3,3-dimethylpyrrolidine-2-carboxylic acid Chemical compound CC1(C)CCN[C@@H]1C(O)=O JQFLYFRHDIHZFZ-RXMQYKEDSA-N 0.000 description 1
• CNPSFBUUYIVHAP-AKGZTFGVSA-N (2s)-3-methylpyrrolidine-2-carboxylic acid Chemical compound CC1CCN[C@@H]1C(O)=O CNPSFBUUYIVHAP-AKGZTFGVSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• QGLWBTPVKHMVHM-KTKRTIGZSA-N (z)-octadec-9-en-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCN QGLWBTPVKHMVHM-KTKRTIGZSA-N 0.000 description 1
• LRGXCBHOBRUTJN-UHFFFAOYSA-N 1,1'-biphenyl;sodium Chemical compound [Na].[Na].C1=CC=CC=C1C1=CC=CC=C1 LRGXCBHOBRUTJN-UHFFFAOYSA-N 0.000 description 1
• UXTFKIJKRJJXNV-UHFFFAOYSA-N 1-$l^{1}-oxidanylethanone Chemical compound CC([O])=O UXTFKIJKRJJXNV-UHFFFAOYSA-N 0.000 description 1
• MAQAHCBWMBGMBK-UHFFFAOYSA-N 1-chloro-n-methylpropan-1-amine Chemical class CCC(Cl)NC MAQAHCBWMBGMBK-UHFFFAOYSA-N 0.000 description 1
• GECBFCPDQHIKOX-UHFFFAOYSA-N 1-ethenylimidazole;1-ethenylpyrrolidin-2-one Chemical compound C=CN1C=CN=C1.C=CN1CCCC1=O GECBFCPDQHIKOX-UHFFFAOYSA-N 0.000 description 1
• OQNZFMZDPKAMHH-UHFFFAOYSA-N 1-methoxyethane-1,1,2-tricarboxylic acid Chemical class COC(C(O)=O)(C(O)=O)CC(O)=O OQNZFMZDPKAMHH-UHFFFAOYSA-N 0.000 description 1
• WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 description 1
• PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
• ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
• OMGHIGVFLOPEHJ-UHFFFAOYSA-N 2,5-dihydro-1h-pyrrol-1-ium-2-carboxylate Chemical compound OC(=O)C1NCC=C1 OMGHIGVFLOPEHJ-UHFFFAOYSA-N 0.000 description 1
• QOVUSIZUVWPIAP-UHFFFAOYSA-N 2,6-bis(methoxycarbonyl)benzenesulfonic acid Chemical compound COC(=O)C1=CC=CC(C(=O)OC)=C1S(O)(=O)=O QOVUSIZUVWPIAP-UHFFFAOYSA-N 0.000 description 1
• MPJQXAIKMSKXBI-UHFFFAOYSA-N 2,7,9,14-tetraoxa-1,8-diazabicyclo[6.6.2]hexadecane-3,6,10,13-tetrone Chemical compound C1CN2OC(=O)CCC(=O)ON1OC(=O)CCC(=O)O2 MPJQXAIKMSKXBI-UHFFFAOYSA-N 0.000 description 1
• GZMAAYIALGURDQ-UHFFFAOYSA-N 2-(2-hexoxyethoxy)ethanol Chemical compound CCCCCCOCCOCCO GZMAAYIALGURDQ-UHFFFAOYSA-N 0.000 description 1
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
• VIFBEEYZXDDZCT-UHFFFAOYSA-N 2-(2-phenylethenyl)benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1C=CC1=CC=CC=C1 VIFBEEYZXDDZCT-UHFFFAOYSA-N 0.000 description 1
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
• FBAQFBBASACECK-UHFFFAOYSA-N 2-amino-6-[2-(2-sulfophenyl)ethenyl]benzenesulfonic acid Chemical compound NC1=CC=CC(C=CC=2C(=CC=CC=2)S(O)(=O)=O)=C1S(O)(=O)=O FBAQFBBASACECK-UHFFFAOYSA-N 0.000 description 1
• JJJOZVFVARQUJV-UHFFFAOYSA-N 2-ethylhexylphosphonic acid Chemical compound CCCCC(CC)CP(O)(O)=O JJJOZVFVARQUJV-UHFFFAOYSA-N 0.000 description 1
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
• QTJISTOHDJAKOQ-UHFFFAOYSA-N 2-hydroxyethylazanium;methyl sulfate Chemical compound [NH3+]CCO.COS([O-])(=O)=O QTJISTOHDJAKOQ-UHFFFAOYSA-N 0.000 description 1
• GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
• PDBMKOUAWURVBE-UHFFFAOYSA-N 2-methyl-2-(2-methylpentan-2-yloxy)pentane Chemical compound CCCC(C)(C)OC(C)(C)CCC PDBMKOUAWURVBE-UHFFFAOYSA-N 0.000 description 1
• CDUUKBXTEOFITR-UHFFFAOYSA-N 2-methylserine zwitterion Chemical compound OCC([NH3+])(C)C([O-])=O CDUUKBXTEOFITR-UHFFFAOYSA-N 0.000 description 1
• YZTJKOLMWJNVFH-UHFFFAOYSA-N 2-sulfobenzene-1,3-dicarboxylic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1S(O)(=O)=O YZTJKOLMWJNVFH-UHFFFAOYSA-N 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• CJAZCKUGLFWINJ-UHFFFAOYSA-N 3,4-dihydroxybenzene-1,2-disulfonic acid Chemical compound OC1=CC=C(S(O)(=O)=O)C(S(O)(=O)=O)=C1O CJAZCKUGLFWINJ-UHFFFAOYSA-N 0.000 description 1
• DVFGEIYOLIFSRX-UHFFFAOYSA-N 3-(2-ethylhexoxy)propan-1-amine Chemical compound CCCCC(CC)COCCCN DVFGEIYOLIFSRX-UHFFFAOYSA-N 0.000 description 1
• KWYJDIUEHHCHCZ-UHFFFAOYSA-N 3-[2-[bis(2-carboxyethyl)amino]ethyl-(2-carboxyethyl)amino]propanoic acid Chemical class OC(=O)CCN(CCC(O)=O)CCN(CCC(O)=O)CCC(O)=O KWYJDIUEHHCHCZ-UHFFFAOYSA-N 0.000 description 1
• NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical class OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 1
• CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 description 1
• GUBGYTABKSRVRQ-PZPXDAEZSA-N 4β-mannobiose Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-PZPXDAEZSA-N 0.000 description 1
• PIJBVCVBCQOWMM-UHFFFAOYSA-N 5-acetyloxypentyl acetate Chemical compound CC(=O)OCCCCCOC(C)=O PIJBVCVBCQOWMM-UHFFFAOYSA-N 0.000 description 1
• XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
• 239000004925 Acrylic resin Substances 0.000 description 1
• 229910002012 Aerosil® Inorganic materials 0.000 description 1
• 229910017090 AlO 2 Inorganic materials 0.000 description 1
• 101710184263 Alkaline serine protease Proteins 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 241000972773 Aulopiformes Species 0.000 description 1
• 241000498991 Bacillus licheniformis DSM 13 = ATCC 14580 Species 0.000 description 1
• 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 1
• 101000740449 Bacillus subtilis (strain 168) Biotin/lipoyl attachment protein Proteins 0.000 description 1
• 101710130006 Beta-glucanase Proteins 0.000 description 1
• 239000002028 Biomass Substances 0.000 description 1
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
• 241001474374 Blennius Species 0.000 description 1
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 108010073997 Bromide peroxidase Proteins 0.000 description 1
• QDFXUOZCDRVBIO-UHFFFAOYSA-N C(CC)N.[O] Chemical compound C(CC)N.[O] QDFXUOZCDRVBIO-UHFFFAOYSA-N 0.000 description 1
• MMLDWVRBNKXIKB-UHFFFAOYSA-N C1OOC(C(=O)OOC1)=O Chemical compound C1OOC(C(=O)OOC1)=O MMLDWVRBNKXIKB-UHFFFAOYSA-N 0.000 description 1
• QDWXBVYRECADHW-UHFFFAOYSA-N CNCC(=O)O.C(C(=O)O)(=O)O Chemical compound CNCC(=O)O.C(C(=O)O)(=O)O QDWXBVYRECADHW-UHFFFAOYSA-N 0.000 description 1
• CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 1
• 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
• 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
• WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 108010022172 Chitinases Proteins 0.000 description 1
• 102000012286 Chitinases Human genes 0.000 description 1
• 108010035722 Chloride peroxidase Proteins 0.000 description 1
• 108090000322 Cholinesterases Proteins 0.000 description 1
• 102000003914 Cholinesterases Human genes 0.000 description 1
• 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 description 1
• 208000036086 Chromosome Duplication Diseases 0.000 description 1
• XXAXVMUWHZHZMJ-UHFFFAOYSA-N Chymopapain Chemical compound OC1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1O XXAXVMUWHZHZMJ-UHFFFAOYSA-N 0.000 description 1
• 108020004638 Circular DNA Proteins 0.000 description 1
• 241000059095 Clausena anisata Species 0.000 description 1
• 108091026890 Coding region Proteins 0.000 description 1
• 244000168525 Croton tiglium Species 0.000 description 1
• 241000195493 Cryptophyta Species 0.000 description 1
• 235000008222 Cyamopsis psoralioides Nutrition 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 238000007399 DNA isolation Methods 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 241001459693 Dipterocarpus zeylanicus Species 0.000 description 1
• QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
• 229940120146 EDTMP Drugs 0.000 description 1
• 239000004278 EU approved seasoning Substances 0.000 description 1
• 108090000371 Esterases Proteins 0.000 description 1
• DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
• 241000628997 Flos Species 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• 229920000926 Galactomannan Polymers 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 108700007698 Genetic Terminator Regions Proteins 0.000 description 1
• 241000193385 Geobacillus stearothermophilus Species 0.000 description 1
• 241000245654 Gladiolus Species 0.000 description 1
• 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
• 102100022624 Glucoamylase Human genes 0.000 description 1
• 229920002488 Hemicellulose Polymers 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 241000223198 Humicola Species 0.000 description 1
• 241000223200 Humicola grisea var. thermoidea Species 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• DZLNHFMRPBPULJ-VKHMYHEASA-N L-thioproline Chemical compound OC(=O)[C@@H]1CSCN1 DZLNHFMRPBPULJ-VKHMYHEASA-N 0.000 description 1
• KKJQZEWNZXRJFG-UHFFFAOYSA-N L-trans-4-Methyl-2-pyrrolidinecarboxylic acid Chemical compound CC1CNC(C(O)=O)C1 KKJQZEWNZXRJFG-UHFFFAOYSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102000003960 Ligases Human genes 0.000 description 1
• 108090000364 Ligases Proteins 0.000 description 1
• 102000003820 Lipoxygenases Human genes 0.000 description 1
• 108090000128 Lipoxygenases Proteins 0.000 description 1
• FSNCEEGOMTYXKY-JTQLQIEISA-N Lycoperodine 1 Natural products N1C2=CC=CC=C2C2=C1CN[C@H](C(=O)O)C2 FSNCEEGOMTYXKY-JTQLQIEISA-N 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 240000003183 Manihot esculenta Species 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
• 229920000881 Modified starch Polymers 0.000 description 1
• 108010064696 N,O-diacetylmuramidase Proteins 0.000 description 1
• 102100031688 N-acetylgalactosamine-6-sulfatase Human genes 0.000 description 1
• 229910000503 Na-aluminosilicate Inorganic materials 0.000 description 1
• 108091092724 Noncoding DNA Proteins 0.000 description 1
• CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
• IFVNATVJZVXOFC-UHFFFAOYSA-N OC(CCC(O)=O)=O.OC(CCC(O)=O)=O.O.O Chemical compound OC(CCC(O)=O)=O.OC(CCC(O)=O)=O.O.O IFVNATVJZVXOFC-UHFFFAOYSA-N 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 239000005662 Paraffin oil Substances 0.000 description 1
• 239000001888 Peptone Substances 0.000 description 1
• 108010080698 Peptones Proteins 0.000 description 1
• 108010064785 Phospholipases Proteins 0.000 description 1
• 102000015439 Phospholipases Human genes 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 229920002257 Plurafac® Polymers 0.000 description 1
• 108010059820 Polygalacturonase Proteins 0.000 description 1
• 239000004642 Polyimide Substances 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 241000206614 Porphyra purpurea Species 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
• 101710180012 Protease 7 Proteins 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 241000589540 Pseudomonas fluorescens Species 0.000 description 1
• 241000145542 Pseudomonas marginata Species 0.000 description 1
• 101000968491 Pseudomonas sp. (strain 109) Triacylglycerol lipase Proteins 0.000 description 1
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
• 239000012564 Q sepharose fast flow resin Substances 0.000 description 1
• 239000012614 Q-Sepharose Substances 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 241000190932 Rhodopseudomonas Species 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
• 101100206899 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TIR2 gene Proteins 0.000 description 1
• 101100534242 Schizosaccharomyces pombe (strain 972 / ATCC 24843) srp2 gene Proteins 0.000 description 1
• 108091058545 Secretory proteins Proteins 0.000 description 1
• 102000040739 Secretory proteins Human genes 0.000 description 1
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
• 239000004141 Sodium laurylsulphate Substances 0.000 description 1
• 102000013275 Somatomedins Human genes 0.000 description 1
• 244000046109 Sorghum vulgare var. nervosum Species 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 description 1
• 229920002359 Tetronic® Polymers 0.000 description 1
• 244000299461 Theobroma cacao Species 0.000 description 1
• 235000009470 Theobroma cacao Nutrition 0.000 description 1
• 241000223258 Thermomyces lanuginosus Species 0.000 description 1
• 241000223262 Trichoderma longibrachiatum Species 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 239000006035 Tryptophane Substances 0.000 description 1
• 102000003425 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• VZXPINFXXMIXPH-UHFFFAOYSA-N [Na].C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O Chemical compound [Na].C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O VZXPINFXXMIXPH-UHFFFAOYSA-N 0.000 description 1
• DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
• JNAHSTZIPLLKBQ-UHFFFAOYSA-N [O].CC=C Chemical group [O].CC=C JNAHSTZIPLLKBQ-UHFFFAOYSA-N 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• JTPLPDIKCDKODU-UHFFFAOYSA-N acetic acid;2-(2-aminoethylamino)ethanol Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCO JTPLPDIKCDKODU-UHFFFAOYSA-N 0.000 description 1
• QTONSPKDOKVNBJ-UHFFFAOYSA-N acetic acid;n'-(2-aminoethyl)ethane-1,2-diamine Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCN QTONSPKDOKVNBJ-UHFFFAOYSA-N 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 238000012867 alanine scanning Methods 0.000 description 1
• 150000001335 aliphatic alkanes Chemical class 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 150000001336 alkenes Chemical class 0.000 description 1
• 125000003545 alkoxy group Chemical group 0.000 description 1
• 125000006177 alkyl benzyl group Chemical group 0.000 description 1
• 125000005907 alkyl ester group Chemical group 0.000 description 1
• 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
• 230000029936 alkylation Effects 0.000 description 1
• 238000005804 alkylation reaction Methods 0.000 description 1
• 125000001118 alkylidene group Chemical group 0.000 description 1
• 108090000637 alpha-Amylases Proteins 0.000 description 1
• 102000004139 alpha-Amylases Human genes 0.000 description 1
• 102000005840 alpha-Galactosidase Human genes 0.000 description 1
• 108010030291 alpha-Galactosidase Proteins 0.000 description 1
• 229940024171 alpha-amylase Drugs 0.000 description 1
• 229910000323 aluminium silicate Inorganic materials 0.000 description 1
• 238000003277 amino acid sequence analysis Methods 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 1
• 101150039703 amyL gene Proteins 0.000 description 1
• 150000008064 anhydrides Chemical class 0.000 description 1
• 238000005349 anion exchange Methods 0.000 description 1
• 238000005571 anion exchange chromatography Methods 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 238000000137 annealing Methods 0.000 description 1
• 101150085125 apr gene Proteins 0.000 description 1
• 238000000149 argon plasma sintering Methods 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 235000012216 bentonite Nutrition 0.000 description 1
• YUUVOSXMIOYUGG-UHFFFAOYSA-N benzenesulfonic acid;hydrate Chemical compound O.OS(=O)(=O)C1=CC=CC=C1.OS(=O)(=O)C1=CC=CC=C1 YUUVOSXMIOYUGG-UHFFFAOYSA-N 0.000 description 1
• JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
• 239000012964 benzotriazole Substances 0.000 description 1
• 108010047754 beta-Glucosidase Proteins 0.000 description 1
• 102000006995 beta-Glucosidase Human genes 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 229960003237 betaine Drugs 0.000 description 1
• 230000002457 bidirectional effect Effects 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000009141 biological interaction Effects 0.000 description 1
• 238000010170 biological method Methods 0.000 description 1
• 210000000081 body of the sternum Anatomy 0.000 description 1
• 229910021538 borax Inorganic materials 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 235000008429 bread Nutrition 0.000 description 1
• 238000009395 breeding Methods 0.000 description 1
• 230000001488 breeding effect Effects 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 150000001669 calcium Chemical class 0.000 description 1
• 239000004281 calcium formate Substances 0.000 description 1
• 235000019255 calcium formate Nutrition 0.000 description 1
• 229940044172 calcium formate Drugs 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 150000001718 carbodiimides Chemical class 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 235000013339 cereals Nutrition 0.000 description 1
• 230000003196 chaotropic effect Effects 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 125000001309 chloro group Chemical group Cl* 0.000 description 1
• 235000011967 chocolate pudding Nutrition 0.000 description 1
• 229940048961 cholinesterase Drugs 0.000 description 1
• 239000012501 chromatography medium Substances 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 229940018560 citraconate Drugs 0.000 description 1
• HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
• 238000005352 clarification Methods 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 229910017052 cobalt Inorganic materials 0.000 description 1
• 239000010941 cobalt Substances 0.000 description 1
• GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
• 235000019864 coconut oil Nutrition 0.000 description 1
• 239000003240 coconut oil Substances 0.000 description 1
• 238000004737 colorimetric analysis Methods 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 238000004590 computer program Methods 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 230000007797 corrosion Effects 0.000 description 1
• 238000005260 corrosion Methods 0.000 description 1
• 239000004064 cosurfactant Substances 0.000 description 1
• 230000037029 cross reaction Effects 0.000 description 1
• 238000009295 crossflow filtration Methods 0.000 description 1
• 238000002425 crystallisation Methods 0.000 description 1
• 230000008025 crystallization Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• NSFKBZXCXCJZDQ-UHFFFAOYSA-N cumene;sodium Chemical compound [Na].CC(C)C1=CC=CC=C1 NSFKBZXCXCJZDQ-UHFFFAOYSA-N 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
• SINKOGOPEQSHQD-UHFFFAOYSA-N cyclopentadienide Chemical compound C=1C=C[CH-]C=1 SINKOGOPEQSHQD-UHFFFAOYSA-N 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000001461 cytolytic effect Effects 0.000 description 1
• CDJGWBCMWHSUHR-UHFFFAOYSA-M decyl(triethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](CC)(CC)CC CDJGWBCMWHSUHR-UHFFFAOYSA-M 0.000 description 1
• RLGGVUPWOJOQHP-UHFFFAOYSA-M decyl-(2-hydroxyethyl)-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCO RLGGVUPWOJOQHP-UHFFFAOYSA-M 0.000 description 1
• 238000005238 degreasing Methods 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• AQEFLFZSWDEAIP-UHFFFAOYSA-N di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 description 1
• 230000002478 diastatic effect Effects 0.000 description 1
• CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 description 1
• 150000005690 diesters Chemical class 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 1
• 238000002050 diffraction method Methods 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 239000004205 dimethyl polysiloxane Substances 0.000 description 1
• IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 description 1
• PGZPBNJYTNQMAX-UHFFFAOYSA-N dimethylazanium;methyl sulfate Chemical compound C[NH2+]C.COS([O-])(=O)=O PGZPBNJYTNQMAX-UHFFFAOYSA-N 0.000 description 1
• REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 description 1
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
• 235000013766 direct food additive Nutrition 0.000 description 1
• UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• JHUXOSATQXGREM-UHFFFAOYSA-N dodecanediperoxoic acid Chemical compound OOC(=O)CCCCCCCCCCC(=O)OO JHUXOSATQXGREM-UHFFFAOYSA-N 0.000 description 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 description 1
• 238000002003 electron diffraction Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• YERABYSOHUZTPQ-UHFFFAOYSA-P endo-1,4-beta-Xylanase Chemical compound C=1C=CC=CC=1C[N+](CC)(CC)CCCNC(C(C=1)=O)=CC(=O)C=1NCCC[N+](CC)(CC)CC1=CC=CC=C1 YERABYSOHUZTPQ-UHFFFAOYSA-P 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 230000007515 enzymatic degradation Effects 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• 238000001952 enzyme assay Methods 0.000 description 1
• HCPOCMMGKBZWSJ-UHFFFAOYSA-N ethyl 3-hydrazinyl-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)NN HCPOCMMGKBZWSJ-UHFFFAOYSA-N 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• KHEHKKAUASTOLD-UHFFFAOYSA-M ethyl-dihydroxy-methylazanium;chloride Chemical compound [Cl-].CC[N+](C)(O)O KHEHKKAUASTOLD-UHFFFAOYSA-M 0.000 description 1
• 229940071087 ethylenediamine disuccinate Drugs 0.000 description 1
• 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 150000002190 fatty acyls Chemical group 0.000 description 1
• 235000013312 flour Nutrition 0.000 description 1
• 239000004088 foaming agent Substances 0.000 description 1
• 235000011194 food seasoning agent Nutrition 0.000 description 1
• 239000010794 food waste Substances 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 description 1
• 150000008195 galaktosides Chemical class 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
• 229960002989 glutamic acid Drugs 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 229930182470 glycoside Natural products 0.000 description 1
• 210000005255 gram-positive cell Anatomy 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 1
• 150000002430 hydrocarbons Chemical group 0.000 description 1
• 125000001183 hydrocarbyl group Chemical group 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1
• 238000007327 hydrogenolysis reaction Methods 0.000 description 1
• KCYQMQGPYWZZNJ-BQYQJAHWSA-N hydron;2-[(e)-oct-1-enyl]butanedioate Chemical compound CCCCCC\C=C\C(C(O)=O)CC(O)=O KCYQMQGPYWZZNJ-BQYQJAHWSA-N 0.000 description 1
• 125000001165 hydrophobic group Chemical group 0.000 description 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
• 238000007654 immersion Methods 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 229910001410 inorganic ion Inorganic materials 0.000 description 1
• 229910010272 inorganic material Inorganic materials 0.000 description 1
• 239000011147 inorganic material Substances 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 229910052740 iodine Inorganic materials 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 239000002563 ionic surfactant Substances 0.000 description 1
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• GCHPUFAZSONQIV-UHFFFAOYSA-N isovaline Chemical compound CCC(C)(N)C(O)=O GCHPUFAZSONQIV-UHFFFAOYSA-N 0.000 description 1
• XUWPJKDMEZSVTP-LTYMHZPRSA-N kalafungina Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1[C@@H](C)O[C@H]1[C@@H]2OC(=O)C1 XUWPJKDMEZSVTP-LTYMHZPRSA-N 0.000 description 1
• HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 239000004816 latex Substances 0.000 description 1
• 229920000126 latex Polymers 0.000 description 1
• 239000000711 locust bean gum Substances 0.000 description 1
• 235000010420 locust bean gum Nutrition 0.000 description 1
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L magnesium chloride Substances [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• 159000000003 magnesium salts Chemical class 0.000 description 1
• 235000019341 magnesium sulphate Nutrition 0.000 description 1
• FODOUIXGKGNSMR-UHFFFAOYSA-L magnesium;2-oxidooxycarbonylbenzoate;hexahydrate Chemical class O.O.O.O.O.O.[Mg+2].[O-]OC(=O)C1=CC=CC=C1C([O-])=O FODOUIXGKGNSMR-UHFFFAOYSA-L 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000001819 mass spectrum Methods 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 239000000155 melt Substances 0.000 description 1
• 108010003855 mesentericopeptidase Proteins 0.000 description 1
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
• LULAYUGMBFYYEX-UHFFFAOYSA-N metachloroperbenzoic acid Chemical class OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 150000001457 metallic cations Chemical class 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
• OPLBRXGCGJXTMH-UHFFFAOYSA-N methyl 2-hydroxy-5-methoxysulfonylbenzoate Chemical compound COC(=O)c1cc(ccc1O)S(=O)(=O)OC OPLBRXGCGJXTMH-UHFFFAOYSA-N 0.000 description 1
• 150000004702 methyl esters Chemical class 0.000 description 1
• VXBSKVAMQMBCCA-UHFFFAOYSA-M methyl sulfate;trimethyl(tetradecyl)azanium Chemical compound COS([O-])(=O)=O.CCCCCCCCCCCCCC[N+](C)(C)C VXBSKVAMQMBCCA-UHFFFAOYSA-M 0.000 description 1
• XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
• 235000010755 mineral Nutrition 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 235000019426 modified starch Nutrition 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• HPEUEJRPDGMIMY-IFQPEPLCSA-N molybdopterin Chemical compound O([C@H]1N2)[C@H](COP(O)(O)=O)C(S)=C(S)[C@@H]1NC1=C2N=C(N)NC1=O HPEUEJRPDGMIMY-IFQPEPLCSA-N 0.000 description 1
• CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical class CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• HOGDNTQCSIKEEV-UHFFFAOYSA-N n'-hydroxybutanediamide Chemical compound NC(=O)CCC(=O)NO HOGDNTQCSIKEEV-UHFFFAOYSA-N 0.000 description 1
• GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
• FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
• ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 description 1
• MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical class OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
• 125000004433 nitrogen atom Chemical group N* 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 101150105920 npr gene Proteins 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 150000002924 oxiranes Chemical class 0.000 description 1
• JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
• 125000005702 oxyalkylene group Chemical group 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 238000002161 passivation Methods 0.000 description 1
• 239000001814 pectin Substances 0.000 description 1
• 235000010987 pectin Nutrition 0.000 description 1
• 229920001277 pectin Polymers 0.000 description 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
• 229960003330 pentetic acid Drugs 0.000 description 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
• 235000019319 peptone Nutrition 0.000 description 1
• 239000002304 perfume Substances 0.000 description 1
• 238000005502 peroxidation Methods 0.000 description 1
• 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
• JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
• 238000002823 phage display Methods 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011574 phosphorus Substances 0.000 description 1
• 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
• 238000005222 photoaffinity labeling Methods 0.000 description 1
• 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 238000005554 pickling Methods 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 description 1
• 150000003053 piperidines Chemical class 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 229920000570 polyether Polymers 0.000 description 1
• 229920000151 polyglycol Polymers 0.000 description 1
• 239000010695 polyglycol Substances 0.000 description 1
• 229920001721 polyimide Polymers 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 229920000137 polyphosphoric acid Polymers 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 150000004804 polysaccharides Polymers 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 150000003138 primary alcohols Chemical class 0.000 description 1
• 239000011164 primary particle Substances 0.000 description 1
• VXPCQISYVPFYRK-UHFFFAOYSA-N profenamine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(CC)CC)C3=CC=CC=C3SC2=C1 VXPCQISYVPFYRK-UHFFFAOYSA-N 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• NJKRDXUWFBJCDI-UHFFFAOYSA-N propane-1,1,2,3-tetracarboxylic acid Chemical class OC(=O)CC(C(O)=O)C(C(O)=O)C(O)=O NJKRDXUWFBJCDI-UHFFFAOYSA-N 0.000 description 1
• NJEVMKZODGWUQT-UHFFFAOYSA-N propane-1,1,3,3-tetracarboxylic acid Chemical class OC(=O)C(C(O)=O)CC(C(O)=O)C(O)=O NJEVMKZODGWUQT-UHFFFAOYSA-N 0.000 description 1
• 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
• 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
• 230000005892 protein maturation Effects 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 238000001243 protein synthesis Methods 0.000 description 1
• 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 238000003259 recombinant expression Methods 0.000 description 1
• 238000006268 reductive amination reaction Methods 0.000 description 1
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
• 239000007320 rich medium Substances 0.000 description 1
• 235000019515 salmon Nutrition 0.000 description 1
• 229940071089 sarcosinate Drugs 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 230000021148 sequestering of metal ion Effects 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 238000012807 shake-flask culturing Methods 0.000 description 1
• 229920002545 silicone oil Polymers 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 238000002791 soaking Methods 0.000 description 1
• 239000000429 sodium aluminium silicate Substances 0.000 description 1
• 235000012217 sodium aluminium silicate Nutrition 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• 229940067741 sodium octyl sulfate Drugs 0.000 description 1
• GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
• 239000004328 sodium tetraborate Substances 0.000 description 1
• 235000010339 sodium tetraborate Nutrition 0.000 description 1
• KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
• WFRKJMRGXGWHBM-UHFFFAOYSA-M sodium;octyl sulfate Chemical compound [Na+].CCCCCCCCOS([O-])(=O)=O WFRKJMRGXGWHBM-UHFFFAOYSA-M 0.000 description 1
• YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
• 238000005063 solubilization Methods 0.000 description 1
• 230000007928 solubilization Effects 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 230000003019 stabilising effect Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 150000003890 succinate salts Chemical class 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• 229950009390 symclosene Drugs 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 239000000271 synthetic detergent Substances 0.000 description 1
• JMSVCTWVEWCHDZ-UHFFFAOYSA-M syringate Chemical compound COC1=CC(C([O-])=O)=CC(OC)=C1O JMSVCTWVEWCHDZ-UHFFFAOYSA-M 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 108010038851 tannase Proteins 0.000 description 1
• 239000008399 tap water Substances 0.000 description 1
• 235000020679 tap water Nutrition 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 238000005496 tempering Methods 0.000 description 1
• 229920001897 terpolymer Polymers 0.000 description 1
• FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
• KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 230000005026 transcription initiation Effects 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 229910052723 transition metal Inorganic materials 0.000 description 1
• 150000003624 transition metals Chemical class 0.000 description 1
• YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical class [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
• OHOTVSOGTVKXEL-UHFFFAOYSA-K trisodium;2-[bis(carboxylatomethyl)amino]propanoate Chemical class [Na+].[Na+].[Na+].[O-]C(=O)C(C)N(CC([O-])=O)CC([O-])=O OHOTVSOGTVKXEL-UHFFFAOYSA-K 0.000 description 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
• 230000001810 trypsinlike Effects 0.000 description 1
• 239000012137 tryptone Substances 0.000 description 1
• 229960004799 tryptophan Drugs 0.000 description 1
• 238000002525 ultrasonication Methods 0.000 description 1
• 238000011144 upstream manufacturing Methods 0.000 description 1
• 239000013598 vector Substances 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 238000009423 ventilation Methods 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 150000003722 vitamin derivatives Chemical class 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 239000008096 xylene Substances 0.000 description 1
• GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
• 239000000811 xylitol Substances 0.000 description 1
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
• 235000010447 xylitol Nutrition 0.000 description 1
• 229960002675 xylitol Drugs 0.000 description 1
• 101150004638 ydhT gene Proteins 0.000 description 1