CN1443171A - 新的杂芳基衍生物及其作为药物的应用 - Google Patents

新的杂芳基衍生物及其作为药物的应用 Download PDF

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Publication number
CN1443171A
CN1443171A CN01813158A CN01813158A CN1443171A CN 1443171 A CN1443171 A CN 1443171A CN 01813158 A CN01813158 A CN 01813158A CN 01813158 A CN01813158 A CN 01813158A CN 1443171 A CN1443171 A CN 1443171A
Authority
CN
China
Prior art keywords
alkyl
alkylamino
aryl
replace
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01813158A
Other languages
English (en)
Chinese (zh)
Inventor
P·艾米格
E·甘特尔
J·施密德
B·尼科尔
B·卡舍尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris AG filed Critical Zentaris AG
Publication of CN1443171A publication Critical patent/CN1443171A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN01813158A 2000-07-21 2001-07-18 新的杂芳基衍生物及其作为药物的应用 Pending CN1443171A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035928.0 2000-07-21
DE10035928A DE10035928A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CN1443171A true CN1443171A (zh) 2003-09-17

Family

ID=7649980

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01813158A Pending CN1443171A (zh) 2000-07-21 2001-07-18 新的杂芳基衍生物及其作为药物的应用

Country Status (23)

Country Link
US (5) US6890926B2 (https=)
EP (1) EP1305290A1 (https=)
JP (1) JP2004504381A (https=)
KR (1) KR20030022287A (https=)
CN (1) CN1443171A (https=)
AR (1) AR033678A1 (https=)
AU (2) AU2001279757B2 (https=)
BG (1) BG107508A (https=)
BR (1) BR0112589A (https=)
CA (1) CA2353369A1 (https=)
CZ (1) CZ2003415A3 (https=)
DE (1) DE10035928A1 (https=)
HU (1) HUP0300838A2 (https=)
IL (1) IL153361A0 (https=)
MX (1) MXPA02012565A (https=)
NO (1) NO20030298D0 (https=)
NZ (1) NZ524154A (https=)
PL (1) PL358788A1 (https=)
RU (1) RU2265602C2 (https=)
SK (1) SK1842003A3 (https=)
TW (1) TWI228505B (https=)
WO (1) WO2002008192A1 (https=)
ZA (1) ZA200210180B (https=)

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US7723362B2 (en) * 2004-01-08 2010-05-25 Syngenta Crop Protection, Inc. Pesticidal heterocyclic dihaloallyl compounds
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FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
US8440692B2 (en) * 2006-12-07 2013-05-14 China Medical University Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents
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US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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CL2009001059A1 (es) * 2008-05-01 2010-11-12 Boehringer Ingelheim Int Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
PH12013500808A1 (en) 2010-11-02 2015-10-07 Boehringer Ingelheim Int Pharmaceutical combinations for the treatment of metabolic disorders
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1830964B (zh) * 2005-03-11 2011-06-15 中国科学院上海药物研究所 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途

Also Published As

Publication number Publication date
US6936615B2 (en) 2005-08-30
PL358788A1 (en) 2004-08-23
RU2265602C2 (ru) 2005-12-10
NO20030298L (no) 2003-01-20
US20050176744A1 (en) 2005-08-11
NO20030298D0 (no) 2003-01-20
US20040132747A1 (en) 2004-07-08
NZ524154A (en) 2005-02-25
AR033678A1 (es) 2004-01-07
US20020103214A1 (en) 2002-08-01
CA2353369A1 (en) 2002-01-21
US7026310B2 (en) 2006-04-11
DE10035928A1 (de) 2002-03-07
AU7975701A (en) 2002-02-05
US7056912B2 (en) 2006-06-06
EP1305290A1 (de) 2003-05-02
ZA200210180B (en) 2003-02-12
AU2001279757B2 (en) 2005-05-26
CZ2003415A3 (cs) 2004-05-12
TWI228505B (en) 2005-03-01
BG107508A (bg) 2003-09-30
IL153361A0 (en) 2003-07-06
KR20030022287A (ko) 2003-03-15
HUP0300838A2 (hu) 2003-07-28
JP2004504381A (ja) 2004-02-12
US20040097530A1 (en) 2004-05-20
BR0112589A (pt) 2003-05-20
US20050245523A1 (en) 2005-11-03
WO2002008192A1 (de) 2002-01-31
SK1842003A3 (en) 2004-10-05
US6890926B2 (en) 2005-05-10
MXPA02012565A (es) 2003-09-22

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