CN1407978A - 用羟基芪、新型芪衍生物及其类似物抗发炎、治疗牛皮癣和抑制蛋白质致活酶 - Google Patents
用羟基芪、新型芪衍生物及其类似物抗发炎、治疗牛皮癣和抑制蛋白质致活酶 Download PDFInfo
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- CN1407978A CN1407978A CN00816755A CN00816755A CN1407978A CN 1407978 A CN1407978 A CN 1407978A CN 00816755 A CN00816755 A CN 00816755A CN 00816755 A CN00816755 A CN 00816755A CN 1407978 A CN1407978 A CN 1407978A
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- XZZNDPSIHUTMOC-UHFFFAOYSA-N triphenyl phosphate Chemical group C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
Images
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- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
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- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
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- C07D303/02—Compounds containing oxirane rings
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- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
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Abstract
Description
成分 | 量 |
活性成分(本发明化合物) | 0.05-20.0mg |
乙醇 | 100μl |
矿物油,USP | 50.0mg |
白色矿脂,USP | 制成1.0g |
成分 | 量 |
活性成分(本发明化合物) | 0.05-20.0mg |
乙醇 | 100μl |
微粒化了的单硬脂酸铝 | 50.0mg |
肉豆蔻酸异丙酯 | 制成1.0g |
成分 | 量 |
活性成分(本发明化合物) | 0.05-20.0mg |
乙醇 | 100μl |
聚乙烯及共聚物(A-C8) | 100.0mg |
轻矿物油 | 制成1.0g |
成分 | 量 |
活性成分(本发明化合物) | 0.05-20.0mg |
乙醇 | 100μl |
基于Glaxal的乳剂 | 制成1.0g |
致活酶 | IC50(mM) | ||
EP | CST | STA | |
Lck | 0.10 | 0.27 | 0.54 |
Ck2 | 0.31 | 0.13 | Nd* |
DNA-Pk | 0.16 | 0.55 | Nd |
Pim-1 | 0.16 | 0.18 | Nd |
Claims (29)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16875899P | 1999-12-06 | 1999-12-06 | |
US60/168,758 | 1999-12-06 | ||
US17330099P | 1999-12-28 | 1999-12-28 | |
US60/173,300 | 1999-12-28 | ||
PCT/CA2000/001433 WO2001042231A2 (en) | 1999-12-06 | 2000-12-06 | Polyhydroxystilbenes and stilbene oxides as antisoriatic agents and protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1407978A true CN1407978A (zh) | 2003-04-02 |
CN1319959C CN1319959C (zh) | 2007-06-06 |
Family
ID=26864425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008167559A Expired - Lifetime CN1319959C (zh) | 1999-12-06 | 2000-12-06 | 抗发炎、治疗牛皮癣和抑制蛋白质致活酶的羟基芪、芪衍生物及其类似物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20030171429A1 (zh) |
EP (1) | EP1248774B1 (zh) |
JP (1) | JP4880847B2 (zh) |
KR (1) | KR100805907B1 (zh) |
CN (1) | CN1319959C (zh) |
AT (1) | ATE444960T1 (zh) |
CA (1) | CA2393297C (zh) |
DE (1) | DE60043120D1 (zh) |
ES (1) | ES2334635T3 (zh) |
HK (1) | HK1051691A1 (zh) |
WO (1) | WO2001042231A2 (zh) |
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CN101564538B (zh) * | 2009-06-08 | 2011-12-07 | 河北科技大学 | 3,5-二羟基-4-异丙基二苯乙烯-丁二酸酐-聚乙二醇复合物及其合成方法 |
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- 2000-12-06 JP JP2001543531A patent/JP4880847B2/ja not_active Expired - Lifetime
- 2000-12-06 CA CA2393297A patent/CA2393297C/en not_active Expired - Lifetime
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- 2000-12-06 WO PCT/CA2000/001433 patent/WO2001042231A2/en active IP Right Grant
- 2000-12-06 KR KR1020027007240A patent/KR100805907B1/ko active IP Right Grant
- 2000-12-06 CN CNB008167559A patent/CN1319959C/zh not_active Expired - Lifetime
- 2000-12-06 AT AT00984681T patent/ATE444960T1/de not_active IP Right Cessation
- 2000-12-06 US US10/148,863 patent/US20030171429A1/en not_active Abandoned
- 2000-12-06 ES ES00984681T patent/ES2334635T3/es not_active Expired - Lifetime
- 2000-12-06 DE DE60043120T patent/DE60043120D1/de not_active Expired - Lifetime
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Cited By (9)
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CN101531571B (zh) * | 2009-04-17 | 2013-03-20 | 河北科技大学 | 六次甲基四胺氧化合成二苯乙烯类化合物的方法 |
CN101543477B (zh) * | 2009-05-06 | 2011-01-19 | 河北科技大学 | 壳聚糖包覆3,5-二羟基-4-异丙基二苯乙烯的缓释微球及其制备方法 |
CN101564538B (zh) * | 2009-06-08 | 2011-12-07 | 河北科技大学 | 3,5-二羟基-4-异丙基二苯乙烯-丁二酸酐-聚乙二醇复合物及其合成方法 |
CN106467502A (zh) * | 2015-08-21 | 2017-03-01 | 南京理工大学 | 2,3-二芳基环氧乙烷化合物及其制备方法 |
CN114206315A (zh) * | 2019-07-24 | 2022-03-18 | 索尔-格尔科技有限公司 | 用局部他匹那洛夫-egfr抑制剂组合物治疗皮肤病 |
CN113735693A (zh) * | 2021-10-20 | 2021-12-03 | 河北维达康生物科技有限公司 | 一种白藜芦醇三甲醚的合成方法 |
WO2023125536A1 (zh) * | 2021-12-28 | 2023-07-06 | 上海泽德曼医药科技有限公司 | 用于抑制血管内皮生长的化合物及其用途 |
WO2023217049A1 (zh) * | 2022-05-07 | 2023-11-16 | 南京济群医药科技股份有限公司 | 作为AhR激动剂的二苯乙烯衍生物及其用途 |
WO2023240678A1 (zh) * | 2022-06-13 | 2023-12-21 | 大连大学 | 一类具有抗炎活性的聚酮类化合物及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
AU2133001A (en) | 2001-06-18 |
ES2334635T3 (es) | 2010-03-15 |
HK1051691A1 (en) | 2003-08-15 |
AU780700B2 (en) | 2005-04-14 |
ATE444960T1 (de) | 2009-10-15 |
CN1319959C (zh) | 2007-06-06 |
DE60043120D1 (de) | 2009-11-19 |
WO2001042231A2 (en) | 2001-06-14 |
CA2393297C (en) | 2010-10-05 |
US20030171429A1 (en) | 2003-09-11 |
JP4880847B2 (ja) | 2012-02-22 |
EP1248774A2 (en) | 2002-10-16 |
EP1248774B1 (en) | 2009-10-07 |
WO2001042231A3 (en) | 2001-11-01 |
JP2003516400A (ja) | 2003-05-13 |
KR20020070310A (ko) | 2002-09-05 |
KR100805907B1 (ko) | 2008-02-21 |
CA2393297A1 (en) | 2001-06-14 |
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