CN1330718A - 植物中的治疗活性蛋白质 - Google Patents
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16736298A | 1998-10-07 | 1998-10-07 | |
US16823198A | 1998-10-07 | 1998-10-07 | |
US09/168,231 | 1998-10-07 | ||
US09/167,362 | 1998-10-07 |
Publications (1)
Publication Number | Publication Date |
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CN1330718A true CN1330718A (zh) | 2002-01-09 |
Family
ID=26863095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN99813154A Pending CN1330718A (zh) | 1998-10-07 | 1999-10-05 | 植物中的治疗活性蛋白质 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1117817A2 (hu) |
JP (1) | JP2002526116A (hu) |
KR (1) | KR20010085901A (hu) |
CN (1) | CN1330718A (hu) |
AR (1) | AR020717A1 (hu) |
AU (2) | AU758817B2 (hu) |
BR (1) | BR9915919A (hu) |
CA (1) | CA2344269A1 (hu) |
HU (1) | HUP0103616A3 (hu) |
IL (1) | IL142041A0 (hu) |
PL (1) | PL347904A1 (hu) |
RU (2) | RU2001111881A (hu) |
TR (1) | TR200101032T2 (hu) |
WO (1) | WO2000020612A2 (hu) |
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CN102307561A (zh) * | 2008-06-30 | 2012-01-04 | 奥夫莱夫塔埃克尼公司 | 植物来源的重组生长因子在皮肤护理中的应用 |
CN104561353A (zh) * | 2015-01-29 | 2015-04-29 | 中国农业科学院蔬菜花卉研究所 | 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用 |
CN104754954A (zh) * | 2012-08-23 | 2015-07-01 | 特郎萨格以色列有限公司 | 转基因微藻和其用于口服递送蛋白质的用途 |
CN106460052A (zh) * | 2014-05-14 | 2017-02-22 | 海德堡鲁普雷希特卡尔斯大学 | 双链核酸的合成 |
US10480002B2 (en) | 2014-02-12 | 2019-11-19 | Transalgae Israel Ltd. | Algal based edible vaccines |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
US7361331B2 (en) * | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
AU6277600A (en) * | 1999-07-27 | 2001-02-13 | Syngenta Participations Ag | Novel chimeric genes |
US7572466B1 (en) | 1999-10-13 | 2009-08-11 | Health Research, Inc. | Oral immunology using plant product containing a non-enteric pathogen antigen |
EP1268832A4 (en) * | 2000-02-29 | 2003-04-02 | Univ Auburn | PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTS |
AU2001252246A1 (en) * | 2000-04-05 | 2001-10-23 | Syngenta Participations Ag | Therapeutically active proteins in plants |
FR2809413B1 (fr) * | 2000-05-29 | 2004-10-22 | Tabacs & Allumettes Ind | Production d'allergenes recombinants dans des cellules vegetales |
JP2002017186A (ja) * | 2000-06-30 | 2002-01-22 | Hayashibara Biochem Lab Inc | トランスジェニック植物 |
GB2364705A (en) * | 2000-07-14 | 2002-02-06 | Icgeb | Fusion protein expression in plastids |
AU8980001A (en) | 2000-08-11 | 2002-02-25 | Syngenta Participations Ag | Methods for stable transformation of plants |
CA2441699A1 (en) * | 2001-04-13 | 2002-10-24 | Boyce Thompson Institute For Plant Research | Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives |
CN1886512B (zh) * | 2002-04-23 | 2015-11-25 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
FR2841906B1 (fr) * | 2002-07-05 | 2006-08-18 | Stallergenes Sa | Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes |
ATE542908T1 (de) | 2002-10-15 | 2012-02-15 | Syngenta Participations Ag | Plastidtransformation |
EP1594956A4 (en) | 2003-02-03 | 2007-08-01 | Fraunhofer Usa Inc | SYSTEM FOR EXPRESSION OF GENES IN PLANTS |
WO2004074491A2 (en) * | 2003-02-18 | 2004-09-02 | Syngeta Participations Ag | Expression in plants of antibodies against enterotoxigenic escherichia coli |
GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
CA2526720C (en) | 2003-05-22 | 2013-10-22 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
US8455717B2 (en) | 2004-09-29 | 2013-06-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
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JP2013040138A (ja) * | 2011-08-17 | 2013-02-28 | Univ Of Tsukuba | 活性化型リコンビナント花粉アレルゲンの作製方法 |
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Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451513A (en) * | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
GB9319429D0 (en) * | 1993-09-21 | 1993-11-03 | London Health Ass | Methods and products for controlling immune responses in mammals |
US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
FR2736930B1 (fr) * | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
WO1997004123A1 (en) * | 1995-07-19 | 1997-02-06 | Gel Tech Group Inc. | Collagen compound production in plants |
ZA965786B (en) * | 1995-07-19 | 1997-01-27 | Kimberly Clark Co | Nonwoven barrier and method of making the same |
CA2225652C (en) * | 1995-08-10 | 2007-11-20 | Pal Maliga | Nuclear-encoded transcription system in plastids of higher plants |
AU732479B2 (en) * | 1996-03-06 | 2001-04-26 | Rutgers University | Plastid transformation in arabidopsis thaliana |
CA2261577A1 (en) * | 1996-08-09 | 1998-02-19 | Calgene, Inc. | Methods for producing carotenoid compounds and speciality oils in plant seeds |
CA2263730A1 (en) * | 1996-08-15 | 1998-02-19 | Agrivax Incorporated | Delivery of tolerogenic antigens via edible plants or plant-derived products |
JP2002513275A (ja) * | 1996-09-12 | 2002-05-08 | ノバルティス アクチエンゲゼルシャフト | セルロース分解性酵素を発現するトランスジェニック植物 |
JP2002513283A (ja) * | 1997-01-17 | 2002-05-08 | ザ スクリップス リサーチ インスティテュート | 組換え分子の発現に有用なrna結合タンパク質及び結合部位 |
ATE296355T1 (de) * | 1997-08-07 | 2005-06-15 | Univ Auburn | Universelle integrations- und expressionsvektoren für chloroplasten, transformierte pflanzen und produkte hiervon |
ATE360072T1 (de) * | 1998-07-10 | 2007-05-15 | Calgene Llc | Expression eukarotischer peptide in pflanzenplastiden |
-
1999
- 1999-10-05 CN CN99813154A patent/CN1330718A/zh active Pending
- 1999-10-05 EP EP99950626A patent/EP1117817A2/en not_active Withdrawn
- 1999-10-05 WO PCT/EP1999/007414 patent/WO2000020612A2/en not_active Application Discontinuation
- 1999-10-05 CA CA002344269A patent/CA2344269A1/en not_active Abandoned
- 1999-10-05 IL IL14204199A patent/IL142041A0/xx unknown
- 1999-10-05 TR TR2001/01032T patent/TR200101032T2/xx unknown
- 1999-10-05 HU HU0103616A patent/HUP0103616A3/hu unknown
- 1999-10-05 AR ARP990105036A patent/AR020717A1/es unknown
- 1999-10-05 RU RU2001111881/13A patent/RU2001111881A/ru not_active Application Discontinuation
- 1999-10-05 AU AU63340/99A patent/AU758817B2/en not_active Ceased
- 1999-10-05 JP JP2000574707A patent/JP2002526116A/ja active Pending
- 1999-10-05 PL PL99347904A patent/PL347904A1/xx not_active Application Discontinuation
- 1999-10-05 KR KR1020017004448A patent/KR20010085901A/ko not_active Application Discontinuation
- 1999-10-05 BR BR9915919-8A patent/BR9915919A/pt not_active IP Right Cessation
-
2003
- 2003-01-15 AU AU2003200126A patent/AU2003200126A1/en not_active Abandoned
- 2003-10-27 RU RU2003131696/13A patent/RU2003131696A/ru not_active Application Discontinuation
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102307561A (zh) * | 2008-06-30 | 2012-01-04 | 奥夫莱夫塔埃克尼公司 | 植物来源的重组生长因子在皮肤护理中的应用 |
CN104754954A (zh) * | 2012-08-23 | 2015-07-01 | 特郎萨格以色列有限公司 | 转基因微藻和其用于口服递送蛋白质的用途 |
US9827280B2 (en) | 2012-08-23 | 2017-11-28 | Transalgae Israel Ltd. | Transgenic microalgae and use thereof for oral delivery of proteins |
CN108929855A (zh) * | 2012-08-23 | 2018-12-04 | 特郎萨格以色列有限公司 | 转基因微藻和其用于口服递送蛋白质的用途 |
US11344590B2 (en) | 2012-08-23 | 2022-05-31 | Transalgae Israel Ltd. | Transgenic microalgae and use thereof for oral delivery of proteins |
US10480002B2 (en) | 2014-02-12 | 2019-11-19 | Transalgae Israel Ltd. | Algal based edible vaccines |
CN106460052A (zh) * | 2014-05-14 | 2017-02-22 | 海德堡鲁普雷希特卡尔斯大学 | 双链核酸的合成 |
US10988795B2 (en) | 2014-05-14 | 2021-04-27 | Ruprecht-Karls-Universitat Heidelberg | Synthesis of double-stranded nucleic acids |
CN104561353A (zh) * | 2015-01-29 | 2015-04-29 | 中国农业科学院蔬菜花卉研究所 | 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用 |
CN104561353B (zh) * | 2015-01-29 | 2017-01-11 | 中国农业科学院蔬菜花卉研究所 | 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
IL142041A0 (en) | 2002-03-10 |
WO2000020612A2 (en) | 2000-04-13 |
HUP0103616A3 (en) | 2003-07-28 |
WO2000020612A3 (en) | 2000-07-06 |
PL347904A1 (en) | 2002-04-22 |
AU2003200126A1 (en) | 2003-04-17 |
TR200101032T2 (tr) | 2001-10-22 |
JP2002526116A (ja) | 2002-08-20 |
EP1117817A2 (en) | 2001-07-25 |
AU2003200126A9 (en) | 2003-04-17 |
AR020717A1 (es) | 2002-05-22 |
RU2001111881A (ru) | 2003-06-20 |
CA2344269A1 (en) | 2000-04-13 |
AU6334099A (en) | 2000-04-26 |
RU2003131696A (ru) | 2005-04-20 |
AU758817B2 (en) | 2003-04-03 |
KR20010085901A (ko) | 2001-09-07 |
HUP0103616A2 (hu) | 2002-01-28 |
BR9915919A (pt) | 2001-08-21 |
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