CN1330718A - 植物中的治疗活性蛋白质 - Google Patents

植物中的治疗活性蛋白质 Download PDF

Info

Publication number
CN1330718A
CN1330718A CN99813154A CN99813154A CN1330718A CN 1330718 A CN1330718 A CN 1330718A CN 99813154 A CN99813154 A CN 99813154A CN 99813154 A CN99813154 A CN 99813154A CN 1330718 A CN1330718 A CN 1330718A
Authority
CN
China
Prior art keywords
plant
protein
gene
promotor
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99813154A
Other languages
English (en)
Chinese (zh)
Inventor
P·B·海费茨
S·A·戈夫
A·B·塔特尔
M·E·格里奥特-温克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of CN1330718A publication Critical patent/CN1330718A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214Plastid transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pain & Pain Management (AREA)
CN99813154A 1998-10-07 1999-10-05 植物中的治疗活性蛋白质 Pending CN1330718A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16736298A 1998-10-07 1998-10-07
US16823198A 1998-10-07 1998-10-07
US09/168,231 1998-10-07
US09/167,362 1998-10-07

Publications (1)

Publication Number Publication Date
CN1330718A true CN1330718A (zh) 2002-01-09

Family

ID=26863095

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99813154A Pending CN1330718A (zh) 1998-10-07 1999-10-05 植物中的治疗活性蛋白质

Country Status (14)

Country Link
EP (1) EP1117817A2 (hu)
JP (1) JP2002526116A (hu)
KR (1) KR20010085901A (hu)
CN (1) CN1330718A (hu)
AR (1) AR020717A1 (hu)
AU (2) AU758817B2 (hu)
BR (1) BR9915919A (hu)
CA (1) CA2344269A1 (hu)
HU (1) HUP0103616A3 (hu)
IL (1) IL142041A0 (hu)
PL (1) PL347904A1 (hu)
RU (2) RU2001111881A (hu)
TR (1) TR200101032T2 (hu)
WO (1) WO2000020612A2 (hu)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307561A (zh) * 2008-06-30 2012-01-04 奥夫莱夫塔埃克尼公司 植物来源的重组生长因子在皮肤护理中的应用
CN104561353A (zh) * 2015-01-29 2015-04-29 中国农业科学院蔬菜花卉研究所 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用
CN104754954A (zh) * 2012-08-23 2015-07-01 特郎萨格以色列有限公司 转基因微藻和其用于口服递送蛋白质的用途
CN106460052A (zh) * 2014-05-14 2017-02-22 海德堡鲁普雷希特卡尔斯大学 双链核酸的合成
US10480002B2 (en) 2014-02-12 2019-11-19 Transalgae Israel Ltd. Algal based edible vaccines

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US7361331B2 (en) * 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
AU6277600A (en) * 1999-07-27 2001-02-13 Syngenta Participations Ag Novel chimeric genes
US7572466B1 (en) 1999-10-13 2009-08-11 Health Research, Inc. Oral immunology using plant product containing a non-enteric pathogen antigen
EP1268832A4 (en) * 2000-02-29 2003-04-02 Univ Auburn PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTS
AU2001252246A1 (en) * 2000-04-05 2001-10-23 Syngenta Participations Ag Therapeutically active proteins in plants
FR2809413B1 (fr) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind Production d'allergenes recombinants dans des cellules vegetales
JP2002017186A (ja) * 2000-06-30 2002-01-22 Hayashibara Biochem Lab Inc トランスジェニック植物
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
AU8980001A (en) 2000-08-11 2002-02-25 Syngenta Participations Ag Methods for stable transformation of plants
CA2441699A1 (en) * 2001-04-13 2002-10-24 Boyce Thompson Institute For Plant Research Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives
CN1886512B (zh) * 2002-04-23 2015-11-25 斯克里普斯研究所 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
ATE542908T1 (de) 2002-10-15 2012-02-15 Syngenta Participations Ag Plastidtransformation
EP1594956A4 (en) 2003-02-03 2007-08-01 Fraunhofer Usa Inc SYSTEM FOR EXPRESSION OF GENES IN PLANTS
WO2004074491A2 (en) * 2003-02-18 2004-09-02 Syngeta Participations Ag Expression in plants of antibodies against enterotoxigenic escherichia coli
GB0307989D0 (en) * 2003-04-07 2003-05-14 Mcewen Lab Ltd Therapeutic composition
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
CA2526720C (en) 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
EP2484768A3 (en) * 2005-07-18 2012-11-21 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
AU2012241058B2 (en) * 2005-07-18 2014-04-17 Protalix Ltd. Mucosal or Enteral Administration of Biologically Active Macromolecules
EP1919504B1 (en) 2005-08-03 2013-10-16 iBio, Inc. Antibody to bacillus anthracis protective antigen
JP2009526526A (ja) 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー, インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
SI2150608T1 (en) 2007-05-07 2018-04-30 Protalix Ltd. An extensive disposable bioreactor
GB2449466B (en) * 2007-05-23 2009-11-18 Algentech Ltd Production of proteins in plant tissue
CA2692933C (en) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CN101951951A (zh) * 2007-10-31 2011-01-19 中佛罗里达大学研究基金有限公司 叶绿体衍生的人类疟疾疫苗抗原
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US9175300B2 (en) 2008-11-27 2015-11-03 Vanga Siva Reddy Method of expressing foreign protein in plastids
US9551005B2 (en) * 2009-07-16 2017-01-24 Kenneth John Piller Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
US20120309092A1 (en) * 2009-11-18 2012-12-06 Agriculture Victoria Services Pty Ltd Angiogenin Expression in Plants
CA2839932C (en) 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
JP2013040138A (ja) * 2011-08-17 2013-02-28 Univ Of Tsukuba 活性化型リコンビナント花粉アレルゲンの作製方法
FR3021328B1 (fr) * 2014-05-23 2018-01-05 Angany Inc. Production commerciale de l'allergene amb a1 par expression transitoire chez les plantes
CN110603046B (zh) * 2016-03-20 2022-10-18 宾夕法尼亚州立大学托管会 用于提高高等植物叶绿体中转基因表达的密码子优化和核糖体图谱分析

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
GB9319429D0 (en) * 1993-09-21 1993-11-03 London Health Ass Methods and products for controlling immune responses in mammals
US5576198A (en) * 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
WO1997004123A1 (en) * 1995-07-19 1997-02-06 Gel Tech Group Inc. Collagen compound production in plants
ZA965786B (en) * 1995-07-19 1997-01-27 Kimberly Clark Co Nonwoven barrier and method of making the same
CA2225652C (en) * 1995-08-10 2007-11-20 Pal Maliga Nuclear-encoded transcription system in plastids of higher plants
AU732479B2 (en) * 1996-03-06 2001-04-26 Rutgers University Plastid transformation in arabidopsis thaliana
CA2261577A1 (en) * 1996-08-09 1998-02-19 Calgene, Inc. Methods for producing carotenoid compounds and speciality oils in plant seeds
CA2263730A1 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
JP2002513275A (ja) * 1996-09-12 2002-05-08 ノバルティス アクチエンゲゼルシャフト セルロース分解性酵素を発現するトランスジェニック植物
JP2002513283A (ja) * 1997-01-17 2002-05-08 ザ スクリップス リサーチ インスティテュート 組換え分子の発現に有用なrna結合タンパク質及び結合部位
ATE296355T1 (de) * 1997-08-07 2005-06-15 Univ Auburn Universelle integrations- und expressionsvektoren für chloroplasten, transformierte pflanzen und produkte hiervon
ATE360072T1 (de) * 1998-07-10 2007-05-15 Calgene Llc Expression eukarotischer peptide in pflanzenplastiden

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307561A (zh) * 2008-06-30 2012-01-04 奥夫莱夫塔埃克尼公司 植物来源的重组生长因子在皮肤护理中的应用
CN104754954A (zh) * 2012-08-23 2015-07-01 特郎萨格以色列有限公司 转基因微藻和其用于口服递送蛋白质的用途
US9827280B2 (en) 2012-08-23 2017-11-28 Transalgae Israel Ltd. Transgenic microalgae and use thereof for oral delivery of proteins
CN108929855A (zh) * 2012-08-23 2018-12-04 特郎萨格以色列有限公司 转基因微藻和其用于口服递送蛋白质的用途
US11344590B2 (en) 2012-08-23 2022-05-31 Transalgae Israel Ltd. Transgenic microalgae and use thereof for oral delivery of proteins
US10480002B2 (en) 2014-02-12 2019-11-19 Transalgae Israel Ltd. Algal based edible vaccines
CN106460052A (zh) * 2014-05-14 2017-02-22 海德堡鲁普雷希特卡尔斯大学 双链核酸的合成
US10988795B2 (en) 2014-05-14 2021-04-27 Ruprecht-Karls-Universitat Heidelberg Synthesis of double-stranded nucleic acids
CN104561353A (zh) * 2015-01-29 2015-04-29 中国农业科学院蔬菜花卉研究所 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用
CN104561353B (zh) * 2015-01-29 2017-01-11 中国农业科学院蔬菜花卉研究所 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用

Also Published As

Publication number Publication date
IL142041A0 (en) 2002-03-10
WO2000020612A2 (en) 2000-04-13
HUP0103616A3 (en) 2003-07-28
WO2000020612A3 (en) 2000-07-06
PL347904A1 (en) 2002-04-22
AU2003200126A1 (en) 2003-04-17
TR200101032T2 (tr) 2001-10-22
JP2002526116A (ja) 2002-08-20
EP1117817A2 (en) 2001-07-25
AU2003200126A9 (en) 2003-04-17
AR020717A1 (es) 2002-05-22
RU2001111881A (ru) 2003-06-20
CA2344269A1 (en) 2000-04-13
AU6334099A (en) 2000-04-26
RU2003131696A (ru) 2005-04-20
AU758817B2 (en) 2003-04-03
KR20010085901A (ko) 2001-09-07
HUP0103616A2 (hu) 2002-01-28
BR9915919A (pt) 2001-08-21

Similar Documents

Publication Publication Date Title
CN1330718A (zh) 植物中的治疗活性蛋白质
CN1049454C (zh) 生产转基因玉米的方法
US6136320A (en) Vaccines expressed in plants
US6034298A (en) Vaccines expressed in plants
US5484719A (en) Vaccines produced and administered through edible plants
RU2266332C2 (ru) Химерный ген, содержащий его рекомбинантный вектор и семенной материал, и способы, предусматривающие использование этого гена
CN1292824A (zh) 海藻糖生物合成基因在植物中的表达
CN101501198A (zh) 用于改变玉米穗轴的木质素组成的方法和基因构建体
CN1378553A (zh) 免疫原性的乙型肝炎表面抗原在转基因植物中的表达
CN1552849A (zh) 表达纤维素分解酶的转基因植物
CN1357040A (zh) 病毒基因表达的调节
CN86107908A (zh) 直接将dna插入质体和线粒体
CN1191357C (zh) 口服的免疫原性细菌肠毒素在转基因植物中的表达
CN1293711A (zh) 编码mlo蛋白质并赋予植物抗真菌抗性的基因
CN1232638C (zh) 对真菌毒素具有抗性的转基因植物和方法
CN1406282A (zh) 种子产量、生物量、和收获指数增加的转基因植物
CN1197482A (zh) 向真核细胞运送的外源dna的改良整合方法
CN1134981A (zh) 携带编码杀虫蛋白质融合基因的表达载体及其转基因植物
CN1309835C (zh) 植物可选择标记物和植物转化方法
CN1772902A (zh) 轮状病毒vp6蛋白的一种编码基因及其应用
CA2509678A1 (en) Immunization of fish with plant-expressed recombinant proteins
CN1311077C (zh) 稳定的转基因植物药的相关方法和组合物以及它们作为抗孕药的用途
WO1997011184A1 (en) Plant geraniol/nerol 10-hydroxylase and dna coding therefor
JPH10510149A (ja) 植物組織における高められたビオチン生合成
US20030138456A1 (en) Vaccines expressed in plants

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication