JP2002526116A - 植物における治療活性タンパク質 - Google Patents

植物における治療活性タンパク質

Info

Publication number
JP2002526116A
JP2002526116A JP2000574707A JP2000574707A JP2002526116A JP 2002526116 A JP2002526116 A JP 2002526116A JP 2000574707 A JP2000574707 A JP 2000574707A JP 2000574707 A JP2000574707 A JP 2000574707A JP 2002526116 A JP2002526116 A JP 2002526116A
Authority
JP
Japan
Prior art keywords
plant
protein
promoter
gene
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000574707A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002526116A5 (hu
Inventor
ピーター・バーナード・ハイフェッツ
スティーブン・アーサー・ゴフ
アンマリー・ブルーム・タトル
モニカ・エルゼ・グリオット−ベンク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of JP2002526116A publication Critical patent/JP2002526116A/ja
Publication of JP2002526116A5 publication Critical patent/JP2002526116A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214Plastid transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pain & Pain Management (AREA)
JP2000574707A 1998-10-07 1999-10-05 植物における治療活性タンパク質 Pending JP2002526116A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16736298A 1998-10-07 1998-10-07
US16823198A 1998-10-07 1998-10-07
US09/168,231 1998-10-07
US09/167,362 1998-10-07
PCT/EP1999/007414 WO2000020612A2 (en) 1998-10-07 1999-10-05 Therapeutically active proteins in plants

Publications (2)

Publication Number Publication Date
JP2002526116A true JP2002526116A (ja) 2002-08-20
JP2002526116A5 JP2002526116A5 (hu) 2005-06-30

Family

ID=26863095

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000574707A Pending JP2002526116A (ja) 1998-10-07 1999-10-05 植物における治療活性タンパク質

Country Status (14)

Country Link
EP (1) EP1117817A2 (hu)
JP (1) JP2002526116A (hu)
KR (1) KR20010085901A (hu)
CN (1) CN1330718A (hu)
AR (1) AR020717A1 (hu)
AU (2) AU758817B2 (hu)
BR (1) BR9915919A (hu)
CA (1) CA2344269A1 (hu)
HU (1) HUP0103616A3 (hu)
IL (1) IL142041A0 (hu)
PL (1) PL347904A1 (hu)
RU (2) RU2001111881A (hu)
TR (1) TR200101032T2 (hu)
WO (1) WO2000020612A2 (hu)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522086A (ja) * 2003-04-07 2006-09-28 エピダイム リミテッド 自己免疫状態の治療組成物
JP2006524506A (ja) * 2003-04-27 2006-11-02 プロタリクス リミテッド 植物培養における高マンノースタンパク質の製造
JP2007522824A (ja) * 2004-02-24 2007-08-16 プロタリクス リミテッド 細胞/組織培養デバイス、システム、および方法
US8227230B2 (en) 2003-04-27 2012-07-24 Protalix Ltd. Human lysosomal proteins from plant cell culture
JP2013040138A (ja) * 2011-08-17 2013-02-28 Univ Of Tsukuba 活性化型リコンビナント花粉アレルゲンの作製方法
JP2019509064A (ja) * 2016-03-20 2019-04-04 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング
US10364413B2 (en) 2007-05-07 2019-07-30 Protalix Ltd. Large scale disposable bioreactor

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* Cited by examiner, † Cited by third party
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US7361331B2 (en) * 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
AU6277600A (en) * 1999-07-27 2001-02-13 Syngenta Participations Ag Novel chimeric genes
US7572466B1 (en) 1999-10-13 2009-08-11 Health Research, Inc. Oral immunology using plant product containing a non-enteric pathogen antigen
EP1268832A4 (en) * 2000-02-29 2003-04-02 Univ Auburn PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTS
AU2001252246A1 (en) * 2000-04-05 2001-10-23 Syngenta Participations Ag Therapeutically active proteins in plants
FR2809413B1 (fr) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind Production d'allergenes recombinants dans des cellules vegetales
JP2002017186A (ja) * 2000-06-30 2002-01-22 Hayashibara Biochem Lab Inc トランスジェニック植物
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
AU8980001A (en) 2000-08-11 2002-02-25 Syngenta Participations Ag Methods for stable transformation of plants
CA2441699A1 (en) * 2001-04-13 2002-10-24 Boyce Thompson Institute For Plant Research Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives
CN1886512B (zh) * 2002-04-23 2015-11-25 斯克里普斯研究所 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
ATE542908T1 (de) 2002-10-15 2012-02-15 Syngenta Participations Ag Plastidtransformation
EP1594956A4 (en) 2003-02-03 2007-08-01 Fraunhofer Usa Inc SYSTEM FOR EXPRESSION OF GENES IN PLANTS
WO2004074491A2 (en) * 2003-02-18 2004-09-02 Syngeta Participations Ag Expression in plants of antibodies against enterotoxigenic escherichia coli
CA2526720C (en) 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
EP2484768A3 (en) * 2005-07-18 2012-11-21 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
AU2012241058B2 (en) * 2005-07-18 2014-04-17 Protalix Ltd. Mucosal or Enteral Administration of Biologically Active Macromolecules
EP1919504B1 (en) 2005-08-03 2013-10-16 iBio, Inc. Antibody to bacillus anthracis protective antigen
JP2009526526A (ja) 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー, インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
GB2449466B (en) * 2007-05-23 2009-11-18 Algentech Ltd Production of proteins in plant tissue
CA2692933C (en) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CN101951951A (zh) * 2007-10-31 2011-01-19 中佛罗里达大学研究基金有限公司 叶绿体衍生的人类疟疾疫苗抗原
MX2011000047A (es) * 2008-06-30 2011-06-16 Orf Liftaekni Hf Uso de factores de crecimiento recombinantes derivados de plantas en el cuidado de la piel.
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US9175300B2 (en) 2008-11-27 2015-11-03 Vanga Siva Reddy Method of expressing foreign protein in plastids
US9551005B2 (en) * 2009-07-16 2017-01-24 Kenneth John Piller Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
US20120309092A1 (en) * 2009-11-18 2012-12-06 Agriculture Victoria Services Pty Ltd Angiogenin Expression in Plants
CA2839932C (en) 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
WO2014030165A1 (en) 2012-08-23 2014-02-27 Transalgae Israel Ltd. Transgenic microalgae and use thereof for oral delivery of proteins
EP3104885A4 (en) 2014-02-12 2017-08-30 Transalgae (Israel) Ltd Algal based edible vaccines
CN106460052B (zh) * 2014-05-14 2021-07-16 海德堡鲁普雷希特卡尔斯大学 双链核酸的合成
FR3021328B1 (fr) * 2014-05-23 2018-01-05 Angany Inc. Production commerciale de l'allergene amb a1 par expression transitoire chez les plantes
CN104561353B (zh) * 2015-01-29 2017-01-11 中国农业科学院蔬菜花卉研究所 与甘蓝育性紧密连锁的InDel标记及其检测方法和应用

Citations (11)

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US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
WO1997004155A1 (en) * 1995-07-19 1997-02-06 Kimberly-Clark Worldwide, Inc. Nonwoven barrier and method of making the same
WO1997006250A1 (en) * 1995-08-10 1997-02-20 Rutgers University Nuclear-encoded transcription system in plastids of higher plants
JPH09507743A (ja) * 1993-09-21 1997-08-12 ヴィクトリア/ユニヴァーシティ・ホスピタル・コーポレイション 哺乳類の免疫応答を制御するための方法及び産物
WO1997032977A1 (en) * 1996-03-06 1997-09-12 Rutgers University Plastid transformation in arabidopsis thaliana
JPH09510342A (ja) * 1993-12-14 1997-10-21 カルジーン,インコーポレイティド 植物プラスチドにおけるトランスジェニック構造体の制御された発現
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
WO1998011235A2 (en) * 1996-09-12 1998-03-19 Novartis Ag Transgenic plants expressing cellulolytic enzymes
WO1998031823A1 (en) * 1997-01-17 1998-07-23 The Scripps Research Institute Rna binding protein and binding site useful for expression of recombinant molecules
WO1999010513A1 (en) * 1997-08-07 1999-03-04 Auburn University Universal chloroplast integration and expression vectors, transformed plants and products thereof
JP2002520019A (ja) * 1998-07-10 2002-07-09 カルジーン エルエルシー 植物色素体における真核性ペプチドの発現

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FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
WO1997004123A1 (en) * 1995-07-19 1997-02-06 Gel Tech Group Inc. Collagen compound production in plants
CA2261577A1 (en) * 1996-08-09 1998-02-19 Calgene, Inc. Methods for producing carotenoid compounds and speciality oils in plant seeds

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US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
JPH09507743A (ja) * 1993-09-21 1997-08-12 ヴィクトリア/ユニヴァーシティ・ホスピタル・コーポレイション 哺乳類の免疫応答を制御するための方法及び産物
JPH09510342A (ja) * 1993-12-14 1997-10-21 カルジーン,インコーポレイティド 植物プラスチドにおけるトランスジェニック構造体の制御された発現
WO1997004155A1 (en) * 1995-07-19 1997-02-06 Kimberly-Clark Worldwide, Inc. Nonwoven barrier and method of making the same
WO1997006250A1 (en) * 1995-08-10 1997-02-20 Rutgers University Nuclear-encoded transcription system in plastids of higher plants
WO1997032977A1 (en) * 1996-03-06 1997-09-12 Rutgers University Plastid transformation in arabidopsis thaliana
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
WO1998011235A2 (en) * 1996-09-12 1998-03-19 Novartis Ag Transgenic plants expressing cellulolytic enzymes
WO1998031823A1 (en) * 1997-01-17 1998-07-23 The Scripps Research Institute Rna binding protein and binding site useful for expression of recombinant molecules
WO1999010513A1 (en) * 1997-08-07 1999-03-04 Auburn University Universal chloroplast integration and expression vectors, transformed plants and products thereof
JP2002524023A (ja) * 1997-08-07 2002-08-06 オーバーン・ユニバーシティ 万能葉緑体組込および発現ベクター、その形質転換植物ならびに生産物
JP2002520019A (ja) * 1998-07-10 2002-07-09 カルジーン エルエルシー 植物色素体における真核性ペプチドの発現

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NATURE MED., vol. 3, JPN4006016008, 1997, pages 793 - 796, ISSN: 0000768187 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522086A (ja) * 2003-04-07 2006-09-28 エピダイム リミテッド 自己免疫状態の治療組成物
JP2006524506A (ja) * 2003-04-27 2006-11-02 プロタリクス リミテッド 植物培養における高マンノースタンパク質の製造
JP2011184445A (ja) * 2003-04-27 2011-09-22 Protalix Ltd 植物培養における高マンノースタンパク質の製造
US8227230B2 (en) 2003-04-27 2012-07-24 Protalix Ltd. Human lysosomal proteins from plant cell culture
US8449876B2 (en) 2003-04-27 2013-05-28 Protalix Ltd. Human lysosomal proteins from plant cell culture
JP2007522824A (ja) * 2004-02-24 2007-08-16 プロタリクス リミテッド 細胞/組織培養デバイス、システム、および方法
US10364413B2 (en) 2007-05-07 2019-07-30 Protalix Ltd. Large scale disposable bioreactor
JP2013040138A (ja) * 2011-08-17 2013-02-28 Univ Of Tsukuba 活性化型リコンビナント花粉アレルゲンの作製方法
JP2019509064A (ja) * 2016-03-20 2019-04-04 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング
JP7145083B2 (ja) 2016-03-20 2022-09-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング

Also Published As

Publication number Publication date
IL142041A0 (en) 2002-03-10
WO2000020612A2 (en) 2000-04-13
HUP0103616A3 (en) 2003-07-28
WO2000020612A3 (en) 2000-07-06
PL347904A1 (en) 2002-04-22
AU2003200126A1 (en) 2003-04-17
TR200101032T2 (tr) 2001-10-22
EP1117817A2 (en) 2001-07-25
AU2003200126A9 (en) 2003-04-17
AR020717A1 (es) 2002-05-22
RU2001111881A (ru) 2003-06-20
CA2344269A1 (en) 2000-04-13
AU6334099A (en) 2000-04-26
RU2003131696A (ru) 2005-04-20
AU758817B2 (en) 2003-04-03
KR20010085901A (ko) 2001-09-07
CN1330718A (zh) 2002-01-09
HUP0103616A2 (hu) 2002-01-28
BR9915919A (pt) 2001-08-21

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