CN1326858C - 三环螺哌啶化合物 - Google Patents

三环螺哌啶化合物 Download PDF

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Publication number
CN1326858C
CN1326858C CNB038191466A CN03819146A CN1326858C CN 1326858 C CN1326858 C CN 1326858C CN B038191466 A CNB038191466 A CN B038191466A CN 03819146 A CN03819146 A CN 03819146A CN 1326858 C CN1326858 C CN 1326858C
Authority
CN
China
Prior art keywords
piperidines
spiral shell
cumarone
chloro
oxygen base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038191466A
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English (en)
Chinese (zh)
Other versions
CN1675218A (zh
Inventor
纳利扎尔·霍赛恩
斯维特拉纳·艾瓦诺瓦
玛格丽特·门索尼德斯-哈斯马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1675218A publication Critical patent/CN1675218A/zh
Application granted granted Critical
Publication of CN1326858C publication Critical patent/CN1326858C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB038191466A 2002-07-08 2003-07-07 三环螺哌啶化合物 Expired - Fee Related CN1326858C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202133A SE0202133D0 (sv) 2002-07-08 2002-07-08 Novel compounds
SE02021335 2002-07-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2006101435561A Division CN1974574A (zh) 2002-07-08 2003-07-07 新的三环螺吡咯烷

Publications (2)

Publication Number Publication Date
CN1675218A CN1675218A (zh) 2005-09-28
CN1326858C true CN1326858C (zh) 2007-07-18

Family

ID=20288470

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB038191466A Expired - Fee Related CN1326858C (zh) 2002-07-08 2003-07-07 三环螺哌啶化合物
CNA2006101435561A Pending CN1974574A (zh) 2002-07-08 2003-07-07 新的三环螺吡咯烷

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2006101435561A Pending CN1974574A (zh) 2002-07-08 2003-07-07 新的三环螺吡咯烷

Country Status (25)

Country Link
US (2) US7449475B2 (https=)
EP (1) EP1521757B1 (https=)
JP (1) JP2005537255A (https=)
CN (2) CN1326858C (https=)
AR (1) AR040475A1 (https=)
AT (1) ATE385235T1 (https=)
AU (1) AU2003243122B2 (https=)
BR (1) BR0312560A (https=)
CA (1) CA2492122A1 (https=)
CY (1) CY1107915T1 (https=)
DE (1) DE60318948T2 (https=)
DK (1) DK1521757T3 (https=)
ES (1) ES2298575T3 (https=)
IS (1) IS7662A (https=)
MX (1) MXPA05000278A (https=)
NO (1) NO20050635L (https=)
NZ (1) NZ537259A (https=)
PL (1) PL374877A1 (https=)
PT (1) PT1521757E (https=)
RU (1) RU2320664C2 (https=)
SE (1) SE0202133D0 (https=)
TW (1) TW200413386A (https=)
UA (1) UA77809C2 (https=)
WO (1) WO2004005295A1 (https=)
ZA (1) ZA200500024B (https=)

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US8071624B2 (en) 2004-06-24 2011-12-06 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
JP5154406B2 (ja) 2005-04-13 2013-02-27 アステックス、セラピューティックス、リミテッド 医薬化合物
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EP2125728A4 (en) * 2007-02-23 2011-06-22 Astrazeneca Ab NOVEL COMBINATION OF COMPOUNDS FOR THE TREATMENT OF AIRWAY DISEASES, IN PARTICULAR CHRONIC OBSTRUCTIVE BRONCHOPNEUMOPATHY (COPD) AND ASTHMA
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WO2009011655A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma
WO2009011654A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Process for the preparation of cyclic spiropiperidines
WO2009015166A1 (en) * 2007-07-24 2009-01-29 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
EP2190286A4 (en) * 2007-08-14 2011-06-01 Glaxo Group Ltd SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
EP2250176B1 (en) * 2008-01-30 2012-08-01 Cephalon, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
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WO1998025605A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO2000014086A1 (en) * 1998-09-04 2000-03-16 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Also Published As

Publication number Publication date
US7449475B2 (en) 2008-11-11
NZ537259A (en) 2006-08-31
US20090062322A1 (en) 2009-03-05
JP2005537255A (ja) 2005-12-08
NO20050635L (no) 2005-03-31
DE60318948T2 (de) 2009-05-20
HK1074622A1 (en) 2005-11-18
CN1974574A (zh) 2007-06-06
MXPA05000278A (es) 2005-03-31
SE0202133D0 (sv) 2002-07-08
WO2004005295A1 (en) 2004-01-15
ES2298575T3 (es) 2008-05-16
EP1521757A1 (en) 2005-04-13
RU2320664C2 (ru) 2008-03-27
US20050245741A1 (en) 2005-11-03
UA77809C2 (en) 2007-01-15
BR0312560A (pt) 2005-05-10
CA2492122A1 (en) 2004-01-15
PL374877A1 (en) 2005-11-14
AU2003243122B2 (en) 2006-09-28
IS7662A (is) 2005-01-24
DE60318948D1 (de) 2008-03-20
ATE385235T1 (de) 2008-02-15
AU2003243122A1 (en) 2004-01-23
CY1107915T1 (el) 2013-09-04
DK1521757T3 (da) 2008-05-05
AR040475A1 (es) 2005-04-06
PT1521757E (pt) 2008-04-03
ZA200500024B (en) 2006-02-22
EP1521757B1 (en) 2008-01-30
CN1675218A (zh) 2005-09-28
RU2004137278A (ru) 2005-09-10
TW200413386A (en) 2004-08-01

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