DE60318948D1 - Tricyclische spiropiperidine oder spiropyrrolidine - Google Patents

Tricyclische spiropiperidine oder spiropyrrolidine

Info

Publication number
DE60318948D1
DE60318948D1 DE60318948T DE60318948T DE60318948D1 DE 60318948 D1 DE60318948 D1 DE 60318948D1 DE 60318948 T DE60318948 T DE 60318948T DE 60318948 T DE60318948 T DE 60318948T DE 60318948 D1 DE60318948 D1 DE 60318948D1
Authority
DE
Germany
Prior art keywords
spiropyrrolidine
spiropiperidine
tricyclic
tricyclic spiropiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60318948T
Other languages
English (en)
Other versions
DE60318948T2 (de
Inventor
Nafizal Hossain
Svetlana Ivanova
Marguerite Mensonides-Harsema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60318948D1 publication Critical patent/DE60318948D1/de
Publication of DE60318948T2 publication Critical patent/DE60318948T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE60318948T 2002-07-08 2003-07-07 Tricyclische spiropiperidine oder spiropyrrolidine Expired - Fee Related DE60318948T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0202133A SE0202133D0 (sv) 2002-07-08 2002-07-08 Novel compounds
SE0202133 2002-07-08
PCT/SE2003/001185 WO2004005295A1 (en) 2002-07-08 2003-07-07 Novel tricyclic spiropiperidines or spiropyrrolidines

Publications (2)

Publication Number Publication Date
DE60318948D1 true DE60318948D1 (de) 2008-03-20
DE60318948T2 DE60318948T2 (de) 2009-05-20

Family

ID=20288470

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318948T Expired - Fee Related DE60318948T2 (de) 2002-07-08 2003-07-07 Tricyclische spiropiperidine oder spiropyrrolidine

Country Status (26)

Country Link
US (2) US7449475B2 (de)
EP (1) EP1521757B1 (de)
JP (1) JP2005537255A (de)
CN (2) CN1974574A (de)
AR (1) AR040475A1 (de)
AT (1) ATE385235T1 (de)
AU (1) AU2003243122B2 (de)
BR (1) BR0312560A (de)
CA (1) CA2492122A1 (de)
CY (1) CY1107915T1 (de)
DE (1) DE60318948T2 (de)
DK (1) DK1521757T3 (de)
ES (1) ES2298575T3 (de)
HK (1) HK1074622A1 (de)
IS (1) IS7662A (de)
MX (1) MXPA05000278A (de)
NO (1) NO20050635L (de)
NZ (1) NZ537259A (de)
PL (1) PL374877A1 (de)
PT (1) PT1521757E (de)
RU (1) RU2320664C2 (de)
SE (1) SE0202133D0 (de)
TW (1) TW200413386A (de)
UA (1) UA77809C2 (de)
WO (1) WO2004005295A1 (de)
ZA (1) ZA200500024B (de)

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SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
WO2005023771A1 (ja) * 2003-09-05 2005-03-17 Ono Pharmaceutical Co., Ltd. ケモカインレセプターアンタゴニストおよびその医薬用途
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
BRPI0512535A (pt) 2004-06-24 2008-03-25 Incyte Corp compostos de piperidinas n-substituìdas, suas composições e métodos de modulações
PT2332909E (pt) 2005-04-13 2014-12-17 Astex Therapeutics Ltd Derivados de hidroxibenzamida e sua utilização como inibidores de hsp90
JP2009507800A (ja) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． 縮合およびスピロ環化合物ならびにその使用
JP5315590B2 (ja) * 2006-02-14 2013-10-16 Ｊｎｃ株式会社 液晶化合物、液晶組成物および液晶表示素子
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
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US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (de) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmazeutische kombinationen
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US9730912B2 (en) 2006-10-12 2017-08-15 Astex Therapeutics Limited Pharmaceutical compounds
EP2081891A2 (de) 2006-10-12 2009-07-29 Astex Therapeutics Limited Pharmazeutische verbindungen mit hsp90-hemmender oder modulierender wirkung
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
WO2008103125A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
CL2008001810A1 (es) * 2007-06-20 2008-12-26 Glaxo Group Ltd Compuestos derivados de espiroindolinas, moduladores de receptores de quimiocinas; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar aterosclerosis, dolor inflamatorio, influenza, sindrome metabolico, entre otras enfermedades.
WO2009011655A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma
WO2009011654A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Process for the preparation of cyclic spiropiperidines
US8536198B2 (en) * 2007-07-24 2013-09-17 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
JP2010536779A (ja) * 2007-08-14 2010-12-02 グラクソ グループ リミテッド ケモカイン受容体のモジュレーターとしてのスピロインデンおよびスピロインダン
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
CA2712897A1 (en) * 2008-01-30 2009-08-06 Pharmacopeia, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP2145891A1 (de) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substierte 5-Carboxy-Oxadiazin-Chinolon-Derivate, ihre Herstellung und ihre Anwendung als antibakterielle Mittel
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
EP3233799B1 (de) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamin-d2-rezeptor-liganden
EP3668840A1 (de) 2017-08-15 2020-06-24 Inflazome Limited Neuartige sulfonamid-carboxamid-verbindungen

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SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
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Also Published As

Publication number Publication date
SE0202133D0 (sv) 2002-07-08
RU2004137278A (ru) 2005-09-10
CY1107915T1 (el) 2013-09-04
US20090062322A1 (en) 2009-03-05
AR040475A1 (es) 2005-04-06
BR0312560A (pt) 2005-05-10
AU2003243122A1 (en) 2004-01-23
ZA200500024B (en) 2006-02-22
CN1675218A (zh) 2005-09-28
CN1326858C (zh) 2007-07-18
IS7662A (is) 2005-01-24
AU2003243122B2 (en) 2006-09-28
WO2004005295A1 (en) 2004-01-15
CA2492122A1 (en) 2004-01-15
US7449475B2 (en) 2008-11-11
UA77809C2 (en) 2007-01-15
DK1521757T3 (da) 2008-05-05
TW200413386A (en) 2004-08-01
DE60318948T2 (de) 2009-05-20
JP2005537255A (ja) 2005-12-08
PT1521757E (pt) 2008-04-03
EP1521757A1 (de) 2005-04-13
MXPA05000278A (es) 2005-03-31
ES2298575T3 (es) 2008-05-16
CN1974574A (zh) 2007-06-06
NO20050635L (no) 2005-03-31
NZ537259A (en) 2006-08-31
ATE385235T1 (de) 2008-02-15
HK1074622A1 (en) 2005-11-18
EP1521757B1 (de) 2008-01-30
RU2320664C2 (ru) 2008-03-27
PL374877A1 (en) 2005-11-14
US20050245741A1 (en) 2005-11-03

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee