CN1324028C - 作为抗癌剂的变曲霉素衍生物 - Google Patents

作为抗癌剂的变曲霉素衍生物 Download PDF

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Publication number
CN1324028C
CN1324028C CNB018153666A CN01815366A CN1324028C CN 1324028 C CN1324028 C CN 1324028C CN B018153666 A CNB018153666 A CN B018153666A CN 01815366 A CN01815366 A CN 01815366A CN 1324028 C CN1324028 C CN 1324028C
Authority
CN
China
Prior art keywords
compound
group
formula
amino
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018153666A
Other languages
English (en)
Chinese (zh)
Other versions
CN1630658A (zh
Inventor
J·C·莫里斯
R·J·安德森
M·雷默恩安
I·曼扎纳雷斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0017055A external-priority patent/GB0017055D0/en
Priority claimed from GB0030689A external-priority patent/GB0030689D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of CN1630658A publication Critical patent/CN1630658A/zh
Application granted granted Critical
Publication of CN1324028C publication Critical patent/CN1324028C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018153666A 2000-07-11 2001-07-11 作为抗癌剂的变曲霉素衍生物 Expired - Fee Related CN1324028C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0017055.5 2000-07-11
GB0017055A GB0017055D0 (en) 2000-07-11 2000-07-11 Synthesis
GB0030689A GB0030689D0 (en) 2000-12-15 2000-12-15 Synthesis
GB0030689.4 2000-12-15

Publications (2)

Publication Number Publication Date
CN1630658A CN1630658A (zh) 2005-06-22
CN1324028C true CN1324028C (zh) 2007-07-04

Family

ID=26244637

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018153666A Expired - Fee Related CN1324028C (zh) 2000-07-11 2001-07-11 作为抗癌剂的变曲霉素衍生物

Country Status (20)

Country Link
US (1) US7320981B2 (enExample)
EP (1) EP1299388B1 (enExample)
JP (1) JP2004502773A (enExample)
KR (1) KR100886161B1 (enExample)
CN (1) CN1324028C (enExample)
AT (1) ATE431349T1 (enExample)
AU (3) AU2001270783B2 (enExample)
BR (1) BR0112413A (enExample)
CA (1) CA2414200C (enExample)
CY (1) CY1109283T1 (enExample)
DE (1) DE60138707D1 (enExample)
DK (1) DK1299388T3 (enExample)
ES (1) ES2327210T3 (enExample)
IL (2) IL153682A0 (enExample)
MX (1) MXPA03000341A (enExample)
NZ (1) NZ523491A (enExample)
PT (1) PT1299388E (enExample)
RU (1) RU2299884C2 (enExample)
SI (1) SI1299388T1 (enExample)
WO (1) WO2002004447A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) * 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
CA2526285A1 (en) 2003-05-15 2004-12-23 Arqule, Inc. Inhibitors of p38 and methods of using the same
US7829560B2 (en) 2004-07-08 2010-11-09 Arqule, Inc. 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase
US8178672B2 (en) 2004-10-19 2012-05-15 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase
EP1666467A1 (en) * 2004-11-08 2006-06-07 Evotec AG 11Beta-HSD1 Inhibitors
WO2006075591A1 (ja) * 2005-01-12 2006-07-20 Kuraray Co., Ltd. 樹脂組成物及びそれからなるフィルム
PL1896470T3 (pl) * 2005-05-16 2011-03-31 Irm Llc Pochodne pirolopirydynowe jako inhibitory kinazy białkowej
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ236494A3 (en) * 1992-04-03 1994-12-15 Upjohn Co Pharmaceutically active bicyclic-heterocyclic amines
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthetic studies towards the 2-aminopyrimidine alkaloidsvarillins and meridianins from marine origin P M FRESNEDA ET AL,TETRAHDERON LETT ERS,Vol.41 2000 *

Also Published As

Publication number Publication date
KR100886161B1 (ko) 2009-02-27
RU2299884C2 (ru) 2007-05-27
SI1299388T1 (sl) 2009-12-31
MXPA03000341A (es) 2004-04-05
AU2001270783B2 (en) 2006-06-15
KR20030017581A (ko) 2003-03-03
AU2006213946A1 (en) 2006-10-05
ES2327210T3 (es) 2009-10-27
EP1299388B1 (en) 2009-05-13
BR0112413A (pt) 2003-05-27
IL153682A0 (en) 2003-07-06
CA2414200A1 (en) 2002-01-17
DE60138707D1 (de) 2009-06-25
WO2002004447A1 (en) 2002-01-17
US20050014778A1 (en) 2005-01-20
AU2006213946B2 (en) 2008-01-10
CA2414200C (en) 2010-05-04
AU7078301A (en) 2002-01-21
ATE431349T1 (de) 2009-05-15
PT1299388E (pt) 2009-08-13
CN1630658A (zh) 2005-06-22
DK1299388T3 (da) 2009-08-31
CY1109283T1 (el) 2014-07-02
EP1299388A1 (en) 2003-04-09
IL153682A (en) 2010-05-31
US7320981B2 (en) 2008-01-22
NZ523491A (en) 2004-06-25
JP2004502773A (ja) 2004-01-29

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070704

Termination date: 20110711