RU2299884C2 - Производные вариолина, способы их получения (варианты), промежуточные продукты, фармацевтическая композиция и способы лечения (варианты) - Google Patents
Производные вариолина, способы их получения (варианты), промежуточные продукты, фармацевтическая композиция и способы лечения (варианты) Download PDFInfo
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- RU2299884C2 RU2299884C2 RU2003103856/04A RU2003103856A RU2299884C2 RU 2299884 C2 RU2299884 C2 RU 2299884C2 RU 2003103856/04 A RU2003103856/04 A RU 2003103856/04A RU 2003103856 A RU2003103856 A RU 2003103856A RU 2299884 C2 RU2299884 C2 RU 2299884C2
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- 238000000034 method Methods 0.000 title claims abstract description 70
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 90
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- 125000002837 carbocyclic group Chemical group 0.000 claims abstract description 14
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- 125000004429 atom Chemical group 0.000 claims abstract description 13
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- 125000005842 heteroatom Chemical group 0.000 claims abstract 5
- -1 NH 2 Chemical group 0.000 claims description 60
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- JGNSVQGODIWUGL-UHFFFAOYSA-N pyrido[3,4]pyrrolo[3,5-a]pyrimidine Chemical group C1=NC=CC2=CC3=CC=CN=C3N21 JGNSVQGODIWUGL-UHFFFAOYSA-N 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- QJDUDPQVDAASMV-UHFFFAOYSA-M sodium;ethanethiolate Chemical compound [Na+].CC[S-] QJDUDPQVDAASMV-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0017055.5 | 2000-07-11 | ||
| GB0017055A GB0017055D0 (en) | 2000-07-11 | 2000-07-11 | Synthesis |
| GB0030689A GB0030689D0 (en) | 2000-12-15 | 2000-12-15 | Synthesis |
| GB0030689.4 | 2000-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003103856A RU2003103856A (ru) | 2004-08-20 |
| RU2299884C2 true RU2299884C2 (ru) | 2007-05-27 |
Family
ID=26244637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003103856/04A RU2299884C2 (ru) | 2000-07-11 | 2001-07-11 | Производные вариолина, способы их получения (варианты), промежуточные продукты, фармацевтическая композиция и способы лечения (варианты) |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7320981B2 (enExample) |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) * | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
| CA2526285A1 (en) | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
| US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
| US8178672B2 (en) | 2004-10-19 | 2012-05-15 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase |
| EP1666467A1 (en) * | 2004-11-08 | 2006-06-07 | Evotec AG | 11Beta-HSD1 Inhibitors |
| WO2006075591A1 (ja) * | 2005-01-12 | 2006-07-20 | Kuraray Co., Ltd. | 樹脂組成物及びそれからなるフィルム |
| PL1896470T3 (pl) * | 2005-05-16 | 2011-03-31 | Irm Llc | Pochodne pirolopirydynowe jako inhibitory kinazy białkowej |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2103272C1 (ru) * | 1992-04-03 | 1998-01-27 | Дзе Апджон Компани | Бициклические гетероциклические амины и их фармацевтически приемлемые соли, бициклические гетероциклические амины и их фармацевтически приемлемые соли в качестве ингибитора реакционноспособного кислорода |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
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- 2001-07-11 BR BR0112413-7A patent/BR0112413A/pt not_active Application Discontinuation
- 2001-07-11 JP JP2002509312A patent/JP2004502773A/ja active Pending
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- 2001-07-11 RU RU2003103856/04A patent/RU2299884C2/ru not_active IP Right Cessation
- 2001-07-11 KR KR1020027018072A patent/KR100886161B1/ko not_active Expired - Fee Related
- 2001-07-11 EP EP01949663A patent/EP1299388B1/en not_active Expired - Lifetime
- 2001-07-11 AU AU7078301A patent/AU7078301A/xx active Pending
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- 2001-07-11 WO PCT/GB2001/003111 patent/WO2002004447A1/en not_active Ceased
- 2001-07-11 DK DK01949663T patent/DK1299388T3/da active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2103272C1 (ru) * | 1992-04-03 | 1998-01-27 | Дзе Апджон Компани | Бициклические гетероциклические амины и их фармацевтически приемлемые соли, бициклические гетероциклические амины и их фармацевтически приемлемые соли в качестве ингибитора реакционноспособного кислорода |
Non-Patent Citations (1)
| Title |
|---|
| P.M.FRESNEDA ET AL. Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from maririne origin. TETRAHEDRON LETTERS, 2000, v.41, p.4777-4780 J.MENDIOLA ET AL. Reaction of 2-bromomethylazoles and TosMIC:A Domino process to azolopyrimidines. Synthesis of Core Tricyclic of the variolins alkaloids. Organic LETTERS, 2000, v.2, no.21, p.3253-3256. * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100886161B1 (ko) | 2009-02-27 |
| SI1299388T1 (sl) | 2009-12-31 |
| MXPA03000341A (es) | 2004-04-05 |
| AU2001270783B2 (en) | 2006-06-15 |
| KR20030017581A (ko) | 2003-03-03 |
| AU2006213946A1 (en) | 2006-10-05 |
| ES2327210T3 (es) | 2009-10-27 |
| EP1299388B1 (en) | 2009-05-13 |
| BR0112413A (pt) | 2003-05-27 |
| IL153682A0 (en) | 2003-07-06 |
| CA2414200A1 (en) | 2002-01-17 |
| DE60138707D1 (de) | 2009-06-25 |
| WO2002004447A1 (en) | 2002-01-17 |
| US20050014778A1 (en) | 2005-01-20 |
| AU2006213946B2 (en) | 2008-01-10 |
| CA2414200C (en) | 2010-05-04 |
| AU7078301A (en) | 2002-01-21 |
| ATE431349T1 (de) | 2009-05-15 |
| PT1299388E (pt) | 2009-08-13 |
| CN1630658A (zh) | 2005-06-22 |
| DK1299388T3 (da) | 2009-08-31 |
| CY1109283T1 (el) | 2014-07-02 |
| CN1324028C (zh) | 2007-07-04 |
| EP1299388A1 (en) | 2003-04-09 |
| IL153682A (en) | 2010-05-31 |
| US7320981B2 (en) | 2008-01-22 |
| NZ523491A (en) | 2004-06-25 |
| JP2004502773A (ja) | 2004-01-29 |
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