KR100886161B1 - 항암제로서의 배리올린 유도체 - Google Patents

항암제로서의 배리올린 유도체 Download PDF

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Publication number
KR100886161B1
KR100886161B1 KR1020027018072A KR20027018072A KR100886161B1 KR 100886161 B1 KR100886161 B1 KR 100886161B1 KR 1020027018072 A KR1020027018072 A KR 1020027018072A KR 20027018072 A KR20027018072 A KR 20027018072A KR 100886161 B1 KR100886161 B1 KR 100886161B1
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KR
South Korea
Prior art keywords
group
formula
compound
alkyl
groups
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Expired - Fee Related
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KR1020027018072A
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English (en)
Korean (ko)
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KR20030017581A (ko
Inventor
모리스조나단찰스
앤더슨리건제임스
레무이냔모데스또
만자나레스이그나씨오
Original Assignee
파르마 마르, 에스.에이.
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Publication date
Priority claimed from GB0017055A external-priority patent/GB0017055D0/en
Priority claimed from GB0030689A external-priority patent/GB0030689D0/en
Application filed by 파르마 마르, 에스.에이. filed Critical 파르마 마르, 에스.에이.
Publication of KR20030017581A publication Critical patent/KR20030017581A/ko
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Publication of KR100886161B1 publication Critical patent/KR100886161B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020027018072A 2000-07-11 2001-07-11 항암제로서의 배리올린 유도체 Expired - Fee Related KR100886161B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0017055.5 2000-07-11
GB0017055A GB0017055D0 (en) 2000-07-11 2000-07-11 Synthesis
GB0030689A GB0030689D0 (en) 2000-12-15 2000-12-15 Synthesis
GB0030689.4 2000-12-15
PCT/GB2001/003111 WO2002004447A1 (en) 2000-07-11 2001-07-11 Variolin derivatives as anti-cancer agents

Publications (2)

Publication Number Publication Date
KR20030017581A KR20030017581A (ko) 2003-03-03
KR100886161B1 true KR100886161B1 (ko) 2009-02-27

Family

ID=26244637

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027018072A Expired - Fee Related KR100886161B1 (ko) 2000-07-11 2001-07-11 항암제로서의 배리올린 유도체

Country Status (20)

Country Link
US (1) US7320981B2 (enExample)
EP (1) EP1299388B1 (enExample)
JP (1) JP2004502773A (enExample)
KR (1) KR100886161B1 (enExample)
CN (1) CN1324028C (enExample)
AT (1) ATE431349T1 (enExample)
AU (3) AU7078301A (enExample)
BR (1) BR0112413A (enExample)
CA (1) CA2414200C (enExample)
CY (1) CY1109283T1 (enExample)
DE (1) DE60138707D1 (enExample)
DK (1) DK1299388T3 (enExample)
ES (1) ES2327210T3 (enExample)
IL (2) IL153682A0 (enExample)
MX (1) MXPA03000341A (enExample)
NZ (1) NZ523491A (enExample)
PT (1) PT1299388E (enExample)
RU (1) RU2299884C2 (enExample)
SI (1) SI1299388T1 (enExample)
WO (1) WO2002004447A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) * 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
AU2004247626B8 (en) 2003-05-15 2011-05-19 Arqule, Inc. Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38
WO2006010082A1 (en) 2004-07-08 2006-01-26 Arqule, Inc. 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
WO2006044869A1 (en) 2004-10-19 2006-04-27 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
EP1666467A1 (en) * 2004-11-08 2006-06-07 Evotec AG 11Beta-HSD1 Inhibitors
EP1837373B1 (en) * 2005-01-12 2019-03-13 Kuraray Co., Ltd. Resin composition and film made of same
US20080300267A1 (en) * 2005-05-16 2008-12-04 Barun Okram Compounds and Compositions as Protein Kinase Inhibitors
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70954A (en) * 1992-04-03 1995-11-28 Upjohn Co Bicyclic-heterocyclic amines containing nitrogen heteroatoms
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedron, 50(13), 3987-3992(1994)*

Also Published As

Publication number Publication date
US20050014778A1 (en) 2005-01-20
ES2327210T3 (es) 2009-10-27
IL153682A (en) 2010-05-31
CY1109283T1 (el) 2014-07-02
PT1299388E (pt) 2009-08-13
AU2006213946B2 (en) 2008-01-10
JP2004502773A (ja) 2004-01-29
WO2002004447A1 (en) 2002-01-17
IL153682A0 (en) 2003-07-06
US7320981B2 (en) 2008-01-22
CA2414200A1 (en) 2002-01-17
EP1299388B1 (en) 2009-05-13
DK1299388T3 (da) 2009-08-31
SI1299388T1 (sl) 2009-12-31
NZ523491A (en) 2004-06-25
EP1299388A1 (en) 2003-04-09
AU2006213946A1 (en) 2006-10-05
AU2001270783B2 (en) 2006-06-15
KR20030017581A (ko) 2003-03-03
RU2299884C2 (ru) 2007-05-27
CN1324028C (zh) 2007-07-04
CN1630658A (zh) 2005-06-22
DE60138707D1 (de) 2009-06-25
BR0112413A (pt) 2003-05-27
AU7078301A (en) 2002-01-21
MXPA03000341A (es) 2004-04-05
CA2414200C (en) 2010-05-04
ATE431349T1 (de) 2009-05-15

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