CA2414200C - Variolin derivatives as anti-cancer agents - Google Patents

Variolin derivatives as anti-cancer agents Download PDF

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Publication number
CA2414200C
CA2414200C CA2414200A CA2414200A CA2414200C CA 2414200 C CA2414200 C CA 2414200C CA 2414200 A CA2414200 A CA 2414200A CA 2414200 A CA2414200 A CA 2414200A CA 2414200 C CA2414200 C CA 2414200C
Authority
CA
Canada
Prior art keywords
group
formula
compound
groups
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2414200A
Other languages
English (en)
French (fr)
Other versions
CA2414200A1 (en
Inventor
Jonathan Charles Morris
Regan James Anderson
Modesto Remuinan
Ignacio Manzanares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0017055A external-priority patent/GB0017055D0/en
Priority claimed from GB0030689A external-priority patent/GB0030689D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of CA2414200A1 publication Critical patent/CA2414200A1/en
Application granted granted Critical
Publication of CA2414200C publication Critical patent/CA2414200C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
CA2414200A 2000-07-11 2001-07-11 Variolin derivatives as anti-cancer agents Expired - Fee Related CA2414200C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0017055.5 2000-07-11
GB0017055A GB0017055D0 (en) 2000-07-11 2000-07-11 Synthesis
GB0030689A GB0030689D0 (en) 2000-12-15 2000-12-15 Synthesis
GB0030689.4 2000-12-15
PCT/GB2001/003111 WO2002004447A1 (en) 2000-07-11 2001-07-11 Variolin derivatives as anti-cancer agents

Publications (2)

Publication Number Publication Date
CA2414200A1 CA2414200A1 (en) 2002-01-17
CA2414200C true CA2414200C (en) 2010-05-04

Family

ID=26244637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2414200A Expired - Fee Related CA2414200C (en) 2000-07-11 2001-07-11 Variolin derivatives as anti-cancer agents

Country Status (20)

Country Link
US (1) US7320981B2 (enExample)
EP (1) EP1299388B1 (enExample)
JP (1) JP2004502773A (enExample)
KR (1) KR100886161B1 (enExample)
CN (1) CN1324028C (enExample)
AT (1) ATE431349T1 (enExample)
AU (3) AU2001270783B2 (enExample)
BR (1) BR0112413A (enExample)
CA (1) CA2414200C (enExample)
CY (1) CY1109283T1 (enExample)
DE (1) DE60138707D1 (enExample)
DK (1) DK1299388T3 (enExample)
ES (1) ES2327210T3 (enExample)
IL (2) IL153682A0 (enExample)
MX (1) MXPA03000341A (enExample)
NZ (1) NZ523491A (enExample)
PT (1) PT1299388E (enExample)
RU (1) RU2299884C2 (enExample)
SI (1) SI1299388T1 (enExample)
WO (1) WO2002004447A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
US7902192B2 (en) 2003-05-15 2011-03-08 Arqule, Inc. Inhibitors of P38 and methods of using the same
WO2006010082A1 (en) 2004-07-08 2006-01-26 Arqule, Inc. 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
EP2258704A1 (en) 2004-10-19 2010-12-08 ArQule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
EP1666467A1 (en) * 2004-11-08 2006-06-07 Evotec AG 11Beta-HSD1 Inhibitors
JP5025270B2 (ja) * 2005-01-12 2012-09-12 株式会社クラレ 樹脂組成物及びそれからなるフィルム
BRPI0610828A2 (pt) * 2005-05-16 2010-07-27 Irm Llc compostos e composições como inibidores de proteìna quinase
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT633886E (pt) * 1992-04-03 2001-03-30 Upjohn Co Aminas biciclicas-heterociclicas farmaceuticamente activas
GB0019117D0 (en) 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
RU2299884C2 (ru) 2007-05-27
AU2006213946A1 (en) 2006-10-05
DK1299388T3 (da) 2009-08-31
DE60138707D1 (de) 2009-06-25
CY1109283T1 (el) 2014-07-02
AU2001270783B2 (en) 2006-06-15
CA2414200A1 (en) 2002-01-17
ES2327210T3 (es) 2009-10-27
ATE431349T1 (de) 2009-05-15
US20050014778A1 (en) 2005-01-20
CN1630658A (zh) 2005-06-22
IL153682A0 (en) 2003-07-06
EP1299388A1 (en) 2003-04-09
WO2002004447A1 (en) 2002-01-17
US7320981B2 (en) 2008-01-22
BR0112413A (pt) 2003-05-27
JP2004502773A (ja) 2004-01-29
KR100886161B1 (ko) 2009-02-27
AU7078301A (en) 2002-01-21
KR20030017581A (ko) 2003-03-03
SI1299388T1 (sl) 2009-12-31
IL153682A (en) 2010-05-31
MXPA03000341A (es) 2004-04-05
EP1299388B1 (en) 2009-05-13
NZ523491A (en) 2004-06-25
CN1324028C (zh) 2007-07-04
AU2006213946B2 (en) 2008-01-10
PT1299388E (pt) 2009-08-13

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