MXPA03000341A - Derivados de variolina como agentes anit-cancer. - Google Patents
Derivados de variolina como agentes anit-cancer.Info
- Publication number
- MXPA03000341A MXPA03000341A MXPA03000341A MXPA03000341A MXPA03000341A MX PA03000341 A MXPA03000341 A MX PA03000341A MX PA03000341 A MXPA03000341 A MX PA03000341A MX PA03000341 A MXPA03000341 A MX PA03000341A MX PA03000341 A MXPA03000341 A MX PA03000341A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- group
- unsubstituted
- variolin
- compounds
- Prior art date
Links
- 229930186114 Variolin Natural products 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 abstract 2
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 abstract 2
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- -1 CO2R ́ Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invencion proporciona derivados de variolina de la formula (l), en donde: R1 y R2 se seleccionan cada uno independientemente del grupo que consiste de H, OH, OR, SH, SR, SOR, SO2R, NO2, NH2, NHR, N(R)2, NHCOR, N(COR2), NHSO2R, CN, halogeno, C(=O)H, C(=O)R, CO2H, CO2R, alquilo C1-C12, haloalquilo C1-C12, alquenilo C2-C12, alquinilo C2-C12, arilo substituido o no substituido, aralquilo substituido o no substituido y heteroaromatico substituido o no substituido; y R3 se selecciona del grupo que consiste de H, OH y OMe; en donde el o cada grupo R¦ se selecciona independientemente del grupo que consiste de OH, alquilo C1-C12, haloalquilo C1-C12, alquenilo C2-C12, alquinilo C2-C12, arilo substituido o no substituido, aralquilo substituido o no substituido, arilalquenilo substituido o no substituido y heteroaromatico substituido o no substituido; y en donde el grupo R1, R2 o R3 es un grupo de la formula N(R)2, o N(COR)2, cada uno de los grupos R pueden ser el mismo o diferente, o los dos grupos R, junto con el atomo de nitrogeno al cual se unen, pueden formar una cadena heterociclica de 5-14 miembros. Estos compuestos despliegan actividad contra un rango de estirpes de cancer mamiferas. Las nuevas vias sinteticas a compuestos de variolina nuevos y conocidos, junto con compuestos intermedios nuevos, tambien se describen. Nueva actividad anti-tumor de compuestos de variolina tambien se describe.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0017055A GB0017055D0 (en) | 2000-07-11 | 2000-07-11 | Synthesis |
| GB0030689A GB0030689D0 (en) | 2000-12-15 | 2000-12-15 | Synthesis |
| PCT/GB2001/003111 WO2002004447A1 (en) | 2000-07-11 | 2001-07-11 | Variolin derivatives as anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03000341A true MXPA03000341A (es) | 2004-04-05 |
Family
ID=26244637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03000341A MXPA03000341A (es) | 2000-07-11 | 2001-07-11 | Derivados de variolina como agentes anit-cancer. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7320981B2 (es) |
| EP (1) | EP1299388B1 (es) |
| JP (1) | JP2004502773A (es) |
| KR (1) | KR100886161B1 (es) |
| CN (1) | CN1324028C (es) |
| AT (1) | ATE431349T1 (es) |
| AU (3) | AU2001270783B2 (es) |
| BR (1) | BR0112413A (es) |
| CA (1) | CA2414200C (es) |
| CY (1) | CY1109283T1 (es) |
| DE (1) | DE60138707D1 (es) |
| DK (1) | DK1299388T3 (es) |
| ES (1) | ES2327210T3 (es) |
| IL (2) | IL153682A0 (es) |
| MX (1) | MXPA03000341A (es) |
| NZ (1) | NZ523491A (es) |
| PT (1) | PT1299388E (es) |
| RU (1) | RU2299884C2 (es) |
| SI (1) | SI1299388T1 (es) |
| WO (1) | WO2002004447A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
| DE10260235B4 (de) | 2002-12-20 | 2010-10-28 | Infineon Technologies Ag | Verfahren zum Strukturieren einer Resistschicht und Negativ-Resistschicht |
| EP1633758B1 (en) | 2003-05-15 | 2011-11-23 | Arqule, Inc. | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
| US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
| EP2258704A1 (en) | 2004-10-19 | 2010-12-08 | ArQule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
| EP1666467A1 (en) * | 2004-11-08 | 2006-06-07 | Evotec AG | 11Beta-HSD1 Inhibitors |
| US8084536B2 (en) * | 2005-01-12 | 2011-12-27 | Kuraray Co., Ltd. | Resin composition and film made of same |
| CA2608333A1 (en) * | 2005-05-16 | 2006-11-23 | Irm Llc | Pyrrolopyridine derivatives as protein kinase inhibitors |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
-
2001
- 2001-07-11 ES ES01949663T patent/ES2327210T3/es not_active Expired - Lifetime
- 2001-07-11 CA CA2414200A patent/CA2414200C/en not_active Expired - Fee Related
- 2001-07-11 BR BR0112413-7A patent/BR0112413A/pt not_active Application Discontinuation
- 2001-07-11 IL IL15368201A patent/IL153682A0/xx unknown
- 2001-07-11 AU AU2001270783A patent/AU2001270783B2/en not_active Revoked
- 2001-07-11 PT PT01949663T patent/PT1299388E/pt unknown
- 2001-07-11 SI SI200130927T patent/SI1299388T1/sl unknown
- 2001-07-11 MX MXPA03000341A patent/MXPA03000341A/es active IP Right Grant
- 2001-07-11 CN CNB018153666A patent/CN1324028C/zh not_active Expired - Fee Related
- 2001-07-11 WO PCT/GB2001/003111 patent/WO2002004447A1/en active IP Right Grant
- 2001-07-11 JP JP2002509312A patent/JP2004502773A/ja active Pending
- 2001-07-11 KR KR1020027018072A patent/KR100886161B1/ko not_active IP Right Cessation
- 2001-07-11 AU AU7078301A patent/AU7078301A/xx active Pending
- 2001-07-11 NZ NZ523491A patent/NZ523491A/en unknown
- 2001-07-11 DK DK01949663T patent/DK1299388T3/da active
- 2001-07-11 US US10/332,562 patent/US7320981B2/en not_active Expired - Fee Related
- 2001-07-11 AT AT01949663T patent/ATE431349T1/de not_active IP Right Cessation
- 2001-07-11 EP EP01949663A patent/EP1299388B1/en not_active Expired - Lifetime
- 2001-07-11 DE DE60138707T patent/DE60138707D1/de not_active Expired - Lifetime
- 2001-07-11 RU RU2003103856/04A patent/RU2299884C2/ru not_active IP Right Cessation
-
2002
- 2002-12-26 IL IL153682A patent/IL153682A/en not_active IP Right Cessation
-
2006
- 2006-09-13 AU AU2006213946A patent/AU2006213946B2/en not_active Ceased
-
2009
- 2009-08-11 CY CY20091100849T patent/CY1109283T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE431349T1 (de) | 2009-05-15 |
| CN1324028C (zh) | 2007-07-04 |
| AU2001270783B2 (en) | 2006-06-15 |
| PT1299388E (pt) | 2009-08-13 |
| NZ523491A (en) | 2004-06-25 |
| EP1299388B1 (en) | 2009-05-13 |
| SI1299388T1 (sl) | 2009-12-31 |
| CN1630658A (zh) | 2005-06-22 |
| RU2299884C2 (ru) | 2007-05-27 |
| DK1299388T3 (da) | 2009-08-31 |
| ES2327210T3 (es) | 2009-10-27 |
| CA2414200A1 (en) | 2002-01-17 |
| IL153682A0 (en) | 2003-07-06 |
| CY1109283T1 (el) | 2014-07-02 |
| IL153682A (en) | 2010-05-31 |
| EP1299388A1 (en) | 2003-04-09 |
| AU7078301A (en) | 2002-01-21 |
| JP2004502773A (ja) | 2004-01-29 |
| BR0112413A (pt) | 2003-05-27 |
| AU2006213946B2 (en) | 2008-01-10 |
| AU2006213946A1 (en) | 2006-10-05 |
| KR20030017581A (ko) | 2003-03-03 |
| US7320981B2 (en) | 2008-01-22 |
| US20050014778A1 (en) | 2005-01-20 |
| CA2414200C (en) | 2010-05-04 |
| DE60138707D1 (de) | 2009-06-25 |
| KR100886161B1 (ko) | 2009-02-27 |
| WO2002004447A1 (en) | 2002-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |