DK0535231T3 - Pyrimidinnucleosid-derivater - Google Patents

Pyrimidinnucleosid-derivater

Info

Publication number
DK0535231T3
DK0535231T3 DK91911192.2T DK91911192T DK0535231T3 DK 0535231 T3 DK0535231 T3 DK 0535231T3 DK 91911192 T DK91911192 T DK 91911192T DK 0535231 T3 DK0535231 T3 DK 0535231T3
Authority
DK
Denmark
Prior art keywords
pyrimidine nucleoside
nucleoside derivatives
hydroxy
hydrogen
represent
Prior art date
Application number
DK91911192.2T
Other languages
English (en)
Inventor
Tohru Ueda
Akira Matsuda
Takuma Sasaki
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK0535231T3 publication Critical patent/DK0535231T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK91911192.2T 1990-06-15 1991-06-13 Pyrimidinnucleosid-derivater DK0535231T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15668890 1990-06-15

Publications (1)

Publication Number Publication Date
DK0535231T3 true DK0535231T3 (da) 1995-08-21

Family

ID=15633157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91911192.2T DK0535231T3 (da) 1990-06-15 1991-06-13 Pyrimidinnucleosid-derivater

Country Status (13)

Country Link
US (2) US5616567A (da)
EP (1) EP0535231B1 (da)
JP (1) JP2559917B2 (da)
KR (1) KR970011306B1 (da)
AT (1) ATE122041T1 (da)
CA (1) CA2085345C (da)
DE (1) DE69109482T2 (da)
DK (1) DK0535231T3 (da)
ES (1) ES2074719T3 (da)
HK (1) HK1005871A1 (da)
HU (1) HU218924B (da)
RU (1) RU2116306C1 (da)
WO (1) WO1991019713A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2085557C1 (ru) * 1991-09-30 1997-07-27 Санкио Компани Лимитед Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
TW200637870A (en) 2005-01-31 2006-11-01 Taiho Pharmaceutical Co Ltd Novel pyrimidine nucleoside compound and salt thereof
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
US20100216736A2 (en) * 2006-07-21 2010-08-26 Taiho Pharmaceutical Co., Ltd. 2'-cyanopyrimidine nucleoside compound
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
EP2205073A4 (en) * 2007-09-26 2013-03-06 Sinai School Medicine AZACYTIDINE ANALOGS AND USES THEREOF
US8124593B2 (en) 2007-11-05 2012-02-28 Cyclacel Limited Methods of treatment using sapacitabine
US7863255B2 (en) * 2008-04-29 2011-01-04 Taiho Pharmaceutical Co., Ltd. Methods of administering antitumor agent comprising deoxycytidine derivative
GB0808357D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
GB0808359D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
CN102088969B (zh) 2008-06-09 2013-06-12 西克拉塞尔有限公司 沙帕他滨或cndac与dna甲基转移酶抑制剂如地西他滨和普鲁卡因的组合
RU2538593C2 (ru) * 2009-05-15 2015-01-10 Дельта-Флай Фарма, Инк. НОВЫЕ СТАБИЛЬНЫЕ КРИСТАЛЛЫ МОНОГИДРОХЛОРИДА 1-(2-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА
EP2696878B1 (en) 2011-04-14 2019-07-10 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
SG11201402826YA (en) 2011-12-22 2014-12-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
JP6286421B2 (ja) 2012-05-15 2018-02-28 サイクラセル リミテッド サパシタビン及びセリシクリブの投与レジメン
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
WO2022014025A1 (ja) 2020-07-17 2022-01-20 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 血液がんの新規治療法及び新規治療剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2007094A6 (es) * 1987-07-29 1989-06-01 Consejo Superior Investigacion Procedimiento para la preparacion de 3 -c- ciano-2,3 -didesoxinucleosido.

Also Published As

Publication number Publication date
RU2116306C1 (ru) 1998-07-27
ATE122041T1 (de) 1995-05-15
JPH04235182A (ja) 1992-08-24
US5616567A (en) 1997-04-01
EP0535231A4 (en) 1993-06-30
ES2074719T3 (es) 1995-09-16
US5654420A (en) 1997-08-05
EP0535231A1 (en) 1993-04-07
CA2085345A1 (en) 1991-12-16
KR970011306B1 (ko) 1997-07-09
KR930700485A (ko) 1993-03-15
WO1991019713A1 (en) 1991-12-26
DE69109482D1 (en) 1995-06-08
EP0535231B1 (en) 1995-05-03
CA2085345C (en) 2001-08-07
DE69109482T2 (de) 1996-02-15
JP2559917B2 (ja) 1996-12-04
HUT62582A (en) 1993-05-28
HU218924B (hu) 2000-12-28
HU9203967D0 (en) 1993-03-29
HK1005871A1 (en) 1999-01-29

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