CN1307194C - 大环内酯类化合物 - Google Patents

大环内酯类化合物 Download PDF

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Publication number
CN1307194C
CN1307194C CNB028270452A CN02827045A CN1307194C CN 1307194 C CN1307194 C CN 1307194C CN B028270452 A CNB028270452 A CN B028270452A CN 02827045 A CN02827045 A CN 02827045A CN 1307194 C CN1307194 C CN 1307194C
Authority
CN
China
Prior art keywords
amino
dihydro
oxo
ethyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028270452A
Other languages
English (en)
Chinese (zh)
Other versions
CN1612888A (zh
Inventor
S·阿利霍德兹克
D·安德雷奥蒂
A·贝尔迪克
I·比恩蒂内斯
S·比安迪
M·茨拉科
F·达米亚尼
M·德耶雷克
M·杜米克
V·埃拉科维克
A·胡蒂内克
G·拉扎雷夫斯基
S·罗丘罗
N·马西克
Z·马鲁西克－伊斯图克
S·穆塔克
A·派奥
D·帕夫罗维克
A·夸格利亚
W·舍恩费尔德
V·斯蒂马克
J·蒂巴斯各
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Pliva Farmaceutika dd
Original Assignee
Glaxo Group Ltd
Pliva Farmaceutika dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Pliva Farmaceutika dd filed Critical Glaxo Group Ltd
Publication of CN1612888A publication Critical patent/CN1612888A/zh
Application granted granted Critical
Publication of CN1307194C publication Critical patent/CN1307194C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
CNB028270452A 2001-11-14 2002-11-13 大环内酯类化合物 Expired - Fee Related CN1307194C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0127349.9 2001-11-14
GBGB0127349.9A GB0127349D0 (en) 2001-11-14 2001-11-14 Macrolides

Publications (2)

Publication Number Publication Date
CN1612888A CN1612888A (zh) 2005-05-04
CN1307194C true CN1307194C (zh) 2007-03-28

Family

ID=9925777

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028270452A Expired - Fee Related CN1307194C (zh) 2001-11-14 2002-11-13 大环内酯类化合物

Country Status (20)

Country Link
US (1) US7202221B2 (OSRAM)
EP (1) EP1453846B1 (OSRAM)
JP (1) JP2005515978A (OSRAM)
CN (1) CN1307194C (OSRAM)
AR (1) AR037371A1 (OSRAM)
AT (1) ATE362479T1 (OSRAM)
BR (1) BR0214132A (OSRAM)
CA (1) CA2466975A1 (OSRAM)
DE (1) DE60220180T2 (OSRAM)
EA (1) EA007433B1 (OSRAM)
ES (1) ES2287332T3 (OSRAM)
GB (1) GB0127349D0 (OSRAM)
HR (1) HRP20040433A2 (OSRAM)
HU (1) HUP0402225A3 (OSRAM)
IL (1) IL161710A0 (OSRAM)
PL (1) PL371472A1 (OSRAM)
RS (1) RS41904A (OSRAM)
UA (1) UA77210C2 (OSRAM)
WO (1) WO2003042228A1 (OSRAM)
ZA (1) ZA200403684B (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
WO2005070918A1 (en) 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
CA2484308A1 (en) * 2002-05-14 2003-11-27 The Regents Of The University Of California Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
ES2278319T3 (es) * 2003-05-13 2007-08-01 Glaxo Group Limited Nuevos compuestos con 14 y 15 miembros en el anillo.
GB0310986D0 (en) 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US7265094B2 (en) 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20080249033A1 (en) * 2004-05-06 2008-10-09 Sulejman Alihodzic Carbamate Linked Macrolides Useful For The Treatment Of Microbial Infections
DE602005015963D1 (de) * 2004-05-06 2009-09-24 Glaxosmithkline Zagreb Estergebundene makrolide, die sich für die behandlung von mikrobiellen infektionen eignen
WO2006047167A2 (en) * 2004-10-21 2006-05-04 Janssen Pharmaceutica, N.V. 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials
GB0424961D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424951D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
PT2049556E (pt) 2006-08-09 2013-08-22 Basilea Pharmaceutica Ag Novos macrólidos úteis contra doenças inflamatórias e alérgicas
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
CN101939327B (zh) 2008-02-08 2015-03-11 巴斯利尔药物股份公司 新的大环内酯类及其用途
RU2011153353A (ru) 2009-05-27 2013-07-10 Вокхардт Рисерч Сентер Кетолидные соединения, обладающие противомикробной активностью
EP3216798A3 (en) 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
WO2012105562A1 (ja) * 2011-01-31 2012-08-09 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規マクロライド誘導体
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
CN119060110A (zh) * 2023-05-30 2024-12-03 北京理工大学 一种红霉素衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (en) 1983-05-20 1984-11-28 Abbott Laboratories Tripeptide esters of therapeutic agents
EP0465581B1 (en) 1989-03-28 1995-10-04 Abbott Laboratories Erythromycin derivatives
DK1007530T3 (da) 1996-05-07 2006-04-03 Abbott Lab 6-O-substituerede erythromycinforbindelser samt fremgangsmåde til fremstilling heraf
US6262030B1 (en) 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
IL145739A0 (en) 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
ATE315042T1 (de) 1999-08-24 2006-02-15 Abbott Lab 9a-azalide mit antibakterieller wirkung
ATE312839T1 (de) 2000-02-24 2005-12-15 Abbott Lab Anti-infektionsmittel, die gegen gegenüber mehreren arzneimitteln resistente bakterienstämme nützlich sind
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
JP2002173498A (ja) 2000-09-27 2002-06-21 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Also Published As

Publication number Publication date
DE60220180D1 (de) 2007-06-28
EP1453846B1 (en) 2007-05-16
EA007433B1 (ru) 2006-10-27
HUP0402225A2 (hu) 2005-02-28
ATE362479T1 (de) 2007-06-15
RS41904A (sr) 2006-10-27
UA77210C2 (en) 2006-11-15
CA2466975A1 (en) 2003-05-22
ZA200403684B (en) 2005-09-13
PL371472A1 (en) 2005-06-13
BR0214132A (pt) 2004-09-14
AR037371A1 (es) 2004-11-03
JP2005515978A (ja) 2005-06-02
HRP20040433A2 (en) 2005-04-30
DE60220180T2 (de) 2008-01-17
EA200400536A1 (ru) 2004-12-30
IL161710A0 (en) 2004-09-27
HUP0402225A3 (en) 2006-01-30
EP1453846A1 (en) 2004-09-08
ES2287332T3 (es) 2007-12-16
GB0127349D0 (en) 2002-01-02
WO2003042228A1 (en) 2003-05-22
US7202221B2 (en) 2007-04-10
CN1612888A (zh) 2005-05-04
US20050080025A1 (en) 2005-04-14

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070328

Termination date: 20091214