CN1306916C - 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用 - Google Patents

响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用 Download PDF

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Publication number
CN1306916C
CN1306916C CNB028063848A CN02806384A CN1306916C CN 1306916 C CN1306916 C CN 1306916C CN B028063848 A CNB028063848 A CN B028063848A CN 02806384 A CN02806384 A CN 02806384A CN 1306916 C CN1306916 C CN 1306916C
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hydrogel
porogen
group
hydrogels
reaction mixture
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Expired - Lifetime
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Chinese (zh)
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CN1617694A (zh
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格雷戈里·M·克鲁斯
迈克尔·J·康斯坦特
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Micro Cents America Ltd
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MicroVention Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/36—Amides or imides
    • C08F22/38—Amides
    • C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Medicinal Preparation (AREA)
CNB028063848A 2001-03-13 2002-02-28 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用 Expired - Lifetime CN1306916C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/804,935 US6878384B2 (en) 2001-03-13 2001-03-13 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
US09/804,935 2001-03-13

Related Child Applications (1)

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CNA2007100077925A Division CN101024729A (zh) 2001-03-13 2002-02-28 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用

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CN1617694A CN1617694A (zh) 2005-05-18
CN1306916C true CN1306916C (zh) 2007-03-28

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CNB028063848A Expired - Lifetime CN1306916C (zh) 2001-03-13 2002-02-28 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用
CNA2007100077925A Pending CN101024729A (zh) 2001-03-13 2002-02-28 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用

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CNA2007100077925A Pending CN101024729A (zh) 2001-03-13 2002-02-28 响应周围环境变化发生体积膨胀的水凝胶及其生产方法和应用

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US (5) US6878384B2 (https=)
EP (3) EP2363104B1 (https=)
JP (2) JP4416151B2 (https=)
CN (2) CN1306916C (https=)
AU (3) AU2002306605B2 (https=)
BR (1) BRPI0208034B8 (https=)
CA (1) CA2439925C (https=)
ES (3) ES2478992T3 (https=)
WO (1) WO2002071994A1 (https=)

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