BRPI0208034B8 - polímero de hidrogel poroso sensível ao ph, e, método para a preparação do mesmo - Google Patents

polímero de hidrogel poroso sensível ao ph, e, método para a preparação do mesmo

Info

Publication number
BRPI0208034B8
BRPI0208034B8 BRPI0208034A BRPI0208034A BRPI0208034B8 BR PI0208034 B8 BRPI0208034 B8 BR PI0208034B8 BR PI0208034 A BRPI0208034 A BR PI0208034A BR PI0208034 A BRPI0208034 A BR PI0208034A BR PI0208034 B8 BRPI0208034 B8 BR PI0208034B8
Authority
BR
Brazil
Prior art keywords
hydrogel
hydrogels
expand
change
preparing
Prior art date
Application number
BRPI0208034A
Other languages
English (en)
Inventor
M Cruise Gregory
J Constant Michael
Original Assignee
Microvention Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microvention Inc filed Critical Microvention Inc
Publication of BR0208034A publication Critical patent/BR0208034A/pt
Publication of BRPI0208034B1 publication Critical patent/BRPI0208034B1/pt
Publication of BRPI0208034B8 publication Critical patent/BRPI0208034B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/36—Amides or imides
    • C08F22/38—Amides
    • C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)

Abstract

"métodos para o tratamento de uma doença, deformação ou distúrbio de um paciente humano ou veterinário, e para a preparação de um polímero de hidrogel ambientalmente sensível, e, hidrogel". hidrogéis que se expandem volumetricamente em resposta a uma mudança em seu ambiente (por exemplo, uma mudança no ph ou temperatura) e seus métodos de fabricação e uso. geralmente, os hidrogéis são preparados pela formação de uma mistura de reação líquida que contém a) monômero(s) e/ou polímero(s), pelo menos parte(s) dos quais são sensíveis a mudanças ambientais (por exemplo, mudanças no ph ou temperatura ambiente), b) um reticulador e c) um iniciador da polimerização. se desejável, um porosigênio pode ser incorporado na mistura de reação líquida para criar poros. após o hidrogel ser formado, o porosigênio é removido para criar poros no hidrogel. o hidrogel pode também ser tratado para fazer com que ele assuma um volume não expandido em que permanece até que uma mudança em seu ambiente faça com que ele se expanda. estes hidrogéis podem ser preparados em muitas formas incluindo grânulos, filamentos e partículas. usos biomédicos destes hidrogéis incluem aplicações em que o hidrogel é implantado no corpo de um paciente e uma condição ambiental no sítio de implantação faz com que o hidrogel se expanda in situ.
BRPI0208034A 2001-03-13 2002-02-28 polímero de hidrogel poroso sensível ao ph, e, método para a preparação do mesmo BRPI0208034B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/804,935 US6878384B2 (en) 2001-03-13 2001-03-13 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
US09/804935 2001-03-13
PCT/US2002/005988 WO2002071994A1 (en) 2001-03-13 2002-02-28 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use

Publications (3)

Publication Number Publication Date
BR0208034A BR0208034A (pt) 2004-02-25
BRPI0208034B1 BRPI0208034B1 (pt) 2018-02-06
BRPI0208034B8 true BRPI0208034B8 (pt) 2021-07-27

Family

ID=25190260

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0208034A BRPI0208034B8 (pt) 2001-03-13 2002-02-28 polímero de hidrogel poroso sensível ao ph, e, método para a preparação do mesmo

Country Status (9)

Country Link
US (5) US6878384B2 (pt)
EP (3) EP2363104B1 (pt)
JP (2) JP4416151B2 (pt)
CN (2) CN1306916C (pt)
AU (3) AU2002306605B2 (pt)
BR (1) BRPI0208034B8 (pt)
CA (1) CA2439925C (pt)
ES (3) ES2478992T3 (pt)
WO (1) WO2002071994A1 (pt)

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US20130274362A1 (en) 2013-10-17
US20120302654A1 (en) 2012-11-29
US20020176880A1 (en) 2002-11-28
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AU2009213041A1 (en) 2009-10-08
AU2007216682B2 (en) 2009-10-01
EP2308431B1 (en) 2012-07-04
AU2002306605B2 (en) 2007-06-14
BR0208034A (pt) 2004-02-25
JP4416151B2 (ja) 2010-02-17
JP2010022847A (ja) 2010-02-04
US8734834B2 (en) 2014-05-27
US6878384B2 (en) 2005-04-12
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US8231890B2 (en) 2012-07-31
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AU2007216682A1 (en) 2007-09-27
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