CN1280289C - 用作ip拮抗剂的烷氧基羰基氨基杂芳基羧酸衍生物 - Google Patents

用作ip拮抗剂的烷氧基羰基氨基杂芳基羧酸衍生物 Download PDF

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Publication number
CN1280289C
CN1280289C CNB028058690A CN02805869A CN1280289C CN 1280289 C CN1280289 C CN 1280289C CN B028058690 A CNB028058690 A CN B028058690A CN 02805869 A CN02805869 A CN 02805869A CN 1280289 C CN1280289 C CN 1280289C
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China
Prior art keywords
compound
phenyl
pharmaceutically acceptable
acceptable salt
formula
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Expired - Fee Related
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CNB028058690A
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English (en)
Chinese (zh)
Other versions
CN1494544A (zh
Inventor
F·J·洛佩斯-塔比亚
D·尼灿
C·欧阳
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1494544A publication Critical patent/CN1494544A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB028058690A 2001-03-02 2002-02-25 用作ip拮抗剂的烷氧基羰基氨基杂芳基羧酸衍生物 Expired - Fee Related CN1280289C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27284901P 2001-03-02 2001-03-02
US60/272,849 2001-03-02

Publications (2)

Publication Number Publication Date
CN1494544A CN1494544A (zh) 2004-05-05
CN1280289C true CN1280289C (zh) 2006-10-18

Family

ID=23041569

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028058690A Expired - Fee Related CN1280289C (zh) 2001-03-02 2002-02-25 用作ip拮抗剂的烷氧基羰基氨基杂芳基羧酸衍生物

Country Status (14)

Country Link
US (1) US6569860B2 (https=)
EP (1) EP1368345B1 (https=)
JP (1) JP2004526721A (https=)
KR (1) KR100589990B1 (https=)
CN (1) CN1280289C (https=)
AR (1) AR033429A1 (https=)
AT (1) ATE321041T1 (https=)
BR (1) BR0207730A (https=)
CA (1) CA2438813C (https=)
DE (1) DE60210058T2 (https=)
ES (1) ES2260425T3 (https=)
MX (1) MXPA03007864A (https=)
WO (1) WO2002070514A1 (https=)
ZA (1) ZA200306283B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054008A1 (en) 2002-09-13 2004-03-18 Tohru Araki Medicament for treatment of nocturia
JP2006517576A (ja) * 2003-02-14 2006-07-27 メディカル リサーチ カウンシル 病理的子宮症状の治療のためのｉｐレセプターアンタゴニスト
WO2007046646A1 (en) * 2005-10-20 2007-04-26 Lg Chem, Ltd. Novel organic silane compound
KR100840114B1 (ko) * 2005-10-20 2008-06-19 주식회사 엘지화학 점착제 조성물
AR069650A1 (es) * 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
US9321745B2 (en) * 2013-03-12 2016-04-26 Allergan, Inc. Inhibition of neovascularization by inhibition of prostanoid IP receptors
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP4119138A1 (en) * 2021-07-12 2023-01-18 Universität Hamburg Dhodh inhibitors and their use as antiviral agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908842A (en) 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US6184242B1 (en) 1997-09-04 2001-02-06 Syntex Usa (Llc) 2-(substituted-phenyl)amino-imidazoline derivatives
WO1999026925A1 (en) * 1997-11-26 1999-06-03 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitors comprising heterocyclic amide compounds
AU754253B2 (en) * 1998-10-06 2002-11-07 Dainippon Pharmaceutical Co. Ltd. 2,3-disubstituted pyridine derivatives, processes for the preparation thereof, pharmaceutical compositions containing the same and intermediates therefor
US6335459B1 (en) * 1998-12-23 2002-01-01 Syntex (U.S.A.) Llc Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
KR20020060160A (ko) * 1999-08-12 2002-07-16 파마시아 이탈리아 에스.피.에이. 3(5)-아미노-피라졸 유도체, 이의 제조 방법 및항종양제로서의 이의 용도
YU68102A (sh) * 2000-03-16 2006-01-16 F. Hoffmann-La Roche Ag. Derivati karboksilne kiseline kao ip antagonisti

Also Published As

Publication number Publication date
CN1494544A (zh) 2004-05-05
JP2004526721A (ja) 2004-09-02
CA2438813C (en) 2008-07-29
AR033429A1 (es) 2003-12-17
KR20030078962A (ko) 2003-10-08
DE60210058T2 (de) 2006-11-09
CA2438813A1 (en) 2002-09-12
DE60210058D1 (de) 2006-05-11
BR0207730A (pt) 2004-03-23
US6569860B2 (en) 2003-05-27
MXPA03007864A (es) 2003-12-04
KR100589990B1 (ko) 2006-06-15
ES2260425T3 (es) 2006-11-01
ATE321041T1 (de) 2006-04-15
EP1368345A1 (en) 2003-12-10
US20020169171A1 (en) 2002-11-14
EP1368345B1 (en) 2006-03-22
ZA200306283B (en) 2004-11-15
WO2002070514A1 (en) 2002-09-12

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061018