CN1279900C - 用于睡眠障碍的加巴喷丁类似物 - Google Patents

用于睡眠障碍的加巴喷丁类似物 Download PDF

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Publication number
CN1279900C
CN1279900C CNB018110487A CN01811048A CN1279900C CN 1279900 C CN1279900 C CN 1279900C CN B018110487 A CNB018110487 A CN B018110487A CN 01811048 A CN01811048 A CN 01811048A CN 1279900 C CN1279900 C CN 1279900C
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CN
China
Prior art keywords
aminomethyl
acetic acid
cyclopentyl
cyclobutyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018110487A
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English (en)
Chinese (zh)
Other versions
CN1436075A (zh
Inventor
J·S·布莱恩斯
L·T·梅尔泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
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Warner Lambert Co LLC
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Publication of CN1436075A publication Critical patent/CN1436075A/zh
Application granted granted Critical
Publication of CN1279900C publication Critical patent/CN1279900C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018110487A 2000-06-26 2001-05-18 用于睡眠障碍的加巴喷丁类似物 Expired - Fee Related CN1279900C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
US60/214,171 2000-06-26

Publications (2)

Publication Number Publication Date
CN1436075A CN1436075A (zh) 2003-08-13
CN1279900C true CN1279900C (zh) 2006-10-18

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018110487A Expired - Fee Related CN1279900C (zh) 2000-06-26 2001-05-18 用于睡眠障碍的加巴喷丁类似物

Country Status (23)

Country Link
US (1) US7141606B2 (https=)
EP (1) EP1296671B1 (https=)
JP (1) JP3909842B2 (https=)
KR (1) KR100785182B1 (https=)
CN (1) CN1279900C (https=)
AT (1) ATE390133T1 (https=)
AU (2) AU2001264736B2 (https=)
BR (1) BR0111913A (https=)
CA (1) CA2414008C (https=)
CZ (1) CZ20024110A3 (https=)
DE (1) DE60133389T2 (https=)
DK (1) DK1296671T3 (https=)
ES (1) ES2300332T3 (https=)
HU (1) HUP0300833A3 (https=)
IL (2) IL152770A0 (https=)
MX (1) MXPA02010668A (https=)
NZ (1) NZ522480A (https=)
PL (1) PL359872A1 (https=)
PT (1) PT1296671E (https=)
SK (1) SK17922002A3 (https=)
TW (1) TWI298020B (https=)
WO (1) WO2002000209A2 (https=)
ZA (1) ZA200209418B (https=)

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BR0208922A (pt) 2001-04-19 2004-04-20 Warner Lambert Co Aminoácidos bicìclicos ou tricìclicos fundidos
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2449729C (en) 2001-06-11 2009-11-03 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
AU2002345638A1 (en) 2001-06-11 2002-12-23 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
AU2003243180A1 (en) 2002-05-17 2003-12-12 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US7060727B2 (en) 2002-12-11 2006-06-13 Xenoport, Inc. Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
KR100709159B1 (ko) * 2002-12-13 2007-04-19 워너-램버트 캄파니 엘엘씨 섬유근육통 및 기타 관련 장애를 위한 가바펜틴 유사체
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
EP1622603A4 (en) * 2003-03-25 2010-03-24 Kiel Lab Inc GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE
KR20060119971A (ko) 2003-09-11 2006-11-24 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방
NZ579515A (en) 2003-09-17 2011-09-30 Xenoport Inc Treating or preventing restless legs syndrome using prodrugs of gaba analogs
SG147437A1 (en) 2003-10-14 2008-11-28 Xenoport Inc Crystalline form of gamma-aminobutyric acid analog
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
MX2007005306A (es) 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
AU2007222112A1 (en) * 2006-03-06 2007-09-13 Pfizer Products Inc. Alpha-2-delta ligands for non-restorative sleep
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
ES2601852T3 (es) 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
ES2589915T3 (es) 2008-10-08 2016-11-17 Xgene Pharmaceutical Inc Conjugados de GABA y métodos de utilización de los mismos
ES2758554T3 (es) 2009-12-08 2020-05-05 Univ Case Western Reserve Aminoácidos gama para tratamiento de trastornos oculares
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
CA2903000C (en) 2013-01-28 2021-10-12 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor
EP3466427A4 (en) * 2016-05-26 2020-02-05 Amino Up Chemical Co., Ltd. SLEEPING AGENT
CA3099775A1 (en) 2018-05-14 2019-11-21 Xgene Pharmaceutical Inc. Process for making 1-(acyloxy)-alkyl-carabmate drug conjugates of naproxen and pregabalin
CN117776950B (zh) * 2022-09-20 2025-12-23 中科中山药物创新研究院 一种γ-氨基丁酸衍生物、药物组合物和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5084479A (en) * 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) * 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
US6020370A (en) * 1996-03-14 2000-02-01 Warner-Lambert Company Bridged cyclic amino acids as pharmaceutical agents
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
HUP0004310A3 (en) * 1997-10-27 2001-11-28 Warner Lambert Co Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents
JP2002520277A (ja) * 1998-07-09 2002-07-09 ワーナー−ランバート・カンパニー 不眠症を治療する方法
BR0011236A (pt) * 1999-06-02 2002-03-05 Warner Lambert Co Amino heterociclos úteis como agentes farmacêuticos
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
WO2001042190A1 (en) * 1999-12-08 2001-06-14 Warner-Lambert Company Method for the stereoselective synthesis of cyclic amino acids
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
ZA200209418B (en) 2005-03-10
JP3909842B2 (ja) 2007-04-25
MXPA02010668A (es) 2003-03-10
BR0111913A (pt) 2004-01-06
TWI298020B (en) 2008-06-21
WO2002000209A2 (en) 2002-01-03
DK1296671T3 (da) 2008-06-16
HUP0300833A3 (en) 2009-08-28
CA2414008C (en) 2011-04-26
EP1296671B1 (en) 2008-03-26
HUP0300833A2 (hu) 2003-08-28
IL152770A (en) 2009-12-24
PL359872A1 (en) 2004-09-06
IL152770A0 (en) 2003-06-24
HK1056681A1 (en) 2004-02-27
NZ522480A (en) 2005-06-24
WO2002000209A3 (en) 2003-01-16
ATE390133T1 (de) 2008-04-15
KR20030019455A (ko) 2003-03-06
CN1436075A (zh) 2003-08-13
EP1296671A2 (en) 2003-04-02
AU6473601A (en) 2002-01-08
SK17922002A3 (sk) 2003-11-04
DE60133389D1 (de) 2008-05-08
US7141606B2 (en) 2006-11-28
ES2300332T3 (es) 2008-06-16
DE60133389T2 (de) 2008-06-26
JP2004501189A (ja) 2004-01-15
AU2001264736B2 (en) 2006-04-27
US20030212133A1 (en) 2003-11-13
KR100785182B1 (ko) 2007-12-11
CA2414008A1 (en) 2002-01-03
PT1296671E (pt) 2008-05-09
CZ20024110A3 (cs) 2003-10-15

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Granted publication date: 20061018

Termination date: 20130518