HUP0300833A2 - Gabapentin analogonok alvászavarok kezelésére - Google Patents

Gabapentin analogonok alvászavarok kezelésére

Info

Publication number
HUP0300833A2
HUP0300833A2 HU0300833A HUP0300833A HUP0300833A2 HU P0300833 A2 HUP0300833 A2 HU P0300833A2 HU 0300833 A HU0300833 A HU 0300833A HU P0300833 A HUP0300833 A HU P0300833A HU P0300833 A2 HUP0300833 A2 HU P0300833A2
Authority
HU
Hungary
Prior art keywords
group
atom
sleep disorders
treatment
treating sleep
Prior art date
Application number
HU0300833A
Other languages
English (en)
Inventor
Justin Stephen Bryans
Leonard Theodore Meltzer
Original Assignee
Warner-Lambert Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP0300833A2 publication Critical patent/HUP0300833A2/hu
Publication of HUP0300833A3 publication Critical patent/HUP0300833A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Abstract

Eljárás emlősök alvászavarainak kezelésére a kezelés szükségleténekmegfelelően, amelynek során az (1) vagy (1A) általános képletűvegyületek vagy gyógyszerészetileg elfogadható sóik gyógyászatilaghatásos mennyiségét adagolják, ahol a képletekben R jelentésehidrogénatom vagy rövid szénláncú alkilcsoport; R1-R14 jelentéseegymástól függetlenül hidrogénatom, egyenes vagy elágazó láncú 1-6szénatomos alkilcsoport, fenilcsoport, benzilcsoport, fluoratom,klóratom, brómatom, hidroxilcsoport, hidroxi- metil-csoport,aminocsoport, amino-metil-csoport, trifluor-metil- csoport, -CO2H, -CO2R15, -CH2CO2H, -CH2CO2R15, OR15 ahol R15 jelentése egyenes vagyelágazó láncú 1-6 szénatomos alkilcsoport, fenilcsoport vagybenzilcsoport és R1 és R8 jelentése egyidejűleg nem lehethidrogénatom. (1) (1A) Ó
HU0300833A 2000-06-26 2001-05-18 Gabapentin analogues for treating sleep disorders HUP0300833A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
PCT/US2001/016343 WO2002000209A2 (en) 2000-06-26 2001-05-18 Gabapentin analogues for sleep disorders

Publications (2)

Publication Number Publication Date
HUP0300833A2 true HUP0300833A2 (hu) 2003-08-28
HUP0300833A3 HUP0300833A3 (en) 2009-08-28

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300833A HUP0300833A3 (en) 2000-06-26 2001-05-18 Gabapentin analogues for treating sleep disorders

Country Status (24)

Country Link
US (1) US7141606B2 (hu)
EP (1) EP1296671B1 (hu)
JP (1) JP3909842B2 (hu)
KR (1) KR100785182B1 (hu)
CN (1) CN1279900C (hu)
AT (1) ATE390133T1 (hu)
AU (2) AU6473601A (hu)
BR (1) BR0111913A (hu)
CA (1) CA2414008C (hu)
CZ (1) CZ20024110A3 (hu)
DE (1) DE60133389T2 (hu)
DK (1) DK1296671T3 (hu)
ES (1) ES2300332T3 (hu)
HK (1) HK1056681A1 (hu)
HU (1) HUP0300833A3 (hu)
IL (2) IL152770A0 (hu)
MX (1) MXPA02010668A (hu)
NZ (1) NZ522480A (hu)
PL (1) PL359872A1 (hu)
PT (1) PT1296671E (hu)
SK (1) SK17922002A3 (hu)
TW (1) TWI298020B (hu)
WO (1) WO2002000209A2 (hu)
ZA (1) ZA200209418B (hu)

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ES2380287T3 (es) * 2001-06-11 2012-05-10 Xenoport, Inc. Profármacos de análogos de GABA, composiciones y sus usos
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1412324A4 (en) 2001-06-11 2004-09-29 Xenoport Inc AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
WO2003080588A1 (en) 2002-03-20 2003-10-02 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
WO2003099338A2 (en) 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
WO2004052360A1 (en) 2002-12-11 2004-06-24 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
BR0316751A (pt) * 2002-12-13 2005-10-25 Warner Lambert Co Análogos de gabapentina para fibromialgia e outros distúrbios relacionados
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
WO2004093827A2 (en) * 2003-03-25 2004-11-04 Kiel Laboratories, Inc. Phenolic acid salts of gabapentin in solid dosage forms and methods of use
KR20060119971A (ko) 2003-09-11 2006-11-24 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방
MXPA06003043A (es) 2003-09-17 2006-05-31 Xenoport Inc Tratamiento o prevencion del sindrome piernas inquietas utilizando prodrogas de analogos gaba.
SG147437A1 (en) 2003-10-14 2008-11-28 Xenoport Inc Crystalline form of gamma-aminobutyric acid analog
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
RU2440112C2 (ru) 2004-11-04 2012-01-20 Ксенопорт, Инк. Пероральная дозированная форма габапентина замедленного высвобождения
CA2612186A1 (en) 2005-06-23 2007-01-04 Emory University Imaging agents
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
KR20080100284A (ko) * 2006-03-06 2008-11-14 화이자 프로덕츠 인코포레이티드 비-회복성 수면을 위한 알파-2-델타 리간드
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
CA2706575C (en) 2008-01-25 2015-07-14 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
AU2009302241B2 (en) 2008-10-08 2015-10-29 Xgene Pharmaceutical Inc. GABA conjugates and methods of use thereof
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
EP2948139B1 (en) 2013-01-28 2019-06-12 Lopez, Hector, L. Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor
SG10201912843YA (en) * 2016-05-26 2020-02-27 Amino Up Chemical Co Ltd Sleep improving agent
AU2019271799B2 (en) 2018-05-14 2023-10-12 Xgene Pharmaceutical Inc. Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin

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DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
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Also Published As

Publication number Publication date
CZ20024110A3 (cs) 2003-10-15
WO2002000209A3 (en) 2003-01-16
CN1279900C (zh) 2006-10-18
KR20030019455A (ko) 2003-03-06
IL152770A0 (en) 2003-06-24
JP2004501189A (ja) 2004-01-15
WO2002000209A2 (en) 2002-01-03
DK1296671T3 (da) 2008-06-16
US7141606B2 (en) 2006-11-28
MXPA02010668A (es) 2003-03-10
PT1296671E (pt) 2008-05-09
HUP0300833A3 (en) 2009-08-28
CA2414008C (en) 2011-04-26
US20030212133A1 (en) 2003-11-13
NZ522480A (en) 2005-06-24
PL359872A1 (en) 2004-09-06
SK17922002A3 (sk) 2003-11-04
JP3909842B2 (ja) 2007-04-25
TWI298020B (en) 2008-06-21
DE60133389T2 (de) 2008-06-26
AU2001264736B2 (en) 2006-04-27
EP1296671A2 (en) 2003-04-02
CA2414008A1 (en) 2002-01-03
HK1056681A1 (en) 2004-02-27
CN1436075A (zh) 2003-08-13
DE60133389D1 (de) 2008-05-08
ES2300332T3 (es) 2008-06-16
ATE390133T1 (de) 2008-04-15
KR100785182B1 (ko) 2007-12-11
ZA200209418B (en) 2005-03-10
AU6473601A (en) 2002-01-08
IL152770A (en) 2009-12-24
EP1296671B1 (en) 2008-03-26
BR0111913A (pt) 2004-01-06

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees