ATE390133T1 - Gabapentinanaloga für schlafstörungen - Google Patents

Gabapentinanaloga für schlafstörungen

Info

Publication number
ATE390133T1
ATE390133T1 AT01939192T AT01939192T ATE390133T1 AT E390133 T1 ATE390133 T1 AT E390133T1 AT 01939192 T AT01939192 T AT 01939192T AT 01939192 T AT01939192 T AT 01939192T AT E390133 T1 ATE390133 T1 AT E390133T1
Authority
AT
Austria
Prior art keywords
gabapentine
analogues
sleep disorders
compounds
insomnia
Prior art date
Application number
AT01939192T
Other languages
English (en)
Inventor
Justin Stephen Bryans
Leonard Theodore Meltzer
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE390133T1 publication Critical patent/ATE390133T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01939192T 2000-06-26 2001-05-18 Gabapentinanaloga für schlafstörungen ATE390133T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26

Publications (1)

Publication Number Publication Date
ATE390133T1 true ATE390133T1 (de) 2008-04-15

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01939192T ATE390133T1 (de) 2000-06-26 2001-05-18 Gabapentinanaloga für schlafstörungen

Country Status (23)

Country Link
US (1) US7141606B2 (de)
EP (1) EP1296671B1 (de)
JP (1) JP3909842B2 (de)
KR (1) KR100785182B1 (de)
CN (1) CN1279900C (de)
AT (1) ATE390133T1 (de)
AU (2) AU6473601A (de)
BR (1) BR0111913A (de)
CA (1) CA2414008C (de)
CZ (1) CZ20024110A3 (de)
DE (1) DE60133389T2 (de)
DK (1) DK1296671T3 (de)
ES (1) ES2300332T3 (de)
HU (1) HUP0300833A3 (de)
IL (2) IL152770A0 (de)
MX (1) MXPA02010668A (de)
NZ (1) NZ522480A (de)
PL (1) PL359872A1 (de)
PT (1) PT1296671E (de)
SK (1) SK17922002A3 (de)
TW (1) TWI298020B (de)
WO (1) WO2002000209A2 (de)
ZA (1) ZA200209418B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA006396B1 (ru) 2001-04-19 2005-12-29 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си Конденсированные бициклические аминокислоты
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002100344A2 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
WO2002100347A2 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
WO2003099338A2 (en) 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
AU2003297927A1 (en) 2002-12-11 2004-06-30 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
NZ540336A (en) * 2002-12-13 2008-03-28 Warner Lambert Co Gabapentin analogues for fibromyalgia and other related disorders
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
EP1622603A4 (de) * 2003-03-25 2010-03-24 Kiel Lab Inc Phenolsäuresalze von gabapentin in festen dosierformen und anwendungsverfahren
CA2537837A1 (en) 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
MXPA06003043A (es) 2003-09-17 2006-05-31 Xenoport Inc Tratamiento o prevencion del sindrome piernas inquietas utilizando prodrogas de analogos gaba.
WO2005037784A2 (en) 2003-10-14 2005-04-28 Xenoport, Inc. Crystalline form of gamma-aminobutyric acid analog
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
EP1811986B1 (de) 2004-11-04 2014-03-26 XenoPort, Inc. Orale darreichungsformen von gabapentin-prodrug mit verzögerter freisetzung
EP1893244A4 (de) 2005-06-23 2009-06-24 Univ Emory Kontrastmittel
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
RU2008135907A (ru) * 2006-03-06 2010-04-20 Пфайзер Продактс Инк. (Us) Альфа-2-дельта лиганды для невосстановительного сна
JP5563483B2 (ja) 2008-01-25 2014-07-30 ゼノポート，インコーポレイティド アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
BRPI0919811B1 (pt) 2008-10-08 2022-04-19 Xgene Pharmaceutical Inc Conjugados de gaba e métodos de uso dos mesmos
EP2509596B1 (de) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminosäure zur behandlung von augenerkrankungen
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
AU2014209028C1 (en) 2013-01-28 2019-08-29 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor
SG10201912843YA (en) 2016-05-26 2020-02-27 Amino Up Chemical Co Ltd Sleep improving agent
AU2019271799B2 (en) 2018-05-14 2023-10-12 Xgene Pharmaceutical Inc. Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin
CN117776950B (zh) * 2022-09-20 2025-12-23 中科中山药物创新研究院 一种γ-氨基丁酸衍生物、药物组合物和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5084479A (en) * 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) * 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
WO1997033859A1 (en) * 1996-03-14 1997-09-18 Warner-Lambert Company Novel bridged cyclic amino acids as pharmaceutical agents
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
DE69834204T2 (de) 1997-10-27 2007-03-29 Warner-Lambert Co. Llc Zyklische aminosäuren und deren derivate als arzneimittel
JP2002520277A (ja) * 1998-07-09 2002-07-09 ワーナー−ランバート・カンパニー 不眠症を治療する方法
PT1187832E (pt) * 1999-06-02 2003-03-31 Warner Lambert Co Amino heterociclos uteis como agentes farmaceuticos
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
MXPA02004829A (es) * 1999-12-08 2003-10-14 Warner Lambert Co Metodo para la sintesis estereoselectiva de aminoacidos ciclicos.
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
ES2300332T3 (es) 2008-06-16
CZ20024110A3 (cs) 2003-10-15
HUP0300833A3 (en) 2009-08-28
KR100785182B1 (ko) 2007-12-11
HK1056681A1 (en) 2004-02-27
NZ522480A (en) 2005-06-24
MXPA02010668A (es) 2003-03-10
CA2414008A1 (en) 2002-01-03
WO2002000209A2 (en) 2002-01-03
DK1296671T3 (da) 2008-06-16
IL152770A (en) 2009-12-24
TWI298020B (en) 2008-06-21
PT1296671E (pt) 2008-05-09
JP3909842B2 (ja) 2007-04-25
ZA200209418B (en) 2005-03-10
EP1296671B1 (de) 2008-03-26
WO2002000209A3 (en) 2003-01-16
SK17922002A3 (sk) 2003-11-04
CN1279900C (zh) 2006-10-18
IL152770A0 (en) 2003-06-24
AU2001264736B2 (en) 2006-04-27
AU6473601A (en) 2002-01-08
PL359872A1 (en) 2004-09-06
BR0111913A (pt) 2004-01-06
CN1436075A (zh) 2003-08-13
US7141606B2 (en) 2006-11-28
EP1296671A2 (de) 2003-04-02
JP2004501189A (ja) 2004-01-15
CA2414008C (en) 2011-04-26
DE60133389T2 (de) 2008-06-26
HUP0300833A2 (hu) 2003-08-28
KR20030019455A (ko) 2003-03-06
US20030212133A1 (en) 2003-11-13
DE60133389D1 (de) 2008-05-08

Similar Documents

Publication Publication Date Title
ATE390133T1 (de) Gabapentinanaloga für schlafstörungen
SE9603669D0 (sv) New combination
GB0223040D0 (en) Therapeutic compounds
DE60124684D1 (de) Sulfonamido-substituierte verbrückte bicycloalkylderivative
BG108269A (en) Pyrazolopyrimidines as therapeutic agents
GB0005251D0 (en) Therapeutic compounds
ATE350375T1 (de) 17beta-hydroxysteroid dehydrogenase type 3 inhibitoren zur behandlung von androgen- abhängigen erkrankungen
DE60223694D1 (de) Pflaster zur behandlung von funktionsstörungen und störungen des nagelwachstums
ATE334668T1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
IS6069A (is) N-cýanómetýlamíð sem próteasalatar
MY127980A (en) A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
BR0213358A (pt) Uso de flibanserina
SI1395567T1 (sl) 4-(fenil-piperazinil-metil)benzamidni derivati in njihova uporaba za zdravljenje bolečine, tesnobe ali gastrointestinalnih motenj
ATE357438T1 (de) 1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
ATE432068T1 (de) Cetirizin und pseudoephedrin enthaltende tablette
PL376894A1 (pl) Pochodne 4-(fenylopiperazynylometylo) benzamidu i ich zastosowanie do leczenia bólu lub zaburzeń żołądkowo-jelitowych
PL376895A1 (pl) Pochodne 4-(fenylopiperazynylometylo) benzamidu i ich zastosowanie do leczenia bólu lub zaburzeń żołądkowo-jelitowych
ITMI20010957A0 (it) Derivati dell'aoe-emodina e loro impiego nel trattamento di patologieneoplastiche
AU2003278664A1 (en) 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
JO3446B1 (ar) طريقة لمعالجة الأرق الأولي
HUP0103712A2 (hu) Paroxetin sók, eljárás az előállításukra és gyógyászati alkalmazásuk
DE60117122D1 (de) Verwendung von mirtazapin zur behandlung von schlafstörungen
DE60015098D1 (de) 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose
ITMI20001216A0 (it) Impiego dell'aloe-emodin nel trattamento di patologie neoplastiche diorigine neuroectodermica
SE0203778D0 (sv) A new oral immediated release dosage form

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1296671

Country of ref document: EP

REN Ceased due to non-payment of the annual fee