ATE289583T1 - Stereoisomere von propyl-isopropylacetamid, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zubereitungen - Google Patents
Stereoisomere von propyl-isopropylacetamid, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE289583T1 ATE289583T1 AT99914733T AT99914733T ATE289583T1 AT E289583 T1 ATE289583 T1 AT E289583T1 AT 99914733 T AT99914733 T AT 99914733T AT 99914733 T AT99914733 T AT 99914733T AT E289583 T1 ATE289583 T1 AT E289583T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- ethyl
- stereoisomers
- methyl
- compound
- Prior art date
Links
- PLNIVBFEUDBHBP-UHFFFAOYSA-N 2-propan-2-ylpentanamide Chemical compound CCCC(C(C)C)C(N)=O PLNIVBFEUDBHBP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 206010019233 Headaches Diseases 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 2
- 208000019022 Mood disease Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 208000028017 Psychotic disease Diseases 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 231100000869 headache Toxicity 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000000926 neurological effect Effects 0.000 abstract 2
- 230000000707 stereoselective effect Effects 0.000 abstract 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960000604 valproic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL124118A IL124118A (en) | 1998-04-16 | 1998-04-16 | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them |
| PCT/IL1999/000197 WO1999054282A1 (en) | 1998-04-16 | 1999-04-12 | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289583T1 true ATE289583T1 (de) | 2005-03-15 |
Family
ID=11071421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99914733T ATE289583T1 (de) | 1998-04-16 | 1999-04-12 | Stereoisomere von propyl-isopropylacetamid, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zubereitungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6630602B1 (de) |
| EP (1) | EP1077926B1 (de) |
| AT (1) | ATE289583T1 (de) |
| AU (1) | AU3342899A (de) |
| DE (1) | DE69923838T2 (de) |
| ES (1) | ES2238831T3 (de) |
| IL (2) | IL124118A (de) |
| WO (1) | WO1999054282A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| IL157751A0 (en) * | 2003-02-28 | 2004-03-28 | Yissum Res Dev Co | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
| US20060004098A1 (en) * | 2003-07-28 | 2006-01-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neurological disorders |
| US20060025477A1 (en) * | 2004-07-22 | 2006-02-02 | Artman Linda D | Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases |
| EP1845976A4 (de) * | 2005-01-10 | 2010-10-27 | Univ California | Verwendung von hemmern löslicher epoxidhydrolase zur synergierung der aktivität von cox- und 5-lox-hemmern |
| JP2009504785A (ja) * | 2005-08-19 | 2009-02-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 鎮痛剤としてのｓＥＨ阻害剤の使用 |
| EP2124928A4 (de) * | 2006-12-15 | 2011-01-05 | Univ California | Verwendung von cis-epoxyeicosatriensäuren und hemmern von löslicher epoxid-hydrolase zur behandlung von erkrankungen, die durch pbr, cb2 und nk hervorgerufen werden |
| TW200914409A (en) * | 2007-07-16 | 2009-04-01 | Wyeth Corp | Processes and intermediates for the preparation of heterocyclic sulfonamide compounds |
| WO2009062073A1 (en) * | 2007-11-08 | 2009-05-14 | Regents Of The University Of California | Alleviating neuropathic pain with eets and seh inhibitors |
| WO2016133788A1 (en) | 2015-02-20 | 2016-08-25 | The Regents Of The University Of California | Methods of inhibiting pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231085A1 (de) * | 1992-09-12 | 1994-03-17 | Desitin Arzneimittel Gmbh | VPA-analoge Antiepileptika |
| DE69408373T2 (de) * | 1993-06-01 | 1998-07-16 | Ono Pharmaceutical Co | Pentansäurederivate |
| IL120006A (en) * | 1997-01-14 | 2000-12-06 | Yissum Res Dev Co | Valnoctamide stereoisomers and a method for their synthesis and separation |
-
1998
- 1998-04-16 IL IL124118A patent/IL124118A/en not_active IP Right Cessation
-
1999
- 1999-04-12 WO PCT/IL1999/000197 patent/WO1999054282A1/en not_active Ceased
- 1999-04-12 US US09/673,296 patent/US6630602B1/en not_active Expired - Fee Related
- 1999-04-12 ES ES99914733T patent/ES2238831T3/es not_active Expired - Lifetime
- 1999-04-12 AU AU33428/99A patent/AU3342899A/en not_active Abandoned
- 1999-04-12 DE DE69923838T patent/DE69923838T2/de not_active Expired - Lifetime
- 1999-04-12 AT AT99914733T patent/ATE289583T1/de not_active IP Right Cessation
- 1999-04-12 EP EP99914733A patent/EP1077926B1/de not_active Expired - Lifetime
-
2000
- 2000-05-09 IL IL13603000A patent/IL136030A0/xx active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69923838D1 (de) | 2005-03-31 |
| IL124118A (en) | 2007-09-20 |
| ES2238831T3 (es) | 2005-09-01 |
| AU3342899A (en) | 1999-11-08 |
| EP1077926B1 (de) | 2005-02-23 |
| WO1999054282A1 (en) | 1999-10-28 |
| IL136030A0 (en) | 2001-05-20 |
| EP1077926A1 (de) | 2001-02-28 |
| DE69923838T2 (de) | 2006-04-06 |
| US6630602B1 (en) | 2003-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |