CN1279900C - 用于睡眠障碍的加巴喷丁类似物 - Google Patents

用于睡眠障碍的加巴喷丁类似物 Download PDF

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Publication number
CN1279900C
CN1279900C CNB018110487A CN01811048A CN1279900C CN 1279900 C CN1279900 C CN 1279900C CN B018110487 A CNB018110487 A CN B018110487A CN 01811048 A CN01811048 A CN 01811048A CN 1279900 C CN1279900 C CN 1279900C
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CN
China
Prior art keywords
aminomethyl
acetic acid
cyclopentyl
cyclobutyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018110487A
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English (en)
Chinese (zh)
Other versions
CN1436075A (zh
Inventor
J·S·布莱恩斯
L·T·梅尔泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
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Warner Lambert Co LLC
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Publication of CN1436075A publication Critical patent/CN1436075A/zh
Application granted granted Critical
Publication of CN1279900C publication Critical patent/CN1279900C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018110487A 2000-06-26 2001-05-18 用于睡眠障碍的加巴喷丁类似物 Expired - Fee Related CN1279900C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
US60/214,171 2000-06-26

Publications (2)

Publication Number Publication Date
CN1436075A CN1436075A (zh) 2003-08-13
CN1279900C true CN1279900C (zh) 2006-10-18

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018110487A Expired - Fee Related CN1279900C (zh) 2000-06-26 2001-05-18 用于睡眠障碍的加巴喷丁类似物

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Country Link
US (1) US7141606B2 (enExample)
EP (1) EP1296671B1 (enExample)
JP (1) JP3909842B2 (enExample)
KR (1) KR100785182B1 (enExample)
CN (1) CN1279900C (enExample)
AT (1) ATE390133T1 (enExample)
AU (2) AU6473601A (enExample)
BR (1) BR0111913A (enExample)
CA (1) CA2414008C (enExample)
CZ (1) CZ20024110A3 (enExample)
DE (1) DE60133389T2 (enExample)
DK (1) DK1296671T3 (enExample)
ES (1) ES2300332T3 (enExample)
HU (1) HUP0300833A3 (enExample)
IL (2) IL152770A0 (enExample)
MX (1) MXPA02010668A (enExample)
NZ (1) NZ522480A (enExample)
PL (1) PL359872A1 (enExample)
PT (1) PT1296671E (enExample)
SK (1) SK17922002A3 (enExample)
TW (1) TWI298020B (enExample)
WO (1) WO2002000209A2 (enExample)
ZA (1) ZA200209418B (enExample)

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CA2444053C (en) 2001-04-19 2008-06-17 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
AU2002345638A1 (en) 2001-06-11 2002-12-23 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
DK1404324T4 (da) 2001-06-11 2011-07-11 Xenoport Inc Prolægemidler af GABA analoger, sammensætninger og anvendelser deraf
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
WO2003080588A1 (en) 2002-03-20 2003-10-02 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
AU2003243180A1 (en) 2002-05-17 2003-12-12 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
AU2003297927A1 (en) 2002-12-11 2004-06-30 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
MXPA05005815A (es) * 2002-12-13 2005-08-18 Warner Lambert Co Analogos de gabapentina para fibromialgia y otros trastornos.
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
EP1622603A4 (en) * 2003-03-25 2010-03-24 Kiel Lab Inc GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE
CA2537837A1 (en) 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
US8114909B2 (en) 2003-09-17 2012-02-14 Xenoport, Inc. Treating or preventing restless legs syndrome using prodrugs of GABA analogs
ATE516801T1 (de) 2003-10-14 2011-08-15 Xenoport Inc Kristalline form eines gamma-aminobuttersäure- analogons
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
US8795725B2 (en) 2004-11-04 2014-08-05 Xenoport, Inc. GABA analog prodrug sustained release oral dosage forms
JP2009505947A (ja) 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
CN101420947A (zh) * 2006-03-06 2009-04-29 辉瑞产品公司 用于非恢复性睡眠的α-2-δ配体
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
EP2250143B1 (en) 2008-01-25 2016-04-20 XenoPort, Inc. Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
CN102216257B (zh) 2008-10-08 2015-11-25 凯飞药业公司 Gaba偶联物及其使用方法
CA2783699C (en) 2009-12-08 2019-01-15 Case Western Reserve University Primary amine compounds for treating ocular disorders
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
HUE047629T2 (hu) 2013-01-28 2020-05-28 Lopez Hector L Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása
EP3466427A4 (en) 2016-05-26 2020-02-05 Amino Up Chemical Co., Ltd. SLEEP ENHANCEMENT AGENT
KR102750784B1 (ko) 2018-05-14 2025-01-06 엑스진 파마슈티컬 인크. 나프록센 및 프레가발린의 1-(아실옥시)-알킬 카르바메이트 약물 복합체의 제조방법 및 그 중간체

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US5084479A (en) * 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) * 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
KR100487032B1 (ko) * 1996-03-14 2005-12-21 워너-램버트 캄파니 엘엘씨 약제로서신규한브리지된시클릭아미노산
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
BR9813284B1 (pt) 1997-10-27 2012-08-21 aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica.
KR20010071778A (ko) * 1998-07-09 2001-07-31 로즈 암스트롱, 크리스틴 에이. 트러트웨인 불면증의 치료를 위한 ｇａｂａ 유사체의 용도
ES2185591T3 (es) * 1999-06-02 2003-05-01 Warner Lambert Co Amino hererociclos utiles como agentes farmaceuticos.
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
EA004984B1 (ru) * 1999-12-08 2004-10-28 Уорнер-Ламберт Компани Способ стереоселективного синтеза циклических аминокислот
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
CA2414008C (en) 2011-04-26
PL359872A1 (en) 2004-09-06
JP3909842B2 (ja) 2007-04-25
SK17922002A3 (sk) 2003-11-04
KR100785182B1 (ko) 2007-12-11
AU6473601A (en) 2002-01-08
HUP0300833A2 (hu) 2003-08-28
ATE390133T1 (de) 2008-04-15
WO2002000209A3 (en) 2003-01-16
JP2004501189A (ja) 2004-01-15
ZA200209418B (en) 2005-03-10
CZ20024110A3 (cs) 2003-10-15
CA2414008A1 (en) 2002-01-03
DE60133389T2 (de) 2008-06-26
IL152770A (en) 2009-12-24
IL152770A0 (en) 2003-06-24
KR20030019455A (ko) 2003-03-06
TWI298020B (en) 2008-06-21
HK1056681A1 (en) 2004-02-27
CN1436075A (zh) 2003-08-13
WO2002000209A2 (en) 2002-01-03
HUP0300833A3 (en) 2009-08-28
ES2300332T3 (es) 2008-06-16
DK1296671T3 (da) 2008-06-16
DE60133389D1 (de) 2008-05-08
US20030212133A1 (en) 2003-11-13
MXPA02010668A (es) 2003-03-10
PT1296671E (pt) 2008-05-09
NZ522480A (en) 2005-06-24
BR0111913A (pt) 2004-01-06
AU2001264736B2 (en) 2006-04-27
US7141606B2 (en) 2006-11-28
EP1296671B1 (en) 2008-03-26
EP1296671A2 (en) 2003-04-02

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Granted publication date: 20061018

Termination date: 20130518