AU2001264736B2 - Gabapentin analogues for sleep disorders - Google Patents
Gabapentin analogues for sleep disorders Download PDFInfo
- Publication number
- AU2001264736B2 AU2001264736B2 AU2001264736A AU2001264736A AU2001264736B2 AU 2001264736 B2 AU2001264736 B2 AU 2001264736B2 AU 2001264736 A AU2001264736 A AU 2001264736A AU 2001264736 A AU2001264736 A AU 2001264736A AU 2001264736 B2 AU2001264736 B2 AU 2001264736B2
- Authority
- AU
- Australia
- Prior art keywords
- acetic acid
- aminomethyl
- cyclopentyl
- cyclobutyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 12
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- 238000000034 method Methods 0.000 claims description 12
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Life Sciences & Earth Sciences (AREA)
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- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21417100P | 2000-06-26 | 2000-06-26 | |
| US60/214,171 | 2000-06-26 | ||
| PCT/US2001/016343 WO2002000209A2 (en) | 2000-06-26 | 2001-05-18 | Gabapentin analogues for sleep disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2001264736A1 AU2001264736A1 (en) | 2002-03-28 |
| AU2001264736B2 true AU2001264736B2 (en) | 2006-04-27 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001264736A Ceased AU2001264736B2 (en) | 2000-06-26 | 2001-05-18 | Gabapentin analogues for sleep disorders |
| AU6473601A Pending AU6473601A (en) | 2000-06-26 | 2001-05-18 | Gabapentin analogues for sleep disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU6473601A Pending AU6473601A (en) | 2000-06-26 | 2001-05-18 | Gabapentin analogues for sleep disorders |
Country Status (23)
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|---|---|
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| EP (1) | EP1296671B1 (enExample) |
| JP (1) | JP3909842B2 (enExample) |
| KR (1) | KR100785182B1 (enExample) |
| CN (1) | CN1279900C (enExample) |
| AT (1) | ATE390133T1 (enExample) |
| AU (2) | AU2001264736B2 (enExample) |
| BR (1) | BR0111913A (enExample) |
| CA (1) | CA2414008C (enExample) |
| CZ (1) | CZ20024110A3 (enExample) |
| DE (1) | DE60133389T2 (enExample) |
| DK (1) | DK1296671T3 (enExample) |
| ES (1) | ES2300332T3 (enExample) |
| HU (1) | HUP0300833A3 (enExample) |
| IL (2) | IL152770A0 (enExample) |
| MX (1) | MXPA02010668A (enExample) |
| NZ (1) | NZ522480A (enExample) |
| PL (1) | PL359872A1 (enExample) |
| PT (1) | PT1296671E (enExample) |
| SK (1) | SK17922002A3 (enExample) |
| TW (1) | TWI298020B (enExample) |
| WO (1) | WO2002000209A2 (enExample) |
| ZA (1) | ZA200209418B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL157932A0 (en) | 2001-04-19 | 2004-03-28 | Warner Lambert Co | Fused bicyclic or tricyclic amino acids |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7420002B2 (en) | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| JP4216713B2 (ja) | 2001-06-11 | 2009-01-28 | ゼノポート，インコーポレイティド | Ｇａｂａ類似体のプロドラッグ、組成物およびその使用 |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6927036B2 (en) | 2002-02-19 | 2005-08-09 | Xero Port, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US7026351B2 (en) | 2002-03-20 | 2006-04-11 | Xenoport, Inc. | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof |
| AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| BR0316751A (pt) * | 2002-12-13 | 2005-10-25 | Warner Lambert Co | Análogos de gabapentina para fibromialgia e outros distúrbios relacionados |
| EP1622603A4 (en) * | 2003-03-25 | 2010-03-24 | Kiel Lab Inc | GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE |
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| MXPA06003043A (es) | 2003-09-17 | 2006-05-31 | Xenoport Inc | Tratamiento o prevencion del sindrome piernas inquietas utilizando prodrogas de analogos gaba. |
| KR101096480B1 (ko) | 2003-10-14 | 2011-12-20 | 제노포트 인코포레이티드 | 감마-아미노부티르산 유사체의 결정질 형태 |
| JP4613031B2 (ja) * | 2004-05-06 | 2011-01-12 | エスエス製薬株式会社 | 催眠剤組成物 |
| JP2005325070A (ja) * | 2004-05-14 | 2005-11-24 | Ss Pharmaceut Co Ltd | 睡眠改善剤 |
| NZ554737A (en) | 2004-11-04 | 2011-04-29 | Xenoport Inc | Gabapentin prodrug sustained release oral dosage forms |
| US7837982B2 (en) | 2005-06-23 | 2010-11-23 | Emory University | Imaging agents |
| KR20070070307A (ko) * | 2005-08-24 | 2007-07-04 | 에스에스 세야쿠 가부시키 가이샤 | 수면 개선 의약 조성물 |
| EP1993529A1 (en) * | 2006-03-06 | 2008-11-26 | Pfizer Products Inc. | Alpha-2-delta ligands for non-restorative sleep |
| US7872046B2 (en) | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| ES2601852T3 (es) | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| WO2010042759A2 (en) | 2008-10-08 | 2010-04-15 | Kyphia Pharmaceuticals Inc | Gaba conjugates and methods of use thereof |
| WO2011071995A2 (en) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| HUE047629T2 (hu) | 2013-01-28 | 2020-05-28 | Lopez Hector L | Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása |
| JP7381000B2 (ja) | 2016-05-26 | 2023-11-15 | 株式会社アミノアップ | 睡眠改善剤 |
| JP7441181B2 (ja) | 2018-05-14 | 2024-02-29 | エックスジーン ファーマシューティカル インク． | ナプロキセンとプレガバリンの１－（アシルオキシ）－アルキルカルバメート薬品複合体の結晶形態 |
| CN117776950B (zh) * | 2022-09-20 | 2025-12-23 | 中科中山药物创新研究院 | 一种γ-氨基丁酸衍生物、药物组合物和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5084479A (en) * | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US5510381A (en) * | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
| DE19525598C2 (de) * | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| AU731279B2 (en) * | 1996-03-14 | 2001-03-29 | Warner-Lambert Company | Novel bridged cyclic amino acids as pharmaceutical agents |
| US6372792B1 (en) * | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
| BR9813284B1 (pt) * | 1997-10-27 | 2012-08-21 | aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica. | |
| BR9911887A (pt) * | 1998-07-09 | 2001-03-27 | Warner Lambert Co | Método para o tratamento da insÈnia |
| ES2185591T3 (es) * | 1999-06-02 | 2003-05-01 | Warner Lambert Co | Amino hererociclos utiles como agentes farmaceuticos. |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| DE60028076T2 (de) * | 1999-12-08 | 2006-11-02 | Warner-Lambert Co. Llc | Verfahren zur stereoselektiven synthese zyklischer aminosäuren |
| GB9930083D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
-
2001
- 2001-05-18 HU HU0300833A patent/HUP0300833A3/hu unknown
- 2001-05-18 AU AU2001264736A patent/AU2001264736B2/en not_active Ceased
- 2001-05-18 WO PCT/US2001/016343 patent/WO2002000209A2/en not_active Ceased
- 2001-05-18 SK SK1792-2002A patent/SK17922002A3/sk not_active Application Discontinuation
- 2001-05-18 PL PL35987201A patent/PL359872A1/xx not_active Application Discontinuation
- 2001-05-18 JP JP2002504991A patent/JP3909842B2/ja not_active Expired - Fee Related
- 2001-05-18 ES ES01939192T patent/ES2300332T3/es not_active Expired - Lifetime
- 2001-05-18 BR BR0111913-3A patent/BR0111913A/pt not_active Application Discontinuation
- 2001-05-18 EP EP01939192A patent/EP1296671B1/en not_active Expired - Lifetime
- 2001-05-18 MX MXPA02010668A patent/MXPA02010668A/es active IP Right Grant
- 2001-05-18 CN CNB018110487A patent/CN1279900C/zh not_active Expired - Fee Related
- 2001-05-18 AU AU6473601A patent/AU6473601A/xx active Pending
- 2001-05-18 PT PT01939192T patent/PT1296671E/pt unknown
- 2001-05-18 CA CA2414008A patent/CA2414008C/en not_active Expired - Fee Related
- 2001-05-18 NZ NZ522480A patent/NZ522480A/en unknown
- 2001-05-18 CZ CZ20024110A patent/CZ20024110A3/cs unknown
- 2001-05-18 DK DK01939192T patent/DK1296671T3/da active
- 2001-05-18 US US10/297,827 patent/US7141606B2/en not_active Expired - Fee Related
- 2001-05-18 DE DE60133389T patent/DE60133389T2/de not_active Expired - Lifetime
- 2001-05-18 KR KR1020027017609A patent/KR100785182B1/ko not_active Expired - Fee Related
- 2001-05-18 IL IL15277001A patent/IL152770A0/xx unknown
- 2001-05-18 AT AT01939192T patent/ATE390133T1/de not_active IP Right Cessation
- 2001-06-19 TW TW090114841A patent/TWI298020B/zh not_active IP Right Cessation
-
2002
- 2002-11-11 IL IL152770A patent/IL152770A/en not_active IP Right Cessation
- 2002-11-19 ZA ZA200209418A patent/ZA200209418B/en unknown
Non-Patent Citations (1)
| Title |
|---|
| References cited in WO 02/00209 * |
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