CN1269818C - 内酰胺化合物及其药物用途 - Google Patents

内酰胺化合物及其药物用途 Download PDF

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Publication number
CN1269818C
CN1269818C CNB018223559A CN01822355A CN1269818C CN 1269818 C CN1269818 C CN 1269818C CN B018223559 A CNB018223559 A CN B018223559A CN 01822355 A CN01822355 A CN 01822355A CN 1269818 C CN1269818 C CN 1269818C
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China
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group
ring
acyl
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Expired - Fee Related
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CNB018223559A
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English (en)
Chinese (zh)
Other versions
CN1487940A (zh
Inventor
饭野幸生
池上孝雄
近藤信雄
松枝裕之
畑中敏宏
平间龙介
增泽阳子
太田史生
山崎晶代
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EA Pharma Co Ltd
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Ajinomoto Co Inc
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Publication of CN1487940A publication Critical patent/CN1487940A/zh
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Publication of CN1269818C publication Critical patent/CN1269818C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
CNB018223559A 2000-12-01 2001-11-29 内酰胺化合物及其药物用途 Expired - Fee Related CN1269818C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP367175/2000 2000-12-01
JP2000367175 2000-12-01
JP367175/00 2000-12-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200610095903A Division CN100577651C (zh) 2000-12-01 2001-11-29 内酰胺化合物及其药物用途

Publications (2)

Publication Number Publication Date
CN1487940A CN1487940A (zh) 2004-04-07
CN1269818C true CN1269818C (zh) 2006-08-16

Family

ID=18837660

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB018223559A Expired - Fee Related CN1269818C (zh) 2000-12-01 2001-11-29 内酰胺化合物及其药物用途
CN200610095903A Expired - Fee Related CN100577651C (zh) 2000-12-01 2001-11-29 内酰胺化合物及其药物用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200610095903A Expired - Fee Related CN100577651C (zh) 2000-12-01 2001-11-29 内酰胺化合物及其药物用途

Country Status (26)

Country Link
US (3) US7153850B2 (https=)
EP (1) EP1346993B1 (https=)
JP (2) JP3826400B2 (https=)
KR (1) KR100826818B1 (https=)
CN (2) CN1269818C (https=)
AT (1) ATE446297T1 (https=)
AU (3) AU1850202A (https=)
BG (1) BG107857A (https=)
BR (1) BR0115852A (https=)
CA (1) CA2430124C (https=)
CZ (1) CZ20031520A3 (https=)
DE (1) DE60140270D1 (https=)
ES (1) ES2331299T3 (https=)
HU (1) HUP0400806A3 (https=)
IL (1) IL156158A0 (https=)
MX (1) MXPA03004876A (https=)
NO (1) NO325401B1 (https=)
NZ (1) NZ526164A (https=)
PL (1) PL362835A1 (https=)
RU (1) RU2287530C2 (https=)
SK (1) SK6582003A3 (https=)
TW (1) TWI241302B (https=)
UA (1) UA76969C2 (https=)
WO (1) WO2002044180A1 (https=)
YU (1) YU42603A (https=)
ZA (1) ZA200304100B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1850202A (en) * 2000-12-01 2002-06-11 Ajinomoto Kk Lactam compounds and medicinal use thereof
CN101822834A (zh) 2003-02-07 2010-09-08 味之素株式会社 糖尿病治疗药
WO2005042536A1 (ja) * 2003-10-31 2005-05-12 Ajinomoto Co., Inc. 複素環を有する新規縮合多環式化合物及びその医薬用途
JPWO2005068467A1 (ja) 2004-01-14 2007-12-27 味の素株式会社 新規縮環化合物
WO2006040036A1 (en) * 2004-10-13 2006-04-20 F. Hoffmann-La Roche Ag Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer
BRPI0610034A2 (pt) 2005-04-28 2011-10-18 Ajinomoto Kk composto, agente de icremento do transporte de açúcar, agente hipoglicêmico, agente para prevenção e/ou tratamento de uma doença, medicamento, composição farmacêutica , uso do composto, e, método de preparação para o composto
WO2008126920A1 (ja) 2007-04-11 2008-10-23 Ajinomoto Co., Inc. 糖尿病治療薬
WO2008136392A1 (ja) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. 経口投与用製剤
WO2008139575A1 (ja) * 2007-04-27 2008-11-20 Ajinomoto Co., Inc. 経口投与用製剤
WO2008139574A1 (ja) * 2007-04-27 2008-11-20 Ajinomoto Co., Inc. ラクタム化合物の結晶形およびその製造方法
CN101619041B (zh) * 2008-07-02 2012-07-04 重庆华邦制药股份有限公司 一种二酮基含氮环化合物的合成方法及其中间体
JP2012180283A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
JP2012180282A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
EP3238723B1 (en) * 2014-12-22 2020-02-05 EA Pharma Co., Ltd. Drug for treating disorders of corneal epithelium
AU2017208970A1 (en) 2016-01-18 2018-08-02 Arisan Therapeutics Adamatane derivatives for the treatment of filovirus infection
WO2019018185A1 (en) 2017-07-15 2019-01-24 Arisan Therapeutics Inc. ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS
MX2021008937A (es) * 2019-01-23 2021-11-12 Glycolysis Biomed Co Ltd Compuestos de beta-lactama o sales de los mismos para su uso en la prevencion o tratamiento de accion prolongada del trastorno del metabolismo de la glucosa.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US189597A (en) * 1877-04-17 Improvement in portable wash-stands
US48847A (en) * 1865-07-18 Improvement in vessels for reception and transportation of night-soil
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
BR9811559A (pt) 1997-07-30 2000-09-12 American Home Prod Agonistas tricìclicos de vasopressina
JP4204657B2 (ja) 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤
AU1850202A (en) 2000-12-01 2002-06-11 Ajinomoto Kk Lactam compounds and medicinal use thereof
CN101822834A (zh) * 2003-02-07 2010-09-08 味之素株式会社 糖尿病治疗药

Also Published As

Publication number Publication date
PL362835A1 (en) 2004-11-02
MXPA03004876A (es) 2004-01-27
BG107857A (bg) 2004-06-30
CN100577651C (zh) 2010-01-06
US7632830B2 (en) 2009-12-15
EP1346993A1 (en) 2003-09-24
CN1487940A (zh) 2004-04-07
EP1346993A4 (en) 2005-12-21
US20080096862A1 (en) 2008-04-24
ES2331299T3 (es) 2009-12-29
AU2002218502B2 (en) 2006-09-21
YU42603A (sh) 2006-03-03
WO2002044180A1 (en) 2002-06-06
US7326701B2 (en) 2008-02-05
ZA200304100B (en) 2004-08-22
IL156158A0 (en) 2003-12-23
US20060189597A1 (en) 2006-08-24
ATE446297T1 (de) 2009-11-15
DE60140270D1 (de) 2009-12-03
KR100826818B1 (ko) 2008-05-02
SK6582003A3 (en) 2003-09-11
AU2006241377A1 (en) 2006-12-14
HUP0400806A2 (hu) 2004-07-28
NO20032439D0 (no) 2003-05-28
UA76969C2 (en) 2006-10-16
AU2006241377B2 (en) 2009-01-08
EP1346993B1 (en) 2009-10-21
US7153850B2 (en) 2006-12-26
CZ20031520A3 (cs) 2003-10-15
CN1911915A (zh) 2007-02-14
NZ526164A (en) 2004-09-24
JP3826400B2 (ja) 2006-09-27
TWI241302B (en) 2005-10-11
RU2287530C2 (ru) 2006-11-20
JP4505753B2 (ja) 2010-07-21
HUP0400806A3 (en) 2007-11-28
NO20032439L (no) 2003-07-18
AU1850202A (en) 2002-06-11
CA2430124A1 (en) 2002-06-06
BR0115852A (pt) 2003-12-23
JP2006213732A (ja) 2006-08-17
US20040048847A1 (en) 2004-03-11
KR20030051893A (ko) 2003-06-25
CA2430124C (en) 2011-01-11
NO325401B1 (no) 2008-04-21
JPWO2002044180A1 (ja) 2004-04-02

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20160727

Address after: Tokyo, Japan, Japan

Patentee after: EA pharmaceutical KK

Address before: All of central Tokyo Japan

Patentee before: Ajinomoto K. K.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060816

Termination date: 20181129

CF01 Termination of patent right due to non-payment of annual fee