CN1268743C - 编码细胞靶向部分和异源前体药物活化酶的基因构建体及其应用 - Google Patents

编码细胞靶向部分和异源前体药物活化酶的基因构建体及其应用 Download PDF

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CN1268743C
CN1268743C CNB988049295A CN98804929A CN1268743C CN 1268743 C CN1268743 C CN 1268743C CN B988049295 A CNB988049295 A CN B988049295A CN 98804929 A CN98804929 A CN 98804929A CN 1268743 C CN1268743 C CN 1268743C
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CN1255163A (zh
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S·C·埃默里
D·C·布拉凯
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AstraZeneca UK Ltd
Syngenta Ltd
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Zeneca Ltd
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    • B82—NANOTECHNOLOGY
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/802—Virus-based particle
    • Y10S977/803—Containing biological material in its interior
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Enzymes And Modification Thereof (AREA)
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CNB988049295A 1997-05-10 1998-05-05 编码细胞靶向部分和异源前体药物活化酶的基因构建体及其应用 Expired - Fee Related CN1268743C (zh)

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GB9709421.3 1997-05-10
GBGB9709421.3A GB9709421D0 (en) 1997-05-10 1997-05-10 Chemical compounds

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CN1255163A CN1255163A (zh) 2000-05-31
CN1268743C true CN1268743C (zh) 2006-08-09

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US (1) US6339070B1 (enExample)
EP (1) EP0979292B1 (enExample)
JP (1) JP2001526539A (enExample)
KR (1) KR100508136B1 (enExample)
CN (1) CN1268743C (enExample)
AT (1) ATE412755T1 (enExample)
AU (1) AU734915B2 (enExample)
BR (1) BR9808769A (enExample)
CA (1) CA2286875A1 (enExample)
DE (1) DE69840165D1 (enExample)
ES (1) ES2314990T3 (enExample)
GB (2) GB9709421D0 (enExample)
HU (1) HUP0001931A3 (enExample)
IL (1) IL132348A0 (enExample)
MY (1) MY140975A (enExample)
NO (1) NO995475L (enExample)
NZ (1) NZ500014A (enExample)
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RU (1) RU2218404C2 (enExample)
SK (1) SK153599A3 (enExample)
TR (1) TR199902731T2 (enExample)
WO (1) WO1998051787A2 (enExample)
ZA (1) ZA983931B (enExample)

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Publication number Publication date
ATE412755T1 (de) 2008-11-15
PL337007A1 (en) 2000-07-31
CA2286875A1 (en) 1998-11-19
KR100508136B1 (ko) 2005-08-10
SK153599A3 (en) 2000-06-12
IL132348A0 (en) 2001-03-19
HUP0001931A3 (en) 2003-10-28
ES2314990T3 (es) 2009-03-16
EP0979292A2 (en) 2000-02-16
BR9808769A (pt) 2000-08-01
GB9922815D0 (en) 1999-11-24
NZ500014A (en) 2001-08-31
HUP0001931A2 (hu) 2000-09-28
EP0979292B1 (en) 2008-10-29
NO995475L (no) 2000-01-07
TR199902731T2 (xx) 2000-06-21
GB2338484A (en) 1999-12-22
WO1998051787A2 (en) 1998-11-19
AU734915B2 (en) 2001-06-28
US6339070B1 (en) 2002-01-15
KR20010012441A (ko) 2001-02-15
JP2001526539A (ja) 2001-12-18
CN1255163A (zh) 2000-05-31
AU7225498A (en) 1998-12-08
WO1998051787A3 (en) 1999-04-01
ZA983931B (en) 1998-11-10
MY140975A (en) 2010-02-12
RU2218404C2 (ru) 2003-12-10
GB2338484B (en) 2001-11-07
NO995475D0 (no) 1999-11-09
DE69840165D1 (de) 2008-12-11
GB9709421D0 (en) 1997-07-02

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