BR9808769A - Construção de gene, uso de uma construção de gene, sistema de dois componentes emparelhados, designado para o uso em um hospedeiro mamìfero, e, processo para transferência de um medicamento citotóxico para um sìtio - Google Patents
Construção de gene, uso de uma construção de gene, sistema de dois componentes emparelhados, designado para o uso em um hospedeiro mamìfero, e, processo para transferência de um medicamento citotóxico para um sìtioInfo
- Publication number
- BR9808769A BR9808769A BR9808769-0A BR9808769A BR9808769A BR 9808769 A BR9808769 A BR 9808769A BR 9808769 A BR9808769 A BR 9808769A BR 9808769 A BR9808769 A BR 9808769A
- Authority
- BR
- Brazil
- Prior art keywords
- mammalian host
- gene
- site
- cell
- paired
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000010276 construction Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 101710160107 Outer membrane protein A Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
- Y10S977/803—Containing biological material in its interior
- Y10S977/804—Containing nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- External Artificial Organs (AREA)
Abstract
''CONSTRUçãO DE GENE, USO DE UMA CONSTRUçãO DE GENE, SISTEMA DE DOIS COMPONENTES EMPARELHADOS, DESIGNADO PARA O USO EM UM HOSPEDEIRO MAMìFERO, E, PROCESSO PARA TRANSFERêNCIA DE UM MEDICAMENTO CITOTóXICO PARA UM SìTIO". A invenção fornece uma construção de gene que codifica uma porção alvo de célula e uma enzima heteróloga ativadora de pró-medicamento para o uso como um medicamento em um hospedeiro mamífero em que a construção de gene é capaz de expressar a porção alvo de célula e a enzima como um conjugado dentro de uma célula alvo no hospedeiro mamífero e em que o conjugado é direcionado para deixar a célula depois disso para a localização seletiva em um antígeno de superfície celular reconhecido pela porção alvo de célula.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9709421.3A GB9709421D0 (en) | 1997-05-10 | 1997-05-10 | Chemical compounds |
PCT/GB1998/001294 WO1998051787A2 (en) | 1997-05-10 | 1998-05-05 | Gene construct encoding a heterologous prodrug-activating enzyme and a cell targeting moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808769A true BR9808769A (pt) | 2000-08-01 |
Family
ID=10812048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808769-0A BR9808769A (pt) | 1997-05-10 | 1998-05-05 | Construção de gene, uso de uma construção de gene, sistema de dois componentes emparelhados, designado para o uso em um hospedeiro mamìfero, e, processo para transferência de um medicamento citotóxico para um sìtio |
Country Status (23)
Country | Link |
---|---|
US (1) | US6339070B1 (pt) |
EP (1) | EP0979292B1 (pt) |
JP (1) | JP2001526539A (pt) |
KR (1) | KR100508136B1 (pt) |
CN (1) | CN1268743C (pt) |
AT (1) | ATE412755T1 (pt) |
AU (1) | AU734915B2 (pt) |
BR (1) | BR9808769A (pt) |
CA (1) | CA2286875A1 (pt) |
DE (1) | DE69840165D1 (pt) |
ES (1) | ES2314990T3 (pt) |
GB (2) | GB9709421D0 (pt) |
HU (1) | HUP0001931A3 (pt) |
IL (1) | IL132348A0 (pt) |
MY (1) | MY140975A (pt) |
NO (1) | NO995475L (pt) |
NZ (1) | NZ500014A (pt) |
PL (1) | PL337007A1 (pt) |
RU (1) | RU2218404C2 (pt) |
SK (1) | SK153599A3 (pt) |
TR (1) | TR199902731T2 (pt) |
WO (1) | WO1998051787A2 (pt) |
ZA (1) | ZA983931B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9910077D0 (en) | 1999-05-01 | 1999-06-30 | Univ Manchester | Chemical compounds |
DE19946142A1 (de) * | 1999-09-27 | 2001-03-29 | Bundesrepublik Deutschland Let | Gentransfer in humane Lymphocyten mittels retroviraler scFv-Zelltargeting Vektoren |
GB0001653D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Uk Ltd | Chemical compound |
GB0102239D0 (en) | 2001-01-29 | 2001-03-14 | Cancer Res Ventures Ltd | Methods of chemical synthisis |
WO2002094318A1 (en) * | 2001-05-18 | 2002-11-28 | University Of Southern California | Vector for targeted delivery to cells |
US7244592B2 (en) * | 2002-03-07 | 2007-07-17 | Dyax Corp. | Ligand screening and discovery |
WO2003104425A2 (en) * | 2002-06-07 | 2003-12-18 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Novel stable anti-cd22 antibodies |
WO2004069269A1 (en) * | 2003-01-30 | 2004-08-19 | Neurologix, Inc. | Method for making a cell more susceptible for a compound by expressing the protein, on which said compound acts, in said cell |
PT2382990E (pt) | 2003-04-30 | 2014-12-29 | Univ Zuerich | Método para tratamento do cancro usando uma imunotoxina |
US20110160440A1 (en) * | 2003-12-12 | 2011-06-30 | Genencor International, Inc. | Cab Molecules |
BRPI0509732A (pt) | 2004-04-09 | 2007-09-25 | Chugai Pharmaceutical Co Ltd | pró-fármaco solúvel em água, composição farmacêutica, agente terapêutico, agente antifungo e uso do referido pró-fármaco |
US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
AU2006328882B2 (en) * | 2005-12-21 | 2011-06-16 | Amgen Research (Munich) Gmbh | Pharmaceutical antibody compositions with resistance to soluble CEA |
WO2008128330A1 (en) * | 2007-04-19 | 2008-10-30 | Viventia Biotech Inc. | Optimized nucleotide sequences of vb6-845 for expression of recombinant proteins |
US8318472B2 (en) * | 2007-09-27 | 2012-11-27 | Viventia Biotechnologies Inc. | Optimized nucleic acid sequences for the expression of VB4-845 |
US8771679B2 (en) * | 2008-08-13 | 2014-07-08 | The John Hopkins University | Prodrug activation in cancer cells using molecular switches |
WO2010085665A2 (en) | 2009-01-23 | 2010-07-29 | Cedars-Sinai Medical Center | Targeted delivery system |
KR102096224B1 (ko) * | 2011-10-28 | 2020-04-03 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 폴리펩티드 구축물 및 이의 용도 |
CA2881582A1 (en) | 2012-08-03 | 2014-02-06 | Cedars-Sinai Medical Center | Isolating traffic-enhancing mutants of drug delivery protein |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
HUE046673T2 (hu) | 2013-10-02 | 2020-03-30 | Viventia Bio Inc | Anti-EpCAM antitestek és alkalmazási eljárások |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
US10544199B2 (en) | 2014-10-29 | 2020-01-28 | Teva Pharmaceuticals Australia Pty Ltd | Interferon alpha 2B variants |
WO2016145349A1 (en) | 2015-03-12 | 2016-09-15 | Viventia Bio Inc. | Methods of treatment for epcam positive bladder cancer |
US10583198B2 (en) | 2015-03-12 | 2020-03-10 | Viventia Bio Inc. | Dosing strategies for targeting EPCAM positive bladder cancer |
AU2021244559A1 (en) | 2020-03-24 | 2022-11-17 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for expressing Gaucher therapeutics |
IL296660A (en) | 2020-03-24 | 2022-11-01 | Generation Bio Co | Non-viral DNA vectors and their use for therapeutic expression of factor ix |
WO2024040222A1 (en) | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Cleavable closed-ended dna (cedna) and methods of use thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US5632990A (en) * | 1988-04-22 | 1997-05-27 | Cancer Research Campaign Tech. Ltd. | Treatment for tumors comprising conjugated antibody A5B7 and a prodrug |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
WO1991002805A2 (en) | 1989-08-18 | 1991-03-07 | Viagene, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
US6337209B1 (en) | 1992-02-26 | 2002-01-08 | Glaxo Wellcome Inc. | Molecular constructs containing a carcinoembryonic antigen regulatory sequence |
DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
DE4110409C2 (de) | 1991-03-29 | 1999-05-27 | Boehringer Ingelheim Int | Neue Protein-Polykation-Konjugate |
WO1993019163A1 (en) | 1992-03-18 | 1993-09-30 | Yeda Research And Development Co, Ltd. | Chimeric receptor genes and cells transformed therewith |
GB9314960D0 (en) * | 1992-07-23 | 1993-09-01 | Zeneca Ltd | Chemical compounds |
JPH08504091A (ja) | 1992-09-22 | 1996-05-07 | メディカル・リサーチ・カウンシル | 外部表面に非ウィルス性ポリペプチドを提示する組換えウィルス |
GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
GB9323008D0 (en) | 1993-11-05 | 1994-01-05 | Connors Thomas | Improvements relating to cancer therapy |
GB9324807D0 (en) * | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
GB9415167D0 (en) | 1994-07-27 | 1994-09-14 | Springer Caroline J | Improvements relating to cancer therapy |
GB9423367D0 (en) | 1994-11-18 | 1995-01-11 | Wellcome Found | Enzyme prodrug therapy |
ES2181805T3 (es) * | 1994-12-23 | 2003-03-01 | Astrazeneca Ab | Compuestos quimicos. |
PL325017A1 (en) * | 1995-08-16 | 1998-07-06 | Zeneca Ltd | Chemical compounds |
GB9523703D0 (en) | 1995-11-20 | 1996-01-24 | Wellcome Found | Enzyme prodrug thearapy |
GB9601640D0 (en) | 1996-01-26 | 1996-03-27 | Cancer Res Campaign Tech | Ligand directed enzyme prodrug therapy |
JP2000510692A (ja) * | 1996-05-04 | 2000-08-22 | ゼネカ リミテッド | Ceaに対するモノクローナル抗体、その抗体を含む結合体、およびadeptシステムにおけるそれらの治療的使用 |
CA2292760A1 (en) | 1997-06-04 | 1998-12-10 | Oxford Biomedica (Uk) Limited | Vector |
-
1997
- 1997-05-10 GB GBGB9709421.3A patent/GB9709421D0/en active Pending
-
1998
- 1998-05-05 KR KR10-1999-7010394A patent/KR100508136B1/ko not_active IP Right Cessation
- 1998-05-05 ES ES98919380T patent/ES2314990T3/es not_active Expired - Lifetime
- 1998-05-05 AT AT98919380T patent/ATE412755T1/de not_active IP Right Cessation
- 1998-05-05 JP JP54889298A patent/JP2001526539A/ja not_active Ceased
- 1998-05-05 HU HU0001931A patent/HUP0001931A3/hu not_active Application Discontinuation
- 1998-05-05 CN CNB988049295A patent/CN1268743C/zh not_active Expired - Fee Related
- 1998-05-05 PL PL98337007A patent/PL337007A1/xx unknown
- 1998-05-05 RU RU99126647/13A patent/RU2218404C2/ru active
- 1998-05-05 GB GB9922815A patent/GB2338484B/en not_active Expired - Fee Related
- 1998-05-05 NZ NZ500014A patent/NZ500014A/en unknown
- 1998-05-05 TR TR1999/02731T patent/TR199902731T2/xx unknown
- 1998-05-05 BR BR9808769-0A patent/BR9808769A/pt not_active IP Right Cessation
- 1998-05-05 US US09/423,439 patent/US6339070B1/en not_active Expired - Fee Related
- 1998-05-05 SK SK1535-99A patent/SK153599A3/sk unknown
- 1998-05-05 CA CA002286875A patent/CA2286875A1/en not_active Abandoned
- 1998-05-05 IL IL13234898A patent/IL132348A0/xx unknown
- 1998-05-05 AU AU72254/98A patent/AU734915B2/en not_active Ceased
- 1998-05-05 EP EP98919380A patent/EP0979292B1/en not_active Expired - Lifetime
- 1998-05-05 DE DE69840165T patent/DE69840165D1/de not_active Expired - Fee Related
- 1998-05-05 WO PCT/GB1998/001294 patent/WO1998051787A2/en not_active Application Discontinuation
- 1998-05-08 MY MYPI98002086A patent/MY140975A/en unknown
- 1998-05-08 ZA ZA983931A patent/ZA983931B/xx unknown
-
1999
- 1999-11-09 NO NO995475A patent/NO995475L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL132348A0 (en) | 2001-03-19 |
ES2314990T3 (es) | 2009-03-16 |
NO995475D0 (no) | 1999-11-09 |
GB9922815D0 (en) | 1999-11-24 |
ZA983931B (en) | 1998-11-10 |
NO995475L (no) | 2000-01-07 |
ATE412755T1 (de) | 2008-11-15 |
AU7225498A (en) | 1998-12-08 |
WO1998051787A3 (en) | 1999-04-01 |
JP2001526539A (ja) | 2001-12-18 |
AU734915B2 (en) | 2001-06-28 |
MY140975A (en) | 2010-02-12 |
TR199902731T2 (xx) | 2000-06-21 |
HUP0001931A3 (en) | 2003-10-28 |
EP0979292B1 (en) | 2008-10-29 |
US6339070B1 (en) | 2002-01-15 |
KR100508136B1 (ko) | 2005-08-10 |
CA2286875A1 (en) | 1998-11-19 |
PL337007A1 (en) | 2000-07-31 |
GB2338484A (en) | 1999-12-22 |
HUP0001931A2 (hu) | 2000-09-28 |
WO1998051787A2 (en) | 1998-11-19 |
CN1268743C (zh) | 2006-08-09 |
EP0979292A2 (en) | 2000-02-16 |
SK153599A3 (en) | 2000-06-12 |
GB2338484B (en) | 2001-11-07 |
KR20010012441A (ko) | 2001-02-15 |
RU2218404C2 (ru) | 2003-12-10 |
DE69840165D1 (de) | 2008-12-11 |
GB9709421D0 (en) | 1997-07-02 |
NZ500014A (en) | 2001-08-31 |
CN1255163A (zh) | 2000-05-31 |
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