CN1245974C - 卡维地洛 - Google Patents
卡维地洛 Download PDFInfo
- Publication number
- CN1245974C CN1245974C CNB018146163A CN01814616A CN1245974C CN 1245974 C CN1245974 C CN 1245974C CN B018146163 A CNB018146163 A CN B018146163A CN 01814616 A CN01814616 A CN 01814616A CN 1245974 C CN1245974 C CN 1245974C
- Authority
- CN
- China
- Prior art keywords
- carvedilol
- solvent
- chemical compound
- type
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229960004195 carvedilol Drugs 0.000 title claims abstract description 236
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 claims abstract description 71
- 230000008569 process Effects 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims description 69
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 33
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 31
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 30
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 25
- 238000006243 chemical reaction Methods 0.000 claims description 23
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 13
- 239000000376 reactant Substances 0.000 claims description 13
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- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 8
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- SVWKIGRDISDRLO-UHFFFAOYSA-N 4-(oxiran-2-ylmethoxy)-9h-carbazole Chemical compound C=1C=CC=2NC3=CC=CC=C3C=2C=1OCC1CO1 SVWKIGRDISDRLO-UHFFFAOYSA-N 0.000 claims description 5
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- OGHNVEJMJSYVRP-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2 OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 description 234
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- VLNNJWRDIPGHBE-UHFFFAOYSA-N 1-(oxiran-2-ylmethoxy)-9h-carbazole Chemical compound C=1C=CC(C2=CC=CC=C2N2)=C2C=1OCC1CO1 VLNNJWRDIPGHBE-UHFFFAOYSA-N 0.000 description 26
- 238000010438 heat treatment Methods 0.000 description 21
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
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| US24635800P | 2000-11-07 | 2000-11-07 | |
| US60/246,358 | 2000-11-07 |
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| CN 200510086095 Division CN1733727A (zh) | 2000-06-28 | 2001-06-28 | 结晶卡维地洛、其制备方法、药物组合物和制药用途 |
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| CN1449286A CN1449286A (zh) | 2003-10-15 |
| CN1245974C true CN1245974C (zh) | 2006-03-22 |
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| CNB018146163A Expired - Fee Related CN1245974C (zh) | 2000-06-28 | 2001-06-28 | 卡维地洛 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104592096A (zh) * | 2014-12-24 | 2015-05-06 | 江苏苏南药业实业有限公司 | 一种s-卡维地洛的制备方法 |
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- 2001-06-28 KR KR1020027017817A patent/KR20030017569A/ko active Search and Examination
- 2001-06-28 HU HU0301802A patent/HUP0301802A3/hu unknown
- 2001-06-28 CN CNB018146163A patent/CN1245974C/zh not_active Expired - Fee Related
- 2001-06-28 SK SK86-2003A patent/SK862003A3/sk unknown
- 2001-06-28 MX MXPA02012795A patent/MXPA02012795A/es unknown
- 2001-06-28 EP EP01950671A patent/EP1299101A4/en not_active Withdrawn
- 2001-06-28 JP JP2002504998A patent/JP2004501191A/ja active Pending
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- 2001-06-28 AU AU2001271639A patent/AU2001271639A1/en not_active Abandoned
- 2001-06-28 PL PL01365694A patent/PL365694A1/xx not_active Application Discontinuation
- 2001-06-28 KR KR1020087014587A patent/KR20080064908A/ko not_active Application Discontinuation
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- 2008-04-15 US US12/148,070 patent/US7605274B2/en not_active Expired - Fee Related
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- 2009-09-01 US US12/584,205 patent/US20090326033A1/en not_active Abandoned
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104592096A (zh) * | 2014-12-24 | 2015-05-06 | 江苏苏南药业实业有限公司 | 一种s-卡维地洛的制备方法 |
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| WO2002000216A1 (en) | 2002-01-03 |
| US7126008B2 (en) | 2006-10-24 |
| KR20030017569A (ko) | 2003-03-03 |
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| AU2001271639A1 (en) | 2002-01-08 |
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| US7605274B2 (en) | 2009-10-20 |
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| HUP0301802A3 (en) | 2009-04-28 |
| IL153688A0 (en) | 2003-07-06 |
| KR20080064908A (ko) | 2008-07-09 |
| US20080194838A1 (en) | 2008-08-14 |
| US6699997B2 (en) | 2004-03-02 |
| US7485663B2 (en) | 2009-02-03 |
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| US20090326033A1 (en) | 2009-12-31 |
| CA2413702A1 (en) | 2002-01-03 |
| HRP20030027A2 (en) | 2004-02-29 |
| KR20080015888A (ko) | 2008-02-20 |
| US7056942B2 (en) | 2006-06-06 |
| JP2004501191A (ja) | 2004-01-15 |
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