DE602005025222D1 - Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors - Google Patents
Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptorsInfo
- Publication number
- DE602005025222D1 DE602005025222D1 DE602005025222T DE602005025222T DE602005025222D1 DE 602005025222 D1 DE602005025222 D1 DE 602005025222D1 DE 602005025222 T DE602005025222 T DE 602005025222T DE 602005025222 T DE602005025222 T DE 602005025222T DE 602005025222 D1 DE602005025222 D1 DE 602005025222D1
- Authority
- DE
- Germany
- Prior art keywords
- histamine
- heterocyclic
- receptor modulators
- nonimidazole compounds
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55793604P | 2004-03-31 | 2004-03-31 | |
| PCT/US2005/010632 WO2005096734A2 (en) | 2004-03-31 | 2005-03-31 | Non-imidazole heterocyclic compounds as histamine h3 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005025222D1 true DE602005025222D1 (de) | 2011-01-20 |
Family
ID=35125517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005025222T Active DE602005025222D1 (de) | 2004-03-31 | 2005-03-31 | Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7429659B2 (de) |
| EP (1) | EP1771432B1 (de) |
| JP (1) | JP2007531755A (de) |
| CN (1) | CN1960981A (de) |
| AT (1) | ATE490959T1 (de) |
| AU (1) | AU2005231375A1 (de) |
| CA (1) | CA2561945A1 (de) |
| DE (1) | DE602005025222D1 (de) |
| MX (1) | MXPA06011410A (de) |
| WO (1) | WO2005096734A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008089485A2 (en) * | 2007-01-19 | 2008-07-24 | The Cleveland Clinic Foundation | Carboxyethylpyrrole compounds and methods of their production |
| WO2008089487A2 (en) * | 2007-01-19 | 2008-07-24 | The Cleveland Clinic Foundation | Carboxyethylpyrrole compounds and methods of their production |
| UA103468C2 (ru) | 2007-11-20 | 2013-10-25 | Янссен Фармацевтика Н.В. | Соединения циклоалкилокси- и гетероциклоалкилоксипиридина как модуляторы гистаминового рецептора н3 |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| WO2011133920A1 (en) | 2010-04-23 | 2011-10-27 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| JP5916730B2 (ja) * | 2010-09-06 | 2016-05-11 | グアンジョウ インスティテュート オブ バイオメディスン アンド ヘルス，チャイニーズ アカデミー オブ サイエンスィズ | アミド化合物 |
| TWI684450B (zh) | 2013-03-13 | 2020-02-11 | 南韓商愛思開生物製藥股份有限公司 | 猝倒症之治療 |
| WO2018089493A1 (en) * | 2016-11-08 | 2018-05-17 | Navitor Pharmaceuticals, Inc. | PYRROLE mTORC INHIBITORS AND USES THEREOF |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217986A (en) | 1992-03-26 | 1993-06-08 | Harbor Branch Oceanographic Institution, Inc. | Anti-allergy agent |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| KR100300566B1 (ko) * | 1994-09-17 | 2001-11-22 | 조생현 | 피리미디논유도체와그의제조방법및용도 |
| JPH1017564A (ja) * | 1996-07-02 | 1998-01-20 | Yamanouchi Pharmaceut Co Ltd | 新規チオフェン誘導体 |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| PE107899A1 (es) | 1997-09-09 | 1999-11-17 | Glaxo Group Ltd | Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria |
| GB9905418D0 (en) | 1999-03-09 | 1999-05-05 | Glaxo Group Ltd | Process |
| CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
| US7067507B2 (en) * | 2001-06-12 | 2006-06-27 | Pharmacia & Upjohn Company | Macrocycles useful in the treatment of Alzheimer's disease |
| AU2003301552B2 (en) | 2002-10-23 | 2010-04-22 | Janssen Pharmaceutica, N.V. | Piperazinyl and diazapanyl benzamides and benzthioamides |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| CL2004002050A1 (es) * | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
-
2005
- 2005-03-31 DE DE602005025222T patent/DE602005025222D1/de active Active
- 2005-03-31 US US11/095,225 patent/US7429659B2/en active Active
- 2005-03-31 CA CA002561945A patent/CA2561945A1/en not_active Abandoned
- 2005-03-31 EP EP05731129A patent/EP1771432B1/de active Active
- 2005-03-31 MX MXPA06011410A patent/MXPA06011410A/es active IP Right Grant
- 2005-03-31 AU AU2005231375A patent/AU2005231375A1/en not_active Abandoned
- 2005-03-31 CN CNA2005800176578A patent/CN1960981A/zh active Pending
- 2005-03-31 JP JP2007506498A patent/JP2007531755A/ja active Pending
- 2005-03-31 WO PCT/US2005/010632 patent/WO2005096734A2/en active Application Filing
- 2005-03-31 AT AT05731129T patent/ATE490959T1/de not_active IP Right Cessation
-
2008
- 2008-08-20 US US12/194,695 patent/US20080317671A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1771432A2 (de) | 2007-04-11 |
| CN1960981A (zh) | 2007-05-09 |
| MXPA06011410A (es) | 2007-04-20 |
| WO2005096734A3 (en) | 2006-04-20 |
| US7429659B2 (en) | 2008-09-30 |
| WO2005096734A2 (en) | 2005-10-20 |
| AU2005231375A1 (en) | 2005-10-20 |
| US20080317671A1 (en) | 2008-12-25 |
| EP1771432B1 (de) | 2010-12-08 |
| ATE490959T1 (de) | 2010-12-15 |
| JP2007531755A (ja) | 2007-11-08 |
| US20050222129A1 (en) | 2005-10-06 |
| CA2561945A1 (en) | 2005-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE490959T1 (de) | Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors | |
| NL301145I2 (nl) | Tirbanibulin | |
| MY146506A (en) | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor | |
| MY145305A (en) | Cyclopropyl amines as modulators of the histamine h3 receptor | |
| EA200971077A1 (ru) | Гетероциклические модуляторы киназы | |
| ECSP077360A (es) | Compuestos sulfonamida | |
| MX2009009415A (es) | Compuestos de tetrahidroisoquinolina como moduladores del receptor h3 de la histamina. | |
| EA200600203A1 (ru) | Производные 2-(хиноксалин-5-илсульфониламино)бензамида в качестве модуляторов сск2 | |
| DE602005026508D1 (de) | Monozyklische heterozyklen als kinase-hemmer | |
| NO20070908L (no) | Sammensmeltede ringheterocykelkinasemodulatorer | |
| ATE477249T1 (de) | Heteroarylbenzamidderivate zur verwendung als glk-aktivatoren bei der behandlung von diabetes | |
| DE602005009748D1 (de) | 3-phenyl-pyrazol-derivate als modulatoren des zur behandlung damit zusammenhängender störungen nützlichen 5-ht-2a-serotonin-rezeptors | |
| DK1942898T3 (da) | Dipeptidylpeptidase-inhibitorer til behandling af diabetes | |
| DE602006008945D1 (de) | Isochinolinderivate als inhibitoren von rho-kinase | |
| ATE539753T1 (de) | Pyrimidin-verbindungen als serotonin-rezeptor- modulatoren | |
| ATE412656T1 (de) | Bicyclische heterocyclen als hiv-integrase- inhibitoren | |
| DE602006017980D1 (de) | 3,4-substituierte pyrrolidin-derivate zur behandlung von hypertonie | |
| ATE447559T1 (de) | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3- carboxamid derivate als mek inhibitoren zur behandlung von hyperproliferativen erkrankungen | |
| DE602005005080D1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| ATE524467T1 (de) | Neuartige aza-heterozyklen als kinase-inhibitoren | |
| EA200700262A1 (ru) | Арилидены для лечения заболеваний, опосредуемых эстроген-родственным рецепторам альфа | |
| ATE486601T1 (de) | Verwendung von 3- (4-amino-1-oxo-1,3-dihydro- isoindol-2-yl)-piperidin--2,6-dion zur behandlung von mantelzelllymphomen | |
| EA200900091A1 (ru) | Новые показания к применению прямых ингибиторов тромбина в лечении сердечно-сосудистых заболеваний | |
| ATE512948T1 (de) | Biphenyl-sulfonyl- und phenyl-heteroaryl-sulfonyl-modulatoren des histamin-h3-rezeptors zur behandlung von damit verbundenen erkrankungen | |
| NO20080265L (no) | 2-(1H-indolylsulfanyl)-arylaminderivater |