CN1230436C - 作为GABAA受体调节剂的咪唑并[1,5－a]嘧啶并[5,4－d][1]苯并氮杂䓬衍生物 - Google Patents

作为GABAA受体调节剂的咪唑并[1,5－a]嘧啶并[5,4－d][1]苯并氮杂䓬衍生物 Download PDF

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Publication number
CN1230436C
CN1230436C CNB028101774A CN02810177A CN1230436C CN 1230436 C CN1230436 C CN 1230436C CN B028101774 A CNB028101774 A CN B028101774A CN 02810177 A CN02810177 A CN 02810177A CN 1230436 C CN1230436 C CN 1230436C
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benzo
aza
compound
imidazo
methyl
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Chinese (zh)
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CN1509289A (zh
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R·马夏德里
A·W·托马斯
J·维希曼
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB028101774A 2001-05-18 2002-05-08 作为GABAA受体调节剂的咪唑并[1,5－a]嘧啶并[5,4－d][1]苯并氮杂䓬衍生物 Expired - Fee Related CN1230436C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112222.3 2001-05-18
EP01112222 2001-05-18

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CN1509289A CN1509289A (zh) 2004-06-30
CN1230436C true CN1230436C (zh) 2005-12-07

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CNB028101774A Expired - Fee Related CN1230436C (zh) 2001-05-18 2002-05-08 作为GABAA受体调节剂的咪唑并[1,5－a]嘧啶并[5,4－d][1]苯并氮杂䓬衍生物

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US (1) US6686352B2 (https=)
EP (1) EP1399448B1 (https=)
JP (1) JP4068466B2 (https=)
KR (1) KR100533406B1 (https=)
CN (1) CN1230436C (https=)
AR (1) AR033753A1 (https=)
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CN101735211A (zh) * 2008-11-04 2010-06-16 复旦大学 2,3-二氢[1,5]苯并噻氮杂䓬类化合物或其盐在制备GSK-3β抑制剂中的用途

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ES2540987T3 (es) 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
AU2005294575B2 (en) * 2004-10-04 2011-11-24 Millennium Pharmaceuticals, Inc. Lactam compounds useful as protein kinase inhibitors
ES2399439T3 (es) * 2004-10-20 2013-04-01 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina
AU2005299031B2 (en) * 2004-10-20 2011-11-10 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
KR101009860B1 (ko) * 2005-10-11 2011-01-19 에프. 호프만-라 로슈 아게 이미다조 벤조다이아제핀 유도체
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
US7998952B2 (en) 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CA2788774A1 (en) 2010-02-19 2011-08-25 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6987384B2 (ja) 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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FR2607503B1 (fr) * 1986-12-02 1989-02-24 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
TW201311B (https=) 1991-06-17 1993-03-01 Hoffmann La Roche
RU2119496C1 (ru) * 1992-04-14 1998-09-27 Научно-исследовательский институт фармакологии Российской академии медицинских наук Производные n-ацилпролилдипептидов
FR2728902B1 (fr) * 1994-12-29 1997-01-31 Synthelabo Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique
WO1999043682A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
US6177569B1 (en) * 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
CN1390217A (zh) 1999-11-12 2003-01-08 神经原公司 二环和三环杂芳族化合物
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101735211A (zh) * 2008-11-04 2010-06-16 复旦大学 2,3-二氢[1,5]苯并噻氮杂䓬类化合物或其盐在制备GSK-3β抑制剂中的用途
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途

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KR100533406B1 (ko) 2005-12-02
PE20030041A1 (es) 2003-02-07
WO2002094834A1 (en) 2002-11-28
ZA200308544B (en) 2005-01-31
EP1399448A1 (en) 2004-03-24
YU90003A (sh) 2006-08-17
HRP20030890A2 (en) 2005-08-31
IL158572A (en) 2010-02-17
AU2002338898B8 (en) 2002-12-03
NO20035104D0 (no) 2003-11-17
SK15252003A3 (sk) 2004-08-03
JO2297B1 (en) 2005-09-12
US20030055042A1 (en) 2003-03-20
IL158572A0 (en) 2004-05-12
DE60202147D1 (de) 2005-01-05
MY127570A (en) 2006-12-29
JP2004531563A (ja) 2004-10-14
AU2002338898B2 (en) 2007-03-15
ECSP034851A (es) 2003-12-24
SI1399448T1 (en) 2005-02-28
HUP0400743A3 (en) 2007-09-28
CA2446903A1 (en) 2002-11-28
BG108369A (bg) 2005-01-31
PA8545201A1 (es) 2003-02-28
US6686352B2 (en) 2004-02-03
MA27024A1 (fr) 2004-12-20
PT1399448E (pt) 2005-03-31
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29
TWI251489B (en) 2006-03-21
HUP0400743A2 (hu) 2004-07-28
CN1509289A (zh) 2004-06-30
RU2287531C2 (ru) 2006-11-20
GT200200087A (es) 2003-06-19
ES2232778T3 (es) 2005-06-01
DK1399448T3 (da) 2005-04-11
JP4068466B2 (ja) 2008-03-26
DE60202147T2 (de) 2005-12-01
CA2446903C (en) 2008-12-30
EP1399448B1 (en) 2004-12-01
NO20035104L (no) 2003-11-17
KR20040002975A (ko) 2004-01-07
AR033753A1 (es) 2004-01-07
RU2003136078A (ru) 2005-05-27
BR0209859A (pt) 2004-06-15
ATE283857T1 (de) 2004-12-15
CZ20033355A3 (en) 2004-07-14
HK1066544A1 (en) 2005-03-24
PL366846A1 (en) 2005-02-07

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