CN1090631C - 新的杂环化合物、其制备方法和含有它们的药物组合物 - Google Patents
新的杂环化合物、其制备方法和含有它们的药物组合物 Download PDFInfo
- Publication number
- CN1090631C CN1090631C CN98116645A CN98116645A CN1090631C CN 1090631 C CN1090631 C CN 1090631C CN 98116645 A CN98116645 A CN 98116645A CN 98116645 A CN98116645 A CN 98116645A CN 1090631 C CN1090631 C CN 1090631C
- Authority
- CN
- China
- Prior art keywords
- dihydro
- compound
- branched
- straight
- selectivity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
受体或位点 | 放射性配体 | 非特异性 | 组织 |
I1 | [3H]可乐定+10μM去甲肾上腺素 | 10-5M可乐定 | 牛外侧网状核 |
I2 | [3H]咪唑克生+10μM去甲肾上腺素 | 10-5咪唑克生 | 兔肾皮质 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9709709A FR2766824B1 (fr) | 1997-07-30 | 1997-07-30 | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR9709709 | 1997-07-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1206712A CN1206712A (zh) | 1999-02-03 |
CN1090631C true CN1090631C (zh) | 2002-09-11 |
Family
ID=9509815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98116645A Expired - Fee Related CN1090631C (zh) | 1997-07-30 | 1998-07-29 | 新的杂环化合物、其制备方法和含有它们的药物组合物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US6057317A (zh) |
EP (1) | EP0894796B1 (zh) |
JP (1) | JPH1192476A (zh) |
CN (1) | CN1090631C (zh) |
AT (1) | ATE201871T1 (zh) |
AU (1) | AU736460B2 (zh) |
BR (1) | BR9802803A (zh) |
CA (1) | CA2244435A1 (zh) |
DE (1) | DE69800883T2 (zh) |
DK (1) | DK0894796T3 (zh) |
ES (1) | ES2159921T3 (zh) |
FR (1) | FR2766824B1 (zh) |
GR (1) | GR3036474T3 (zh) |
HK (1) | HK1017685A1 (zh) |
HU (1) | HUP9801713A1 (zh) |
NO (1) | NO311256B1 (zh) |
NZ (1) | NZ331154A (zh) |
PL (1) | PL327747A1 (zh) |
PT (1) | PT894796E (zh) |
ZA (1) | ZA986815B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2799757B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7763610B2 (en) | 2003-09-01 | 2010-07-27 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derived benzoxazines as agents for the treatment of respiratory diseases |
CN1845911B (zh) * | 2003-09-01 | 2012-07-04 | 小野药品工业株式会社 | 稠环化合物及其应用 |
US20070197512A1 (en) * | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
WO2007086504A1 (ja) * | 2006-01-27 | 2007-08-02 | Japan Tobacco Inc. | カルボン酸化合物及びその用途 |
TWI469965B (zh) * | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
WO2011162222A1 (ja) | 2010-06-21 | 2011-12-29 | 小野薬品工業株式会社 | 4,4'-[4-フルオロ-7-({4-[4-(3-フルオロ-2-メチルフェニル)ブトキシ]フェニル}エチニル)-2-メチル-1h-インドール-1,3-ジイル]ジブタン酸、4,4'-[2-メチル-7-({4-[4-(ペンタフルオロフェニル)ブトキシ]フェニル}エチニル)-1h-インドール-1,3-ジイル]ジブタン酸および4,4'-[4-フルオロ-2-メチル-7-({4-[4-(2,3,4,6-テトラフルオロフェニル)ブトキシ]フェニル}エチニル)-1h-インドール-1,3-ジイル]ジブタン酸の新規結晶形 |
US9216998B2 (en) * | 2012-02-15 | 2015-12-22 | Janssen Pharmaceutica Nv | Tricyclic indole derivatives useful endothelial lipase inhibitors |
RU2687979C1 (ru) * | 2018-03-19 | 2019-05-17 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ коррекции стрептозотоцин-индуцированного сахарного диабета у крыс с использованием лекарственного средства на основе амида гетероциклических кислот |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ199469A (en) * | 1981-01-30 | 1984-03-16 | Reckitt & Colmann Prod Ltd | Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions |
US4436914A (en) * | 1981-08-03 | 1984-03-13 | Kluge Arthur F | Benzodioxane-imidazoline compounds as antihypertensives |
NZ203680A (en) * | 1982-04-17 | 1985-08-16 | Reckitt & Colmann Prod Ltd | Imidazolines and pharmaceutical compositions |
-
1997
- 1997-07-30 FR FR9709709A patent/FR2766824B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-20 US US09/119,423 patent/US6057317A/en not_active Expired - Fee Related
- 1998-07-28 NO NO19983478A patent/NO311256B1/no not_active IP Right Cessation
- 1998-07-28 EP EP98401919A patent/EP0894796B1/fr not_active Expired - Lifetime
- 1998-07-28 AT AT98401919T patent/ATE201871T1/de not_active IP Right Cessation
- 1998-07-28 DE DE69800883T patent/DE69800883T2/de not_active Expired - Fee Related
- 1998-07-28 PT PT98401919T patent/PT894796E/pt unknown
- 1998-07-28 ES ES98401919T patent/ES2159921T3/es not_active Expired - Lifetime
- 1998-07-28 DK DK98401919T patent/DK0894796T3/da active
- 1998-07-29 CN CN98116645A patent/CN1090631C/zh not_active Expired - Fee Related
- 1998-07-29 JP JP10213603A patent/JPH1192476A/ja active Pending
- 1998-07-29 NZ NZ331154A patent/NZ331154A/xx unknown
- 1998-07-29 HU HU9801713A patent/HUP9801713A1/hu unknown
- 1998-07-29 CA CA002244435A patent/CA2244435A1/fr not_active Abandoned
- 1998-07-29 PL PL98327747A patent/PL327747A1/xx unknown
- 1998-07-30 AU AU78609/98A patent/AU736460B2/en not_active Ceased
- 1998-07-30 ZA ZA986815A patent/ZA986815B/xx unknown
- 1998-07-30 BR BR9802803A patent/BR9802803A/pt not_active IP Right Cessation
-
1999
- 1999-07-05 HK HK99102823A patent/HK1017685A1/xx not_active IP Right Cessation
-
2001
- 2001-08-30 GR GR20010401333T patent/GR3036474T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6057317A (en) | 2000-05-02 |
NZ331154A (en) | 1999-05-28 |
JPH1192476A (ja) | 1999-04-06 |
FR2766824A1 (fr) | 1999-02-05 |
PT894796E (pt) | 2001-09-28 |
DE69800883T2 (de) | 2002-03-28 |
NO983478D0 (no) | 1998-07-28 |
AU736460B2 (en) | 2001-07-26 |
DE69800883D1 (de) | 2001-07-12 |
EP0894796B1 (fr) | 2001-06-06 |
DK0894796T3 (da) | 2001-09-03 |
GR3036474T3 (en) | 2001-11-30 |
FR2766824B1 (fr) | 1999-09-10 |
HU9801713D0 (en) | 1998-09-28 |
HUP9801713A1 (hu) | 1999-12-28 |
CA2244435A1 (fr) | 1999-01-30 |
CN1206712A (zh) | 1999-02-03 |
BR9802803A (pt) | 2000-03-21 |
ATE201871T1 (de) | 2001-06-15 |
ES2159921T3 (es) | 2001-10-16 |
NO983478L (no) | 1999-02-01 |
EP0894796A1 (fr) | 1999-02-03 |
PL327747A1 (en) | 1999-02-01 |
NO311256B1 (no) | 2001-11-05 |
HK1017685A1 (en) | 1999-11-26 |
ZA986815B (en) | 1999-02-02 |
AU7860998A (en) | 1999-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
CI01 | Publication of corrected invention patent application |
Correction item: Inventor Correct: G. Jiyomete|J-Y may Rolle|F. Tozeor|B Pfeiffer|Renard Pierre|Scalbert Elizabeth False: G. Jiyomete|J-Y may Rolle|F. Tozeor Number: 5 Page: 29 Volume: 15 |
|
ERR | Gazette correction |
Free format text: CORRECT: INVENTOR; FROM: G. JIYOMETE J-Y.MEIROY F.TUZEO TO: G. JIYOMETE J-Y.MEIROY F.TUZEO B METHODYIFU P. RENARD E SHIKAERBAITE |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Applicant after: Laboratoires Therwill Applicant before: Adir Et Compagnie |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: ADIR ET CO. TO: SERVIER LAB |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |