ATE201871T1 - Durch einen heterocyclischen ring substituierte imidazoline als alpha-2 antagonisten - Google Patents
Durch einen heterocyclischen ring substituierte imidazoline als alpha-2 antagonistenInfo
- Publication number
- ATE201871T1 ATE201871T1 AT98401919T AT98401919T ATE201871T1 AT E201871 T1 ATE201871 T1 AT E201871T1 AT 98401919 T AT98401919 T AT 98401919T AT 98401919 T AT98401919 T AT 98401919T AT E201871 T1 ATE201871 T1 AT E201871T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- alkyl
- substituted
- cycloalkyl
- alkoxy
- Prior art date
Links
- 239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 title 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical group C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 Heterocyclic imidazoline derivatives Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004385 trihaloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9709709A FR2766824B1 (fr) | 1997-07-30 | 1997-07-30 | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201871T1 true ATE201871T1 (de) | 2001-06-15 |
Family
ID=9509815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98401919T ATE201871T1 (de) | 1997-07-30 | 1998-07-28 | Durch einen heterocyclischen ring substituierte imidazoline als alpha-2 antagonisten |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6057317A (de) |
| EP (1) | EP0894796B1 (de) |
| JP (1) | JPH1192476A (de) |
| CN (1) | CN1090631C (de) |
| AT (1) | ATE201871T1 (de) |
| AU (1) | AU736460B2 (de) |
| BR (1) | BR9802803A (de) |
| CA (1) | CA2244435A1 (de) |
| DE (1) | DE69800883T2 (de) |
| DK (1) | DK0894796T3 (de) |
| ES (1) | ES2159921T3 (de) |
| FR (1) | FR2766824B1 (de) |
| GR (1) | GR3036474T3 (de) |
| HU (1) | HUP9801713A1 (de) |
| NO (1) | NO311256B1 (de) |
| NZ (1) | NZ331154A (de) |
| PL (1) | PL327747A1 (de) |
| PT (1) | PT894796E (de) |
| ZA (1) | ZA986815B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2799757B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN1845911B (zh) * | 2003-09-01 | 2012-07-04 | 小野药品工业株式会社 | 稠环化合物及其应用 |
| KR101135911B1 (ko) * | 2003-09-01 | 2012-04-16 | 오노 야꾸힝 고교 가부시키가이샤 | 축합 고리 화합물 및 그 용도 |
| WO2007086504A1 (ja) * | 2006-01-27 | 2007-08-02 | Japan Tobacco Inc. | カルボン酸化合物及びその用途 |
| US20070197512A1 (en) * | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
| TWI469965B (zh) * | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| CN103080085B (zh) | 2010-06-21 | 2014-08-13 | 小野药品工业株式会社 | 4,4’-[4-氟-7-({4-[4-(3-氟-2-甲基苯基)丁氧基]苯基}乙炔基)-2-甲基-1h-吲哚-1,3-二基]二丁酸的新晶型 |
| US9216998B2 (en) * | 2012-02-15 | 2015-12-22 | Janssen Pharmaceutica Nv | Tricyclic indole derivatives useful endothelial lipase inhibitors |
| RU2687979C1 (ru) * | 2018-03-19 | 2019-05-17 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ коррекции стрептозотоцин-индуцированного сахарного диабета у крыс с использованием лекарственного средства на основе амида гетероциклических кислот |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199469A (en) * | 1981-01-30 | 1984-03-16 | Reckitt & Colmann Prod Ltd | Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions |
| US4436914A (en) * | 1981-08-03 | 1984-03-13 | Kluge Arthur F | Benzodioxane-imidazoline compounds as antihypertensives |
| NZ203680A (en) * | 1982-04-17 | 1985-08-16 | Reckitt & Colmann Prod Ltd | Imidazolines and pharmaceutical compositions |
-
1997
- 1997-07-30 FR FR9709709A patent/FR2766824B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-20 US US09/119,423 patent/US6057317A/en not_active Expired - Fee Related
- 1998-07-28 AT AT98401919T patent/ATE201871T1/de not_active IP Right Cessation
- 1998-07-28 NO NO19983478A patent/NO311256B1/no not_active IP Right Cessation
- 1998-07-28 PT PT98401919T patent/PT894796E/pt unknown
- 1998-07-28 DK DK98401919T patent/DK0894796T3/da active
- 1998-07-28 ES ES98401919T patent/ES2159921T3/es not_active Expired - Lifetime
- 1998-07-28 DE DE69800883T patent/DE69800883T2/de not_active Expired - Fee Related
- 1998-07-28 EP EP98401919A patent/EP0894796B1/de not_active Expired - Lifetime
- 1998-07-29 CN CN98116645A patent/CN1090631C/zh not_active Expired - Fee Related
- 1998-07-29 PL PL98327747A patent/PL327747A1/xx unknown
- 1998-07-29 NZ NZ331154A patent/NZ331154A/xx unknown
- 1998-07-29 CA CA002244435A patent/CA2244435A1/fr not_active Abandoned
- 1998-07-29 HU HU9801713A patent/HUP9801713A1/hu unknown
- 1998-07-29 JP JP10213603A patent/JPH1192476A/ja active Pending
- 1998-07-30 AU AU78609/98A patent/AU736460B2/en not_active Ceased
- 1998-07-30 BR BR9802803A patent/BR9802803A/pt not_active IP Right Cessation
- 1998-07-30 ZA ZA986815A patent/ZA986815B/xx unknown
-
2001
- 2001-08-30 GR GR20010401333T patent/GR3036474T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7860998A (en) | 1999-02-11 |
| AU736460B2 (en) | 2001-07-26 |
| CA2244435A1 (fr) | 1999-01-30 |
| HU9801713D0 (en) | 1998-09-28 |
| FR2766824A1 (fr) | 1999-02-05 |
| CN1090631C (zh) | 2002-09-11 |
| CN1206712A (zh) | 1999-02-03 |
| NO311256B1 (no) | 2001-11-05 |
| NO983478L (no) | 1999-02-01 |
| GR3036474T3 (en) | 2001-11-30 |
| PL327747A1 (en) | 1999-02-01 |
| EP0894796B1 (de) | 2001-06-06 |
| DE69800883D1 (de) | 2001-07-12 |
| ZA986815B (en) | 1999-02-02 |
| DE69800883T2 (de) | 2002-03-28 |
| HK1017685A1 (en) | 1999-11-26 |
| DK0894796T3 (da) | 2001-09-03 |
| BR9802803A (pt) | 2000-03-21 |
| EP0894796A1 (de) | 1999-02-03 |
| US6057317A (en) | 2000-05-02 |
| NZ331154A (en) | 1999-05-28 |
| NO983478D0 (no) | 1998-07-28 |
| ES2159921T3 (es) | 2001-10-16 |
| FR2766824B1 (fr) | 1999-09-10 |
| JPH1192476A (ja) | 1999-04-06 |
| PT894796E (pt) | 2001-09-28 |
| HUP9801713A1 (hu) | 1999-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |