ATE148463T1 - N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents

N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Info

Publication number
ATE148463T1
ATE148463T1 AT90916723T AT90916723T ATE148463T1 AT E148463 T1 ATE148463 T1 AT E148463T1 AT 90916723 T AT90916723 T AT 90916723T AT 90916723 T AT90916723 T AT 90916723T AT E148463 T1 ATE148463 T1 AT E148463T1
Authority
AT
Austria
Prior art keywords
pct
substituted
azazyclic
acyl
compounds
Prior art date
Application number
AT90916723T
Other languages
English (en)
Inventor
Roberto Dr Lo Zambeletti Colle
Giulio Dr Lo Zambeletti Dondio
Guiseppe Dr Lo Zambel Giardina
Lorenzo Dr Lo Zambelet Leurini
Vittorio Dr Lo Zamb Vecchietti
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926561A external-priority patent/GB8926561D0/en
Priority claimed from GB909003137A external-priority patent/GB9003137D0/en
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Application granted granted Critical
Publication of ATE148463T1 publication Critical patent/ATE148463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT90916723T 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel ATE148463T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898926561A GB8926561D0 (en) 1989-11-24 1989-11-24 Novel compounds
GB909003137A GB9003137D0 (en) 1990-02-12 1990-02-12 Novel compounds

Publications (1)

Publication Number Publication Date
ATE148463T1 true ATE148463T1 (de) 1997-02-15

Family

ID=26296247

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90916723T ATE148463T1 (de) 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Country Status (12)

Country Link
US (1) US5322848A (de)
EP (1) EP0501997B1 (de)
JP (1) JPH05501551A (de)
KR (1) KR927003571A (de)
AT (1) ATE148463T1 (de)
AU (1) AU641955B2 (de)
CA (1) CA2069423A1 (de)
DE (1) DE69029861T2 (de)
IE (1) IE904230A1 (de)
NZ (1) NZ236186A (de)
PT (1) PT95963A (de)
WO (1) WO1991008206A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2081351A1 (en) * 1990-04-28 1991-10-29 Vittorio Vecchietti 1-(2h-1-oxo-3, 4-dihydronaphtyl-6) -acetyl-piperidines, process for their preparation and therapeutic use
EP0585296A1 (de) * 1991-05-21 1994-03-09 Smithkline Beecham Farmaceutici S.p.A. 2-(pyrrolidinyl-1-methyl)-piperidinderivate und ihre verwendung als kappa-rezeptor-agonisten
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
DE4407047A1 (de) * 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
US6750216B2 (en) 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
CN101677997B (zh) 2007-03-30 2012-05-09 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0261842B1 (de) * 1986-09-17 1990-11-22 Dr. Lo. Zambeletti S.p.A. N-1-acylierte-[1-(phenyl- oder benzyl-)]-1,2-Äthylendiamine
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
GB8804104D0 (en) * 1988-02-23 1988-03-23 Glaxo Group Ltd Chemical compounds
EP0330467A1 (de) * 1988-02-23 1989-08-30 Glaxo Group Limited Heterocyclische Verbindungen
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
NZ228331A (en) * 1988-03-16 1991-10-25 Zambeletti Spa L Amine- and amido-containing heterocyclic compounds and pharmaceutical compositions
EP0361791B1 (de) * 1988-09-26 1995-11-08 Smithkline Beecham Farmaceutici S.p.A. Azacyclische Verbindungen, verwendbar als Arzneimittel
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
NZ236186A (en) 1993-09-27
US5322848A (en) 1994-06-21
AU641955B2 (en) 1993-10-07
CA2069423A1 (en) 1991-05-25
KR927003571A (ko) 1992-12-18
PT95963A (pt) 1991-09-30
EP0501997A1 (de) 1992-09-09
DE69029861D1 (de) 1997-03-13
IE904230A1 (en) 1991-06-05
AU6723190A (en) 1991-06-26
WO1991008206A1 (en) 1991-06-13
JPH05501551A (ja) 1993-03-25
DE69029861T2 (de) 1997-07-10
EP0501997B1 (de) 1997-01-29

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties