ATE148463T1 - N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents

N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Info

Publication number
ATE148463T1
ATE148463T1 AT90916723T AT90916723T ATE148463T1 AT E148463 T1 ATE148463 T1 AT E148463T1 AT 90916723 T AT90916723 T AT 90916723T AT 90916723 T AT90916723 T AT 90916723T AT E148463 T1 ATE148463 T1 AT E148463T1
Authority
AT
Austria
Prior art keywords
pct
substituted
azazyclic
acyl
compounds
Prior art date
Application number
AT90916723T
Other languages
English (en)
Inventor
Roberto Dr Lo Zambeletti Colle
Giulio Dr Lo Zambeletti Dondio
Guiseppe Dr Lo Zambel Giardina
Lorenzo Dr Lo Zambelet Leurini
Vittorio Dr Lo Zamb Vecchietti
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926561A external-priority patent/GB8926561D0/en
Priority claimed from GB909003137A external-priority patent/GB9003137D0/en
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Application granted granted Critical
Publication of ATE148463T1 publication Critical patent/ATE148463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT90916723T 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel ATE148463T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898926561A GB8926561D0 (en) 1989-11-24 1989-11-24 Novel compounds
GB909003137A GB9003137D0 (en) 1990-02-12 1990-02-12 Novel compounds

Publications (1)

Publication Number Publication Date
ATE148463T1 true ATE148463T1 (de) 1997-02-15

Family

ID=26296247

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90916723T ATE148463T1 (de) 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Country Status (12)

Country Link
US (1) US5322848A (de)
EP (1) EP0501997B1 (de)
JP (1) JPH05501551A (de)
KR (1) KR927003571A (de)
AT (1) ATE148463T1 (de)
AU (1) AU641955B2 (de)
CA (1) CA2069423A1 (de)
DE (1) DE69029861T2 (de)
IE (1) IE904230A1 (de)
NZ (1) NZ236186A (de)
PT (1) PT95963A (de)
WO (1) WO1991008206A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506650A (ja) * 1990-04-28 1993-09-30 スミスクライン　ビーチャム　ファルマシューティッチ　エッセ　ピ　ア アザ環式誘導体
JPH06511231A (ja) * 1991-05-21 1994-12-15 スミスクライン・ビーチャム・ファーマシューティチ・ソシエタ・ペル・アチオニ ２−（ピロリジニル−１−メチル）−ピペリジン誘導体およびκ受容体アゴニストとしてのその使用
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
DE4407047A1 (de) * 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
US6750216B2 (en) 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
KR101208326B1 (ko) 2007-03-30 2012-12-05 티오가 파마슈티칼스, 인코포레이티드 설사-우세형 및 교대형 과민성 장 증후군의 치료를 위한 카파-아편제 작용제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0261842B1 (de) * 1986-09-17 1990-11-22 Dr. Lo. Zambeletti S.p.A. N-1-acylierte-[1-(phenyl- oder benzyl-)]-1,2-Äthylendiamine
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
KR890012970A (ko) * 1988-02-23 1989-09-20 추후보충 테트라히드로 이소퀴놀린 유도체
EP0330467A1 (de) * 1988-02-23 1989-08-30 Glaxo Group Limited Heterocyclische Verbindungen
GB8804104D0 (en) * 1988-02-23 1988-03-23 Glaxo Group Ltd Chemical compounds
US4999359A (en) * 1988-03-16 1991-03-12 Dr. Lo Zambeletti S.P.A. Heterocyclic ethylene diamine compounds and their pharmaceutical compositions and methods
EP0361791B1 (de) * 1988-09-26 1995-11-08 Smithkline Beecham Farmaceutici S.p.A. Azacyclische Verbindungen, verwendbar als Arzneimittel
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
US5322848A (en) 1994-06-21
JPH05501551A (ja) 1993-03-25
AU6723190A (en) 1991-06-26
KR927003571A (ko) 1992-12-18
AU641955B2 (en) 1993-10-07
PT95963A (pt) 1991-09-30
IE904230A1 (en) 1991-06-05
WO1991008206A1 (en) 1991-06-13
DE69029861D1 (de) 1997-03-13
EP0501997A1 (de) 1992-09-09
CA2069423A1 (en) 1991-05-25
DE69029861T2 (de) 1997-07-10
NZ236186A (en) 1993-09-27
EP0501997B1 (de) 1997-01-29

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Legal Events

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